Léopold Thabault - Thesis Defence

Bruxelles Woluwe

Interrogating the Lactate Dehydrogenase Tetrameric Interface Using (Stapled) Peptides and Short Proteins: An Original Approach to Protein Inhibition

Léopold THABAULT, Medicinal Chemistry (CMFA), LDRI

Promoters : Raphaël Frédérick and Pierre Sonveaux

Related publications :

-Thabault, L., Brisson, L., Brustenga, C., Gache, S. A. M., Kozlova, A., Spillier, Q., Liberelle, M., Benyahia, Z., Messens, J., Copetti, T., Sonveaux, P., and Frédérick, R. (2020) Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides. J. Med. Chem. 63, 4628–4643.

-Thabault, L., Liberelle, M., Frédérick, R. Targeting Proteins Self-Association in Drug Design. Drug Discov. Today. provisionnally accepted

-Thabault, L., Liberelle, M., Koruza, K., Yildiz, E., Messens, J., Wouters, J., Sonveaux, P., Frédérick, R. Exploration of Lactate dehydrogenase Tetrameric Interface Unravels a New Tetrameric Site with Related Peptide Ligands. Under preparation.

 

The thesis defence took place on October 23, 2020

Published on October 30, 2020