At the end of this learning unit, the student is able to :
At the end of this course, the students will be able :
(1) to understand and to explain the cellular and molecular mechanisms influenced by nutrients (e.g.: different type of lipids, proteins and amino acids, specific carbohydrates) and their cellular metabolites (e.g.: ceramides, DAG, endocannabinoids, ...),
(2) to describe the mechanisms regulating gene expression directly connected with energy, glucose and lipid metabolism,
(3) to understand the key features regulating physiology and metabolism and that may be involved in the onset of specific pathological disorders such as obesity, type 2 diabetes, metabolic inflammation, cardiovascular diseases, pancreatic and hepatic diseases.
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
(1) understand and explain the molecular and cellular mechanisms influenced by various nutrients, by the gut microbiota and certain cellular metabolites
(2) describe the mechanisms regulating the expression of different genes directly involved in energy, carbohydrates and lipid metabolism, and
(3) understand the key physiological regulations of metabolism and also understand the mechanisms involved in triggering different pathologies such as obesity, type 2 diabetes, metabolic inflammation, cardio-metabolic disorders, pancreatic and hepatic diseases.
The course focuses on the mechanisms involved in the regulation of cellular/molecular activities and metabolism. The molecular and cellular mechanisms influenced by various kinds of energetic or non-energetic nutrients (for example: different types of lipids, proteins and amino acids, specific carbohydrates, vitamins and trace elements) or the impact of the intestinal microbiota and related metabolites are being studied.
More precisely, the different professors address both molecular aspects and the regulation of different membrane and nuclear receptors, but also various transcription factors directly regulated by nutrients (for example: PPAR's, LXR, chREBP, TLR's, GPR40 / 120 / 119/ 41/ 43) as well as the regulatory mechanisms of certain signaling pathways involved in energy, lipid and carbohydrate homeostasis (eg: insulin, AMPK, mTOR, etc.).
Due to the COVID-19 crisis, the information in this section is particularly likely to change.The course will be fully given in the auditorium.
The team of teachers is composed of professors that have a specific knowledge and complementary expertise in molecular and cellular aspects. Each member of the team will teach themes that are in his field of expertise and for some of them directly developed in their research practice. It is worth noting that this will be coordinated between the different members of the teaching team in order to integrate as much as possible all the different aspects of the course. Finally, this approach will help to maintain the content of the course relatively up to date in this fast moving field.
Due to the COVID-19 crisis, the information in this section is particularly likely to change.Written exam on all parts of the course. The student should provide criticism and integrate the different themes addressed during the course