wfarm2501  2020-2021  Bruxelles Woluwe

Due to the COVID-19 crisis, the information below is subject to change, in particular that concerning the teaching mode (presential, distance or in a comodal or hybrid format).
3 credits
22.5 h
Q2
Teacher(s)
Frédérick Raphaël; Frédérick Raphaël (compensates Lambert Didier); Lambert Didier; Muccioli Giulio (coordinator);
Language
French
Prerequisites
organic chemistry and medicinal chemistry
Main themes
The general theme is drug discovery / drug design. During this EU the students will approach one or more drug discovery / drug design methodologies of their choice through a work allowing the deepening of the chosen techniques / methods. 
In addition, all students participating in the EU will have the opportunity to have an overview of these methods through the presentation of each student's work.
In a non-exhaustive way the students will have the opportunity to deepen, according to their interest, techniques allowing the identification of hits for a given target (high throughput screening; computer-aided design (de novo design), ...), hit-to-lead strategies (e.g. structure-activity relationships; docking; etc).  
Aims

At the end of this learning unit, the student is able to :

1
  • To interpret the results of a scientific article dealing with the development of a medication
    To propose a strategy to identify a new potential therapeutic target
    To propose a strategy to identify new leads for a given target (receptor, enzyme)
    To propose a strategy to optimize the activity of a compound for its target.
    To present orally a "fictitious" research project based on the theme chosen.
 

The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
  • Lipidomics applied to the discovery of novel targets
  • Exploring the proteome looking for novel targets :  the enzymes ' the receptors
  • Proteins as therapeutic target
    • Determination of their 3D structure
    • Role of protein's 3D models in drug design
  • The interest of establishing structure-activity relationships in drug design
Faculty or entity


Programmes / formations proposant cette unité d'enseignement (UE)

Title of the programme
Sigle
Credits
Prerequisites
Aims
Master [120] in Pharmacy