Cancer cells deactivate their ‘Velcro’ to go on the attack

Cancer cells remain clumped together via a sort of ‘Velcro’ which allows them to adhere to each other wherever they appear. In order for cancer cells to leave a tumour and spread throughout the body during metastatic processes, cancer cells must reduce their adhesion and increase their ability to migrate. They can do this by changing the amount and type of proteins on their surface.

Our research conducted by Henri-François Renard, François Tyckaert, Camille Lemaigre and Pierre Morsomme targeted these surface proteins, particularly one called CD166, a kind of microscopic ‘Velcro’ which allows the cells to stick together.

We observed that certain cancer cells are, in fact, capable of decreasing the abundance of this ‘Velcro’ (CD166) on their surface. More specifically, these cells have found a way to reduce the adhesion of their surface by redirecting it into small internal vesicles: this is a mechanism called endocytosis, which we highlighted in our study published in Nature Communications.

If there is less adhesion, owing to less ‘Velcro’ (CD166) on the surface of cancer cells, they stick together less and therefore migrate more easily.

The next step? This fundamental mechanism still has many secrets to reveal. But we hypothesise that it could contribute to the formation of metastases which allow cancer to spread. And who knows, in the future this will perhaps make it possible to develop new solutions that block metastases and thus slow down the development of certain cancers.

Animation

Article

 

Published on May 20, 2020