October 24, 2019
Mechanistic study of PHGDH enzyme inhibition: Towards the development of new anticancer drugs
- Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, et al. α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). J Med Chem 2017;60:1591–7.
- Ravez S, Spillier Q, Marteau R, Feron O, Frédérick R. Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy. J Med Chem 2017;60:1227–37.
- Spillier Q, Vertommen D, Ravez S, Marteau R, Thémans Q, Corbet C, et al. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. Sci Rep 2019;9:4737.
Promotor : Raphaël Frédérick / Co-promotor : Olivier Feron