Our research focuses on the epidemiology and the quality of use of medicines in clinical practice, including the detection of inappropriate prescriptions and drug related admissions, and the individualisation of specific drug treatments.
In particular, our work is performed in different practice settings and focuses on high risk populations (older people, patients with chronic diseases, patients in intensive care), high risk medications (anticoagulants, antibiotics), and high risk situations (polymedication, multimorbidity, infections, and patients transiting across settings of care).
We use quantitative as well as qualitative research methods, and we:
- develop and/or validate instruments and tools to measure the quality of use of medicines;
- collect and use observational data for pharmacoepidemiological reasearch to assess the appropriateness of prescription and use of drugs, as well as their effects on patients in daily practice to optimise and individualize treatments;
- perform qualitative studies and/or surveys to identify the determinants of suboptimal practice and to evaluate patients’ attitudes;
- design, implement and evaluate various approaches for optimisation, that address the causes of suboptimal practice. Evaluation usually involves using (quasi)-experimental designs, continuous quality improvement studies and observational studies;
- conduct systematic reviews on the effect of approaches for optimisation.
Our three group leaders (Anne Spinewine, Olivia Dalleur and Séverine Henrard) have part-time activities in other settings (clinical appointment at UCL teaching hospitals, or other research institute). This feature brings a singular dynamic to our group and is a strength to elaborate a sound research group strategy, to reinforce leadership, facilitate development, collaboration and raise funding.