10 novembre 2020
16h
Louvain-la-Neuve
will take place in the form of a video conference Teams
Organic Electrochemistry Applied to the Kolbe Anodic Cyclization of Functionalized 2-Pyrrolidinones by Mathilde QUERTENMONT
Pour l’obtention du grade de Docteur en sciences
The nootropic compounds are a group of pharmacologically active 2-pyrrolidinones. These molecules, enhancing cognition properties and possessing a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry.
We envision the development of a novel pyrrolidinone synthesis by organic electrochemistry, using the mixed Kolbe electrolysis as our key-step. Our methodology is derived from the five-and six-membered-ring compounds synthesis developed previously in the research group of the prof. István Markó. The electrochemically based cyclization strategy includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.
Electrochemistry has been chosen since this technology is environmentally friendly, relatively inexpensive and easily transposed to batch reactors and continuous-flow systems. This synthesis would be an original and innovative approach to form therapeutically active molecules.
Jury members :
- Prof. Olivier Riant (UCLouvain), supervisor
- Prof. Jean-François Gohy (UCLouvain), chairperson
- Prof. Benjamin Elias (UCLouvain), secretary
- Prof. Raphaël Robiette (UCLouvain)
- Prof. Laurence Grimaud (Ecole Normale Supérieure, France)
- Dr. Kevin Lam (University of Greenwich, UK)
- Prof. Christian Stevens (Ghent University, Belgium)
Pay attention :
The public defense of Mathilde Quertenmont scheduled for Tuesday 10 November at 16:00 will take place in the form of a video conference Teams