ASS
Avenue Mounier 50/B1.50.02
1200 Woluwe-Saint-Lambert
Christophe Depoix
EDUCATION
PhD in Molecular Biology January, 2002
University of Lille, FRANCEMSc in Molecular Biology June, 1998
University of Lille, FRANCEBSc in Cellular biology June, 1995
University of Lille, FRANCEPROFESSIONAL EXPERIENCE
RESEARCH PROJECT COORDINATOR February 2022-Present
Responsibilities: supporting the UCLouvain researchers of the health sciences sector (SSS).
Duties:
International (and national) grant applications
Participating in the grant preparation—Coordinating a virtual unit (team) bringing together the various administrative and scientific people (ADRE, ADFI, ARH, CTC, the Ethical Committee, Hospitals, Biobanks)—Communicating with the funding agencies—Ensuring that the grant proposal submission deadlines are respected.
Coordination of accepted research projects
Communicating and answering the questions of the funding agency (ex: EU commission) concerning the project—Coordinating the participation of the consortium’s partners—Scheduling/organizing the Technical Committee meetings and preparing their minutes—Ensuring the proper completion and on time submission of the financial and technical reports by all the consortium partners—Ensuring the correct submission of deliverables.
Local representative of uclouvain research office (adre)
Relaying ADRE’s messages and enabling a better targeting of opening announcements for funding applications
Single point of contact for the various departments of the central administration
Finding the answers to researchers’ questions or redirecting them to the right persons in the central administration concerning research (ADRE), finance (ADFI), staff management (ARH), international relations (ADRI)… Example: use of resources for the recruitment of PhD candidates/postdoc/technicians, work contracts, work or student visa applications, etc.
Others
Proposing solutions to promoters to facilitate project management (connecting with clinical research organizations, improving coordination with the various offices of the central administration, setting up a database of documents such as the DMPs)—Optimizing and record keeping of the procedures—Knowing and applying the regulatory constraints related to research project managementSENIOR SCIENTIST May 2009-present
Department of Obstetrics, Catholic University of Louvain, Institute of Experimental and Clinical Research, Brussels, Belgium
Laboratory management: Setting up of a cell culture laboratory, Reorganization of the laboratory, Supervision of one research assistant, 9 bachelor, 2 master and 2 PhD students, Equipment, reagent and consumables inventory management, Daily laboratory operations.
Research Project Development: Effects of oxygen tension on trophoblast syncytialisation, Effects of chemotherapy on placental development during pregnancy.INSTRUCTOR (faculty member) October 2005-April 2009
Department of Gynecology and Obstetrics, Emory University, School of Medicine, Atlanta, Georgia, USA
Endometriosis and placental angiogenesis: Deciphering the molecular interactions controlling the expression of genes coding for proteins that are potential pharmaceutical targets in diseases affecting women reproduction, in particular the nuclear receptors controlling the lipid metabolism and inflammation in the placenta and the endometriumPOSTDOCTORAL FELLOW November 2002-September 2005
Center for Reproductive Sciences, University of California at San Francisco, California, USA
Principal Investigator: Pr. Synthia Mellon
Role of SET/TAF-I protein in the transcriptional regulation of rat P450c17 geneMASTER-PhD August 1997-January 2002
National Institute of Health and Medical Research (INSERM)
Lille University, Lille, FRANCE
Promoter: Pr. Pierre Formstecher
Funded by « la Fondation pour la Recherche Médicale (FRM) »
Effects of ligand binding on nuclear receptor dimerizationTECHNICAL EXPERTISE
Molecular biology: Nucleic Acid Extraction and Purification, Cloning (Restriction Enzymes, Gibson, In-fusion, Gateway), RT-PCR, real time-qPCR, complementary DNA Libraries, protein biology (expression, purification, GST-pull down, Immunoprecipitation, Western Blotting, EMSA; ELISA)
Cell culture: cell lines, primary cells, transfection-reporter assays, RNA silencing.
Fluorescent Microscopy and imaging
Computing: Vector NTI, Snapgene, GraphPad Prism, Endnote, MS OfficeLANGUAGES
French: native
English: advanced
Turkish: intermediatePROFESSIONAL ACTIVITIES
Regular Member of the Endocrine Society from 2006 to 2021
Regular Member of the Society for Reproductive Investigation from 2016 to 2021
Poster Judge for the 65th SRI Annual Meeting in San Diego, CA, March 6-10, 2018 in the session Placenta II
Special Awards Judge for the Endocrine Society at the 2008 Intel International Science and Engineering Fair, May 13 and 14, 2008, Atlanta, Georgia, USAEDITORIAL ACTIVITIES
Peer Review Activities for:
Molecular Human Reproduction (Oxford Academic): 2014 (2), 2017 (1)
Gynecologic and Obstetric Investigation (Karger): 2019 (2), 2020 (2)
Scientific Reports (Nature Research Journals): 2020 (1), 2021 (1)COMITIES AND AWARDS
Young Investigator Travel Award, International Society for the Study of Hypertension in Pregnancy (ISSHP) 2008, WashingtonTEACHING (past and present)
Supervisory teaching Present
Catholic University of Louvain, School of Medicine, Brussels, Belgium
Member of the scientific advisory committee of 2 PhD students (Dr Patricia Steenhaut and Dr Arthur Colson)
Tutoring a total of 9 students for their final projects for the Bachelor’s degree in Medical Biology at Institut Paul Lambin
Internship supervisor of two students in the Master’s programs “pharmaceutical Sciences” and “Biomedical Sciences”
Supervising MD candidates to the admission exam for the specialized Master’s Degree in Gynecology-Obstetrics, Catholic University of Louvain (Brussels, Belgium)Laboratory instructor September 1999 to July 2000
Catholic University of Lille, France
Teaching first-year histology and cellular biology courses and directing lab sessions.Natural Science Teacher September 1995 to July 1997
French International School Pierre Loti, Istanbul, Turkey
Position fulfilled as part of the compulsory military service (Coopération du Service National à l’Étranger, CSNE).- Diploma
Year Label Educational Organization 1995 Licence Université des Sciences et Technologie de Lille : Lille I 2002 Doctorat en biochimie et biologie moléculaire et cellulaire Université du Droit et de la Santé : Lille II
Balligand, Jean-Luc ; Brito, Dulce ; Brosteanu, Oana ; Casadei, Barbara ; Depoix, Christophe ; Edelmann, Frank ; Ferreira, Vanessa ; Filippatos, Gerasimos ; Gerber, Bernhard ; Gruson, Damien ; Hasenclever, Dirk ; Hellenkamp, Kristian ; Ikonomidis, Ignatios ; Krakowiak, Bartosz ; Lhommel, Renaud ; Mahmod, Masliza ; Neubauer, Stefan ; Persu, Alexandre ; Piechnik, Stefan ; Pieske, Burkert ; Pieske-Kraigher, Elisabeth ; Pinto, Fausto ; Ponikowski, Piotr ; Senni, Michele ; Trochu, Jean-Noël ; Van Overstraeten, Nancy ; Wachter, Rolf ; Pouleur, Anne-Catherine. Repurposing the β3-Adrenergic Receptor Agonist Mirabegron in Patients With Structural Cardiac Disease: The Beta3-LVH Phase 2b Randomized Clinical Trial.. In: JAMA cardiology, Vol. 8, no.11, p. 1031-1040 (2023). doi:10.1001/jamacardio.2023.3003.
Colson, Arthur ; Depoix, Christophe ; Lambert, Isaline ; Leducq, Camille ; Bedin, Marie ; De Beukelaer, Michèle ; Gatto, Laurent ; Loriot, Axelle ; Peers de Nieuwburgh, Maureen ; Bouhna, Khadija ; Baldin, Paméla ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Specific hypoxia-inducible factor-2 (HIF-2α) inhibitor PT2385 mitigates placental dysfunction in vitro and in a rat model of preeclampsia (RUPP). In: Hypertension., Vol. 80, no. 5, p. 1011-1023 (2023). doi:10.1161/HYPERTENSIONAHA.122.20739.
Colson, Arthur ; Depoix, Christophe ; Dessilly, Géraldine ; Baldin, Paméla ; Danhaive, Olivier ; Hubinont, Corinne ; Sonveaux, Pierre ; Debieve, Frédéric. COVID-19 during Pregnancy: Clinical and In Vitro Evidence against Placenta Infection at Term by SARS-CoV-2.. In: The American journal of pathology, Vol. 191, no. 9, p. 1610-1623 (2021). doi:10.1016/j.ajpath.2021.05.009.
Colson, Arthur ; Depoix, Christophe ; Dessilly, Géraldine ; Baldin, Paméla ; Danhaive, Olivier ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2.. In: The American journal of pathology, Vol. 191, no. 9, p. 1610-1623 (2021). doi:10.1016/j.ajpath.2021.05.009.
Colson, Arthur ; Depoix, Christophe ; Hubinont, Corinne ; Debiève, Frédéric. Isolation of Primary Cytotrophoblasts From Human Placenta at Term. In: BIO-PROTOCOL, Vol. 11, no.19, p. 1 (2021). doi:10.21769/bioprotoc.4185.
Depoix, Christophe ; Colson, Arthur ; Mhallem Gziri, Mina ; Hubinont, Corinne ; Debiève, Frédéric. Effects of chemotherapy on placental development and function using in vitro culture of human primary cytotrophoblasts.. In: Investigational new drugs, Vol. 38, no. 3, p. 547-557 (2020). doi:10.1007/s10637-019-00800-9.
Colson, Arthur ; Depoix, Christophe ; Baldin, Paméla ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Hypoxia-inducible factor 2 alpha impairs human cytotrophoblast syncytialization: new insights in placental dysfunction and fetal growth restriction. In: The FASEB Journal, Vol. 34, no. 11, p. 15222-15235 (2020). doi:10.1096/fj.202001681R.
Depoix, Christophe ; Colson, Arthur ; Hubinont, Corinne ; Debieve, Frédéric. Impaired vascular endothelial growth factor expression and secretion during in vitro differentiation of human primary term cytotrophoblasts.. In: Angiogenesis, Vol. 23, no. 2, p. 221-230 (2020). doi:10.1007/s10456-019-09702-z.
Steenhaut, Patricia ; Depoix, Christophe ; Hubinont, Corinne ; Debiève, Frédéric. Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage.. In: International journal of gynaecology and obstetrics, Vol. 146, no.2, p. 223-230 (2019). doi:10.1002/ijgo.12826.
Depoix, Christophe ; Haegeman, Frédéric ; Debiève, Frédéric ; Hubinont, Corinne. Is 8% O2 more normoxic than 21% O2 for long-term in vitro cultures of human primary term cytotrophoblasts?. In: Molecular human reproduction, Vol. 24, no. 4, p. 211-220 (2018). doi:10.1093/molehr/gax069.
Depoix, Christophe ; de Selliers, I. ; Hubinont, Corinne ; Debiève, Frédéric. HIF1A and EPAS1 potentiate hypoxia-induced upregulation of inhibin alpha chain expression in human term cytotrophoblastsin vitro. In: Molecular Human Reproduction, Vol. 23, no. 3, p. 199-209 (2017). doi:10.1093/molehr/gax002.
Depoix, Christophe ; Flabat, Olivier ; Debiève, Frédéric ; Hubinont, Corinne. HIF1A and EPAS1 mRNA and protein expression during in vitro culture of human primary term cytotrophoblasts and effect of oxygen tension on their expression.. In: Reproductive Biology, Vol. 16, no. 3, p. 203-211 (2016). doi:10.1016/j.repbio.2016.05.001.
Depoix, Christophe ; Hubinont, Corinne ; Debiève, Frédéric. Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways. In: Molecular Reproduction and Development, Vol. 81, no. 11, p. 1009-1018 (2014). doi:10.1002/mrd.22421.
Depoix, Christophe ; Debiève, Frédéric ; Hubinont, Corinne. Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways.. In: Mol Reprod Dev, Vol. 81, no.11, p. 1009-1018 (2014). doi:10.1002/mrd.22421.
Debiève, Frédéric ; Depoix, Christophe ; Gruson, Damien ; Hubinont, Corinne. Reversible effects of oxygen partial pressure on genes associated with placental angiogenesis and differentiation in primary-term cytotrophoblast cell culture. In: Molecular Reproduction and Development, Vol. 80, no. 9, p. 774-784 (2013). doi:10.1002/mrd.22209.
Depoix, Christophe ; Barret, Laure-Anne ; Hubinont, Corinne ; Debiève, Frédéric. Viability of primary term cytotrophoblast cell culture in normoxia and hypoxia. In: Molecular Human Reproduction : basic science of reproductive medicine, Vol. 19, no. 1, p. 29-34 (2013). doi:10.1093/molehr/gas042.
Depoix, Christophe ; Tee, Meng Kian ; Taylor, Robert N. Molecular regulation of human placental growth factor (PlGF) gene expression in placental villi and trophoblast cells is mediated via the protein kinase a pathway.. In: Reproductive Sciences, Vol. 18, no.3, p. 219-28 (2011). doi:10.1177/1933719110389337.
Debiève, Frédéric ; Depoix, Christophe ; Hubinont, Corinne. Transcription factor AP2 regulates human inhibin α subunit gene expression during in vitro trophoblast differentiation.. In: Molecular Human Reproduction : basic science of reproductive medicine, Vol. 17, no. 11, p. 702-709 (2011). doi:10.1093/molehr/gar045.
Wieser, Fritz ; Waite, Leslie ; Depoix, Christophe ; Taylor, Robert N.. PPAR Action in Human Placental Development and Pregnancy and Its Complications. In: PPAR Research, Vol. 2008, no.2008, p. 1-14 (2008). doi:10.1155/2008/527048.
Mellon, Synthia H. ; Bair, Susanna R. ; Depoix, Christophe ; Vigne, Jean-Louis ; Hecht, Norman B. ; Brake, Paul B.. Translin Coactivates Steroidogenic Factor-1-Stimulated Transcription. In: Molecular Endocrinology, Vol. 21, no.1, p. 89-105 (2007). doi:10.1210/me.2005-0355.
Depoix, Christophe ; Delmotte, Marie-Hélène ; Formstecher, Pierre ; Lefebvre, Philippe. Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. A novel mechanism of action for retinoid antagonists.. In: Journal of Biological Chemistry, Vol. 276, no.12, p. 9452-9 (2001).
Prima, Valérie ; Depoix, Christophe ; Masselot, Bernadette ; Formstecher, Pierre ; Lefebvre, Philippe. Alteration of the glucocorticoid receptor subcellular localization by non steroidal compounds. In: The Journal of Steroid Biochemistry and Molecular Biology, Vol. 72, no.1-2, p. 1-12 (2000). doi:10.1016/S0960-0760(99)00146-6.
Colson, Arthur ; Depoix, Christophe ; Baldin, Paméla ; Mhallem Gziri, Mina ; Steenhaut, Patricia ; van der Monde, Julie ; Van Grambezen, Aurianne ; Bernard, Pierre ; Danhaive, Olivier ; Hubinont, Corinne ; Debieve, Frédéric. Assessment of SARS-CoV-2 vertical transmission: analysis of the 31 placentas from the PREG-COV study. 27th European Congress of Obstetrics and Gynaecology (EBCOG) (Athens, du 02/09/2021 au 04/09/2021).
Colson, Arthur ; Depoix, Christophe ; Dessilly, Géraldine ; Baldin, Paméla ; Hubinont, Corinne ; Danhaive, Olivier ; Sonveaux, Pierre ; Debieve, Frédéric. Risk of COVID-19 maternofetal transmission at term: new evidence against placental infection by SARS-CoV-2. IFPA Annual Meeting 2021 (Virtual, du 30/08/2021 au 02/09/2021).
Colson, Arthur ; Lambert, Isaline ; Depoix, Christophe ; Hubinont, Corinne ; Sonveaux, Pierre ; Debieve, Frédéric. Use of the Hypoxia-Inducible Factor (HIF)-2α Inhibitor PT2385 in Placental Dysfunction: New Intervention Addressing Fetal Growth Restriction and Preeclampsia. 68th annual meeting of the Society for Reproductive Investigation (Boston, du 06/07/2021 au 09/07/2021).
Colson, Arthur ; Depoix, Christophe ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Hypoxia-Inducible Factor 2α (HIF-2α) Impairs Placental Development in Fetal Growth Restriction (FGR). 22th annual meeting of the Society for Reproductive Investigation (Vancouver, du 10/03/2020 au 14/03/2020).
Colson, Arthur ; Depoix, Christophe ; Hubinont, Corinne ; Debiève, Frédéric. Hypoxia-Inducible Factor 2 (EPAS1) Decreases Syncytialization in Primary Villous Cytotrophoblasts. 21th annual meeting of the Society for Reproductive Investigation (Paris, du 12/03/2019 au 16/03/2019).
Colson, Arthur ; Depoix, Christophe ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Oxygen-resistant Hypoxia-Inducible Factor-2a (EPAS1) Mutant Inhibits Forskolin-induced Differentiation of Choriocarcinoma Cell Line BeWo. CTR Annual Conference (Cambridge, du 08/07/2019 au 09/07/2019).