IMCN - Soutenance publique de thèse - Sébastien LELOUX

Study of reactions catalyzed by Copper (I) complexes : hydrosilylation, hydroboration and investigation of carbonylation reactions

During this thesis, three different projects have been realized. In the first one, new NHC-Capped Cyclodextrins (ICyDs) Cu complexes developed by Sollogoub and his team have been applied in different reactions for which our group had known success in the past. It was decided to study a copper catalyzed reaction that could be performed under mild conditions (temperature, pressure, etc.) but also in which side reactions were reduced to a minimum. Among the previous works done in the group, hydrosilylation of ketones answers all of these criteria and was therefore selected for this study.
In the second chapter of this project, our mechanistic in situ experience was further developed through the hydroboration of alkynes using Cu complexes.
Finally, in the last chapter of this project, several new copper based catalytic methodologies have been studied. Starting with alkynes (as they were used during the second part of this thesis), carbonylation reactions were performed using a dual Cu/Pd catalysis as previously studied in our team. In addition, alkenes were also used for the development of new methodologies leading to the synthesis of a,b-unsaturated ketones.

Jury members :

• Prof. Olivier Riant (UCLouvain), supervisor
• Prof. Yann Garcia (UCLouvain), chairperson
• Prof. Sophie Hermans (UCLouvain), secretary
• Prof. Tom Leyssens (UCLouvain)
• Prof. Troels Skrydstrup (Aarhus University, Denmark)
• Prof. Matthieu Sollogoub (Sorbonne Université, France)

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