The thesis of Emilie Catry (SSS/LDRI/MNUT) was awarded on Saturday 8th of September. Her work, based on preclinical and mechanistic approach in mice, supports the role of gut microbiota in the control of cardio-metabolic risk, showing that that the modulation of the microbial composition occurs upon hypocholesterolemic drugs. Moreover, prebiotics (inulin type fructans) improve the NO-dependent endothelial function, in an innovative mice model of endothelial dysfunction, by a mechanism involving bile acids homeostasis and the release of gut endocrine peptides like glucagon-like peptide 1.
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related papers :
1)Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction. Catry E, Bindels LB, Tailleux A, Lestavel S, Neyrinck AM, Goossens JF, Lobysheva I, Plovier H, Essaghir A, Demoulin JB, Bouzin C, Pachikian BD, Cani PD, Staels B, Dessy C, Delzenne NM. Gut. 2018 Feb;67(2):271-283. doi: 10.1136/gutjnl-2016-313316. Epub 2017 Apr 4.;
2)Nutritional depletion in n-3 PUFA in apoE knock-out mice: A new model of endothelial dysfunction associated with fatty liver disease. Catry E, Neyrinck AM, Lobysheva I, Pachikian BD, Van Hul M, Cani PD, Dessy C, Delzenne NM.Mol Nutr Food Res. 2016 Oct;60(10):2198-2207. doi: 10.1002/mnfr.201500930. Epub 2016 Jun 1.
3) Ezetimibe and simvastatin modulate gut microbiota and expression of genes related to cholesterol metabolism. Catry E, Pachikian BD, Salazar N, Neyrinck AM, Cani PD, Delzenne NM. Life Sci. 2015 Jul 1;132:77-84. doi: 10.1016/j.lfs.2015.04.004. Epub 2015 Apr 25.