How fibrinogen activates the capture of human plasminogen by staphylococcal surface proteins

Invasive bacterial pathogens can capture host plasminogen and allow it to form plasmin, a process of medical importance as surface-bound plasmin promotes bacterial spreading by cleaving tissue components and favours immune evasion by degrading opsonins. Together with the Speziale and Foster teams, we discovered that Staphylococcus aureus fibronectin-binding proteins bind plasminogen by a sophisticated activation mechanism involving fibrinogen, another ligand found in the blood. The work has just been published in mBio.

Published on September 06, 2017