Veille sur la vaccination

Vaccination de base contre la COVID-19 et consolidation périodique de l’immunité

22 juin 2022

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Cet avis vise à définir le nombre de doses qui constituent une « vaccination de base contre la COVID-19 », c’est-à-dire le nombre de doses qu’un individu devrait avoir reçu pour développer une réponse immunitaire satisfaisante, réponse qui pourra ensuite être consolidée lors des campagnes périodiques de vaccination.

Vaccination contre l’influenza et la COVID-19 à l’automne 2022

21 juin 2022

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Le but de cet avis scientifique est d’émettre des recommandations concernant la vaccination contre l’influenza et contre la COVID-19 à l’automne 2022, notamment les groupes à cibler et le moment optimal pour les vacciner.

Coping with COVID-19: Survey data assessing psychological distress to COVID-19 and vaccine hesitancy with measures of Theory of Planned Behavior, mindfulness, compassion, cultural orientation, and pandemic fatigue

21 juin 2022

Data Brief. 2022 Jun 14:108390. doi: 10.1016/j.dib.2022.108390. Online ahead of print.

ABSTRACT

As the COVID-19 pandemic extends into another year, the causes and consequences of pandemic fatigue and vaccine hesitancy have become prominent concerns. This dataset contains MTurk survey responses from 658 vaccinated USA samples indicating: (a) pandemic fatigue and psychological distress (physical and trauma symptoms); (b) delays in receiving medical care due to COVID-19 restrictions; (c) vaccine-related behavior and beliefs (type of vaccine and vaccine hesitancy), and (d) COVID-19 preventive health behaviors. Several predictor variables were also collected including: (a) demographic variables; (b) COVID-19 health risk factors; (c) perceived susceptibility to disease and intolerance of uncertainty; (d) attitudes, subjective norms and perceived behavioral control about COVID-19 vaccine from the Theory of Planned Behavior; (e) compassion for self and others; (f) psychological flexibility and inflexibility; (g) Buddhist mindfulness insight (impermanence, acceptance of suffering, nonself attachment, mindfulness); and (h) cultural orientation and authoritarianism. The data were collected between August 28th and October 18th of 2021. Out of the 746 MTurk workers who responded to the survey, 88 were removed from the dataset due to failing attention checks and problems with quality data. The responses from the remaining 658 allow an examination of the associations between fatigue and distress from COVID-19; COVID-19 vaccine related behaviors and beliefs; preventive health behaviors for COVID-19; COVID-19 susceptibility; intolerance of uncertainty; together with compassion, psychological flexibility, mindfulness, cultural orientation, as well as authoritarianism as possible moderators of COVID-19 fatigue, distress, and vaccine beliefs.

PMID:35721375 | PMC:PMC9195342 | DOI:10.1016/j.dib.2022.108390

Treating Anti-Vax Patients, a New Occupational Stressor-Data from the 4th Wave of the Prospective Study of Intensivists and COVID-19 (PSIC)

14 juin 2022

Int J Environ Res Public Health. 2022 May 12;19(10):5889. doi: 10.3390/ijerph19105889.

ABSTRACT

The Prospective Study of Intensivists and COVID-19 (PSIC) is a longitudinal study that besides investigating a cohort of intensivists from one of the two COVID-19 hub hospitals in Central Italy since the beginning of the pandemic (first wave, April 2020), has conducted a new survey at each successive wave. In addition to the variables investigated in previous surveys (job changes due to the pandemic, justice of safety procedures, job stress, sleep quality, satisfaction, happiness, anxiety, depression, burnout, and intention to quit), the latest fourth wave (December 2021) study has evaluated discomfort in caring for anti-vax patients. A multivariate logistic regression model confirmed that high levels of occupational stress (distressed 75.8%) were associated with isolation, monotony, lack of time for meditation, and poor relationships with anti-vaccination patients. Compared to the first phase, there was a reduction in levels of insomnia and anxiety, but the percentage of intensivists manifesting symptoms of depression remained high (58.9%). The study underlined the efficacy of organizational interventions and psychological support.

PMID:35627425 | DOI:10.3390/ijerph19105889

Variole simienne : mesures de prévention et de contrôle pour les cliniques médicales et les centres hospitaliers de soins de courte durée

14 juin 2022

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Cette fiche présente des recommandations intérimaires du Comité sur les infections nosocomiales du Québec (CINQ) sur les mesures de prévention et de contrôle du virus de la variole simienne pour les cliniques médicales, dans les groupes de médecine de famille (GMF), les cliniques ITSS (infections transmises sexuellement et par le sang) et les centres hospitaliers de soins de courte durée du Québec (incluant les cliniques externes). Des précisions quant aux équipements de protection individuelle (ÉPI) requis lors de la vaccination sont également disponibles pour les milieux visés par les activités de vaccination.

L’éclosion de lésions ulcéreuses associées à la variole simienne décrite jusqu’à maintenant au Québec semble associée à un contact étroit et prolongé entre humains lors...

A high-affinity aptamer with base-appended base-modified DNA bound to isolated authentic SARS-CoV-2 strains wild-type and B.1.617.2 (delta variant)

14 juin 2022

Biochem Biophys Res Commun. 2022 May 2;614:207-212. doi: 10.1016/j.bbrc.2022.04.071. Online ahead of print.

ABSTRACT

Simple, highly sensitive detection technologies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial for the effective implementation of public health policies. We used the systematic evolution of ligands by exponential enrichment with a modified DNA library, including a base-appended base (uracil with a guanine base at its fifth position), to create an aptamer with a high affinity for the receptor-binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. The aptamer had a dissociation constant of 1.2 and < 1 nM for the RBD and spike trimer, respectively. Furthermore, enzyme-linked aptamer assays confirmed that the aptamer binds to isolated authentic SARS-CoV-2 wild-type and B.1.617.2 (delta variant). The binding signal was larger that of commercially available anti-SARS-CoV-2 RBD antibody. Thus, this aptamer as a sensing element will enable the highly sensitive detection of SARS-CoV-2.

PMID:35617879 | DOI:10.1016/j.bbrc.2022.04.071

Vaccination contre la variole simienne

14 juin 2022

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Des cas de variole simienne ont été rapportés mondialement, avec un agrégat de cas à Montréal et ailleurs au Québec. La transmission se fait principalement par contact avec un animal ou un humain infecté ou, dans une moindre mesure, avec du matériel contaminé par le virus (contact direct et indirect). La transmission interhumaine peut également se faire par gouttelettes lors d’un contact face à face prolongé, en l’absence de port d’équipement de protection individuelle.

Impact of low vaccine coverage on the resurgence of COVID-19 in Central and Eastern Europe

14 juin 2022

One Health. 2022 May 19:100402. doi: 10.1016/j.onehlt.2022.100402. Online ahead of print.

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has caused a tremendous global impact both socially and economically. The mechanisms behind the disparity in the severity, vaccine coverage, and variant replacement patterns across European countries are unclear. In this work, we aim to reveal the possible reasons via data visualization and model fitting. We developed a model with a vaccination component to simulate the mortality waves in these countries. Deaths averted by the vaccination campaign were estimated. Finally, we discuss the potential reasons behind the differences in vaccine coverage across European countries. Contemporary transportation and global trade bring significant convenience to our daily life but also facilitate the spread of the novel virus COVID-19 to anywhere globally within a short time. The observations and results in this work highlight the importance of the global campaign to mitigate the COVID-19 pandemic and future pandemics under the One Health approach.

PMID:35611185 | PMC:PMC9119166 | DOI:10.1016/j.onehlt.2022.100402

Impact of low vaccine coverage on the resurgence of COVID-19 in Central and Eastern Europe

31 mai 2022

Publication date: Available online 19 May 2022

Source: One Health

Author(s): Guihong Fan, Haitao Song, Stan Yip, Tonghua Zhang, Daihai He

Potential Influencers of COVID-19 Vaccine Acceptance Among Adults Living in the United States Who Have Accepted or Plan to Accept the Vaccine: An Online Survey

24 mai 2022
American Journal of Health Promotion, Ahead of Print.
PurposeThe purpose of this study was to 1) determine the demographic differences between adults who have accepted, or plan to accept, the COVID-19 vaccine and those who will not accept the COVID-19 vaccine and 2) describe the potential influencers in deciding to accept the COVID-19 vaccine among adults living in the United States who have accepted or plan to accept the vaccine.DesignA cross-sectional design utilizing an online survey was deployed using social media and a crowdsourcing platform.SettingUnited States.SubjectsOne thousand three hundred ninety-five (1395) adults completed the survey. The majority were white, male, between the ages of 25 and 45, and with representation from 50 states and Puerto Rico.MeasuresA two-branched survey was used to assess demographic information, vaccination intention, and 19 potential influencers of COVID-19 vaccine acceptance.AnalysisAnalysis included descriptive statistics and Chi-square tests to determine differences between groups.ResultsA higher proportion of male (P < .001), married (P < .001), and college-educated (P < .001) participants reported acceptance of the vaccine. The factors with the highest mean score of reported level of influence were duty to protect the vulnerable and contribution to move society back to a sense of normalcy.ConclusionUnderstanding the potential influencers of vaccine acceptance may provide insight into strategies that could increase vaccination uptake.

Acceptabilité de la vaccination contre la COVID 19 au Québec : analyse des données collectées de décembre 2020 à septembre 2021

24 mai 2022

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Cette étude visait à évaluer les enjeux d’acceptabilité entourant la vaccination contre la COVID-19 et la stratégie de priorisation de la vaccination chez les professionnels de la santé publique responsables de l’organisation de la campagne, auprès de différents groupes de la population et chez les travailleurs de la santé.

Infodémie et vaccination contre la COVID-19 au Québec – Aperçu des conversations en ligne de décembre 2020 à juillet 2021

24 mai 2022

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L'une des principales causes évoquées pour expliquer la montée de l’hésitation à la vaccination, incluant celle contre la COVID-19, est la désinformation en ligne, qui réfère à des informations erronées diffusées de façon volontaire dans le but de nuire ou d’influencer l’opinion publique. Cette désinformation s’est vue décuplée lors de la pandémie, générant ainsi une infodémie, amplifiée par les médias traditionnels et sociaux

Communications to Promote Interest and Confidence in COVID-19 Vaccines

24 mai 2022
American Journal of Health Promotion, Ahead of Print.
PurposeCommunicating about COVID-19 vaccine side effects and efficacy is crucial for promoting transparency and informed decision-making, but there is limited evidence on how to do so effectively.DesignA within-subjects experiment.SettingOnline survey from January 21 to February 6, 2021.Subjects596 US Veterans and 447 non-Veterans.Intervention5 messages about COVID-19 vaccine side effects and 4 messages about COVID-19 vaccine efficacy.MeasuresCOVID-19 vaccine interest (1 = “I definitely do NOT want the vaccine” to 7 = “I definitely WANT the vaccine” with the midpoint 4 = “Unsure”). Confidence about COVID-19 vaccine efficacy (1= “Not at all confident,” 2 = “Slightly confident,” 3 = “Somewhat confident,” 4 = “Moderately confident,” 5 = “Extremely confident”).ResultsCompared to providing information about side effects alone (M = 5.62 [1.87]), messages with additional information on the benefits of vaccination (M = 5.77 [1.82], P < .001, dz = .25), reframing the likelihood of side effects (M = 5.74 [1.84], P < .001, dz = .23), and emphasizing that post-vaccine symptoms indicate the vaccine is working (M = 5.72 [1.84], P < .001, dz = .17) increased vaccine interest. Compared to a vaccine efficacy message containing verbal uncertainty and an efficacy range (M = 3.97 [1.25]), messages conveying verbal certainty with an efficacy range (M = 4.00 [1.24], P = .042, dz=.08), verbal uncertainty focused on the upper efficacy limit (M = 4.03 [1.26], P < .001, dz = .13), and communicating the point estimate with certainty (M = 4.02 [1.25], P < .001, dz = .11) increased confidence. Overall, Veteran respondents were more interested (MVeterans = 5.87 [1.72] vs MNonVeterans = 5.45 [2.00], P < .001, d = .22) and confident (MVeterans = 4.13 [1.19] vs MNonVeterans = 3.84 [1.32], P < .001, d = .23) about COVID-19 vaccines than non-Veterans.ConclusionsThese strategies can be implemented in large-scale communications (e.g., webpages, social media, and leaflets/posters) and can help guide healthcare professionals when discussing vaccinations in clinics to promote interest and confidence in COVID-19 vaccines.