LDRI
Avenue Mounier 73/B1.73.05
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Françoise Van Bambeke
Françoise Van Bambeke
Directrice de recherche FNRS
Professeure extraordinaire
see also: http://www.facm.ucl.ac.be/CV-F-Van-Bambeke.htm
- Diplômes
Année Label Institution 1991 Pharmacien Université catholique de Louvain 1995 Docteur en sciences pharmaceutiques Université catholique de Louvain 2005 Agrégée de l'enseignement supérieur Université catholique de Louvain
- Les cours
Nom ID Compléments de microbiologie WBICL2102 Médicaments et développement durable WFARM1375 Pharmacothérapie intégrée WFARM2111 Pharmacologie spéciale et éléments de pharmacothérapie 1re partie WFARM2114 Pharmacologie spéciale et éléments de pharmacothérapie 2e partie WFARM2116 Processus de découverte, de développement et de mise sur le marché du médicament WFARM2128 Etude critique d'un article de recherche en sciences pharmaceutiques WFARM2175 Présentation d'un travail de recherche en sciences pharmaceutiques WFARM2176 Séminaire de pharmacothérapie intégrée WFARM2211 Exercice de communication scientifique WFARM2275 Médicaments vétérinaires WFARM2510 Gestion de l'antibiothérapie et prévention et contrôle des infections en milieu hospitalier WHOPI2106
Main research activities
- Cellular pharmacokinetics of antibiotics : study of the mechanisms of penetration, accumulation, distribution, and efflux of antibiotics in eucaryotic cells, including the study of their transport by eucaryotic efflux pumps.
- Pharmacodynamics of antibiotics in persistent infections: parameters modulating antibiotic activity against intracellular infections or biofilms; elaboration of strategies to modulate intracellular activity (inhibition of efflux pumps, e.g.)
- Cellular toxicodynamics of antibiotics: morphological and biochemical studies of storage disorders induced by antibiotics will cellular tropism
- Search and pharmacological evaluation of new antibiotics directed against new targets, either by screening of well characterized natural sources or by rational design and chemical synthesis.
See https://uclouvain.be/en/research-institutes/ldri/cellular-and-molecular-pharmacology-facm.html
2024
Fiogbe, Dessièdé Ariane ; Dohou, Angèle Modupè ; Yehouenou, Carine Laurence ; Henrard, Séverine ; Van Bambeke, Françoise ; Dossou, Francis Moïse Djidénou ; Dalleur, Olivia. Antibiotic prophylaxis practice in gastrointestinal surgery in five hospitals in southern Benin. In: Infection Prevention in Practice, Vol. 6, no.4, p. 100405 (2024). doi:10.1016/j.infpip.2024.100405.
2024
De Soir, Steven ; Parée, Hortence ; Kamarudin, Nur Hidayatul Nazirah ; Wagemans, Jeroen ; Lavigne, Rob ; Braem, Annabel ; Merabishvili, Maya ; De Vos, Daniel ; Pirnay, Jean-Paul ; Van Bambeke, Françoise. Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections. In: Microbiology Spectrum, Vol. Jan, no. 12(1), p. e0321923 (2024). doi:10.1128/spectrum.03219-23.
2024
van Os, Wisse ; Nussbaumer-Pröll, Alina ; Pham, Anh Duc ; Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Van Bambeke, Françoise ; van Hasselt, Johan ; Zeitlinger, Markus. Pharmacokinetic-pharmacodynamic model-based optimisation of temocillin dosing strategies for the treatment of systemic infections. In: Journal of Antimicrobial Chemotherapy, p. in the press (2024) (Accepté/Sous presse).
2024
Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Coessens, Marie ; Cottone, Eleonora ; Ermtraud, Julian ; Goeman, Lieven ; Vervaeke, Steven ; Wicha, Sebastian ; Van Bambeke, Françoise. Pharmacokinetics and pharmacological target attainment of standard temocillin dosing in non-critically ill patients with complicated urinary tract infections. In: Journal of Antimicrobial Chemotherapy, p. in the press (2024) (Accepté/Sous presse).
2024
Ngougni Pokem, Perrin ; Liu, Xin ; Parker, Suzanne L ; Verroken, Alexia ; Collienne, Christine ; Finet, Patrice ; Wijnant, Gert-Jan ; Laterre, Pierre-François ; Roberts, Jason A ; Van Bambeke, Françoise ; Wittebole, Xavier. Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis. In: Journal of Antimicrobial Chemotherapy, Vol. 79, no. 2, p. 429-442 (2024). doi:10.1093/jac/dkad398.
2024
Wang, Zhifen ; Vanbever, Rita ; Lorent, Joseph H. ; Solis, Jessica ; Knoop, Christiane ; Van Bambeke, Françoise. Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics. In: Journal of Cystic Fibrosis, Vol. Feb213, no.none, p. S1569-1993(24)00027-4 (2024). doi:10.1016/j.jcf.2024.02.012.
2024
Thirot, Hélène ; Fage, David ; Leonhardt, Antonia ; Clevenbergh, Philippe ; Besse-Hammer, Tatiana H ; Yombi, Jean Cyr ; Cornu, Olivier ; Briquet, Caroline ; Hites, Maya ; Jacobs, Frédérique ; Wijnant, Gert-Jan ; Wicha, Sebastian G ; Cotton, Frédéric ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers. In: Frontiers in pharmacology, Vol. 15, p. 1310309 [1-11] (2024). doi:10.3389/fphar.2024.1310309.
2024
Goormaghtigh, Frédéric ; Van Bambeke, Françoise. Understanding Staphylococcus aureus internalization and induction of antimicrobial tolerance. In: Expert Review of Anti-infective Therapy, Vol. 22, p. 87-101 (2024). doi:10.1080/14787210.2024.2303018.
2024
Mahieu, Gwenaëlle ; Sennesael, Anne-Laure ; Pochet, Lionel ; Haufroid, Vincent ; Van Bambeke, Françoise ; Spinewine, Anne ; Elens, Laure. assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines.. In: Research and practice in thrombosis and haemostasis, Vol. 8, no.5, p. 102521 (2024). doi:10.1016/j.rpth.2024.102521.
2023
Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. Correction for Ruiz-Sorribas et al., "Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model".. In: Microbiology spectrum, Vol. 11, no.1, p. e0467122 (2023). doi:10.1128/spectrum.04671-22.
2023
Van Bambeke, Françoise ; Wicha, Sebastian ; Tulkens, Paul M. ; Zeitlinger, Markus. Editorial for the Special Issue: A Themed Issue in Honor of Professor Hartmut Derendorf-Outstanding Contributions in the Fields of Quantitative Clinical Pharmacology... In: Antibiotics, Vol. 12, no.2, p. 353 (2023). doi:10.3390/antibiotics12020353.
2023
Catteau, Lucy ; Iglesias, Yvan Diaz ; Tsunemoto, Hannah ; Pogliano, Joseph ; Van Bambeke, Françoise ; Nizet, Victor ; Sakoulas, George. Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis. In: International Journal of Antimicrobial Agents, Vol. 61, no.6, p. 106758 (2023). doi:10.1016/j.ijantimicag.2023.106758.
2022
Dohou, Angèle ; Buda, Valentina ; Yemoa, Achille ; Anagonu, Séverin ; Van Bambeke, Françoise ; Van Hees, Thierry ; Dossou, Francis ; Dalleur, Olivia. Antibiotic Usage in Patients Having Undergone Caesarean Section: A Three-Level Study in Benin. In: Antibiotics, Vol. 11, no. 5, p. 617 [1-12] (2022). doi:10.3390/ antibiotics11050617.
2022
Ngougni Pokem, Perrin ; Matzneller, Peter ; Vervaeke, Steven ; Wittebole, Xavier ; Goeman, Lieven ; Coessens, Marie ; Cottone, Eleonora ; Capron, Arnaud ; Wulkersdorfer, Beatrix ; Wallemacq, Pierre ; Mouton, Johan W ; Muller, Anouk E ; Zeitlinger, Markus ; Laterre, Pierre-François ; Tulkens, Paul M. ; Van Bambeke, Françoise. Binding of temocillin to plasma proteins in vitro and in vivo: the importance of plasma protein levels in different populations and of co-medications. In: Journal of Antimicrobial Chemotherapy, Vol. 77, no. 10, p. 2742-2753 (2022). doi:10.1093/jac/dkac286.
2022
Poilvache, Hervé ; Van Bambeke, Françoise ; Cornu, Olivier. Development of an innovative model of PJI treated with DAIR.. In: Frontiers in medicine, Vol. 9, p. 984814 [1-14] (2022). doi:10.3389/fmed.2022.984814.
2022
De Bels, David ; Maillart, Evelyne ; Van Bambeke, Françoise ; Redant, Sebastien ; Honoré, Patrick. Existing and emerging therapies for the treatment of invasive candidiasis and candidemia. In: Expert opinion on emerging drugs, Vol. 27, no. 4, p. 405-416 (2022). doi:10.1080/14728214.2022.2142207.
2022
Dohou, Angèle Modupè ; Buda, Valentina Oana ; Anagonou, Severin ; Van Bambeke, Françoise ; Van Hees, Thierry ; Dossou, Francis Moïse ; Dalleur, Olivia. Healthcare Professionals’ Knowledge and Beliefs on Antibiotic Prophylaxis in Cesarean Section: A Mixed-Methods Study in Benin. In: Antibiotics, Vol. 11, no. 7, p. 872 [1-14] (2022). doi:10.3390/antibiotics11070872.
2022
Peyrusson, Frédéric ; Nguyen, Tiep Khac ; Najdovski, Tome ; Van Bambeke, Françoise. Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters. In: Microbiology Spectrum, Vol. 10, no.1, p. e0231321 (2022). doi:10.1128/spectrum.02313-21.
2022
Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model. In: Microbiology spectrum, Vol. 10, no. 1, p. e0258921 [1-16] (2022). doi:10.1128/spectrum.02589-21.
2022
Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Van Bambeke, Françoise. Pharmacodynamics of Moxifloxacin, Meropenem, Caspofungin, and Their Combinations against In Vitro Polymicrobial Interkingdom Biofilms. In: Antimicrobial agents and chemotherapy, Vol. 66, no. 2, p. e02149-21 [1-17] (2022). doi:10.1128/aac.02149-21.
2022
Ngougni Pokem, Perrin ; Wittebole, Xavier ; Collienne, Christine ; Rodriguez-Villalobos, Hector ; Tulkens, Paul M. ; Elens, Laure ; Van Bambeke, Françoise ; Laterre, Pierre-François. Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. In: Antibiotics, Vol. 11, no. 7, p. 898 [1-19] (2022). doi:10.3390/antibiotics11070898.
2022
Chalhoub, Hussein ; Kampmeier, Stefanie ; Kahl, Barbara C. ; Van Bambeke, Françoise. Role of Efflux in Antibiotic Resistance of Achromobacter xylosoxidans and Achromobacter insuavis Isolates From Patients With Cystic Fibrosis. In: Frontiers in Microbiology, Vol. 13, no.March 28, p. 762307 (2022). doi:10.3389/fmicb.2022.762307.
2022
Meléndez-Carmona, María Ángeles ; Mancheño-Losa, Mikel ; Ruiz-Sorribas, Albert ; Muñoz-Gallego, Irene ; Viedma, Esther ; Chaves, Fernando ; Van Bambeke, Françoise ; Lora-Tamayo, Jaime. Strain-to-strain variability among Staphylococcus aureus causing prosthetic joint infection drives heterogeneity in response to levofloxacin and rifampicin. In: Journal of Antimicrobial Chemotherapy, Vol. 77, no.12, p. 3265-3269 (2022). doi:10.1093/jac/dkac311.
2022
Wang, Gang ; Brunel, Jean-Michel ; Preusse, Matthias ; Mozaheb, Negar ; Willger, Sven D. ; Larrouy-Maumus, Gerald ; Baatsen, Pieter ; Häussler, Susanne ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence. In: Communications biology, Vol. 5, no. 1, p. 871 [1-17] (2022). doi:10.1038/s42003-022-03836-5.
2022
Wang, Gang ; Brunel, Jean-Michel ; Rodriguez-Villalobos, Hector ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The polyamino-isoprenyl potentiator NV716 revives disused antibiotics against Gram-negative bacteria in broth, infected monocytes, or biofilms, by disturbing the barrier effect of their outer membrane.. In: European journal of medicinal chemistry, Vol. 238, no. 11, p. 114496 [1-14] (2022). doi:10.1016/j.ejmech.2022.114496.
2021
Nguyen, Tiep Khac ; Peyrusson, Frédéric ; Siala, Wafi ; Pham, Nhung H ; Nguyen, Hoang Anh ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activity of moxifloxacin against biofilms formed by clinical isolates of Staphylococcus aureus differing by their resistant or persister character to fluoroquinolones. In: Frontiers in Microbiology, Vol. 12, no. Dec, p. 785573 (2021). doi:10.3389/fmicb.2021.785573.
2021
Sounouvou, Hope T ; Toukourou, Kolawole Habib ; Catteau, Lucy ; Toukourou, Fatiou ; Evrard, Brigitte ; Van Bambeke, Françoise ; Gbaguidi, Fernand ; Quetin-Leclercq, Joëlle. Antimicrobial potentials of essential oils extracted from West African aromatic plants on common skin infections. In: Scientific African, Vol. 11, p. e00706 [1-12] (2021). doi:10.1016/j.sciaf.2021.e00706.
2021
Thirot, Hélène ; Briquet, Caroline ; Frippiat, Frédéric ; Jacobs, Frédérique ; Holemans, Xavier ; Henrard, Séverine ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Clinical Use and Adverse Drug Reactions of Linezolid: A Retrospective Study in Four Belgian Hospital Centers. In: Antibiotics, Vol. 10, no. 5, p. 530 [1-12] (2021). doi:10.3390/antibiotics10050530.
2021
Yehouenou, Carine ; Bogaerts, Bert ; Vanneste, Kevin ; Roosens, Nancy H. C. ; De Keersmaecker, Sigrid C. J. ; Marchal, Kathleen ; Affolabi, Dissou ; Soleimani, Reza ; Rodriguez-Villalobos, Hector ; Van Bambeke, Françoise ; Dalleur, Olivia ; Simon, Anne. First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin. In: Annals of clinical microbiology and antimicrobials, Vol. 20, no. 1, p. 5 [1-7] (2021). doi:10.1186/s12941-020-00411-w.
2021
Ruiz Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. In vitro polymicrobial inter-kingdom three-species biofilm model: influence of hyphae on biofilm formation and bacterial physiology. In: Biofouling, Vol. 37, no.5, p. 481-493 (2021). doi:10.1080/08927014.2021.1919301.
2021
Poilvache, Hervé ; Ruiz Sorribas, Albert ; Cornu, Olivier ; Van Bambeke, Françoise. In-vitro study of the synergistic effect of an enzyme cocktail and antibiotics against biofilms in a prosthetic joint infection model. In: Antimicrobial Agents and Chemotherapy, Vol. 65, no. 4, p. e01699-20 [1-24] (2021). doi:10.1128/AAC.01699-20.
2021
Peyrusson, Frédéric ; Whelan, Adam O ; Hartley, M G ; Norville, Isobel H ; Harding, Sarah V ; Van Bambeke, Françoise. Intracellular activity of antibiotics against Coxiella burnetii in a model of activated human THP-1 cells. In: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0106121 (2021). doi:10.1128/aac.01061-21.
2021
Nguyen, Thu-Minh ; Ngo, Thu-Hue ; Truong, Anh-Quan ; Vu, Dinh-Hoa ; Le, Dinh-Chi ; Vu, Ngan-Binh ; Can, Tuyet-Nga ; Nguyen, Hoang-Anh ; Phan, Thu-Phuong ; Van Bambeke, Françoise ; Vidaillac, Céline ; Ngo, Quy-Chau. Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease. In: Pharmaceutics, Vol. 13, no.4, p. 456 (2021). doi:10.3390/pharmaceutics13040456.
2021
Wang, Gang ; Brunel, Jean-Michel ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The Polyaminoisoprenyl Potentiator NV716 Revives Old Disused Antibiotics against Intracellular Forms of Infection by Pseudomonas aeruginosa.. In: Antimicrobial agents and chemotherapy, Vol. 65, no.3, p. e02028-20 (2021). doi:10.1128/AAC.02028-20.
2021
Kerkez, Ivana ; Tulkens, Paul M. ; Tenson, Tanel ; Van Bambeke, Françoise ; Putrinš, Marta. Uropathogenic Escherichia coli shows antibiotic tolerance and growth heterogeneity in an in-vitro model of intracellular infection. In: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0146821 (2021). doi:10.1128/aac.01468-21.
2020
Diaz Iglesias, Yvan ; Van Bambeke, Françoise. Activity of Antibiotics against Pseudomonas aeruginosa in an In Vitro Model of Biofilms in the Context of Cystic Fibrosis: Influence of the Culture Medium. In: Antimicrobial Agents and Chemotherapy, Vol. 64, no.4, p. e02204-19 (2020). doi:10.1128/aac.02204-19.
2020
Nguyen, Tiep Khac ; Argudín, Maria A ; Deplano, Ariane ; Nhung, Pham Hong ; Nguyen, Hoang Anh ; Tulkens, Paul M ; Dodemont, Magali ; Van Bambeke, Françoise. Antibiotic Resistance, Biofilm Formation, and Intracellular Survival As Possible Determinants of Persistent or Recurrent Infections by in a Vietnamese Tertiary Hospital: Focus on Bacterial Response to Moxifloxacin.. In: Microbial drug resistance (Larchmont, N.Y.), Vol. 26, no.6, p. 537-544 (2020). doi:10.1089/mdr.2019.0282.
2020
Yehouenou, Carine ; Kpangon, Arsène A ; Affolabi, Dissou ; Rodriguez-Villalobos, Hector ; Van Bambeke, Françoise ; Dalleur, Olivia ; Simon, Anne. Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin.. In: Annals of clinical microbiology and antimicrobials, Vol. 19, no. 1, p. 54 [1-10] (2020). doi:10.1186/s12941-020-00398-4.
2020
Kapepula, Paulin M. ; Kabengele, Jimmy K. ; Kingombe, Micheline ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Sadiki Kishabongo, Antoine ; Decloedt, Eric ; Zumla, Adam ; Tiberi, Simon ; Suleman, Fatima ; Tshilolo, Léon ; Muyembe-TamFum, Jean-Jacques ; Zumla, Alimuddin ; Nachega, Jean B.. Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials. In: The American Journal of Tropical Medicine and Hygiene, Vol. 103, no.3, p. 960-964 (2020). doi:10.4269/ajtmh.20-0820.
2020
Peyrusson, Frédéric ; Van Wessem, Astrid ; Dieppois, Guennaëlle ; Van Bambeke, Françoise ; Tulkens, Paul M. Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor, afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells.. In: International journal of antimicrobial agents, Vol. 55, no.2, p. 105848 (2020). doi:10.1016/j.ijantimicag.2019.11.005.
2020
Delattre, Isabelle ; Briquet, Caroline ; Wallemacq, Pierre ; Tulkens, Paul M. ; Van Bambeke, Françoise. Comparative in vitro antimicrobial potency, stability, colouration and dissolution time of generics versus innovator of meropenem in Europe.. In: International journal of antimicrobial agents, Vol. 55, no. 1, p. 105825 [1-5] (2020). doi:10.1016/j.ijantimicag.2019.10.006.
2020
Toukourou, Kolawole Habib ; Sounouvou, Hope ; Catteau, Lucy ; Toukourou, Fatiou ; Van Bambeke, Françoise ; Gbaguidi, Fernand ; Quetin-Leclercq, Joëlle. Cymbopogon giganteus Chiov. essential oil: Direct effects or activity in combination with antibiotics against multi-drug resistant bacteria. In: Journal of Applied Biology & Biotechnology, Vol. 8, no.1, p. 84-89 (2020). doi:10.7324/jabb.2020.80114.
2020
Poilvache, Hervé ; Van Bambeke, Françoise. Dangerous Slimes: How Bacterial Biofilms Make You Sick and How to Combat Them. In: Frontiers for Young Minds, Vol. May, no.8, p. 62 (2020). doi:10.3389/frym.2020.00062.
2020
Meerwein, Milton ; Tarnutzer, Andrea ; Böni, Michelle ; Van Bambeke, Françoise ; Hombach, Michael ; Zinkernagel, Annelies S. Increased Azithromycin Susceptibility of Multidrug-Resistant Gram-Negative Bacteria on RPMI-1640 Agar Assessed by Disk Diffusion Testing.. In: Antibiotics (Basel, Switzerland), Vol. 9, no.5, p. E218 (2020). doi:10.3390/antibiotics9050218.
2020
Chalhoub, Houssein ; Harding, Sarah V ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of pH on the activity of finafloxacin against extracellular and intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis and Francisella philomiragia and on its cellular pharmacokinetics in THP-1 monocytes.. In: Clinical Microbiology and Infection, Vol. 26, no.9, p. 1254.e1-1254.e8 (2020). doi:10.1016/j.cmi.2019.07.028.
2020
Peyrusson, Frédéric ; Varet, Hugo ; Nguyen, Tiep Khac ; Legendre, Rachel ; Sismeiro, Odile ; Coppée, Jean-Yves ; Wolz, Christiane ; Tenson, Tanel ; Van Bambeke, Françoise. Intracellular Staphylococcus aureus persisters upon antibiotic exposure.. In: Nature communications, Vol. 11, no.1, p. 2200 (2020). doi:10.1038/s41467-020-15966-7.
2020
Theuretzbacher, Ursula ; Barbee, Lindley ; Connolly, Kristie ; Drusano, George ; Fernandes, Prabha ; Hook, Edward ; Jerse, Ann ; O'Donnell, John ; Unemo, Magnus ; Van Bambeke, Françoise ; VanScoy, Brian ; Warn, Peter ; Werth, Brian J. ; Franceschi, François ; Alirol, Emilie. Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities. In: Clinical Microbiology and Infection, Vol. 26, no.12, p. 1630-1635 (2020). doi:10.1016/j.cmi.2020.08.006.
2020
Ameryckx, Alice ; Pochet, Lionel ; Wang, Gang ; Yildiz, Esra ; Es Saadi, Bouazza ; Wouters, Johan ; Van Bambeke, Françoise ; Frédérick, Raphaël. Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting D-alanyl-D-alanine ligase in bacterio. In: European Journal of Medicinal Chemistry, Vol. 200, no.1, p. 112444 (2020). doi:10.1016/j.ejmech.2020.112444.
2020
Matzneller, Peter ; Ngougni Pokem, Perrin ; Capron, Arnaud ; Lackner, Edith ; Wulkersdorfer, Beatrix ; Nussbaumer-Pröll, Alina ; Österreicher, Zoe ; Duchek, Michael ; Van de Velde, Sebastien ; Wallemacq, Pierre ; Mouton, Johan W ; Van Bambeke, Françoise ; Zeitlinger, Markus. Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial. In: The Journal of antimicrobial chemotherapy, Vol. 75, no. 9, p. 2650–2656 (2020). doi:10.1093/jac/dkaa176.
2020
Poilvache, Hervé ; Ruiz Sorribas, Albert ; Sakoulas, George ; Rodriguez-Villalobos, Hector ; Cornu, Olivier ; Van Bambeke, Françoise. Synergistic Effects of Pulsed Lavage and Antimicrobial Therapy Against Staphylococcus aureus Biofilms in an in-vitro Model. In: Frontiers in Medicine, Vol. 7, p. 527 [1-9] (2020). doi:10.3389/fmed.2020.00527.
2020
Nguyen, Tiep K. ; Peyrusson, Frédéric ; Dodémont, Magali ; Pham, Nhung H. ; Nguyen, Hoang A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin. In: Frontiers in Microbiology, Vol. 11 (2020), p. 587364 (2020). doi:10.3389/fmicb.2020.587364.
2019
Diaz Iglesias, Yvan ; Wilms, Tobias ; Vanbever, Rita ; Van Bambeke, Françoise. Activity of Antibiotics against Staphylococcus aureus in an Model of Biofilms in the Context of Cystic Fibrosis: Influence of the Culture Medium.. In: Antimicrobial agents and chemotherapy, Vol. 63, no.7, p. pii: e00602-19 (2019). doi:10.1128/AAC.00602-19.
2019
Vu, Dinh H. ; Nguyen, Duy A. ; Delattre, Isabelle K. ; Ho, Trong T. ; Do, Hong G. ; Pham, Hong N. ; Dao, Xuan C. ; Tran, Nhan T. ; Nguyen, Gia B. ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Nguyen, Hoang A.. Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes. In: International Journal of Antimicrobial Agents, Vol. 54, no.6, p. 702-708 (2019). doi:10.1016/j.ijantimicag.2019.09.018.
2019
Fage, David ; Deprez, Guillaume ; Wolff, Fleur ; Hites, Maya ; Jacobs, Frédérique ; Van Bambeke, Françoise ; Cotton, Frédéric. Investigation of unbound colistin A and B in clinical samples using a mass spectrometry method.. In: International journal of antimicrobial agents, Vol. 2019, no. 3, p. 330-336 (2019). doi:10.1016/j.ijantimicag.2018.10.017.
2019
Tulkens, Paul M ; Van Bambeke, Françoise ; Zinner, Stephen H. Profile of a Novel Anionic Fluoroquinolone-Delafloxacin.. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 68, no.Supplement_3, p. S213-S222 (2019). doi:10.1093/cid/ciy1079.
2019
Milosevic, Tamara ; Vertenoeil, Gaëlle ; Payen, Valéry ; Sonveaux, Pierre ; Tulkens, Paul M. ; Constantinescu, Stefan N. ; Van Bambeke, Françoise. Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.. In: International journal of antimicrobial agents, Vol. 54, no. 5, p. 661-667 (2019). doi:10.1016/j.ijantimicag.2019.07.021.
2019
Ngougni Pokem, Perrin ; Capron, Arnaud ; Wallemacq, Pierre ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Laterre, Pierre-François. Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.. In: The Journal of antimicrobial chemotherapy, Vol. 74, no.5, p. 1459–1461 (2019). doi:10.1093/jac/dky565.
2018
Ameryckx, Alice ; Thabault, Léopold ; Pochet, Lionel ; Leimanis, Serge ; Poupaert, Jacques ; Wouters, Johan ; Joris, Bernard ; Van Bambeke, Françoise ; Frédérick, Raphaël. 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. In: European Journal of Medicinal Chemistry, Vol. 159, p. 324-338 (2018). doi:10.1016/j.ejmech.2018.09.067.
2018
Siala, Wafi ; Rodriguez-Villalobos, Hector ; Fernandes, Prabhavathi ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of Combinations of Antistaphylococcal Antibiotics with Fusidic Acid against Staphylococcal Biofilms in In Vitro Static and Dynamic Models. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 7, p. e00598-18 [1-12] (2018). doi:10.1128/aac.00598-18.
2018
Rogiers, Ona ; Holtappels, Michelle ; Siala, Wafi ; Lamkanfi, Mohamed ; Van Bambeke, Françoise ; Lagrou, Katrien ; Van Dijck, Patrick ; Kucharíková, Soňa. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies. In: Journal of Antimicrobial Chemotherapy, Vol. 73, no.10, p. 2806-2814 (2018). doi:10.1093/jac/dky246.
2018
Peyrusson, Frédéric ; Tulkens, Paul M ; Van Bambeke, Françoise. Cellular Pharmacokinetics and Intracellular Activity of Gepotidacin against Staphylococcus aureus Isolates with Different Resistance Phenotypes in Models of Cultured Phagocytic Cells.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no.4, p. e02245-17 (2018). doi:10.1128/AAC.02245-17.
2018
Lozano, Carmen ; Azcona-Gutiérrez, José Manuel ; Van Bambeke, Françoise ; Sáenz, Yolanda. Great phenotypic and genetic variation among successive chronic Pseudomonas aeruginosa from a cystic fibrosis patient. In: PLOS ONE, Vol. 13, no. 9, p. e0204167 (2018). doi:10.1371/journal.pone.0204167.
2018
Chalhoub, Hussein ; Sáenz, Yolanda ; Nichols, Wright W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Loss of activity of ceftazidime-avibactam due to MexAB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis. In: International Journal of Antimicrobial Agents, Vol. 52, no.5, p. 697-701 (2018). doi:10.1016/j.ijantimicag.2018.07.027.
2018
Milosevic, Tamara ; Payen, Valéry ; Sonveaux, Pierre ; Muccioli, Giulio ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 3, p. e01599-17 [1-17] (2018). doi:10.1128/AAC.01599-17.
2018
Catteau, Lucy ; Zhu, Li ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Natural and hemi-synthetic pentacyclic triterpenes as antimicrobials and resistance modifying agents against Staphylococcus aureus: a review. In: Phytochemistry Reviews, Vol. 17, no. 5, p. 1129-1163 (2018). doi:10.1007/s11101-018-9564-2.
2018
Coenye, Tom ; Goeres, Darla ; Van Bambeke, Françoise ; Bjarnsholt, Thomas. Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?. In: Clinical Microbiology and Infection, Vol. 24, no. 6, p. 570-572 (2018). doi:10.1016/j.cmi.2018.01.003.
2018
Miranda Bastos, Ana C ; Vandecasteele, Stefaan J ; Spinewine, Anne ; Tulkens, Paul M ; Van Bambeke, Françoise. Temocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations.. In: Journal of Antimicrobial Chemotherapy, Vol. 73, no.6, p. 1630-1638 (2018). doi:10.1093/jac/dky078.
2018
Khandekar, Shaunak ; Liebens, Veerle ; Fauvart, Maarten ; Tulkens, Paul M. ; Michiels, Jan ; Van Bambeke, Françoise. The putative de-N-acetylase DnpA contributes to intracellular and biofilm-associated persistence of Pseudomonas aeruginosa exposed to fluoroquinolones. In: Frontiers in microbiology, . doi:10.3389/fmicb.2018.01455.
2017
Mustafa, Muhammad Hariri ; Khandekar, Shaunak ; Tunney, Michael M. ; Elborn, Stuart J. ; Kahl, Barbara C. ; Denis, Olivier ; Plésiat, Patrick ; Traore, Hamidou ; Tulkens, Paul M. ; Vanderbist, Francis ; Van Bambeke, Françoise. Acquired resistance to macrolides inPseudomonas aeruginosafrom cystic fibrosis patients. In: The European Respiratory Journal, Vol. 49, no.5, p. 1601847 (2017). doi:10.1183/13993003.01847-2016.
2017
Defraine, Valerie ; Verstraete, Laure ; Van Bambeke, Françoise ; Anantharajah, Ahalieyah ; Townsend, Eleanor M. ; Ramage, Gordon ; Corbau, Romu ; Marchand, Arnaud ; Chaltin, Patrick ; Fauvart, Maarten ; Michiels, Jan. Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models. In: Frontiers in Microbiology, Vol. 8, p. 1-10 (2017). doi:10.3389/fmicb.2017.02585.
2017
Tam, Vincent H. ; Chang, Kai-Tai ; Zhou, Jian ; Ledesma, Kimberly R. ; Phe, Kady ; Gao, Song ; Van Bambeke, Françoise ; Sánchez-Díaz, Ana María ; Zamorano, Laura ; Oliver, Antonio ; Cantón, Rafael. Determining β-lactam exposure threshold to suppress resistance development in Gram-negative bacteria. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1421-1428 (2017). doi:10.1093/jac/dkx001.
2017
Chalhoub, Houssein ; Pletzer, Daniel ; Weingart, Helge ; Braun, Yvonne ; Tunney, Michael M. ; Elborn, J. Stuart ; Rodriguez-Villalobos, Hector ; Plésiat, Patrick ; Kahl, Barbara C. ; Denis, Olivier ; Winterhalter, Mathias ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic. In: Scientific Reports, Vol. 7, p. 40208 [1-14] (2017). doi:10.1038/srep40208.
2017
Delattre, Isabelle ; Taccone, Fabio S. ; Jacobs, Frédérique ; Hites, Maya ; Dugernier, Thierry ; Spapen, Herbert ; Laterre, Pierre-François ; Wallemacq, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M.. Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?. In: Expert Review of Anti-infective Therapy, Vol. 15, no. 7, p. 677-688 (2017). doi:10.1080/14787210.2017.1338139.
2017
Buyck, Julien ; Luyckx, C. ; Muccioli, Giulio ; Krause, K.M. ; Nichols, W. W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1400-1409 (2017). doi:10.1093/jac/dkw587.
2017
Anantharajah , Ahalieyah ; Buyck, Julien ; Sundin, Charlotta ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms.. In: Antimicrobial Agents and Chemotherapy, Vol. 61, no. 6 (2017), p. e02566-16 (2017). doi:10.1128/AAC.02566-16.
2017
Catteau, Lucy ; Reichmann, Nathalie ; Olson, Joshua ; Pinho, Mariana ; Nizet, Victor ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms. In: Molecules, Vol. 22, p. 2245 (2017). doi:10.3390/molecules22122245.
2016
Mustafa, Muhammad Hariri ; Chalhoub, Hussein ; Denis, Olivier ; Deplano, Ariane ; Vergison, Anne ; Rodriguez-Villalobos, Hector ; Tunney, Michael M ; Elborn, J Stuart ; Kahl, Barbara C ; Traore, Hamidou ; Vanderbist, Francis ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients through Northern Europe.. In: Antimicrobial Agents and Chemotherapy, Vol. 60, no. 11, p. 6735-6741 (2016). doi:10.1128/AAC.01046-16.
2016
Van Bambeke, Françoise ; Tulkens, Paul M.. Editorial Commentary: Colistin and a New Paradigm in Drug Development.. In: Clinical Infectious Diseases, Vol. 62, no. 5, p. 559-560 (2016). doi:10.1093/cid/civ968.
2016
Chalhoub, Hussein ; Sáenz, Yolanda ; Rodriguez-Villalobos, Hector ; Denis, Olivier ; Kahl, Barbara C. ; Tulkens, Paul ; Van Bambeke, Françoise. High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations. In: International Journal of Antimicrobial Agents, Vol. 48, no. 6, p. 740-743 (2016). doi:10.1016/j.ijantimicag.2016.09.012.
2016
Riou, Mickaël ; Avrain, Laëtitia ; Carbonnelle, Sylviane ; El Garch, Farid ; Pirnay, Jean-Paul ; De Vos, Daniel ; Plésiat, Patrick ; Tulkens, Paul M. ; Van Bambeke, Françoise. Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia. In: International Journal of Antimicrobial Agents, Vol. 47, no. 1, p. 77-83 (2016). doi:10.1016/j.ijantimicag.2015.11.004.
2016
Anantharajah, Ahalieyah ; Faure, Emmanuel ; Buyck, Julien ; Sundin, Charlotta ; Lindmark, Tuulikki ; Mecsas, Joan ; Yahr, Timothy L ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Guery, Benoît ; Van Bambeke, Françoise. Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.. In: The Journal of Infectious Diseases, Vol. 214, no.7, p. 1105-1116 (2016). doi:10.1093/infdis/jiw295.
2016
Vandevelde, Nathalie M. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach.. In: Drug Discovery Today, Vol. 21, no. 7, p. 1114-1129 (16). doi:10.1016/j.drudis.2016.04.001.
2016
Ceyssens, Pieter-Jan ; Van Bambeke, Françoise ; Mattheus, Wesley ; Bertrand, Sophie ; Fux, Frédéric ; Van Bossuyt, Eddie ; Damée, Sabrina ; Nyssen, Henry-Jean ; De Craeye, Stéphane ; Verhaegen, Jan ; The Belgian Streptococcus pneumoniae Study Group ; Tulkens, Paul M. ; Vanhoof, Raymond. Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014).. In: PLoS One, Vol. 11, no. 5, p. e0154816 [1-17] (2016). doi:10.1371/journal.pone.0154816.
2016
Siala, Wafi ; Van Bambeke, Françoise ; Taresco, Vincenzo ; Piozzi, Antonella ; Francolini, Iolanda. Synergistic activity between an antimicrobial polyacrylamide and Daptomycin vs. Staphylococcus aureus biofilm.. In: Pathogens and Disease, Vol. non applicable, no.non applicable, p. ftw042 (2016). doi:10.1093/femspd/ftw042 (Accepté/Sous presse).
2016
Anantharajah, Ahalieyah ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Targeting Type Three Secretion System in Pseudomonas aeruginosa. In: Trends in Pharmacological Sciences, Vol. 37, no. 9, p. 734-749 (2016). doi:10.1016/j.tips.2016.05.011.
2016
Siala, Wafi ; Kucharíková, Soňa ; Braem, Annabel ; Vleugels, Jef ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Dijck, Patrick ; Van Bambeke, Françoise. The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase. In: Nature Communications, Vol. 7, no.Nov.3, p. 13286 (2016). doi:10.1038/ncomms13286.
2016
Van Bambeke, Françoise ; Tulkens, Paul M.. The role of solithromycin in the management of bacterial community-acquired pneumonia.. In: Expert Review of Anti-infective Therapy, Vol. 14, no.3, p. 311-324 (2016). doi:10.1586/14787210.2016.1138857.
2015
Buyck, Julien ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of antibiotic combinations against resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no. 1, p. 258-268 (2015). doi:10.1128/AAC.04011-14.
2015
Chalhoub, Hussein ; Tunney, Michael ; Elborn, J Stuart ; Vergison, Anne ; Denis, Olivier ; Plésiat, Patrick ; Kahl, Barbara C ; Van Bambeke, Françoise ; Tulkens, Paul M.. Avibactam confers susceptibility to a large proportion of ceftazidime-resistant Pseudomonas aeruginosa isolates recovered from cystic fibrosis patients. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 5, p. 1596-1598 (2015). doi:10.1093/jac/dku551.
2015
Peyrusson, Frédéric ; Butler, Déborah ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes. Studies with human THP-1 monocytes and J774 murine macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no. 9, p. 5747-5760 (2015). doi:10.1128/AAC.00827-15.
2015
Anantharajah, Ahalieyah ; Buyck, Julien ; Faure, Emmanuel ; Glupczynski, Gerald ; Rodriguez-Villalobos, Hector ; De Vos, Daniel ; Pirnay, Jean-Paul ; Bilocq, Florence ; Guery, Benoît ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes.. In: Pathogens and Disease, Vol. 73, no. 7, p. ftv049 [1-5] (2015). doi:10.1093/femspd/ftv049.
2015
Van Bambeke, Françoise. Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy. In: Future Microbiology, Vol. 10, no.00, p. 1-13 (2015). doi:10.2217/fmb.15.39.
2015
Van Bambeke, Françoise. Lipoglycopeptide Antibacterial Agents in Gram-Positive Infections: A Comparative Review.. In: Drugs, Vol. 75, no.18, p. 2073-2095 (2015). doi:10.1007/s40265-015-0505-8.
2015
Frippiat, Frédéric ; Musuamba, Flora Tshinanu ; Seidel, Laurence ; Albert, Adelin ; Denooz, Raphaël ; Charlier, Corinne ; Van Bambeke, Françoise ; Wallemacq, Pierre ; Descy, Julie ; Lambermont, Bernard ; Layios, Nathalie ; Damas, Pierre ; Moutschen, Michel. Modelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study. In: The Journal of antimicrobial chemotherapy, Vol. 70, no. 1, p. 207-216 (2015). doi:10.1093/jac/dku354.
2015
Vandevelde, Nathalie ; Tulkens, Paul M. ; Muccioli, Giulio ; Van Bambeke, Françoise. Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 6, p. 1713-1726 (2015). doi:10.1093/jac/dkv032.
2015
Catteau, Lucy ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa. In: Phytochem Rev, Vol. 14, no. not applicable, p. 975-991 (2015). doi:10.1007/s11101-015-9437-x.
2015
Buyck, Julien M ; Peyrusson, Frédéric ; Tulkens, Paul M. ; Van Bambeke, Françoise. RX-P873, a novel protein synthesis inhibitor, accumulates in human THP-1 monocytes and is active against intracellular infections by Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria.. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no.00, p. AAC.00428-15 (2015). doi:10.1128/AAC.00428-15 (Accepté/Sous presse).
2015
Theuretzbacher, Ursula ; Van Bambeke, Françoise ; Cantón, Rafael ; Giske, Christian G ; Mouton, Johan W ; Nation, Roger L ; Paul, Mical ; Turnidge, John D ; Kahlmeter, Gunnar. Reviving old antibiotics.. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 00, p. 2177-2181 (2015). doi:10.1093/jac/dkv157.
2015
Vandecasteele, Stefaan J ; Miranda Bastos, Ana ; Capron, Arnaud ; Spinewine, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Thrice-weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients.. In: International Journal of Antimicrobial Agents, Vol. 46, no. 6, p. 660-665 (2015). doi:10.1016/j.ijantimicag.2015.09.005.
2015
Ngougni Pokem, Perrin ; Miranda Bastos, Ana ; Tulkens, Paul M. ; Wallemacq, Pierre ; Van Bambeke, Françoise ; Capron, Arnaud. Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum.. In: Clinical Biochemistry, Vol. 48, no. 7-8, p. 542-545 (2015). doi:10.1016/j.clinbiochem.2015.02.006.
2014
Vandevelde, Nathalie ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antibiotic activity against naive and induced Streptococcus pneumoniae biofilms in an in vitro pharmacodynamic model. In: Antimicrobial agents and chemotherapy, Vol. 58, no. 3, p. 1348-1358 (2014). doi:10.1128/AAC.01858-13.
2014
Vandevelde, Nathalie ; Tulkens, Paul M. ; Diaz Iglesias, Yvan ; Verhaegen, Jan ; Rodriguez-Villalobos, Hector ; Philippart, Ivan ; Cadrobbi, Julie ; Coppens, Nathalie ; Boel, An ; Van Vaerenbergh, Kristien ; Francart, Hugo ; Vanhoof, Raymond ; Liistro, Giuseppe ; Jordens, Paul ; d'Odemont, Jean-Paul ; Valcke, Yvan ; Verschuren, Franck ; Van Bambeke, Françoise. Characterisation of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: in vitro susceptibility to antibiotics and biofilm formation in relation to antibiotic efflux and serotypes/serogroups.. In: International journal of antimicrobial agents, Vol. 44, no. 3, p. 209-217 (2014). doi:10.1016/j.ijantimicag.2014.05.016.
2014
Siala, Wafi ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Hallin, Marie ; Denis, Olivier ; Van Bambeke, Françoise. Comparison of the antibiotic activities of Daptomycin, Vancomycin, and the investigational Fluoroquinolone Delafloxacin against biofilms from Staphylococcus aureus clinical isolates.. In: Antimicrobial agents and chemotherapy, Vol. 58, no. 11, p. 6385-6397 (2014). doi:10.1128/AAC.03482-14.
2014
Miranda Bastos, Ana ; Vandecasteele, Stefaan J ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Development and validation of a high performance liquid chromatography assay for the determination of temocillin in serum of haemodialysis patients.. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 90, no. 1, p. 192-197 (2014). doi:10.1016/j.jpba.2013.12.002.
2014
Sautrey, Guillaume ; Zimmermann, Louis ; Deleu, Magali ; Delbar, Alicia ; Machado, Luiza Souza ; Jeannot, Katy ; Van Bambeke, Françoise ; Buyck, Julien ; Decout, Jean-Luc ; Mingeot-Leclercq, Marie-Paule. New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides. In: Antimicrobial Agents and Chemotherapy, Vol. 58, no. 8, p. 4420-4430 (2014). doi:10.1128/AAC.02536-13.
2014
Marquez, Béatrice ; Pourcelle, Vincent ; Vallet, Coralie M ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Marchand-Brynaert, Jacqueline ; Van Bambeke, Françoise. Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.. In: Pharmaceutical research, Vol. 31, no.5, p. 1290-301 (2014). doi:10.1007/s11095-013-1250-x.
2014
Van Bambeke, Françoise. Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.. In: Annals of medicine, Vol. 46, no. 7, p. 512-529 (2014). doi:10.3109/07853890.2014.935470.
2014
Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Study of macrophage functions in murine J774 cells and human activated THP-1 cells exposed to oritavancin, a lipoglycopeptide with high cellular accumulation.. In: Antimicrobial agents and chemotherapy, Vol. 58, no.4, p. 2059-66 (2014). doi:10.1128/AAC.02475-13.
2013
Catalano, Alessia ; Carocci, Alessia ; Defrenza, Ivana ; Muraglia, Marilena ; Carrieri, Antonio ; Van Bambeke, Françoise ; Rosato, Antonio ; Corbo, Filomena ; Franchini, Carlo. 2-Aminobenzothiazole derivatives: Search for new antifungal agents. In: European Journal of Medicinal Chemistry, Vol. 64, no. jun, p. 357-364 (2013). doi:10.1016/j.ejmech.2013.03.064.
2013
Bauer, Julia ; Siala, Wafi ; Tulkens, Paul M. ; Van Bambeke, Françoise. A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of daptomycin and delafloxacin against Staphylococcus aureus biofilms.. In: Antimicrobial agents and chemotherapy, Vol. 57, no. 6, p. 2726-2737 (2013). doi:10.1128/AAC.00181-13.
2013
Melard, Aurélie ; Garcia, Laetitia ; Das, Debaditya ; Rozenberg, Raoul ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Lemaire, Sandrine. Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin. In: Journal of Antimicrobial Chemotherapy, Vol. 68, no. 3, p. 648-658 (2013). doi:10.1093/jac/dks442.
2013
Caceres, Nancy E ; Aerts, Maarten ; Marquez, Béatrice ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Devreese, Bart ; Van Bambeke, Françoise. Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC). In: PLoS One, Vol. 8, no. 3, p. e58285 [1-15] (2013). doi:10.1371/journal.pone.0058285.
2013
Garcia, Laetitia G. ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Denis, Olivier ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data. In: Journal of Antimicrobial Chemotherapy, Vol. 68, no. 7, p. 1455-1464 (2013). doi:10.1093/jac/dkt072.
2013
Buyck, Julien ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the intracellular activity of antibiotics towards Pseudomonas aeruginosa PAO1 in a model of THP-1 human monocytes. In: Antimicrobial Agents and Chemotherapy, Vol. 57, no. 5, p. 2310-2318 (2013). doi:10.1128/AAC.02609-12.
2013
Avrain, Laetitia ; Mertens, Pascal ; Van Bambeke, Françoise. RND efflux pumps in P. aeruginosa: an underestimated resistance mechanism. In: Clinical Laboratory International, Vol. April-May, p. 26/28 (2013).
2012
Lismond, Ann ; Carbonnelle, Sylviane ; Verhaegen, Jan ; Schatt, Patricia ; De Bel, Annelies ; Jordens, Paul ; Jacobs, Frédérique ; Dediste, Anne ; Verschuren, Franck ; Huang, Te-Din ; Tulkens, Paul M. ; Glupczynski, Gerald ; Van Bambeke, Françoise. Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. In: International Journal of Antimicrobial Agents, Vol. 39, no. 3, p. 208-216 (2012). doi:10.1016/j.ijantimicag.2011.11.011.
2012
Imbuluzqueta, Edurne ; Lemaire, Sandrine ; Gamazo, Carlos ; Elizondo, Elisa ; Ventosa, Nora ; Veciana, Jaume ; Van Bambeke, Françoise ; Blanco-Prieto, María J. Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.9, p. 2158-64 (2012). doi:10.1093/jac/dks172.
2012
Buyck, Julien M ; Plésiat, Patrick ; Traore, H ; Vanderbist, F ; Tulkens, Paul M. ; Van Bambeke, Françoise. Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability.. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 55, no.4, p. 534-42 (2012). doi:10.1093/cid/cis473.
2012
Garcia, Laetitia G ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of the protein kinase C activator phorbol myristate acetate on the intracellular activity of antibiotics against hemin- and menadione-auxotrophic small-colony variant mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells.. In: Antimicrobial agents and chemotherapy, Vol. 56, no.12, p. 6166-74 (2012). doi:10.1128/AAC.01031-12.
2012
Garcia, Laetitia G ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Tulkens, Paul M. ; Van Bambeke, Françoise. Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.12, p. 2873-81 (2012). doi:10.1093/jac/dks325.
2012
Baquir, Beverlie ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Lin, Lin ; Spellberg, Brad. Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin. In: Clinical Infectious Diseases, Vol. 54, no. Suppl 3, p. S229-S232 (2012). doi:10.1093/cid/cir921.
2012
Garcia, Laetitia ; Lemaire, S ; Kahl, B C ; Becker, K ; Proctor, R A ; Denis, O ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.. In: Antimicrobial Agents and Chemotherapy, Vol. 56, no. 7, p. 3700-3711 (2012). doi:10.1128/AAC.00285-12.
2012
Buyck, Julien M ; Guénard, Sophie ; Plésiat, Patrick ; Tulkens, Paul M. ; Van Bambeke, Françoise. Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.3, p. 771-5 (2012). doi:10.1093/jac/dkr543.
2011
Van Bambeke, Françoise. ABC Transporters : role in modulation of drug pharmacokinetics and in physiopathology and therapeutic perspectives. In: Current Drug Targets, Vol. 12, no. 5, p. 598-599 (2011). doi:10.2174/138945011795378531.
2011
Marquez, Béatrice ; Van Bambeke, Françoise. ABC multidrug transporters : target for modulation of drug pharmacokinetics and drug-drug interactions. In: Current Drug Targets, Vol. 12, no. 5, p. 600-20 (2011). doi:10.2174/138945011795378504.
2011
Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M.. Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.. In: International Journal of Antimicrobial Agents, Vol. 38, no. 1, p. 52-59 (2011). doi:10.1016/j.ijantimicag.2011.03.002.
2011
Lemaire, Sandrine ; Van Bambeke, Françoise ; Pierard, Denis ; Appelbaum, Peter C. ; Tulkens, Paul M.. Activity of fusidic acid against extracellular and intracellular Staphylococcus aureus : influence of pH and comparison with linezolid and clindamycin.. In: Clinical Infectious Diseases, Vol. 52 Suppl 7, p. S493-503 (2011). doi:10.1093/cid/cir165.
2011
Lemaire, Sandrine ; Kosowska-Shick, Klaudia ; Appelbaum, Peter C. ; Glupczynski, Y. ; Van Bambeke, Françoise ; Tulkens, Paul M.. Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus : comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.. In: Journal of Antimicrobial Chemotherapy, Vol. 66, no. 3, p. 596-607 (2011). doi:10.1093/jac/dkq478.
2011
Vallet, Coralie M. ; Marquez, Béatrice ; Ngabirano, Eva ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity : studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages. In: International Journal of Antimicrobial Agents, Vol. 38, no. 3, p. 249-256 (2011). doi:10.1016/j.ijantimicag.2011.05.011.
2011
Marquez, Béatrice ; Ameye, Geneviève ; Vallet, Coralie M. ; Tulkens, Paul M. ; Poirel, Hélène A. ; Van Bambeke, Françoise. Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin. In: PLoS One, Vol. 6, no. 12, p. e28368 (2011). doi:10.1371/journal.pone.0028368.
2011
Lemaire, Sandrine ; Tulkens, Paul M. ; Van Bambeke, Françoise. Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011). doi:10.1128/AAC.01201-10.
2011
Lismond, Ann ; Carbonnelle, Sylviane ; Tulkens, Paul M. ; Van Bambeke, Françoise. Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia. In: Journal of Antimicrobial Chemotherapy, Vol. 66, no. 4, p. 948-951 (2011). doi:10.1093/jac/dkr004.
2011
Sandberg, Anne ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Hughes, Diarmaid ; von Eiff, Christof ; Frimodt-Møller, Niels. Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model. In: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 4, p. 1443-1452 (2011). doi:10.1128/AAC.00205-10.
2011
Vallet, Coralie M. ; Marquez, Béatrice ; Nhiri, Naïma ; Anantharajah, Ahalieyah ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Lallemand, Jean-Yves ; Jacquet, Eric ; Van Bambeke, Françoise. Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin. In: Toxicology, Vol. 290, no. 2-3, p. 178-186 (2011). doi:10.1016/j.tox.2011.09.003.
2011
Denamur, Sophie ; Tyteca, Donatienne ; Marchand-Brynaert, Jacqueline ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic. In: Free Radical Biology & Medicine, Vol. 51, no. 9, p. 1656-1665 (2011). doi:10.1016/j.freeradbiomed.2011.07.015.
2010
Baudoux, Pierre ; Lemaire, Sandrine ; Denis, Olivier ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Glupczynski, Gerald. Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes.. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 6, p. 1228-1236 (2010). doi:10.1093/jac/dkq110.
2010
Lemaire, Sandrine ; Kosowska-Shick, Klaudia ; Appelbaum, Peter C ; Verween, Gunther ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid : studies with infected phagocytic and non-phagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2549-2559 (2010). doi:10.1128/AAC.01724-09.
2010
Lemaire, Sandrine ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells : studies with macrophages and polymorphonuclear neutrophils. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2540-2548 (2010). doi:10.1128/AAC.01723-09.
2010
Becker, Jean-Paul ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Dynamics and structural changes induced by ATP binding in SAV1866, a bacterial ABC exporter.. In: The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, Vol. 114, no. 48, p. 15948-15957 (2010). doi:10.1021/jp1038392.
2010
El Garch, Farid ; Lismond, Ann ; Piddock, Laura J. V. ; Courvalin, Patrice ; Tulkens, Paul M. ; Van Bambeke, Françoise. Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae.. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 10, p. 2076-2082 (2010). doi:10.1093/jac/dkq287.
2010
Riou, Mickaël ; Carbonnelle, Sylviane ; Avrain, Laetitia ; Mesaros, Narcisa ; Pirnay, Jean-Paul ; Bilocq, Florence ; De Vos, Daniel ; Simon, Anne ; Piérard, Denis ; Jacobs, Frédérique ; Dediste, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Glupczynski, Gerald. In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy.. In: International Journal of Antimicrobial Agents, Vol. 36, no. 6, p. 513-522 (2010). doi:10.1016/j.ijantimicag.2010.08.005.
2010
Domenech, Oscar ; Dufrêne, Yves ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus.. In: BBA - Biomembranes, Vol. 1798, no. 10, p. 1876-1885 (2010). doi:10.1016/j.bbamem.2010.06.011.
2010
Sandberg, Anne ; Jensen, Klaus Skovbo ; Tulkens, Paul M. ; Baudoux, Pierre ; Van Bambeke, Françoise ; Frimodt-Møller, Niels. Intra- and extracellular activity of dicloxacillin against Staphylococcus aureus in vivo and in vitro.. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2391-400 (2010). doi:10.1128/AAC.01400-09.
2010
Sandberg, Anne ; Jensen, Klaus Skovbo ; Baudoux, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Frimodt-Møller, Niels. Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 5, p. 962-73 (2010). doi:10.1093/jac/dkq052.
2010
Brinch, Karoline Sidelmann ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Frimodt-Møller, Niels ; Høiby, Niels ; Kristensen, Hans-Henrik. Intracellular activity of the peptide antibiotic NZ2114 : studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 8, p. 1720-1724 (2010). doi:10.1093/jac/dkq159.
2009
Lemaire, Sandrine ; Glupczynski, Gerald ; Duval, Valérie ; Joris, Bernard ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 6, p. 2289-2297 (2009). doi:10.1128/AAC.01135-08.
2009
Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M.. Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, towards Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 9, p. 3734-3743 (2009). doi:10.1128/AAC.00203-09.
2009
Lemaire, Sandrine ; Van Bambeke, Françoise ; Appelbaum, Peter C ; Tulkens, Paul M.. Cellular pharmacokinetics and intracellular activity of torezolid (TR-700) : studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines. In: Journal of Antimicrobial Chemotherapy, Vol. 64, no. 5, p. 1035-1043 (2009). doi:10.1093/jac/dkp267.
2009
Tytgat, Isabelle ; Colacino, Evelina ; Tulkens, Paul M. ; Poupaert, Jacques ; Prévost, M ; Van Bambeke, Françoise. DD-ligases as a potential target for antibiotics: past, present and future. In: Current Medicinal Chemistry, Vol. 16, no. 20, p. 2566-2580 (2009). doi:10.2174/092986709788682029.
2009
Marquez, Béatrice ; Caceres, Nancy E. ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: Studies with ciprofloxacin-resistant cells. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 6, p. 2410-2416 (2009). doi:10.1128/AAC.01428-08.
2009
Domenech, Oscar ; Francius, Grégory ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Dufrêne, Yves ; Mingeot-Leclercq, Marie-Paule. Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers : effect on membrane permeability and nanoscale lipid membrane organization. In: BBA - Biomembranes, Vol. 1788, no. 9, p. 1832-1840 (2009). doi:10.1016/j.bbamem.2009.05.003.
2009
Nguyen, Hoang Anh ; Denis, Olivier ; Vergison, Anne ; Theunis, Anne ; Tulkens, Paul M. ; Struelens, Marc J. ; Van Bambeke, Françoise. Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : Pharmacodynamic evaluation and comparison with isogenic normal phenotype and revertant strains. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 4, p. 1434-1442 (2009). doi:10.1128/AAC.01145-08.
2009
Nguyen, Hoang ; Denis, Olivier ; Vergison, Anne ; Tulkens, Paul M. ; Struelens, Marc J. ; Van Bambeke, Françoise. Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : study of antibiotic combinations. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 4, p. 1443-1449 (2009). doi:10.1128/AAC.01146-08.
2009
Van de Velde, Sébastien ; Delaive, Edouard ; Dieu, Marc ; Carryn, Stéphane ; Van Bambeke, Françoise ; Devreese, Bart ; Raes, Martine ; Tulkens, Paul M.. Isolation and 2D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes.. In: Proteomics, Vol. 9, no. 24, p. 5484-5496 (2009). doi:10.1002/pmic.200900503.
2009
Becker, Jean-Paul ; Depret, Grégoire ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Molecular models of human P-glycoprotein in two different catalytic states. In: BMC Structural Biology, Vol. 9, no. 3, p. [1-18] (2009). doi:10.1186/1472-6807-9-3.
2009
Van de Velde, Sébastien ; Carryn, Stéphane ; Van Bambeke, Françoise ; Hill, Colin ; Tulkens, Paul M. ; Sleator, Roy D.. Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes.. In: Gut Pathogens, Vol. 1, p. 23 (2009). doi:10.1186/1757-4749-1-23.
2009
Van Bambeke, Françoise ; Tulkens, Paul M.. Pharmacodynamie des antibiotiques dans le LCR : principes et conséquences (facteurs prédictifs d'efficacité). In: Médecine et maladies infectieuses - revue de la Société de pathologie infectieuse de langue française, Vol. 39, no. 7-8, p. 483-492 (2009). doi:10.1016/j.medmal.2009.02.038.
2009
Brinch, Karoline Sidelmann ; Sandberg, Anne ; Baudoux, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Frimodt-Møller, Niels ; Høiby, Niels ; Kristensen, Hans-Henrik. Plectasin shows intracellular activity against staphylococcus aureus in human THP-1 monocytes and in the mouse peritonitis model. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 11, p. 4801-4808 (2009). doi:10.1128/AAC.00685-09.
2009
Olivier, Aurélie C. ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Oldfield, Eric. Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of staphylococcus aureus in human macrophages and endothelial cells. In: The Journal of Infectious Diseases, Vol. 200, no. 9, p. 1367-1370 (2009). doi:10.1086/606012.
2009
Van Bambeke, Françoise ; Tulkens, Paul M.. Safety profile of the respiratory fluoroquinolone moxifloxacin : comparison with other fluoroquinolones and other antibacterial classes. In: Drug Safety, no. 5, p. 359-78 (2009).
2009
Tytgat, Isabelle ; Vandevuer, Stéphane ; Ortmans, Isabelle ; Sirockin, Finton ; Colacino, Evelina ; Van Bambeke, Françoise ; Duez, Colette ; Poupaert, Jacques ; Tulkens, Paul M. ; Dejaegere, Annick ; Prévost, Martine. Structure-based design of benzoxazoles as new inhibitors for D-Alanyl – D-Alanine ligase. In: QSAR & Combinatorial Science, Vol. 28, no. 11-12, p. 1394-1404 (2009). doi:10.1002/qsar.200910054.
2009
Franchini, Carlo ; Muraglia, Marilena ; Corbo, Filomena ; Florio, Marco Antonio ; Di Mola, Antonia ; Rosato, Antonio ; Matucci, Rosanna ; Nesi, Marta ; Van Bambeke, Françoise ; Vitali, Cesare. Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.. In: Archiv der Pharmazie, Vol. 342, no. 10, p. 605-613 (2009). doi:10.1002/ardp.200900092.
2008
Lemaire, Sandrine ; Kosowska-Shick, K. ; Julian, K ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Appelbaum, Peter C.. Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of Staphylococcus aureus isolates from a patient with persistent bacteraemia and endocarditis.. In: Clinical Microbiology and Infection, Vol. 14, no. 8, p. 766-777 (2008). doi:10.1111/j.1469-0691.2008.02035.x.
2008
Denamur, Sophie ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Apoptosis induced by aminoglycosides in LLC-PK1 cells : comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 6, p. 2236-2238 (2008). doi:10.1128/AAC.01680-07.
2008
Barcia Macay, Maritza ; Mouaden, Fatima ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).. In: Journal of Antimicrobial Chemotherapy, Vol. 61, no. 6, p. 1288-1294 (2008). doi:10.1093/jac/dkn120.
2008
Van de Velde, Sébastien ; Nguyen, Hoang Anh ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Grellet, Jean ; Dubois, Véronique ; Quentin, Claudine ; Saux, Marie-Claude. Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.. In: Journal of Antimicrobial Chemotherapy, Vol. 62, no. 3, p. 518-521 (2008). doi:10.1093/jac/dkn232.
2008
Lismond, Ann ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Courvalin, Patrice ; Van Bambeke, Françoise. Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes : studies with ciprofloxacin and moxifloxacin. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 9, p. 3040-3046 (2008). doi:10.1128/AAC.00105-08.
2008
Bensikaddour, Hayet ; Snoussi, Karim ; Lins, Laurence ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Brasseur, Robert ; Goormaghtigh, Erik ; Mingeot-Leclercq, Marie-Paule. Interactions of ciprofloxacin with DPPC and DPPG : fluorescence anisotropy, ATR-FTIR and (31)P NMR spectroscopies and conformational analysis. In: BBA - Biomembranes, Vol. 1778, no. 11, p. 2535-2543 (2008). doi:10.1016/j.bbamem.2008.08.015.
2008
Van Bambeke, Françoise ; Harms, Joerg M ; Van Laethem, Yves ; Tulkens, Paul M.. Ketolides : pharmacological profile and rational positioning in the treatment of respiratory tract infections. In: Expert Opinion on Pharmacotherapy, Vol. 9, no. 2, p. 267-283 (2008). doi:10.1517/14656566.9.2.267.
2008
Van Bambeke, Françoise. L'ABC des hépatites virales. In: Journal de Pharmacie de Belgique, Vol. 63, no. 1, p. 15-20 (2008).
2008
Lemaire, Sandrine ; Olivier, Aurélie ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Appelbaum, Peter C ; Glupczynski, Gerald. Restoration of susceptibility of intracellular methicillin resistant staphylococcus aureus to beta-lactams : comparison between strains, cells, and antibiotics. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 8, p. 2797-2805 (2008). doi:10.1128/AAC.00123-08.
2008
Lemaire, Sandrine ; Fuda, Cosimo ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mobashery, Shahriar. Restoration of susceptibility of methicillin-resistant staphylococcus aureus to beta-lactam antibiotics by acidic pH : role of penicillin-binding protein 2A (PBP 2A). In: Journal of Biological Chemistry, Vol. 283, no. 19, p. 12769-12776 (2008). doi:10.1074/jbc.M800079200.
2008
Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Struelens, Marc J ; Tulkens, Paul M.. The bacterial envelope as a target for novel anti-MRSA antibiotics. In: Trends in Pharmacological Sciences, Vol. 29, no. 3, p. 124-134 (2008). doi:10.1016/j.tips.2007.12.004.
2007
Mesaros, Narcisa ; Glupczynski, Gerald ; Avrain, Laetitia ; Caceres, Nancy E ; Tulkens, Paul M. ; Van Bambeke, Françoise. A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.. In: The Journal of antimicrobial chemotherapy, Vol. 59, no. 3, p. 378-86 (2007). doi:10.1093/jac/dkl504.
2007
Baudoux, Pierre ; Bles, Nathalie ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections. In: Journal of Antimicrobial Chemotherapy, Vol. 59, no. 2, p. 246-253 (2007). doi:10.1093/jac/dkl489.
2007
Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells. In: Antimicrobial Agents and Chemotherapy, Vol. 51, no. 8, p. 2748-2757 (2007). doi:10.1128/AAC.00090-07.
2007
Van Bambeke, Françoise ; Reinert, René R ; Appelbaum, Peter C ; Tulkens, Paul M. ; Peetermans, Willy E. Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.. In: Drugs, Vol. 67, no. 16, p. 2355-82 (2007). doi:10.2165/00003495-200767160-00005.
2007
Mathot, Frédéric ; Schanck, André ; Van Bambeke, Françoise ; Ariën, A ; Noppe, M ; Brewster, M. ; Préat, Véronique. Passive diffusion of polymeric surfactants across lipid bilayers.. In: Journal of Controlled Release, Vol. 120, no. 1-2, p. 79-87 (2007). doi:10.1016/j.jconrel.2007.03.015.
2007
Mesaros, N. ; Nordmann, P. ; Plésiat, P. ; Roussel-Delvallez, M. ; Van Eldere, J. ; Glupczynski, Gerald ; Van Laethem, Y. ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: Résistance et options thérapeutiques à l'aube du deuxième millénaire. In: Louvain médical, Vol. 126, no. 8, p. 305-316 (2007).
2007
Mesaros, Narcisa ; Nordmann, P. ; Plésiat, P. ; Roussel-Delvallez, M. ; Van Eldere, J. ; Glupczynski, Gerald ; Van Laethem, Yves ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: Résistance et options thérapeutiques à l'aube du deuxième millénaire. In: Antibiotiques : journal des agents anti-infectieux, Vol. 9, no. 3, p. 189-198 (2007). doi:10.1016/S1294-5501(07)91378-3.
2007
Mesaros, N ; Glupczynski, Gerald ; Nordmann, Patrick ; Plésiat, Patrick ; Roussel-Delvallez, Micheline ; Van Eldere, Johan ; Van Laethem, Yves ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.. In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 13, no. 6, p. 560-78 (2007). doi:10.1111/j.1469-0691.2007.01681.x.
2007
Mesaros, Narcisa ; Nordmann, Patrice ; Plésiat, Patrick ; Roussel-Delvallez, Micheline ; Van Eldere, Johan ; Glupczynski, Gerald ; Van Laethem, Yves ; Jacobs, Frédérique ; Lebecque, Patrick ; Malfroot, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: résistance et options thérapeutiques à l'aube du nouveau millénaire. In: Louvain médical, Vol. 126, no.8, p. 305-316 (2007).
2007
Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Glupczynski, Gerald ; Tulkens, Paul M.. Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin. In: Antimicrobial Agents and Chemotherapy, Vol. 51, no. 5, p. 1627-1632 (2007). doi:10.1128/AAC.01192-06.
2007
Avrain, Laetitia ; Garvey, Mark ; Mesaros, Narcisa ; Glupczynski, Gerald ; Mingeot-Leclercq, Marie-Paule ; Piddock, Laura J V ; Tulkens, Paul M. ; Vanhoof, Raymond ; Van Bambeke, Françoise. Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations. In: Journal of Antimicrobial Chemotherapy, Vol. 60, no. 5, p. 965-972 (2007). doi:10.1093/jac/dkm292.
2006
Michot, Jean-Michel ; Heremans, Marie F ; Caceres, Nancy E. ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 5, p. 1689-1695 (2006). doi:10.1128/AAC.50.5.1689-1695.2006.
2006
Van Bambeke, Françoise ; Barcia-Macay, Maritza ; Lemaire, Sandrine ; Tulkens, Paul M.. Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.. In: Current opinion in drug discovery & development, Vol. 9, no. 2, p. 218-30 (2006).
2006
Barcia Macay, Maritza ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. In: Journal of Antimicrobial Chemotherapy, Vol. 58, no. 6, p. 1177-1184 (2006). doi:10.1093/jac/dkl424.
2006
Servais, Hélène ; Jossin, Yves ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 4, p. 1213-1221 (2006). doi:10.1128/AAC.50.4.1213-1221.2006.
2006
Van Bambeke, Françoise. Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy.. In: Current opinion in investigational drugs (London, England : 2000), Vol. 7, no. 8, p. 740-9 (2006).
2006
Van Bambeke, Françoise ; Pagès, Jean-Marie ; Lee, Ving J. Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.. In: Recent patents on anti-infective drug discovery, Vol. 1, no. 2, p. 157-75 (2006). doi:10.2174/157489106777452692.
2006
Barcia Macay, Maritza ; Seral, Cristina ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 3, p. 841-851 (2006). doi:10.1128/AAC.50.3.841-851.2006.
2006
Vandevuer, Stéphane ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: insight into the mechanism of ligand migration and binding sites.. In: Proteins, Vol. 63, no. 3, p. 466-78 (2006). doi:10.1002/prot.20892.
2006
Charvalos, Ekatherina ; Tzatzarakis, Manolis N ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Tsatsakis, Aristidis M ; Tzanakakis, George N ; Mingeot-Leclercq, Marie-Paule. Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects. In: Journal of Antimicrobial Chemotherapy, Vol. 57, no. 2, p. 236-244 (2006). doi:10.1093/jac/dki455.
2005
Chanteux, Hugues ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 4, p. 1279-1288 (2005). doi:10.1128/AAC.49.4.1279-1288.2005.
2005
Mesaros, Narcisa ; Van Bambeke, Françoise ; Avrain, Laetitia ; Glupczynski, Gerald ; Vanhoof, Raymond ; Tulkens, Paul M.. Actieve efflux van antibiotica en bactériële resistentie: stand van zake en implicaties. In: Belgisch Tijdschrift voor Geneeskunde, Vol. 61, no.20, p. 1407-1417 (2005).
2005
Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Activity of three {beta}-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus. In: Journal of Antimicrobial Chemotherapy, Vol. 55, no. 6, p. 897-904 (2005). doi:10.1093/jac/dki094.
2005
Seral, Cristina ; Barcia Macay, Maritza ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages. In: Journal of Antimicrobial Chemotherapy, Vol. 55, no. 4, p. 511-517 (2005). doi:10.1093/jac/dki059.
2005
Servais, Hélène ; Van Der Smissen, Patrick ; Thirion, Gaëtan ; Van Der Essen, Gauthier ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. In: Toxicology and Applied Pharmacology : for those working in the fields of toxicology, pharmacology, biochemistry, nutrition, veterinary medicine, Vol. 206, no. 3, p. 321-333 (2005). doi:10.1016/j.taap.2004.11.024.
2005
Michot, Jean-Michel ; Seral, Cristina ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 6, p. 2429-2437 (2005). doi:10.1128/AAC.49.6.2429-2437.2005.
2005
Mesaros, Narcisa ; Van Bambeke, Françoise ; Avrain, Laetitia ; Glupczynski, Gerald ; Vanhoof, Raymond ; Plésiat, Patrick ; Tulkens, Paul M.. L'efflux actif des antibiotiques et la résistance bactérienne: état de la question et implications. In: La Lettre de l'Infectiologue : de la microbiologie à la clinique, Vol. 20, p. 117-126 (2005).
2005
Mesaros, Narcisa ; Van Bambeke, Françoise ; Glupczynski, Gerald ; Vanhoof, Raymond ; Tulkens, Paul M.. L'efflux des antibiotiques: un mécanisme ubiquitaire conduisant à la résistance. État de la question et implications microbiologiques et cliniques. In: Louvain médical, Vol. 124, no.8, p. 308-320 (2005).
2005
Van Bambeke, Françoise ; Saffran, Jennifer ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 5, p. 1695-1700 (2005). doi:10.1128/AAC.49.5.1695-1700.2005.
2005
Piret, Jocelyne ; Schanck, André ; Delfosse, Sylvie ; Van Bambeke, Françoise ; Kishore, Bellamkonda K ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids. In: Chemistry and Physics of Lipids, Vol. 133, no. 1, p. 1-15 (2005). doi:10.1016/j.chemphyslip.2004.08.002.
2005
Van Bambeke, Françoise ; Michot, Jean-Michel ; Van Eldere, Johan ; Tulkens, Paul M.. Quinolones in 2005: an update.. In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 11, no. 4, p. 256-80 (2005). doi:10.1111/j.1469-0691.2005.01131.x.
2004
Michot, Jean-Michel ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter. In: Antimicrobial Agents and Chemotherapy, Vol. 48, no. 7, p. 2673-2682 (2004). doi:10.1128/AAC.48.7.2673-2682.2004.
2004
Van Bambeke, Françoise ; Carryn, Stéphane ; Seral, Cristina ; Chanteux, Hugues ; Tyteca, Donatienne ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 48, no. 8, p. 2853-2860 (2004). doi:10.1128/AAC.48.8.2853-2860.2004.
2004
Nassogne, Marie-Cécile ; Lizarraga, Chantal ; N'Kuli, Francisca ; Van Bambeke, Françoise ; Van Binst, Roger ; Wallemacq, Pierre ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Levade, Thierry ; Courtoy, Pierre J.. Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1. In: Toxicology and Applied Pharmacology, Vol. 194, no. 2, p. 101-110 (2004). doi:10.1016/j.taap.2003.09.026.
2004
Van Bambeke, Françoise ; Van Laethem, Yves ; Courvalin, Patrice ; Tulkens, Paul M.. Glycopeptide antibiotics: from conventional molecules to new derivatives.. In: Drugs, Vol. 64, no. 9, p. 913-936 (2004). doi:10.2165/00003495-200464090-00001.
2004
Van Bambeke, Françoise. Glycopeptides in clinical development: pharmacological profile and clinical perspectives.. In: Current opinion in pharmacology, Vol. 4, no. 5, p. 471-478 (2004). doi:10.1016/j.coph.2004.04.006.
2004
Carryn, Stéphane ; Van de Velde, Sébastien ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide. In: The Journal of Infectious Diseases, Vol. 189, no. 11, p. 2101-2109 (2004). doi:10.1086/420848.
2004
Ben Abdelaziz, Halim ; Lemaire, Sandrine ; Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria. In: Journal of Antimicrobial Chemotherapy, Vol. 54, no. 1, p. 288-289 (2004). doi:10.1093/jac/dkh288.
2003
Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model. In: Journal of Antimicrobial Chemotherapy, Vol. 51, no. 4, p. 1051-1052 (2003). doi:10.1093/jac/dkg189.
2003
Van Bambeke, Françoise ; Michot, J-M ; Tulkens, Paul M.. Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.. In: The Journal of antimicrobial chemotherapy, Vol. 51, no. 5, p. 1067-77 (2003). doi:10.1093/jac/dkg225.
2003
Van Bambeke, Françoise ; Glupczynski, Gerald ; Plésiat, P ; Pechère, J C ; Tulkens, Paul M.. Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy.. In: Journal of Antimicrobial Chemotherapy, Vol. 51, no. 5, p. 1055-1065 (2003). doi:10.1093/jac/dkg224.
2003
Seral, Cristina ; Carryn, Stéphane ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.. In: The Journal of antimicrobial chemotherapy, Vol. 51, no. 5, p. 1167-73 (2003). doi:10.1093/jac/dkg223.
2003
Seral, Cristina ; Michot, Jean-Michel ; Chanteux, Hugues ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 47, no. 3, p. 1047-1051 (2003). doi:10.1128/AAC.47.3.1047-1051.2003.
2003
Chanteux, Hugues ; Mingeot-Leclercq, Marie-Paule ; Sonveaux, Etienne ; Van Bambeke, Françoise ; Tulkens, Paul M.. Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages. In: Journal of Antimicrobial Chemotherapy, Vol. 52, no. 4, p. 610-615 (2003). doi:10.1093/jac/dkg431.
2003
Carryn, Stéphane ; Chanteux, Hugues ; Seral, Cristina ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise ; Tulkens, Paul M.. Intracellular pharmacodynamics of antibiotics. In: Infectious Disease Clinics of North America, Vol. 17, no. 3, p. 615-634 (2003). doi:10.1016/S0891-5520(03)00066-7.
2003
Mingeot-Leclercq, Marie-Paule ; Lins, Laurence ; Bensliman, Mariam ; Thomas, Annick ; Van Bambeke, Françoise ; Peuvot, Jacques ; Schanck, André ; Brasseur, Robert. Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. In: BBA - Biomembranes, Vol. 1609, no. 1, p. 28-38 (2003). doi:10.1016/S0005-2736(02)00654-5.
2003
Seral, Cristina ; Van Bambeke, Françoise ; Tulkens, Paul M.. Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 47, no. 7, p. 2283-2292 (2003). doi:10.1128/aac.47.7.2283-2292.2003.
2002
Tyteca, Donatienne ; Van Der Smissen, Patrick ; Mettlen, Marcel ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Courtoy, Pierre J.. Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages. In: Experimental Cell Research, Vol. 281, no. 1, p. 86-100 (2002). doi:10.1006/excr.2002.5613.
2002
Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations. In: Antimicrobial Agents and Chemotherapy, Vol. 46, no. 7, p. 2095-2103 (2002). doi:10.1128/AAC.46.7.2095-2103.2002.
2002
Mingeot-Leclercq, Marie-Paule ; Lins, Laurence ; Bensliman, Mariam ; Van Bambeke, Françoise ; Van Der Smissen, Patrick ; Peuvot, Jacques ; Schanck, André ; Brasseur, Robert. Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus. In: Chemistry and Physics of Lipids, Vol. 120, no. 1-2, p. 57-74 (2002). doi:10.1016/S0009-3084(02)00108-1.
2001
Tyteca, Donatienne ; Van Der Smissen, Patrick ; Van Bambeke, Françoise ; Leys, Karin ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts. In: European Journal of Cell Biology, Vol. 80, no. 7, p. 466-478 (2001). doi:10.1078/0171-9335-00180.
2001
Van Bambeke, Françoise ; Verhaegen, Jacques ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine en de huidige neomacroliden: klinisch gebruik en perspectieven. In: Tijdschrift voor Geneeskunde, Vol. 57, no. 5, p. 382-395 (2001). doi:10.2143/TVG.57.5.5000995.
2001
Van Bambeke, Françoise ; Verhaegen, J. ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine et néomacrolides actuels, usages cliniques et perspectives. In: Medecine et Hygiene, Vol. 59, no. 2369, p. 2316-2323 (2001).
2001
Van Bambeke, Françoise ; Verhaegen, J. ; Tulkens, Paul M.. Erythromycine, autres macrolides et kétolides: usages cliniques actuels et perspectives. In: La Lettre de l'Infectiologue : de la microbiologie à la clinique, Vol. 57, p. 382-395 (2001).
2001
Mingeot-Leclercq, Marie-Paule ; Gallet, Xavier ; Flore, Chistrel ; Van Bambeke, Françoise ; Peuvot, Jacques ; Brasseur, Robert. Experimental and conformational analyses of interactions between butenafine and lipids. In: Antimicrobial Agents and Chemotherapy, Vol. 45, no. 12, p. 3347-3354 (2001). doi:10.1128/AAC.45.12.3347-3354.2001.
2001
Van Bambeke, Françoise ; Tulkens, Paul M.. Macrolides: pharmacokinetics and pharmacodynamics.. In: International journal of antimicrobial agents, Vol. 18 Suppl 1, p. S17-23 (2001).
2001
Gholizadeh, Y ; Prevost, M ; Van Bambeke, Françoise ; Casadewall, B ; Tulkens, Paul M. ; Courvalin, P.. Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.. In: Protein science : a publication of the Protein Society, Vol. 10, no. 4, p. 836-44 (2001). doi:10.1110/ps.39101.
2000
Van Bambeke, Françoise ; Balzi, E. ; Tulkens, Paul M.. Antibiotic efflux pumps.. In: Biochemical pharmacology, Vol. 60, no. 4, p. 457-70 (2000). doi:10.1016/S0006-2952(00)00291-4.
2000
Tyteca, Donatienne ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Azythomycin, a lysosomotropic antibiotic impairs endocytosis in cultured macrophages. In: Chemistry and Physics of Lipids, Vol. 107, p. 58-59 (2000).
2000
Van Bambeke, Françoise ; Kerkhofs, Anne ; Schanck, André ; Remacle, Claude ; Sonveaux, Etienne ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Biophysical studies and intracellular destabilization of pH-sensitive liposomes. In: Lipids, Vol. 35, no. 2, p. 213-223 (2000). doi:10.1007/BF02664772.
2000
Van Bambeke, Françoise ; Verhaegen, Jacques ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine et némacrolides actuels: usages cliniques et perspectives. In: Louvain médical, Vol. 119, p. 259-286 (2000).
2000
Prévost, M ; Van Belle, D ; Tulkens, Paul M. ; Courvalin, P. ; Van Bambeke, Françoise. Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.. In: Journal of molecular microbiology and biotechnology, Vol. 2, no. 3, p. 321-30 (2000).
1999
Montenez, Jean-Pierre ; Van Bambeke, Françoise ; Piret, Jocelyne ; Brasseur, Robert ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. In: Toxicology and Applied Pharmacology : for those working in the fields of toxicology, pharmacology, biochemistry, nutrition, veterinary medicine, Vol. 156, no. 2, p. 129-140 (1999). doi:10.1006/taap.1999.8632.
1999
Van Bambeke, Françoise ; Tulkens, Paul M.. Optimisation des traitements antibactériens sur base de propriétés pharmacodynamiques des antibiotiques. In: Médisphère, Vol. 93, p. 21-24 (1999).
1999
Van Bambeke, Françoise ; Tyteca, Donatienne ; Ouadrhiri, Youssef ; Tulkens, Paul M.. Optimisation des traitements antibactériens sur base des propriétés pharmacodynamiques des antibiotiques. In: Louvain médical, Vol. 118, p. 43-63 (1999).
1999
Van Bambeke, Françoise ; Chauvel, M ; Reynolds, P E ; Fraimow, H S ; Courvalin, P.. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants.. In: Antimicrobial agents and chemotherapy, Vol. 43, no. 1, p. 41-7 (1999).
1998
Van Bambeke, Françoise ; Bigaignon, Geoffroy ; Ninane, Jacques ; Tulkens, Paul M.. La maladie de Lyme: diagnostic et thérapeutique rationnels. In: Louvain médical, Vol. 117, p. 375-388 (1998).
1998
Van Bambeke, Françoise ; Gerbaux, C ; Michot, Jean-Michel ; d'Yvoire, M B ; Montenez, J P ; Tulkens, Paul M.. Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.. In: The Journal of antimicrobial chemotherapy, Vol. 42, no. 6, p. 761-7 (1998). doi:10.1093/jac/42.6.761.
1997
Nachega, Jean ; Van Bambeke, Françoise ; Vandercam, Bernard ; Tulkens, Paul M.. Usages cliniques actuels et raisonnables des glycopeptides. In: Louvain médical, Vol. 116, no. 6, p. 162-174 (1997).
1996
Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Brasseur, Robert ; Tulkens, Paul M. ; Schanck, André. Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents. In: Chemistry and Physics of Lipids, Vol. 79, no. 2, p. 123-135 (1996). doi:10.1016/0009-3084(95)02520-0.
1996
Gerbaux, C ; Van Bambeke, Françoise ; Montenez, J P ; Piret, J. ; Morlighem, G ; Tulkens, Paul M.. Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.. In: FEBS letters, Vol. 394, no. 3, p. 307-10 (1996). doi:10.1016/0014-5793(96)00975-1.
1996
Van Bambeke, Françoise ; Montenez, Jean-Pierre ; Piret, Jocelyne ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity. In: European Journal of Pharmacology, Vol. 314, no. 1-2, p. 203-214 (1996). doi:10.1016/S0014-2999(96)00552-3.
1996
Montenez, Jean-Pierre ; Van Bambeke, Françoise ; Piret, Jocelyne ; Schanck, André ; Brasseur, Robert ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies. In: European Journal of Pharmacology, Vol. 314, no. 1-2, p. 215-227 (1996). doi:10.1016/S0014-2999(96)00553-5.
1996
Van Bambeke, Françoise ; Nachega, Jean ; Tulkens, Paul M.. Traitement des infections à Herpes simplex, Varicella zoster et cytomegalovirus. In: Louvain médical, Vol. 115, p. 735-744 (1996).
1995
Van Bambeke, Françoise ; Tulkens, Paul M. ; Brasseur, Robert ; Mingeot-Leclercq, Marie-Paule. Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.. In: European Journal of Pharmacology, Vol. 289, no. 2, p. 321-333 (1995). doi:10.1016/0922-4106(95)90110-8.
1995
Mingeot-Leclercq, Marie-Paule ; Schanck, André ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Lins, Laurence ; Brasseur, Roger. Molecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.. In: Pharmacology : international journal of experimental and clinical pharmacology, Vol. 14, p. 71-98 (1995).
1993
Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Schanck, André ; Brasseur, Robert ; Tulkens, Paul M.. Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells. In: European Journal of Pharmacology, Vol. 247, no. 2, p. 155-168 (1993). doi:10.1016/0922-4106(93)90073-I.