IMCN seminar - Prof. I. ARENDS



« Application of Enzymes for Sustainable Chemistry»


Nature uses enzymes to catalyze a wealth of biotransformations. However in practice these transformations are carried out in-vivo under conditions which are far from suitable for large scale production of chemicals. It is our challenge to engineer and design enzymes in such a way that they can be employed in-vitro as catalysts [1]. In 2018 the Nobel prize was awarded to the seminal field of directed evolution of enzymes, which expands our toolbox of enzymes even more rapidly [2]. In the lecture it will be discussed how different classes of enzymes can be employed as highly promising catalysts for redox reactions using the principles of green chemistry. In addition, cascading of reactions is an important strategy to employ green oxidants and reducing agents such as hydrogen peroxide and formate. Notable examples include the evolution of enzymes for conversion of cholic acid derivatives for pharma [3], the use of laccase enyzmes for alcohol oxidation [4], and oxyfunctionalisation using unspecific peroxygenases [5].

[1] E.M.M. Abdelraheem, H. Busch, U. Hanefeld, F. Tonin, React. Chem. Eng. 4 (2019) 1878.
[2] Frances H. Arnold, “for the directed evolution of enzymes”, the Nobel prize in Chemistry 2018.
[3] F. Tonin, L.G. Otten and I.W.C.E. Arends, ChemSusChem 12 (2019) 3192.
[4] P. Könst, S. Kara, S. Kochius, D. Holtmann, I.W.C.E. Arends, R. Ludwig and F. Hollmann, ChemCatChem 5 (2013) 3027.
[5] S.J.P. Willot, M. Dat Hoang, C.E. Paul, M. Alcalde, I.W.C.E. Arends, A.S. Bommarius, B. Bommarius and F. Hollmann, ChemCatChem 12 (2020) 2713.



Publié le 29 mars 2021