wfarm2501  2020-2021  Bruxelles Woluwe

Due to the COVID-19 crisis, the information below is subject to change, in particular that concerning the teaching mode (presential, distance or in a comodal or hybrid format).
3 credits
22.5 h
Q2
Teacher(s)
Frédérick Raphaël; Frédérick Raphaël (compensates Lambert Didier); Lambert Didier; Muccioli Giulio (coordinator);
Language
French
Prerequisites
organic chemistry and medicinal chemistry
Main themes
The general theme is drug discovery / drug design. During this EU the students will approach one or more drug discovery / drug design methodologies of their choice through a work allowing the deepening of the chosen techniques / methods. 
In addition, all students participating in the EU will have the opportunity to have an overview of these methods through the presentation of each student's work.
In a non-exhaustive way the students will have the opportunity to deepen, according to their interest, techniques allowing the identification of hits for a given target (high throughput screening; computer-aided design (de novo design), ...), hit-to-lead strategies (e.g. structure-activity relationships; docking; etc).  
Aims

At the end of this learning unit, the student is able to :

1
  • To interpret the results of a scientific article dealing with the development of a medication
    To propose a strategy to identify a new potential therapeutic target
    To propose a strategy to identify new leads for a given target (receptor, enzyme)
    To propose a strategy to optimize the activity of a compound for its target.
    To present orally a "fictitious" research project based on the theme chosen.
 
Content
  • Lipidomics applied to the discovery of novel targets
  • Exploring the proteome looking for novel targets :  the enzymes ' the receptors
  • Proteins as therapeutic target
    • Determination of their 3D structure
    • Role of protein's 3D models in drug design
  • The interest of establishing structure-activity relationships in drug design
Faculty or entity
FARM


Programmes / formations proposant cette unité d'enseignement (UE)

Title of the programme
Sigle
Credits
Prerequisites
Aims
Master [120] in Pharmacy