Alice Ameryckx - “Design, synthesis and evaluation of D-alanyl-D-Alanine ligase inhibitors: an attractive target for the development of antimicrobial agents

Alice Americkx (CLIP-FACM/LDRI)

“Design, synthesis and evaluation of D-alanyl-D-Alanine ligase inhibitors: an attractive target for the development of antimicrobial agents”

Directors: Pr. Raphaël Frédérick, Pr. Françoise Van Bambeke

Publications :

Ameryckx, A.; Thabault, L.; Pochet, L.; Leimanis, S.; Poupaert, J. H.; Wouters, J.; Joris, B.; Van Bambeke, F.; Frederick, R., "1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio." Eur. J. Med. Chem. 2018, 159, 324-338.

Ameryckx A.; Pochet, L.; Wang G.; Yildiz E.; Es Saadi B.; Wouters J.; Van Bambeke, F.; Frederick, R.; "Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio." Eur. J. Med. Chem. 2020, accepted.