Teacher(s)

Riant Olivier; Singleton Michael;

Language

French

Prerequisites

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.

Main themes

The thermodynamic and kinetic aspects will be reintroduced and completed by notions of reaction control. The electronic effects will be discussed again and linked to the notions of stabilisation of charges and to acid-basic properties of certain classes of organic functions. The HSAB concept will also be introduced and connected to the concepts of electronegativity and polarization. These principles will be applied to aromatic chemistry and the control of orientation in electrophilic aromatic substitution reactions will be developed and applied to concrete problems of everyday's life (paracetamol, ibuprofen, ..). The chemistry of nitrogen will introduce the main classes of functions carrying these heteroatoms as well as their presence in biological molecules (DNA, peptides, ATP, '). A deeper understanding of the mechanisms and the notions of orientation and selectivity will be reached by the study of the main classes of reactions involving the chemistry of these heteroatoms. The interconversions between these functional groups will be completed by the notions of organic intermediates carrying heteroatoms. The knowledge of organic synthesis for the construction of molecules will also be used to illustrate the course in different fields of everyday's life. Introduction to the notion of carbanions. Physico-chemistry and structures. Stabilizing effects. Chemistry of enolates and carbanions will be reintroduced and deepened in the aspects of preparation, reactivity and selectivity. Alkylation reactions, aldol condensations and Michael reaction. Chemistry of unstable organometallics. The organomagnesium, organolithium and organocuprates. Duality between base and nucleophile. Applications in the creation of carbon-carbon bonds. Comparison between different organometallic families.

Faculty or entity

CHIM