Dr Jocelijn MEIJERINK - Wageningen University

Bruxelles Woluwe

January 30, 2023

Monday, January 30, 2023 – Auditoire Maisin – 1pm

PUFA-derived endocannabinoids in inflammation and caloric restriction; Is there a role for nutrition?

Dr Jocelijn MEIJERINK - Wageningen University

Related publications :

  • Schutte S et al., Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity. Am J Clin Nutr. 2022 Jul 6;116(1):132-150. doi: 10.1093/ajcn/nqac025.
  • Meijerink J. The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates. Molecules. 2021; 26(5):1416. https://doi.org/10.3390/molecules26051416
  • Pierluigi Plastina et al., Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products, Food Chemistry, 2019, P 105-113, doi.org/10.1016/j.foodchem.2018.12.007.
  • Wang Y et al., Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 1862(9):823-831. doi: 10.1016/j.bbalip.2017.05.008.
  • Wang Y et al., Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. ACS Chem Neurosci. 2017 Mar 15;8(3):548-557. doi: 10.1021/acschemneuro.6b00298
  • Poland M et al., Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028. doi: 10.1016/j.bbalip.2016.09.012.
  • Meijerink J, et al., Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages. Br J Pharmacol. 2015 Jan;172(1):24-37. doi: 10.1111/bph.12747

Info: mireille.alhouayek@uclouvain.be