Antibiotic efflux and permeability resistance mechanisms

Bruxelles Woluwe

We have provioulsy demonstrated the role of active efflux as a mechanism responsible for the intrinsic resistance of P. aeruginosa to specific antibiotics, like temocillin, or macrolides.

We have now started to evaluate the ipact of this mechanism of resistance in Achromobacter xylosoxidans, a bacterial species which follows P. aeruginosa in the colonization of the lung of patients with cystic fibrosis (CF).

We could demonstrate that efflux indeed plays a major role in the poor susceptibility of this species to commonly used antibiotics. Importantly, also we could evidence some mutations in these proteins that affect their substrate specificity.