Top Health Research stories - Development theme

Cellular and molecular mechanisms controlling neural cells proliferation, migration and differentiation during the development of the cerebral cortex

Y. Jossin, Institute of Neuroscience (IONS)

The mammalian cerebral cortex plays key roles in learning and memory, the control of sensory and motor functions or of our emotions. The proper execution of these tasks depends on a long process of embryonic and postnatal development which relies on the production by neural stem cells of the appropriate number of neurons with proper identities that migrate to their specific location and make connections with each other.

Defective signaling pathways during development are the causes of human brain diseases such as lissencephalies and heterotopias, dyslexia, schizophrenia, autism, epilepsy and many others. The goal of our laboratory is to better define the mechanisms of neural cell proliferation, migration and differentiation in order to understand how the cerebral cortex is built and learn how to treat and prevent devastating brain malformations.