LDRI
Avenue Mounier 73/B1.73.11
1200 Woluwe-Saint-Lambert
Assistante de recherche
LDRI
Avenue Mounier 73/B1.73.11
1200 Woluwe-Saint-Lambert
Research topic
The gut microbiota consists of the trillions of microbes that reside in the gastrointestinal tract of mammals, and has a vast impact on host physiology and metabolism. During my PhD (2018-2023), my research project is mainly dedicated to the investigation of the triangle interactions between the human host, the gut microbiota and drugs.
Oral communications to international conferences and symposiums
2023 Summer School Graduate Programme “Precision health”, Lille, France
2022 20th IATDMCT Congress, Pragua, Czech Republic
2022 Transplant Care Symposium, Madrid, Spain
2022 IATDMCT symposium, Rennes, France
Degraeve, Alexandra ; Haufroid, Vincent ; Loriot, Axelle ; Gatto, Laurent ; Andries, Vanessa ; Vereecke, Lars ; Elens, Laure ; Bindels, Laure B.. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. In: Microbiome, Vol. 11, no. 1, p. 138 [1-20] (2023). doi:10.1186/s40168-023-01578-y.
Degraeve, Alexandra ; Bindels, Laure B. ; Haufroid, Vincent ; Moudio Ebosse Timba, Moussinga Serge ; Boland, Lidvine ; Delongie, Kévin-Alexandre ; Dewulf, Joseph P. ; Chaib Eddour, Djamila ; Mourad, Michel ; Elens, Laure. Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study. In: Clinical pharmacology and therapeutics, (2023). doi:10.1002/cpt.3077 (Accepté/Sous presse).
Degraeve, Alexandra ; Moudio Ebosse Timba, Moussinga Serge ; Haufroid, Vincent ; Chaib Eddour, Djamila ; Mourad, Michel ; Bindels, Laure B. ; Elens, Laure. Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.. In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 16, no. 9, p. 769-782 (2020). doi:10.1080/17425255.2020.1803277.
Degraeve, Alexandra ; Bindels, Laure B.. Microbiote et médicaments. In: Jean-Michel Lecerf, Nathalie Delzenne, Microbiote intestinal et santé humaine, Elsevier Masson: (France) Paris, 2021, 56-61. 9782294769306.
Degraeve, Alexandra. Tacrolimus pharmacokinetics and gut microbiota : from mechanistic to clinical investigations, prom. : Elens, Laure ; Bindels, Laure, 30/08/2023.