Our group is interested in understanding the roles of bioactive lipids both in physiological and pathological situations mainly related to inflammation.
Lipids are essential constituents of biological membranes and control numerous cellular activities. An increasing number of lipids are shown to possess biological activities, thus behaving as transmitters or mediators. A large proportion of these “bioactive lipids” act by binding to and activating their own receptors, and have their levels tightly regulated by specific enzymes. The endocannabinoids and the oxysterols, two of our major research interests, are prime examples of such bioactive lipid signaling systems.
We investigate the role of bioactive lipids (1) by setting up mass spectrometry-based methods allowing the quantification of their endogenous levels and (2) by interrogating the role of selected bioactive lipids in cellular and in-vivo models of inflammation-related diseases.The overall aim of the group is to identify novel lipid-related therapeutic targets amenable to pharmacological modulation.