Françoise Van Bambeke

Fiogbe, Dessièdé Ariane ; Dohou, Angèle Modupè ; Yehouenou, Carine Laurence ; Henrard, Séverine ; Van Bambeke, Françoise ; Dossou, Francis Moïse Djidénou ; Dalleur, Olivia. Antibiotic prophylaxis practice in gastrointestinal surgery in five hospitals in southern Benin. In: Infection Prevention in Practice, Vol. 6, no.4, p. 100405 (2024). doi:10.1016/j.infpip.2024.100405.

http://hdl.handle.net/2078.1/292250

Wang, Zhifen ; De Soir, Steven (co-first author) ; Glorieux, Antoine ; Merabishvili, Maya ; Knoop, Christiane ; De Vos, Daniel ; Pirnay, Jean-Paul ; Van Bambeke, Françoise. Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa. In: International Journal of Antimicrobial Agents, Vol. 64, no.3, p. 107276 (2024). doi:10.1016/j.ijantimicag.2024.107276.

http://hdl.handle.net/2078.1/295233

Ngougni Pokem, Perrin ; Vanneste, Dorian (co-first author) ; Schouwenburg, Stef ; Abdulla, Alan ; Gijsen, Matthias ; Dhont, Evelyn ; Van der Linden, Dimitri ; Spriet, Isabel ; De Cock, Pieter ; Koch, Birgit ; Van Bambeke, Françoise ; Wijnant, Gert-Jan. Dose optimization of β-lactam antibiotics in children: from population pharmacokinetics to individualized therapy.. In: Expert opinion on drug metabolism & toxicology, Vol. 20, no.8, p. 787-804 (2024). doi:10.1080/17425255.2024.2385403.

http://hdl.handle.net/2078.1/294758

De Soir, Steven ; Parée, Hortence ; Kamarudin, Nur Hidayatul Nazirah ; Wagemans, Jeroen ; Lavigne, Rob ; Braem, Annabel ; Merabishvili, Maya ; De Vos, Daniel ; Pirnay, Jean-Paul ; Van Bambeke, Françoise. Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections. In: Microbiology Spectrum, Vol. Jan, no. 12(1), p. e0321923 (2024). doi:10.1128/spectrum.03219-23.

http://hdl.handle.net/2078.1/282743

Milosevic, Tamara V. ; Vertenoeil, Gaëlle (co-first author) ; Vainchenker, William ; Tulkens, Paul M. ; Constantinescu, Stefan N. ; Van Bambeke, Françoise. Oxazolidinone antibiotics impair <i>ex vivo</i> megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets. In: Antimicrobial Agents and Chemotherapy, Vol. 68, no.10, p. e0053324 (2024). doi:10.1128/aac.00533-24.

http://hdl.handle.net/2078.1/295230

van Os, Wisse ; Nussbaumer-Pröll, Alina ; Pham, Anh Duc ; Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Van Bambeke, Françoise ; van Hasselt, Johan ; Zeitlinger, Markus. Pharmacokinetic-pharmacodynamic model-based optimisation of temocillin dosing strategies for the treatment of systemic infections. In: Journal of Antimicrobial Chemotherapy, Vol. 79, p. 2484-2492 (2024).

http://hdl.handle.net/2078.1/288945

van Os, Wisse ; Nussbaumer-Pröll, Alina ; Pham, Anh Duc ; Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Van Bambeke, Françoise ; van Hasselt, J G Coen ; Zeitlinger, Markus. Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections. In: Journal of Antimicrobial Chemotherapy, Vol. 79, no.10, p. 2484-2492 (2024). doi:10.1093/jac/dkae243.

http://hdl.handle.net/2078.1/295232

Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Coessens, Marie ; Cottone, Eleonora ; Ermtraud, Julian ; Goeman, Lieven ; Vervaeke, Steven ; Wicha, Sebastian G ; Van Bambeke, Françoise. Pharmacokinetics and pharmacological target attainment of standard temocillin dosing in non-critically ill patients with complicated urinary tract infections. In: Journal of Antimicrobial Chemotherapy, Vol. 79, no.9, p. 2204-2212 (2024). doi:10.1093/jac/dkae215.

http://hdl.handle.net/2078.1/295234

Wijnant, Gert-Jan ; Ngougni Pokem, Perrin ; Coessens, Marie ; Cottone, Eleonora ; Ermtraud, Julian ; Goeman, Lieven ; Vervaeke, Steven ; Wicha, Sebastian ; Van Bambeke, Françoise. Pharmacokinetics and pharmacological target attainment of standard temocillin dosing in non-critically ill patients with complicated urinary tract infections. In: Journal of Antimicrobial Chemotherapy, no. 79, p. 2204-2212 (2024).

http://hdl.handle.net/2078.1/288942

Ngougni Pokem, Perrin ; Liu, Xin ; Parker, Suzanne L ; Verroken, Alexia ; Collienne, Christine ; Finet, Patrice ; Wijnant, Gert-Jan ; Laterre, Pierre-François ; Roberts, Jason A ; Van Bambeke, Françoise ; Wittebole, Xavier. Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis. In: Journal of Antimicrobial Chemotherapy, Vol. 79, no. 2, p. 429-442 (2024). doi:10.1093/jac/dkad398.

http://hdl.handle.net/2078.1/282741

Wang, Zhifen ; Vanbever, Rita ; Lorent, Joseph H. ; Solis, Jessica ; Knoop, Christiane ; Van Bambeke, Françoise. Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics. In: Journal of Cystic Fibrosis, Vol. Feb213, no.none, p. S1569-1993(24)00027-4 (2024). doi:10.1016/j.jcf.2024.02.012.

http://hdl.handle.net/2078.1/288249

Thirot, Hélène ; Fage, David ; Leonhardt, Antonia ; Clevenbergh, Philippe ; Besse-Hammer, Tatiana H ; Yombi, Jean Cyr ; Cornu, Olivier ; Briquet, Caroline ; Hites, Maya ; Jacobs, Frédérique ; Wijnant, Gert-Jan ; Wicha, Sebastian G ; Cotton, Frédéric ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers. In: Frontiers in pharmacology, Vol. 15, p. 1310309 [1-11] (2024). doi:10.3389/fphar.2024.1310309.

http://hdl.handle.net/2078.1/283082

Goormaghtigh, Frédéric ; Van Bambeke, Françoise. Understanding Staphylococcus aureus internalization and induction of antimicrobial tolerance. In: Expert Review of Anti-infective Therapy, Vol. 22, p. 87-101 (2024). doi:10.1080/14787210.2024.2303018.

http://hdl.handle.net/2078.1/283126

Mahieu, Gwenaëlle ; Sennesael, Anne-Laure ; Pochet, Lionel ; Haufroid, Vincent ; Van Bambeke, Françoise ; Spinewine, Anne ; Elens, Laure. assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines.. In: Research and practice in thrombosis and haemostasis, Vol. 8, no.5, p. 102521 (2024). doi:10.1016/j.rpth.2024.102521.

http://hdl.handle.net/2078.1/291206

Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. Correction for Ruiz-Sorribas et al., "Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model".. In: Microbiology spectrum, Vol. 11, no.1, p. e0467122 (2023). doi:10.1128/spectrum.04671-22.

http://hdl.handle.net/2078.1/285158

Van Bambeke, Françoise ; Wicha, Sebastian ; Tulkens, Paul M. ; Zeitlinger, Markus. Editorial for the Special Issue: A Themed Issue in Honor of Professor Hartmut Derendorf-Outstanding Contributions in the Fields of Quantitative Clinical Pharmacology... In: Antibiotics, Vol. 12, no.2, p. 353 (2023). doi:10.3390/antibiotics12020353.

http://hdl.handle.net/2078.1/288484

Catteau, Lucy ; Iglesias, Yvan Diaz ; Tsunemoto, Hannah ; Pogliano, Joseph ; Van Bambeke, Françoise ; Nizet, Victor ; Sakoulas, George. Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis. In: International Journal of Antimicrobial Agents, Vol. 61, no.6, p. 106758 (2023). doi:10.1016/j.ijantimicag.2023.106758.

http://hdl.handle.net/2078.1/275157

Dohou, Angèle ; Buda, Valentina ; Yemoa, Achille ; Anagonu, Séverin ; Van Bambeke, Françoise ; Van Hees, Thierry ; Dossou, Francis ; Dalleur, Olivia. Antibiotic Usage in Patients Having Undergone Caesarean Section: A Three-Level Study in Benin. In: Antibiotics, Vol. 11, no. 5, p. 617 [1-12] (2022). doi:10.3390/ antibiotics11050617.

http://hdl.handle.net/2078.1/260551

Ngougni Pokem, Perrin ; Matzneller, Peter ; Vervaeke, Steven ; Wittebole, Xavier ; Goeman, Lieven ; Coessens, Marie ; Cottone, Eleonora ; Capron, Arnaud ; Wulkersdorfer, Beatrix ; Wallemacq, Pierre ; Mouton, Johan W ; Muller, Anouk E ; Zeitlinger, Markus ; Laterre, Pierre-François ; Tulkens, Paul M. ; Van Bambeke, Françoise. Binding of temocillin to plasma proteins in vitro and in vivo: the importance of plasma protein levels in different populations and of co-medications. In: Journal of Antimicrobial Chemotherapy, Vol. 77, no. 10, p. 2742-2753 (2022). doi:10.1093/jac/dkac286.

http://hdl.handle.net/2078.1/268883

Poilvache, Hervé ; Van Bambeke, Françoise ; Cornu, Olivier. Development of an innovative model of PJI treated with DAIR.. In: Frontiers in medicine, Vol. 9, p. 984814 [1-14] (2022). doi:10.3389/fmed.2022.984814.

http://hdl.handle.net/2078.1/268169

De Bels, David ; Maillart, Evelyne ; Van Bambeke, Françoise ; Redant, Sebastien ; Honoré, Patrick. Existing and emerging therapies for the treatment of invasive candidiasis and candidemia. In: Expert opinion on emerging drugs, Vol. 27, no. 4, p. 405-416 (2022). doi:10.1080/14728214.2022.2142207.

http://hdl.handle.net/2078.1/268884

Dohou, Angèle Modupè ; Buda, Valentina Oana ; Anagonou, Severin ; Van Bambeke, Françoise ; Van Hees, Thierry ; Dossou, Francis Moïse ; Dalleur, Olivia. Healthcare Professionals’ Knowledge and Beliefs on Antibiotic Prophylaxis in Cesarean Section: A Mixed-Methods Study in Benin. In: Antibiotics, Vol. 11, no. 7, p. 872 [1-14] (2022). doi:10.3390/antibiotics11070872.

http://hdl.handle.net/2078.1/262729

Peyrusson, Frédéric ; Nguyen, Tiep Khac ; Najdovski, Tome ; Van Bambeke, Françoise. Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters. In: Microbiology Spectrum, Vol. 10, no.1, p. e0231321 (2022). doi:10.1128/spectrum.02313-21.

http://hdl.handle.net/2078.1/259573

Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model. In: Microbiology spectrum, Vol. 10, no. 1, p. e0258921 [1-16] (2022). doi:10.1128/spectrum.02589-21.

http://hdl.handle.net/2078.1/259572

Ruiz-Sorribas, Albert ; Poilvache, Hervé ; Van Bambeke, Françoise. Pharmacodynamics of Moxifloxacin, Meropenem, Caspofungin, and Their Combinations against In Vitro Polymicrobial Interkingdom Biofilms. In: Antimicrobial agents and chemotherapy, Vol. 66, no. 2, p. e02149-21 [1-17] (2022). doi:10.1128/aac.02149-21.

http://hdl.handle.net/2078.1/262724

Ngougni Pokem, Perrin ; Wittebole, Xavier ; Collienne, Christine ; Rodriguez-Villalobos, Hector ; Tulkens, Paul M. ; Elens, Laure ; Van Bambeke, Françoise ; Laterre, Pierre-François. Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. In: Antibiotics, Vol. 11, no. 7, p. 898 [1-19] (2022). doi:10.3390/antibiotics11070898.

http://hdl.handle.net/2078.1/264675

Chalhoub, Hussein ; Kampmeier, Stefanie ; Kahl, Barbara C. ; Van Bambeke, Françoise. Role of Efflux in Antibiotic Resistance of Achromobacter xylosoxidans and Achromobacter insuavis Isolates From Patients With Cystic Fibrosis. In: Frontiers in Microbiology, Vol. 13, no.March 28, p. 762307 (2022). doi:10.3389/fmicb.2022.762307.

http://hdl.handle.net/2078.1/262726

Meléndez-Carmona, María Ángeles ; Mancheño-Losa, Mikel ; Ruiz-Sorribas, Albert ; Muñoz-Gallego, Irene ; Viedma, Esther ; Chaves, Fernando ; Van Bambeke, Françoise ; Lora-Tamayo, Jaime. Strain-to-strain variability among Staphylococcus aureus causing prosthetic joint infection drives heterogeneity in response to levofloxacin and rifampicin. In: Journal of Antimicrobial Chemotherapy, Vol. 77, no.12, p. 3265-3269 (2022). doi:10.1093/jac/dkac311.

http://hdl.handle.net/2078.1/268885

Wang, Gang ; Brunel, Jean-Michel ; Preusse, Matthias ; Mozaheb, Negar ; Willger, Sven D. ; Larrouy-Maumus, Gerald ; Baatsen, Pieter ; Häussler, Susanne ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence. In: Communications biology, Vol. 5, no. 1, p. 871 [1-17] (2022). doi:10.1038/s42003-022-03836-5.

http://hdl.handle.net/2078.1/264672

Wang, Gang ; Brunel, Jean-Michel ; Rodriguez-Villalobos, Hector ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The polyamino-isoprenyl potentiator NV716 revives disused antibiotics against Gram-negative bacteria in broth, infected monocytes, or biofilms, by disturbing the barrier effect of their outer membrane.. In: European journal of medicinal chemistry, Vol. 238, no. 11, p. 114496 [1-14] (2022). doi:10.1016/j.ejmech.2022.114496.

http://hdl.handle.net/2078.1/264674

Nguyen, Tiep Khac ; Peyrusson, Frédéric ; Siala, Wafi ; Pham, Nhung H ; Nguyen, Hoang Anh ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activity of moxifloxacin against biofilms formed by clinical isolates of Staphylococcus aureus differing by their resistant or persister character to fluoroquinolones. In: Frontiers in Microbiology, Vol. 12, no. Dec, p. 785573 (2021). doi:10.3389/fmicb.2021.785573.

http://hdl.handle.net/2078.1/253727

Sounouvou, Hope T ; Toukourou, Kolawole Habib ; Catteau, Lucy ; Toukourou, Fatiou ; Evrard, Brigitte ; Van Bambeke, Françoise ; Gbaguidi, Fernand ; Quetin-Leclercq, Joëlle. Antimicrobial potentials of essential oils extracted from West African aromatic plants on common skin infections. In: Scientific African, Vol. 11, p. e00706 [1-12] (2021). doi:10.1016/j.sciaf.2021.e00706.

http://hdl.handle.net/2078.1/243403

Thirot, Hélène ; Briquet, Caroline ; Frippiat, Frédéric ; Jacobs, Frédérique ; Holemans, Xavier ; Henrard, Séverine ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Clinical Use and Adverse Drug Reactions of Linezolid: A Retrospective Study in Four Belgian Hospital Centers. In: Antibiotics, Vol. 10, no. 5, p. 530 [1-12] (2021). doi:10.3390/antibiotics10050530.

http://hdl.handle.net/2078.1/245807

Yehouenou, Carine ; Bogaerts, Bert ; Vanneste, Kevin ; Roosens, Nancy H. C. ; De Keersmaecker, Sigrid C. J. ; Marchal, Kathleen ; Affolabi, Dissou ; Soleimani, Reza ; Rodriguez-Villalobos, Hector ; Van Bambeke, Françoise ; Dalleur, Olivia ; Simon, Anne. First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin. In: Annals of clinical microbiology and antimicrobials, Vol. 20, no. 1, p. 5 [1-7] (2021). doi:10.1186/s12941-020-00411-w.

http://hdl.handle.net/2078.1/240639

Ruiz Sorribas, Albert ; Poilvache, Hervé ; Kamarudin, Nur Hidayatul Nazirah ; Braem, Annabel ; Van Bambeke, Françoise. In vitro polymicrobial inter-kingdom three-species biofilm model: influence of hyphae on biofilm formation and bacterial physiology. In: Biofouling, Vol. 37, no.5, p. 481-493 (2021). doi:10.1080/08927014.2021.1919301.

http://hdl.handle.net/2078.1/251184

Poilvache, Hervé ; Ruiz Sorribas, Albert ; Cornu, Olivier ; Van Bambeke, Françoise. In-vitro study of the synergistic effect of an enzyme cocktail and antibiotics against biofilms in a prosthetic joint infection model. In: Antimicrobial Agents and Chemotherapy, Vol. 65, no. 4, p. e01699-20 [1-24] (2021). doi:10.1128/AAC.01699-20.

http://hdl.handle.net/2078.1/241086

Peyrusson, Frédéric ; Whelan, Adam O ; Hartley, M G ; Norville, Isobel H ; Harding, Sarah V ; Van Bambeke, Françoise. Intracellular activity of antibiotics against Coxiella burnetii in a model of activated human THP-1 cells. In: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0106121 (2021). doi:10.1128/aac.01061-21.

http://hdl.handle.net/2078.1/253073

Nguyen, Thu-Minh ; Ngo, Thu-Hue ; Truong, Anh-Quan ; Vu, Dinh-Hoa ; Le, Dinh-Chi ; Vu, Ngan-Binh ; Can, Tuyet-Nga ; Nguyen, Hoang-Anh ; Phan, Thu-Phuong ; Van Bambeke, Françoise ; Vidaillac, Céline ; Ngo, Quy-Chau. Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease. In: Pharmaceutics, Vol. 13, no.4, p. 456 (2021). doi:10.3390/pharmaceutics13040456.

http://hdl.handle.net/2078.1/245619

Wang, Gang ; Brunel, Jean-Michel ; Bolla, Jean-Michel ; Van Bambeke, Françoise. The Polyaminoisoprenyl Potentiator NV716 Revives Old Disused Antibiotics against Intracellular Forms of Infection by Pseudomonas aeruginosa.. In: Antimicrobial agents and chemotherapy, Vol. 65, no.3, p. e02028-20 (2021). doi:10.1128/AAC.02028-20.

http://hdl.handle.net/2078.1/245616

Kerkez, Ivana ; Tulkens, Paul M. ; Tenson, Tanel ; Van Bambeke, Françoise ; Putrinš, Marta. Uropathogenic Escherichia coli shows antibiotic tolerance and growth heterogeneity in an in-vitro model of intracellular infection. In: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0146821 (2021). doi:10.1128/aac.01468-21.

http://hdl.handle.net/2078.1/253067

Diaz Iglesias, Yvan ; Van Bambeke, Françoise. Activity of Antibiotics against Pseudomonas aeruginosa in an In Vitro Model of Biofilms in the Context of Cystic Fibrosis: Influence of the Culture Medium. In: Antimicrobial Agents and Chemotherapy, Vol. 64, no.4, p. e02204-19 (2020). doi:10.1128/aac.02204-19.

http://hdl.handle.net/2078.1/230114

Nguyen, Tiep Khac ; Argudín, Maria A ; Deplano, Ariane ; Nhung, Pham Hong ; Nguyen, Hoang Anh ; Tulkens, Paul M ; Dodemont, Magali ; Van Bambeke, Françoise. Antibiotic Resistance, Biofilm Formation, and Intracellular Survival As Possible Determinants of Persistent or Recurrent Infections by in a Vietnamese Tertiary Hospital: Focus on Bacterial Response to Moxifloxacin.. In: Microbial drug resistance (Larchmont, N.Y.), Vol. 26, no.6, p. 537-544 (2020). doi:10.1089/mdr.2019.0282.

http://hdl.handle.net/2078.1/240786

Yehouenou, Carine ; Kpangon, Arsène A ; Affolabi, Dissou ; Rodriguez-Villalobos, Hector ; Van Bambeke, Françoise ; Dalleur, Olivia ; Simon, Anne. Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin.. In: Annals of clinical microbiology and antimicrobials, Vol. 19, no. 1, p. 54 [1-10] (2020). doi:10.1186/s12941-020-00398-4.

http://hdl.handle.net/2078.1/243851

Kapepula, Paulin M. ; Kabengele, Jimmy K. ; Kingombe, Micheline ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Sadiki Kishabongo, Antoine ; Decloedt, Eric ; Zumla, Adam ; Tiberi, Simon ; Suleman, Fatima ; Tshilolo, Léon ; Muyembe-TamFum, Jean-Jacques ; Zumla, Alimuddin ; Nachega, Jean B.. Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials. In: The American Journal of Tropical Medicine and Hygiene, Vol. 103, no.3, p. 960-964 (2020). doi:10.4269/ajtmh.20-0820.

http://hdl.handle.net/2078.1/240198

Peyrusson, Frédéric ; Van Wessem, Astrid ; Dieppois, Guennaëlle ; Van Bambeke, Françoise ; Tulkens, Paul M. Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor, afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells.. In: International journal of antimicrobial agents, Vol. 55, no.2, p. 105848 (2020). doi:10.1016/j.ijantimicag.2019.11.005.

http://hdl.handle.net/2078.1/230121

Delattre, Isabelle ; Briquet, Caroline ; Wallemacq, Pierre ; Tulkens, Paul M. ; Van Bambeke, Françoise. Comparative in vitro antimicrobial potency, stability, colouration and dissolution time of generics versus innovator of meropenem in Europe.. In: International journal of antimicrobial agents, Vol. 55, no. 1, p. 105825 [1-5] (2020). doi:10.1016/j.ijantimicag.2019.10.006.

http://hdl.handle.net/2078.1/230113

Toukourou, Kolawole Habib ; Sounouvou, Hope ; Catteau, Lucy ; Toukourou, Fatiou ; Van Bambeke, Françoise ; Gbaguidi, Fernand ; Quetin-Leclercq, Joëlle. Cymbopogon giganteus Chiov. essential oil: Direct effects or activity in combination with antibiotics against multi-drug resistant bacteria. In: Journal of Applied Biology & Biotechnology, Vol. 8, no.1, p. 84-89 (2020). doi:10.7324/jabb.2020.80114.

http://hdl.handle.net/2078.1/231519

Poilvache, Hervé ; Van Bambeke, Françoise. Dangerous Slimes: How Bacterial Biofilms Make You Sick and How to Combat Them. In: Frontiers for Young Minds, Vol. May, no.8, p. 62 (2020). doi:10.3389/frym.2020.00062.

http://hdl.handle.net/2078.1/230118

Meerwein, Milton ; Tarnutzer, Andrea ; Böni, Michelle ; Van Bambeke, Françoise ; Hombach, Michael ; Zinkernagel, Annelies S. Increased Azithromycin Susceptibility of Multidrug-Resistant Gram-Negative Bacteria on RPMI-1640 Agar Assessed by Disk Diffusion Testing.. In: Antibiotics (Basel, Switzerland), Vol. 9, no.5, p. E218 (2020). doi:10.3390/antibiotics9050218.

http://hdl.handle.net/2078.1/230116

Chalhoub, Houssein ; Harding, Sarah V ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of pH on the activity of finafloxacin against extracellular and intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis and Francisella philomiragia and on its cellular pharmacokinetics in THP-1 monocytes.. In: Clinical Microbiology and Infection, Vol. 26, no.9, p. 1254.e1-1254.e8 (2020). doi:10.1016/j.cmi.2019.07.028.

http://hdl.handle.net/2078.1/240788

Peyrusson, Frédéric ; Varet, Hugo ; Nguyen, Tiep Khac ; Legendre, Rachel ; Sismeiro, Odile ; Coppée, Jean-Yves ; Wolz, Christiane ; Tenson, Tanel ; Van Bambeke, Françoise. Intracellular Staphylococcus aureus persisters upon antibiotic exposure.. In: Nature communications, Vol. 11, no.1, p. 2200 (2020). doi:10.1038/s41467-020-15966-7.

http://hdl.handle.net/2078.1/230115

Theuretzbacher, Ursula ; Barbee, Lindley ; Connolly, Kristie ; Drusano, George ; Fernandes, Prabha ; Hook, Edward ; Jerse, Ann ; O'Donnell, John ; Unemo, Magnus ; Van Bambeke, Françoise ; VanScoy, Brian ; Warn, Peter ; Werth, Brian J. ; Franceschi, François ; Alirol, Emilie. Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities. In: Clinical Microbiology and Infection, Vol. 26, no.12, p. 1630-1635 (2020). doi:10.1016/j.cmi.2020.08.006.

http://hdl.handle.net/2078.1/240200

Ameryckx, Alice ; Pochet, Lionel ; Wang, Gang ; Yildiz, Esra ; Es Saadi, Bouazza ; Wouters, Johan ; Van Bambeke, Françoise ; Frédérick, Raphaël. Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting D-alanyl-D-alanine ligase in bacterio. In: European Journal of Medicinal Chemistry, Vol. 200, no.1, p. 112444 (2020). doi:10.1016/j.ejmech.2020.112444.

http://hdl.handle.net/2078.1/230503

Matzneller, Peter ; Ngougni Pokem, Perrin ; Capron, Arnaud ; Lackner, Edith ; Wulkersdorfer, Beatrix ; Nussbaumer-Pröll, Alina ; Österreicher, Zoe ; Duchek, Michael ; Van de Velde, Sebastien ; Wallemacq, Pierre ; Mouton, Johan W ; Van Bambeke, Françoise ; Zeitlinger, Markus. Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial. In: The Journal of antimicrobial chemotherapy, Vol. 75, no. 9, p. 2650–2656 (2020). doi:10.1093/jac/dkaa176.

http://hdl.handle.net/2078.1/230117

Poilvache, Hervé ; Ruiz Sorribas, Albert ; Sakoulas, George ; Rodriguez-Villalobos, Hector ; Cornu, Olivier ; Van Bambeke, Françoise. Synergistic Effects of Pulsed Lavage and Antimicrobial Therapy Against Staphylococcus aureus Biofilms in an in-vitro Model. In: Frontiers in Medicine, Vol. 7, p. 527 [1-9] (2020). doi:10.3389/fmed.2020.00527.

http://hdl.handle.net/2078.1/236184

Nguyen, Tiep K. ; Peyrusson, Frédéric ; Dodémont, Magali ; Pham, Nhung H. ; Nguyen, Hoang A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin. In: Frontiers in Microbiology, Vol. 11 (2020), p. 587364 (2020). doi:10.3389/fmicb.2020.587364.

http://hdl.handle.net/2078.1/240199

Diaz Iglesias, Yvan ; Wilms, Tobias ; Vanbever, Rita ; Van Bambeke, Françoise. Activity of Antibiotics against Staphylococcus aureus in an Model of Biofilms in the Context of Cystic Fibrosis: Influence of the Culture Medium.. In: Antimicrobial agents and chemotherapy, Vol. 63, no.7, p. pii: e00602-19 (2019). doi:10.1128/AAC.00602-19.

http://hdl.handle.net/2078.1/217898

Vu, Dinh H. ; Nguyen, Duy A. ; Delattre, Isabelle K. ; Ho, Trong T. ; Do, Hong G. ; Pham, Hong N. ; Dao, Xuan C. ; Tran, Nhan T. ; Nguyen, Gia B. ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Nguyen, Hoang A.. Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes. In: International Journal of Antimicrobial Agents, Vol. 54, no.6, p. 702-708 (2019). doi:10.1016/j.ijantimicag.2019.09.018.

http://hdl.handle.net/2078.1/225124

Fage, David ; Deprez, Guillaume ; Wolff, Fleur ; Hites, Maya ; Jacobs, Frédérique ; Van Bambeke, Françoise ; Cotton, Frédéric. Investigation of unbound colistin A and B in clinical samples using a mass spectrometry method.. In: International journal of antimicrobial agents, Vol. 2019, no. 3, p. 330-336 (2019). doi:10.1016/j.ijantimicag.2018.10.017.

http://hdl.handle.net/2078.1/208976

Tulkens, Paul M ; Van Bambeke, Françoise ; Zinner, Stephen H. Profile of a Novel Anionic Fluoroquinolone-Delafloxacin.. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 68, no.Supplement_3, p. S213-S222 (2019). doi:10.1093/cid/ciy1079.

http://hdl.handle.net/2078.1/215111

Milosevic, Tamara ; Vertenoeil, Gaëlle ; Payen, Valéry ; Sonveaux, Pierre ; Tulkens, Paul M. ; Constantinescu, Stefan N. ; Van Bambeke, Françoise. Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.. In: International journal of antimicrobial agents, Vol. 54, no. 5, p. 661-667 (2019). doi:10.1016/j.ijantimicag.2019.07.021.

http://hdl.handle.net/2078.1/218913

Ngougni Pokem, Perrin ; Capron, Arnaud ; Wallemacq, Pierre ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Laterre, Pierre-François. Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.. In: The Journal of antimicrobial chemotherapy, Vol. 74, no.5, p. 1459–1461 (2019). doi:10.1093/jac/dky565.

http://hdl.handle.net/2078.1/218318

Ameryckx, Alice ; Thabault, Léopold ; Pochet, Lionel ; Leimanis, Serge ; Poupaert, Jacques ; Wouters, Johan ; Joris, Bernard ; Van Bambeke, Françoise ; Frédérick, Raphaël. 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. In: European Journal of Medicinal Chemistry, Vol. 159, p. 324-338 (2018). doi:10.1016/j.ejmech.2018.09.067.

http://hdl.handle.net/2078.1/208975

Siala, Wafi ; Rodriguez-Villalobos, Hector ; Fernandes, Prabhavathi ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of Combinations of Antistaphylococcal Antibiotics with Fusidic Acid against Staphylococcal Biofilms in In Vitro Static and Dynamic Models. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 7, p. e00598-18 [1-12] (2018). doi:10.1128/aac.00598-18.

http://hdl.handle.net/2078.1/200312

Rogiers, Ona ; Holtappels, Michelle ; Siala, Wafi ; Lamkanfi, Mohamed ; Van Bambeke, Françoise ; Lagrou, Katrien ; Van Dijck, Patrick ; Kucharíková, Soňa. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies. In: Journal of Antimicrobial Chemotherapy, Vol. 73, no.10, p. 2806-2814 (2018). doi:10.1093/jac/dky246.

http://hdl.handle.net/2078.1/208973

Peyrusson, Frédéric ; Tulkens, Paul M ; Van Bambeke, Françoise. Cellular Pharmacokinetics and Intracellular Activity of Gepotidacin against Staphylococcus aureus Isolates with Different Resistance Phenotypes in Models of Cultured Phagocytic Cells.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no.4, p. e02245-17 (2018). doi:10.1128/AAC.02245-17.

http://hdl.handle.net/2078.1/198445

Lozano, Carmen ; Azcona-Gutiérrez, José Manuel ; Van Bambeke, Françoise ; Sáenz, Yolanda. Great phenotypic and genetic variation among successive chronic Pseudomonas aeruginosa from a cystic fibrosis patient. In: PLOS ONE, Vol. 13, no. 9, p. e0204167 (2018). doi:10.1371/journal.pone.0204167.

http://hdl.handle.net/2078.1/204946

Chalhoub, Hussein ; Sáenz, Yolanda ; Nichols, Wright W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Loss of activity of ceftazidime-avibactam due to MexAB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis. In: International Journal of Antimicrobial Agents, Vol. 52, no.5, p. 697-701 (2018). doi:10.1016/j.ijantimicag.2018.07.027.

http://hdl.handle.net/2078.1/208974

Milosevic, Tamara ; Payen, Valéry ; Sonveaux, Pierre ; Muccioli, Giulio ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 3, p. e01599-17 [1-17] (2018). doi:10.1128/AAC.01599-17.

http://hdl.handle.net/2078.1/199907

Catteau, Lucy ; Zhu, Li ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Natural and hemi-synthetic pentacyclic triterpenes as antimicrobials and resistance modifying agents against Staphylococcus aureus: a review. In: Phytochemistry Reviews, Vol. 17, no. 5, p. 1129-1163 (2018). doi:10.1007/s11101-018-9564-2.

http://hdl.handle.net/2078.1/209775

Coenye, Tom ; Goeres, Darla ; Van Bambeke, Françoise ; Bjarnsholt, Thomas. Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?. In: Clinical Microbiology and Infection, Vol. 24, no. 6, p. 570-572 (2018). doi:10.1016/j.cmi.2018.01.003.

http://hdl.handle.net/2078.1/194412

Miranda Bastos, Ana C ; Vandecasteele, Stefaan J ; Spinewine, Anne ; Tulkens, Paul M ; Van Bambeke, Françoise. Temocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations.. In: Journal of Antimicrobial Chemotherapy, Vol. 73, no.6, p. 1630-1638 (2018). doi:10.1093/jac/dky078.

http://hdl.handle.net/2078.1/198443

Khandekar, Shaunak ; Liebens, Veerle ; Fauvart, Maarten ; Tulkens, Paul M. ; Michiels, Jan ; Van Bambeke, Françoise. The putative de-N-acetylase DnpA contributes to intracellular and biofilm-associated persistence of Pseudomonas aeruginosa exposed to fluoroquinolones. In: Frontiers in microbiology, . doi:10.3389/fmicb.2018.01455.

http://hdl.handle.net/2078.1/200313

Mustafa, Muhammad Hariri ; Khandekar, Shaunak ; Tunney, Michael M. ; Elborn, Stuart J. ; Kahl, Barbara C. ; Denis, Olivier ; Plésiat, Patrick ; Traore, Hamidou ; Tulkens, Paul M. ; Vanderbist, Francis ; Van Bambeke, Françoise. Acquired resistance to macrolides inPseudomonas aeruginosafrom cystic fibrosis patients. In: The European Respiratory Journal, Vol. 49, no.5, p. 1601847 (2017). doi:10.1183/13993003.01847-2016.

http://hdl.handle.net/2078.1/185561

Defraine, Valerie ; Verstraete, Laure ; Van Bambeke, Françoise ; Anantharajah, Ahalieyah ; Townsend, Eleanor M. ; Ramage, Gordon ; Corbau, Romu ; Marchand, Arnaud ; Chaltin, Patrick ; Fauvart, Maarten ; Michiels, Jan. Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models. In: Frontiers in Microbiology, Vol. 8, p. 1-10 (2017). doi:10.3389/fmicb.2017.02585.

http://hdl.handle.net/2078.1/191828

Tam, Vincent H. ; Chang, Kai-Tai ; Zhou, Jian ; Ledesma, Kimberly R. ; Phe, Kady ; Gao, Song ; Van Bambeke, Françoise ; Sánchez-Díaz, Ana María ; Zamorano, Laura ; Oliver, Antonio ; Cantón, Rafael. Determining β-lactam exposure threshold to suppress resistance development in Gram-negative bacteria. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1421-1428 (2017). doi:10.1093/jac/dkx001.

http://hdl.handle.net/2078.1/186524

Chalhoub, Houssein ; Pletzer, Daniel ; Weingart, Helge ; Braun, Yvonne ; Tunney, Michael M. ; Elborn, J. Stuart ; Rodriguez-Villalobos, Hector ; Plésiat, Patrick ; Kahl, Barbara C. ; Denis, Olivier ; Winterhalter, Mathias ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic. In: Scientific Reports, Vol. 7, p. 40208 [1-14] (2017). doi:10.1038/srep40208.

http://hdl.handle.net/2078.1/180970

Delattre, Isabelle ; Taccone, Fabio S. ; Jacobs, Frédérique ; Hites, Maya ; Dugernier, Thierry ; Spapen, Herbert ; Laterre, Pierre-François ; Wallemacq, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M.. Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?. In: Expert Review of Anti-infective Therapy, Vol. 15, no. 7, p. 677-688 (2017). doi:10.1080/14787210.2017.1338139.

http://hdl.handle.net/2078.1/186493

Buyck, Julien ; Luyckx, C. ; Muccioli, Giulio ; Krause, K.M. ; Nichols, W. W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1400-1409 (2017). doi:10.1093/jac/dkw587.

http://hdl.handle.net/2078.1/186492

Anantharajah , Ahalieyah ; Buyck, Julien ; Sundin, Charlotta ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms.. In: Antimicrobial Agents and Chemotherapy, Vol. 61, no. 6 (2017), p. e02566-16 (2017). doi:10.1128/AAC.02566-16.

http://hdl.handle.net/2078.1/185982

Catteau, Lucy ; Reichmann, Nathalie ; Olson, Joshua ; Pinho, Mariana ; Nizet, Victor ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms. In: Molecules, Vol. 22, p. 2245 (2017). doi:10.3390/molecules22122245.

http://hdl.handle.net/2078/191827

Mustafa, Muhammad Hariri ; Chalhoub, Hussein ; Denis, Olivier ; Deplano, Ariane ; Vergison, Anne ; Rodriguez-Villalobos, Hector ; Tunney, Michael M ; Elborn, J Stuart ; Kahl, Barbara C ; Traore, Hamidou ; Vanderbist, Francis ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients through Northern Europe.. In: Antimicrobial Agents and Chemotherapy, Vol. 60, no. 11, p. 6735-6741 (2016). doi:10.1128/AAC.01046-16.

http://hdl.handle.net/2078.1/179298

Van Bambeke, Françoise ; Tulkens, Paul M.. Editorial Commentary: Colistin and a New Paradigm in Drug Development.. In: Clinical Infectious Diseases, Vol. 62, no. 5, p. 559-560 (2016). doi:10.1093/cid/civ968.

http://hdl.handle.net/2078.1/174568

Chalhoub, Hussein ; Sáenz, Yolanda ; Rodriguez-Villalobos, Hector ; Denis, Olivier ; Kahl, Barbara C. ; Tulkens, Paul ; Van Bambeke, Françoise. High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations. In: International Journal of Antimicrobial Agents, Vol. 48, no. 6, p. 740-743 (2016). doi:10.1016/j.ijantimicag.2016.09.012.

http://hdl.handle.net/2078.1/180971

Riou, Mickaël ; Avrain, Laëtitia ; Carbonnelle, Sylviane ; El Garch, Farid ; Pirnay, Jean-Paul ; De Vos, Daniel ; Plésiat, Patrick ; Tulkens, Paul M. ; Van Bambeke, Françoise. Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia. In: International Journal of Antimicrobial Agents, Vol. 47, no. 1, p. 77-83 (2016). doi:10.1016/j.ijantimicag.2015.11.004.

http://hdl.handle.net/2078.1/174562

Anantharajah, Ahalieyah ; Faure, Emmanuel ; Buyck, Julien ; Sundin, Charlotta ; Lindmark, Tuulikki ; Mecsas, Joan ; Yahr, Timothy L ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Guery, Benoît ; Van Bambeke, Françoise. Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.. In: The Journal of Infectious Diseases, Vol. 214, no.7, p. 1105-1116 (2016). doi:10.1093/infdis/jiw295.

http://hdl.handle.net/2078.1/177859

Vandevelde, Nathalie M. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach.. In: Drug Discovery Today, Vol. 21, no. 7, p. 1114-1129 (16). doi:10.1016/j.drudis.2016.04.001.

http://hdl.handle.net/2078.1/174564

Ceyssens, Pieter-Jan ; Van Bambeke, Françoise ; Mattheus, Wesley ; Bertrand, Sophie ; Fux, Frédéric ; Van Bossuyt, Eddie ; Damée, Sabrina ; Nyssen, Henry-Jean ; De Craeye, Stéphane ; Verhaegen, Jan ; The Belgian Streptococcus pneumoniae Study Group ; Tulkens, Paul M. ; Vanhoof, Raymond. Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014).. In: PLoS One, Vol. 11, no. 5, p. e0154816 [1-17] (2016). doi:10.1371/journal.pone.0154816.

http://hdl.handle.net/2078.1/174563

Siala, Wafi ; Van Bambeke, Françoise ; Taresco, Vincenzo ; Piozzi, Antonella ; Francolini, Iolanda. Synergistic activity between an antimicrobial polyacrylamide and Daptomycin vs. Staphylococcus aureus biofilm.. In: Pathogens and Disease, Vol. non applicable, no.non applicable, p. ftw042 (2016). doi:10.1093/femspd/ftw042 (Accepté/Sous presse).

http://hdl.handle.net/2078.1/174565

Anantharajah, Ahalieyah ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Targeting Type Three Secretion System in Pseudomonas aeruginosa. In: Trends in Pharmacological Sciences, Vol. 37, no. 9, p. 734-749 (2016). doi:10.1016/j.tips.2016.05.011.

http://hdl.handle.net/2078.1/174566

Siala, Wafi ; Kucharíková, Soňa ; Braem, Annabel ; Vleugels, Jef ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Dijck, Patrick ; Van Bambeke, Françoise. The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase. In: Nature Communications, Vol. 7, no.Nov.3, p. 13286 (2016). doi:10.1038/ncomms13286.

http://hdl.handle.net/2078.1/177860

Van Bambeke, Françoise ; Tulkens, Paul M.. The role of solithromycin in the management of bacterial community-acquired pneumonia.. In: Expert Review of Anti-infective Therapy, Vol. 14, no.3, p. 311-324 (2016). doi:10.1586/14787210.2016.1138857.

http://hdl.handle.net/2078.1/174567

Buyck, Julien ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of antibiotic combinations against resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no. 1, p. 258-268 (2015). doi:10.1128/AAC.04011-14.

http://hdl.handle.net/2078.1/153978

Chalhoub, Hussein ; Tunney, Michael ; Elborn, J Stuart ; Vergison, Anne ; Denis, Olivier ; Plésiat, Patrick ; Kahl, Barbara C ; Van Bambeke, Françoise ; Tulkens, Paul M.. Avibactam confers susceptibility to a large proportion of ceftazidime-resistant Pseudomonas aeruginosa isolates recovered from cystic fibrosis patients. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 5, p. 1596-1598 (2015). doi:10.1093/jac/dku551.

http://hdl.handle.net/2078.1/159373

Peyrusson, Frédéric ; Butler, Déborah ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes. Studies with human THP-1 monocytes and J774 murine macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no. 9, p. 5747-5760 (2015). doi:10.1128/AAC.00827-15.

http://hdl.handle.net/2078.1/162259

Anantharajah, Ahalieyah ; Buyck, Julien ; Faure, Emmanuel ; Glupczynski, Gerald ; Rodriguez-Villalobos, Hector ; De Vos, Daniel ; Pirnay, Jean-Paul ; Bilocq, Florence ; Guery, Benoît ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise. Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes.. In: Pathogens and Disease, Vol. 73, no. 7, p. ftv049 [1-5] (2015). doi:10.1093/femspd/ftv049.

http://hdl.handle.net/2078.1/174560

Van Bambeke, Françoise. Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy. In: Future Microbiology, Vol. 10, no.00, p. 1-13 (2015). doi:10.2217/fmb.15.39.

http://hdl.handle.net/2078.1/162115

Van Bambeke, Françoise. Lipoglycopeptide Antibacterial Agents in Gram-Positive Infections: A Comparative Review.. In: Drugs, Vol. 75, no.18, p. 2073-2095 (2015). doi:10.1007/s40265-015-0505-8.

http://hdl.handle.net/2078.1/168133

Frippiat, Frédéric ; Musuamba, Flora Tshinanu ; Seidel, Laurence ; Albert, Adelin ; Denooz, Raphaël ; Charlier, Corinne ; Van Bambeke, Françoise ; Wallemacq, Pierre ; Descy, Julie ; Lambermont, Bernard ; Layios, Nathalie ; Damas, Pierre ; Moutschen, Michel. Modelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study. In: The Journal of antimicrobial chemotherapy, Vol. 70, no. 1, p. 207-216 (2015). doi:10.1093/jac/dku354.

http://hdl.handle.net/2078.1/153979

Vandevelde, Nathalie ; Tulkens, Paul M. ; Muccioli, Giulio ; Van Bambeke, Françoise. Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 6, p. 1713-1726 (2015). doi:10.1093/jac/dkv032.

http://hdl.handle.net/2078.1/159375

Catteau, Lucy ; Van Bambeke, Françoise ; Quetin-Leclercq, Joëlle. Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa. In: Phytochem Rev, Vol. 14, no. not applicable, p. 975-991 (2015). doi:10.1007/s11101-015-9437-x.

http://hdl.handle.net/2078.1/168136

Buyck, Julien M ; Peyrusson, Frédéric ; Tulkens, Paul M. ; Van Bambeke, Françoise. RX-P873, a novel protein synthesis inhibitor, accumulates in human THP-1 monocytes and is active against intracellular infections by Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria.. In: Antimicrobial Agents and Chemotherapy, Vol. 59, no.00, p. AAC.00428-15 (2015). doi:10.1128/AAC.00428-15 (Accepté/Sous presse).

http://hdl.handle.net/2078.1/162114

Theuretzbacher, Ursula ; Van Bambeke, Françoise ; Cantón, Rafael ; Giske, Christian G ; Mouton, Johan W ; Nation, Roger L ; Paul, Mical ; Turnidge, John D ; Kahlmeter, Gunnar. Reviving old antibiotics.. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 00, p. 2177-2181 (2015). doi:10.1093/jac/dkv157.

http://hdl.handle.net/2078.1/162116

Vandecasteele, Stefaan J ; Miranda Bastos, Ana ; Capron, Arnaud ; Spinewine, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Thrice-weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients.. In: International Journal of Antimicrobial Agents, Vol. 46, no. 6, p. 660-665 (2015). doi:10.1016/j.ijantimicag.2015.09.005.

http://hdl.handle.net/2078.1/168656

Ngougni Pokem, Perrin ; Miranda Bastos, Ana ; Tulkens, Paul M. ; Wallemacq, Pierre ; Van Bambeke, Françoise ; Capron, Arnaud. Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum.. In: Clinical Biochemistry, Vol. 48, no. 7-8, p. 542-545 (2015). doi:10.1016/j.clinbiochem.2015.02.006.

http://hdl.handle.net/2078.1/159374

Vandevelde, Nathalie ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antibiotic activity against naive and induced Streptococcus pneumoniae biofilms in an in vitro pharmacodynamic model. In: Antimicrobial agents and chemotherapy, Vol. 58, no. 3, p. 1348-1358 (2014). doi:10.1128/AAC.01858-13.

http://hdl.handle.net/2078.1/144342

Vandevelde, Nathalie ; Tulkens, Paul M. ; Diaz Iglesias, Yvan ; Verhaegen, Jan ; Rodriguez-Villalobos, Hector ; Philippart, Ivan ; Cadrobbi, Julie ; Coppens, Nathalie ; Boel, An ; Van Vaerenbergh, Kristien ; Francart, Hugo ; Vanhoof, Raymond ; Liistro, Giuseppe ; Jordens, Paul ; d'Odemont, Jean-Paul ; Valcke, Yvan ; Verschuren, Franck ; Van Bambeke, Françoise. Characterisation of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: in vitro susceptibility to antibiotics and biofilm formation in relation to antibiotic efflux and serotypes/serogroups.. In: International journal of antimicrobial agents, Vol. 44, no. 3, p. 209-217 (2014). doi:10.1016/j.ijantimicag.2014.05.016.

http://hdl.handle.net/2078.1/153980

Siala, Wafi ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Hallin, Marie ; Denis, Olivier ; Van Bambeke, Françoise. Comparison of the antibiotic activities of Daptomycin, Vancomycin, and the investigational Fluoroquinolone Delafloxacin against biofilms from Staphylococcus aureus clinical isolates.. In: Antimicrobial agents and chemotherapy, Vol. 58, no. 11, p. 6385-6397 (2014). doi:10.1128/AAC.03482-14.

http://hdl.handle.net/2078.1/153981

Miranda Bastos, Ana ; Vandecasteele, Stefaan J ; Tulkens, Paul M. ; Spinewine, Anne ; Van Bambeke, Françoise. Development and validation of a high performance liquid chromatography assay for the determination of temocillin in serum of haemodialysis patients.. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 90, no. 1, p. 192-197 (2014). doi:10.1016/j.jpba.2013.12.002.

http://hdl.handle.net/2078.1/144344

Sautrey, Guillaume ; Zimmermann, Louis ; Deleu, Magali ; Delbar, Alicia ; Machado, Luiza Souza ; Jeannot, Katy ; Van Bambeke, Françoise ; Buyck, Julien ; Decout, Jean-Luc ; Mingeot-Leclercq, Marie-Paule. New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides. In: Antimicrobial Agents and Chemotherapy, Vol. 58, no. 8, p. 4420-4430 (2014). doi:10.1128/AAC.02536-13.

http://hdl.handle.net/2078.1/159834

Marquez, Béatrice ; Pourcelle, Vincent ; Vallet, Coralie M ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Marchand-Brynaert, Jacqueline ; Van Bambeke, Françoise. Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.. In: Pharmaceutical research, Vol. 31, no.5, p. 1290-301 (2014). doi:10.1007/s11095-013-1250-x.

http://hdl.handle.net/2078.1/144345

Van Bambeke, Françoise. Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.. In: Annals of medicine, Vol. 46, no. 7, p. 512-529 (2014). doi:10.3109/07853890.2014.935470.

http://hdl.handle.net/2078.1/153982

Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Study of macrophage functions in murine J774 cells and human activated THP-1 cells exposed to oritavancin, a lipoglycopeptide with high cellular accumulation.. In: Antimicrobial agents and chemotherapy, Vol. 58, no.4, p. 2059-66 (2014). doi:10.1128/AAC.02475-13.

http://hdl.handle.net/2078.1/144343

Catalano, Alessia ; Carocci, Alessia ; Defrenza, Ivana ; Muraglia, Marilena ; Carrieri, Antonio ; Van Bambeke, Françoise ; Rosato, Antonio ; Corbo, Filomena ; Franchini, Carlo. 2-Aminobenzothiazole derivatives: Search for new antifungal agents. In: European Journal of Medicinal Chemistry, Vol. 64, no. jun, p. 357-364 (2013). doi:10.1016/j.ejmech.2013.03.064.

http://hdl.handle.net/2078.1/131525

Bauer, Julia ; Siala, Wafi ; Tulkens, Paul M. ; Van Bambeke, Françoise. A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of daptomycin and delafloxacin against Staphylococcus aureus biofilms.. In: Antimicrobial agents and chemotherapy, Vol. 57, no. 6, p. 2726-2737 (2013). doi:10.1128/AAC.00181-13.

http://hdl.handle.net/2078.1/140466

Melard, Aurélie ; Garcia, Laetitia ; Das, Debaditya ; Rozenberg, Raoul ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Lemaire, Sandrine. Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin. In: Journal of Antimicrobial Chemotherapy, Vol. 68, no. 3, p. 648-658 (2013). doi:10.1093/jac/dks442.

http://hdl.handle.net/2078.1/124082

Caceres, Nancy E ; Aerts, Maarten ; Marquez, Béatrice ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Devreese, Bart ; Van Bambeke, Françoise. Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC). In: PLoS One, Vol. 8, no. 3, p. e58285 [1-15] (2013). doi:10.1371/journal.pone.0058285.

http://hdl.handle.net/2078.1/131529

Garcia, Laetitia G. ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Denis, Olivier ; Tulkens, Paul M. ; Van Bambeke, Françoise. Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data. In: Journal of Antimicrobial Chemotherapy, Vol. 68, no. 7, p. 1455-1464 (2013). doi:10.1093/jac/dkt072.

http://hdl.handle.net/2078.1/131530

Buyck, Julien ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the intracellular activity of antibiotics towards Pseudomonas aeruginosa PAO1 in a model of THP-1 human monocytes. In: Antimicrobial Agents and Chemotherapy, Vol. 57, no. 5, p. 2310-2318 (2013). doi:10.1128/AAC.02609-12.

http://hdl.handle.net/2078.1/131528

Avrain, Laetitia ; Mertens, Pascal ; Van Bambeke, Françoise. RND efflux pumps in P. aeruginosa: an underestimated resistance mechanism. In: Clinical Laboratory International, Vol. April-May, p. 26/28 (2013).

http://hdl.handle.net/2078.1/134584

Lismond, Ann ; Carbonnelle, Sylviane ; Verhaegen, Jan ; Schatt, Patricia ; De Bel, Annelies ; Jordens, Paul ; Jacobs, Frédérique ; Dediste, Anne ; Verschuren, Franck ; Huang, Te-Din ; Tulkens, Paul M. ; Glupczynski, Gerald ; Van Bambeke, Françoise. Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. In: International Journal of Antimicrobial Agents, Vol. 39, no. 3, p. 208-216 (2012). doi:10.1016/j.ijantimicag.2011.11.011.

http://hdl.handle.net/2078.1/120929

Imbuluzqueta, Edurne ; Lemaire, Sandrine ; Gamazo, Carlos ; Elizondo, Elisa ; Ventosa, Nora ; Veciana, Jaume ; Van Bambeke, Françoise ; Blanco-Prieto, María J. Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.9, p. 2158-64 (2012). doi:10.1093/jac/dks172.

http://hdl.handle.net/2078.1/124070

Buyck, Julien M ; Plésiat, Patrick ; Traore, H ; Vanderbist, F ; Tulkens, Paul M. ; Van Bambeke, Françoise. Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability.. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 55, no.4, p. 534-42 (2012). doi:10.1093/cid/cis473.

http://hdl.handle.net/2078.1/124078

Garcia, Laetitia G ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of the protein kinase C activator phorbol myristate acetate on the intracellular activity of antibiotics against hemin- and menadione-auxotrophic small-colony variant mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells.. In: Antimicrobial agents and chemotherapy, Vol. 56, no.12, p. 6166-74 (2012). doi:10.1128/AAC.01031-12.

http://hdl.handle.net/2078.1/124072

Garcia, Laetitia G ; Lemaire, Sandrine ; Kahl, Barbara C ; Becker, Karsten ; Proctor, Richard A ; Tulkens, Paul M. ; Van Bambeke, Françoise. Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.12, p. 2873-81 (2012). doi:10.1093/jac/dks325.

http://hdl.handle.net/2078.1/124075

Baquir, Beverlie ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Lin, Lin ; Spellberg, Brad. Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin. In: Clinical Infectious Diseases, Vol. 54, no. Suppl 3, p. S229-S232 (2012). doi:10.1093/cid/cir921.

http://hdl.handle.net/2078.1/124080

Garcia, Laetitia ; Lemaire, S ; Kahl, B C ; Becker, K ; Proctor, R A ; Denis, O ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.. In: Antimicrobial Agents and Chemotherapy, Vol. 56, no. 7, p. 3700-3711 (2012). doi:10.1128/AAC.00285-12.

http://hdl.handle.net/2078.1/124267

Buyck, Julien M ; Guénard, Sophie ; Plésiat, Patrick ; Tulkens, Paul M. ; Van Bambeke, Françoise. Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis.. In: The Journal of antimicrobial chemotherapy, Vol. 67, no.3, p. 771-5 (2012). doi:10.1093/jac/dkr543.

http://hdl.handle.net/2078.1/124079

Van Bambeke, Françoise. ABC Transporters : role in modulation of drug pharmacokinetics and in physiopathology and therapeutic perspectives. In: Current Drug Targets, Vol. 12, no. 5, p. 598-599 (2011). doi:10.2174/138945011795378531.

http://hdl.handle.net/2078.1/33495

Marquez, Béatrice ; Van Bambeke, Françoise. ABC multidrug transporters : target for modulation of drug pharmacokinetics and drug-drug interactions. In: Current Drug Targets, Vol. 12, no. 5, p. 600-20 (2011). doi:10.2174/138945011795378504.

http://hdl.handle.net/2078.1/33496

Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M.. Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.. In: International Journal of Antimicrobial Agents, Vol. 38, no. 1, p. 52-59 (2011). doi:10.1016/j.ijantimicag.2011.03.002.

http://hdl.handle.net/2078.1/105981

Lemaire, Sandrine ; Van Bambeke, Françoise ; Pierard, Denis ; Appelbaum, Peter C. ; Tulkens, Paul M.. Activity of fusidic acid against extracellular and intracellular Staphylococcus aureus : influence of pH and comparison with linezolid and clindamycin.. In: Clinical Infectious Diseases, Vol. 52 Suppl 7, p. S493-503 (2011). doi:10.1093/cid/cir165.

http://hdl.handle.net/2078.1/105978

Lemaire, Sandrine ; Kosowska-Shick, Klaudia ; Appelbaum, Peter C. ; Glupczynski, Y. ; Van Bambeke, Françoise ; Tulkens, Paul M.. Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus : comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.. In: Journal of Antimicrobial Chemotherapy, Vol. 66, no. 3, p. 596-607 (2011). doi:10.1093/jac/dkq478.

http://hdl.handle.net/2078.1/105973

Vallet, Coralie M. ; Marquez, Béatrice ; Ngabirano, Eva ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity : studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages. In: International Journal of Antimicrobial Agents, Vol. 38, no. 3, p. 249-256 (2011). doi:10.1016/j.ijantimicag.2011.05.011.

http://hdl.handle.net/2078.1/106004

Marquez, Béatrice ; Ameye, Geneviève ; Vallet, Coralie M. ; Tulkens, Paul M. ; Poirel, Hélène A. ; Van Bambeke, Françoise. Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin. In: PLoS One, Vol. 6, no. 12, p. e28368 (2011). doi:10.1371/journal.pone.0028368.

http://hdl.handle.net/2078.1/106867

Lemaire, Sandrine ; Tulkens, Paul M. ; Van Bambeke, Françoise. Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011). doi:10.1128/AAC.01201-10.

http://hdl.handle.net/2078.1/105976

Lismond, Ann ; Carbonnelle, Sylviane ; Tulkens, Paul M. ; Van Bambeke, Françoise. Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia. In: Journal of Antimicrobial Chemotherapy, Vol. 66, no. 4, p. 948-951 (2011). doi:10.1093/jac/dkr004.

http://hdl.handle.net/2078.1/105982

Sandberg, Anne ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Hughes, Diarmaid ; von Eiff, Christof ; Frimodt-Møller, Niels. Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model. In: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 4, p. 1443-1452 (2011). doi:10.1128/AAC.00205-10.

http://hdl.handle.net/2078.1/105994

Vallet, Coralie M. ; Marquez, Béatrice ; Nhiri, Naïma ; Anantharajah, Ahalieyah ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Lallemand, Jean-Yves ; Jacquet, Eric ; Van Bambeke, Françoise. Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin. In: Toxicology, Vol. 290, no. 2-3, p. 178-186 (2011). doi:10.1016/j.tox.2011.09.003.

http://hdl.handle.net/2078.1/106007

Denamur, Sophie ; Tyteca, Donatienne ; Marchand-Brynaert, Jacqueline ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic. In: Free Radical Biology & Medicine, Vol. 51, no. 9, p. 1656-1665 (2011). doi:10.1016/j.freeradbiomed.2011.07.015.

http://hdl.handle.net/2078.1/114045

Baudoux, Pierre ; Lemaire, Sandrine ; Denis, Olivier ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Glupczynski, Gerald. Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes.. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 6, p. 1228-1236 (2010). doi:10.1093/jac/dkq110.

http://hdl.handle.net/2078.1/32090

Lemaire, Sandrine ; Kosowska-Shick, Klaudia ; Appelbaum, Peter C ; Verween, Gunther ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid : studies with infected phagocytic and non-phagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2549-2559 (2010). doi:10.1128/AAC.01724-09.

http://hdl.handle.net/2078.1/32131

Lemaire, Sandrine ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells : studies with macrophages and polymorphonuclear neutrophils. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2540-2548 (2010). doi:10.1128/AAC.01723-09.

http://hdl.handle.net/2078.1/32130

Becker, Jean-Paul ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Dynamics and structural changes induced by ATP binding in SAV1866, a bacterial ABC exporter.. In: The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, Vol. 114, no. 48, p. 15948-15957 (2010). doi:10.1021/jp1038392.

http://hdl.handle.net/2078.1/68623

El Garch, Farid ; Lismond, Ann ; Piddock, Laura J. V. ; Courvalin, Patrice ; Tulkens, Paul M. ; Van Bambeke, Françoise. Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae.. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 10, p. 2076-2082 (2010). doi:10.1093/jac/dkq287.

http://hdl.handle.net/2078.1/33188

Riou, Mickaël ; Carbonnelle, Sylviane ; Avrain, Laetitia ; Mesaros, Narcisa ; Pirnay, Jean-Paul ; Bilocq, Florence ; De Vos, Daniel ; Simon, Anne ; Piérard, Denis ; Jacobs, Frédérique ; Dediste, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Glupczynski, Gerald. In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy.. In: International Journal of Antimicrobial Agents, Vol. 36, no. 6, p. 513-522 (2010). doi:10.1016/j.ijantimicag.2010.08.005.

http://hdl.handle.net/2078.1/33402

Domenech, Oscar ; Dufrêne, Yves ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus.. In: BBA - Biomembranes, Vol. 1798, no. 10, p. 1876-1885 (2010). doi:10.1016/j.bbamem.2010.06.011.

http://hdl.handle.net/2078.1/32828

Sandberg, Anne ; Jensen, Klaus Skovbo ; Tulkens, Paul M. ; Baudoux, Pierre ; Van Bambeke, Françoise ; Frimodt-Møller, Niels. Intra- and extracellular activity of dicloxacillin against Staphylococcus aureus in vivo and in vitro.. In: Antimicrobial Agents and Chemotherapy, Vol. 54, no. 6, p. 2391-400 (2010). doi:10.1128/AAC.01400-09.

http://hdl.handle.net/2078.1/30699

Sandberg, Anne ; Jensen, Klaus Skovbo ; Baudoux, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Frimodt-Møller, Niels. Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 5, p. 962-73 (2010). doi:10.1093/jac/dkq052.

http://hdl.handle.net/2078.1/33969

Brinch, Karoline Sidelmann ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Frimodt-Møller, Niels ; Høiby, Niels ; Kristensen, Hans-Henrik. Intracellular activity of the peptide antibiotic NZ2114 : studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin. In: Journal of Antimicrobial Chemotherapy, Vol. 65, no. 8, p. 1720-1724 (2010). doi:10.1093/jac/dkq159.

http://hdl.handle.net/2078.1/33670

Lemaire, Sandrine ; Glupczynski, Gerald ; Duval, Valérie ; Joris, Bernard ; Tulkens, Paul M. ; Van Bambeke, Françoise. Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 6, p. 2289-2297 (2009). doi:10.1128/AAC.01135-08.

http://hdl.handle.net/2078.1/21890

Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M.. Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, towards Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 9, p. 3734-3743 (2009). doi:10.1128/AAC.00203-09.

http://hdl.handle.net/2078.1/22759

Lemaire, Sandrine ; Van Bambeke, Françoise ; Appelbaum, Peter C ; Tulkens, Paul M.. Cellular pharmacokinetics and intracellular activity of torezolid (TR-700) : studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines. In: Journal of Antimicrobial Chemotherapy, Vol. 64, no. 5, p. 1035-1043 (2009). doi:10.1093/jac/dkp267.

http://hdl.handle.net/2078.1/24505

Tytgat, Isabelle ; Colacino, Evelina ; Tulkens, Paul M. ; Poupaert, Jacques ; Prévost, M ; Van Bambeke, Françoise. DD-ligases as a potential target for antibiotics: past, present and future. In: Current Medicinal Chemistry, Vol. 16, no. 20, p. 2566-2580 (2009). doi:10.2174/092986709788682029.

http://hdl.handle.net/2078.1/25032

Marquez, Béatrice ; Caceres, Nancy E. ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: Studies with ciprofloxacin-resistant cells. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 6, p. 2410-2416 (2009). doi:10.1128/AAC.01428-08.

http://hdl.handle.net/2078.1/22107

Domenech, Oscar ; Francius, Grégory ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Dufrêne, Yves ; Mingeot-Leclercq, Marie-Paule. Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers : effect on membrane permeability and nanoscale lipid membrane organization. In: BBA - Biomembranes, Vol. 1788, no. 9, p. 1832-1840 (2009). doi:10.1016/j.bbamem.2009.05.003.

http://hdl.handle.net/2078.1/22447

Nguyen, Hoang Anh ; Denis, Olivier ; Vergison, Anne ; Theunis, Anne ; Tulkens, Paul M. ; Struelens, Marc J. ; Van Bambeke, Françoise. Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : Pharmacodynamic evaluation and comparison with isogenic normal phenotype and revertant strains. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 4, p. 1434-1442 (2009). doi:10.1128/AAC.01145-08.

http://hdl.handle.net/2078.1/21422

Nguyen, Hoang ; Denis, Olivier ; Vergison, Anne ; Tulkens, Paul M. ; Struelens, Marc J. ; Van Bambeke, Françoise. Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : study of antibiotic combinations. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 4, p. 1443-1449 (2009). doi:10.1128/AAC.01146-08.

http://hdl.handle.net/2078.1/21415

Van de Velde, Sébastien ; Delaive, Edouard ; Dieu, Marc ; Carryn, Stéphane ; Van Bambeke, Françoise ; Devreese, Bart ; Raes, Martine ; Tulkens, Paul M.. Isolation and 2D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes.. In: Proteomics, Vol. 9, no. 24, p. 5484-5496 (2009). doi:10.1002/pmic.200900503.

http://hdl.handle.net/2078.1/27369

Becker, Jean-Paul ; Depret, Grégoire ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Molecular models of human P-glycoprotein in two different catalytic states. In: BMC Structural Biology, Vol. 9, no. 3, p. [1-18] (2009). doi:10.1186/1472-6807-9-3.

http://hdl.handle.net/2078.1/25034

Van de Velde, Sébastien ; Carryn, Stéphane ; Van Bambeke, Françoise ; Hill, Colin ; Tulkens, Paul M. ; Sleator, Roy D.. Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes.. In: Gut Pathogens, Vol. 1, p. 23 (2009). doi:10.1186/1757-4749-1-23.

http://hdl.handle.net/2078.1/106609

Van Bambeke, Françoise ; Tulkens, Paul M.. Pharmacodynamie des antibiotiques dans le LCR : principes et conséquences (facteurs prédictifs d'efficacité). In: Médecine et maladies infectieuses - revue de la Société de pathologie infectieuse de langue française, Vol. 39, no. 7-8, p. 483-492 (2009). doi:10.1016/j.medmal.2009.02.038.

http://hdl.handle.net/2078.1/25033

Brinch, Karoline Sidelmann ; Sandberg, Anne ; Baudoux, Pierre ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Frimodt-Møller, Niels ; Høiby, Niels ; Kristensen, Hans-Henrik. Plectasin shows intracellular activity against staphylococcus aureus in human THP-1 monocytes and in the mouse peritonitis model. In: Antimicrobial Agents and Chemotherapy, Vol. 53, no. 11, p. 4801-4808 (2009). doi:10.1128/AAC.00685-09.

http://hdl.handle.net/2078.1/24058

Olivier, Aurélie C. ; Lemaire, Sandrine ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Oldfield, Eric. Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of staphylococcus aureus in human macrophages and endothelial cells. In: The Journal of Infectious Diseases, Vol. 200, no. 9, p. 1367-1370 (2009). doi:10.1086/606012.

http://hdl.handle.net/2078.1/25030

Van Bambeke, Françoise ; Tulkens, Paul M.. Safety profile of the respiratory fluoroquinolone moxifloxacin : comparison with other fluoroquinolones and other antibacterial classes. In: Drug Safety, no. 5, p. 359-78 (2009).

http://hdl.handle.net/2078.1/22428

Tytgat, Isabelle ; Vandevuer, Stéphane ; Ortmans, Isabelle ; Sirockin, Finton ; Colacino, Evelina ; Van Bambeke, Françoise ; Duez, Colette ; Poupaert, Jacques ; Tulkens, Paul M. ; Dejaegere, Annick ; Prévost, Martine. Structure-based design of benzoxazoles as new inhibitors for D-Alanyl – D-Alanine ligase. In: QSAR & Combinatorial Science, Vol. 28, no. 11-12, p. 1394-1404 (2009). doi:10.1002/qsar.200910054.

http://hdl.handle.net/2078.1/106618

Franchini, Carlo ; Muraglia, Marilena ; Corbo, Filomena ; Florio, Marco Antonio ; Di Mola, Antonia ; Rosato, Antonio ; Matucci, Rosanna ; Nesi, Marta ; Van Bambeke, Françoise ; Vitali, Cesare. Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.. In: Archiv der Pharmazie, Vol. 342, no. 10, p. 605-613 (2009). doi:10.1002/ardp.200900092.

http://hdl.handle.net/2078.1/25031

Lemaire, Sandrine ; Kosowska-Shick, K. ; Julian, K ; Tulkens, Paul M. ; Van Bambeke, Françoise ; Appelbaum, Peter C.. Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of Staphylococcus aureus isolates from a patient with persistent bacteraemia and endocarditis.. In: Clinical Microbiology and Infection, Vol. 14, no. 8, p. 766-777 (2008). doi:10.1111/j.1469-0691.2008.02035.x.

http://hdl.handle.net/2078.1/14174

Denamur, Sophie ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Apoptosis induced by aminoglycosides in LLC-PK1 cells : comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 6, p. 2236-2238 (2008). doi:10.1128/AAC.01680-07.

http://hdl.handle.net/2078.1/11358

Barcia Macay, Maritza ; Mouaden, Fatima ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).. In: Journal of Antimicrobial Chemotherapy, Vol. 61, no. 6, p. 1288-1294 (2008). doi:10.1093/jac/dkn120.

http://hdl.handle.net/2078.1/11336

Van de Velde, Sébastien ; Nguyen, Hoang Anh ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Grellet, Jean ; Dubois, Véronique ; Quentin, Claudine ; Saux, Marie-Claude. Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.. In: Journal of Antimicrobial Chemotherapy, Vol. 62, no. 3, p. 518-521 (2008). doi:10.1093/jac/dkn232.

http://hdl.handle.net/2078.1/12698

Lismond, Ann ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Courvalin, Patrice ; Van Bambeke, Françoise. Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes : studies with ciprofloxacin and moxifloxacin. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 9, p. 3040-3046 (2008). doi:10.1128/AAC.00105-08.

http://hdl.handle.net/2078.1/12718

Bensikaddour, Hayet ; Snoussi, Karim ; Lins, Laurence ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Brasseur, Robert ; Goormaghtigh, Erik ; Mingeot-Leclercq, Marie-Paule. Interactions of ciprofloxacin with DPPC and DPPG : fluorescence anisotropy, ATR-FTIR and (31)P NMR spectroscopies and conformational analysis. In: BBA - Biomembranes, Vol. 1778, no. 11, p. 2535-2543 (2008). doi:10.1016/j.bbamem.2008.08.015.

http://hdl.handle.net/2078.1/19587

Van Bambeke, Françoise ; Harms, Joerg M ; Van Laethem, Yves ; Tulkens, Paul M.. Ketolides : pharmacological profile and rational positioning in the treatment of respiratory tract infections. In: Expert Opinion on Pharmacotherapy, Vol. 9, no. 2, p. 267-283 (2008). doi:10.1517/14656566.9.2.267.

http://hdl.handle.net/2078.1/11253

Van Bambeke, Françoise. L'ABC des hépatites virales. In: Journal de Pharmacie de Belgique, Vol. 63, no. 1, p. 15-20 (2008).

http://hdl.handle.net/2078.1/107897

Lemaire, Sandrine ; Olivier, Aurélie ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Appelbaum, Peter C ; Glupczynski, Gerald. Restoration of susceptibility of intracellular methicillin resistant staphylococcus aureus to beta-lactams : comparison between strains, cells, and antibiotics. In: Antimicrobial Agents and Chemotherapy, Vol. 52, no. 8, p. 2797-2805 (2008). doi:10.1128/AAC.00123-08.

http://hdl.handle.net/2078.1/12643

Lemaire, Sandrine ; Fuda, Cosimo ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mobashery, Shahriar. Restoration of susceptibility of methicillin-resistant staphylococcus aureus to beta-lactam antibiotics by acidic pH : role of penicillin-binding protein 2A (PBP 2A). In: Journal of Biological Chemistry, Vol. 283, no. 19, p. 12769-12776 (2008). doi:10.1074/jbc.M800079200.

http://hdl.handle.net/2078.1/11322

Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Struelens, Marc J ; Tulkens, Paul M.. The bacterial envelope as a target for novel anti-MRSA antibiotics. In: Trends in Pharmacological Sciences, Vol. 29, no. 3, p. 124-134 (2008). doi:10.1016/j.tips.2007.12.004.

http://hdl.handle.net/2078/114777

Mesaros, Narcisa ; Glupczynski, Gerald ; Avrain, Laetitia ; Caceres, Nancy E ; Tulkens, Paul M. ; Van Bambeke, Françoise. A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.. In: The Journal of antimicrobial chemotherapy, Vol. 59, no. 3, p. 378-86 (2007). doi:10.1093/jac/dkl504.

http://hdl.handle.net/2078.1/10857

Baudoux, Pierre ; Bles, Nathalie ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections. In: Journal of Antimicrobial Chemotherapy, Vol. 59, no. 2, p. 246-253 (2007). doi:10.1093/jac/dkl489.

http://hdl.handle.net/2078.1/10828

Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells. In: Antimicrobial Agents and Chemotherapy, Vol. 51, no. 8, p. 2748-2757 (2007). doi:10.1128/AAC.00090-07.

http://hdl.handle.net/2078.1/10997

Van Bambeke, Françoise ; Reinert, René R ; Appelbaum, Peter C ; Tulkens, Paul M. ; Peetermans, Willy E. Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.. In: Drugs, Vol. 67, no. 16, p. 2355-82 (2007). doi:10.2165/00003495-200767160-00005.

http://hdl.handle.net/2078.1/11181

Mathot, Frédéric ; Schanck, André ; Van Bambeke, Françoise ; Ariën, A ; Noppe, M ; Brewster, M. ; Préat, Véronique. Passive diffusion of polymeric surfactants across lipid bilayers.. In: Journal of Controlled Release, Vol. 120, no. 1-2, p. 79-87 (2007). doi:10.1016/j.jconrel.2007.03.015.

http://hdl.handle.net/2078.1/10981

Mesaros, N. ; Nordmann, P. ; Plésiat, P. ; Roussel-Delvallez, M. ; Van Eldere, J. ; Glupczynski, Gerald ; Van Laethem, Y. ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: Résistance et options thérapeutiques à l'aube du deuxième millénaire. In: Louvain médical, Vol. 126, no. 8, p. 305-316 (2007).

http://hdl.handle.net/2078.1/164856

Mesaros, Narcisa ; Nordmann, P. ; Plésiat, P. ; Roussel-Delvallez, M. ; Van Eldere, J. ; Glupczynski, Gerald ; Van Laethem, Yves ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, A. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: Résistance et options thérapeutiques à l'aube du deuxième millénaire. In: Antibiotiques : journal des agents anti-infectieux, Vol. 9, no. 3, p. 189-198 (2007). doi:10.1016/S1294-5501(07)91378-3.

http://hdl.handle.net/2078.1/164853

Mesaros, N ; Glupczynski, Gerald ; Nordmann, Patrick ; Plésiat, Patrick ; Roussel-Delvallez, Micheline ; Van Eldere, Johan ; Van Laethem, Yves ; Jacobs, F. ; Lebecque, Patrick ; Malfroot, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.. In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 13, no. 6, p. 560-78 (2007). doi:10.1111/j.1469-0691.2007.01681.x.

http://hdl.handle.net/2078.1/10844

Mesaros, Narcisa ; Nordmann, Patrice ; Plésiat, Patrick ; Roussel-Delvallez, Micheline ; Van Eldere, Johan ; Glupczynski, Gerald ; Van Laethem, Yves ; Jacobs, Frédérique ; Lebecque, Patrick ; Malfroot, Anne ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pseudomonas aeruginosa: résistance et options thérapeutiques à l'aube du nouveau millénaire. In: Louvain médical, Vol. 126, no.8, p. 305-316 (2007).

http://hdl.handle.net/2078.1/124271

Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Glupczynski, Gerald ; Tulkens, Paul M.. Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin. In: Antimicrobial Agents and Chemotherapy, Vol. 51, no. 5, p. 1627-1632 (2007). doi:10.1128/AAC.01192-06.

http://hdl.handle.net/2078.1/10863

Avrain, Laetitia ; Garvey, Mark ; Mesaros, Narcisa ; Glupczynski, Gerald ; Mingeot-Leclercq, Marie-Paule ; Piddock, Laura J V ; Tulkens, Paul M. ; Vanhoof, Raymond ; Van Bambeke, Françoise. Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations. In: Journal of Antimicrobial Chemotherapy, Vol. 60, no. 5, p. 965-972 (2007). doi:10.1093/jac/dkm292.

http://hdl.handle.net/2078.1/11068

Michot, Jean-Michel ; Heremans, Marie F ; Caceres, Nancy E. ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 5, p. 1689-1695 (2006). doi:10.1128/AAC.50.5.1689-1695.2006.

http://hdl.handle.net/2078.1/25035

Van Bambeke, Françoise ; Barcia-Macay, Maritza ; Lemaire, Sandrine ; Tulkens, Paul M.. Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.. In: Current opinion in drug discovery & development, Vol. 9, no. 2, p. 218-30 (2006).

http://hdl.handle.net/2078.1/10531

Barcia Macay, Maritza ; Lemaire, Sandrine ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus. In: Journal of Antimicrobial Chemotherapy, Vol. 58, no. 6, p. 1177-1184 (2006). doi:10.1093/jac/dkl424.

http://hdl.handle.net/2078.1/10759

Servais, Hélène ; Jossin, Yves ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 4, p. 1213-1221 (2006). doi:10.1128/AAC.50.4.1213-1221.2006.

http://hdl.handle.net/2078.1/10535

Van Bambeke, Françoise. Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy.. In: Current opinion in investigational drugs (London, England : 2000), Vol. 7, no. 8, p. 740-9 (2006).

http://hdl.handle.net/2078.1/10699

Van Bambeke, Françoise ; Pagès, Jean-Marie ; Lee, Ving J. Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.. In: Recent patents on anti-infective drug discovery, Vol. 1, no. 2, p. 157-75 (2006). doi:10.2174/157489106777452692.

http://hdl.handle.net/2078.1/11260

Barcia Macay, Maritza ; Seral, Cristina ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 3, p. 841-851 (2006). doi:10.1128/AAC.50.3.841-851.2006.

http://hdl.handle.net/2078.1/10489

Vandevuer, Stéphane ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Prévost, Martine. Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: insight into the mechanism of ligand migration and binding sites.. In: Proteins, Vol. 63, no. 3, p. 466-78 (2006). doi:10.1002/prot.20892.

http://hdl.handle.net/2078.1/25036

Charvalos, Ekatherina ; Tzatzarakis, Manolis N ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Tsatsakis, Aristidis M ; Tzanakakis, George N ; Mingeot-Leclercq, Marie-Paule. Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects. In: Journal of Antimicrobial Chemotherapy, Vol. 57, no. 2, p. 236-244 (2006). doi:10.1093/jac/dki455.

http://hdl.handle.net/2078.1/22985

Chanteux, Hugues ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 4, p. 1279-1288 (2005). doi:10.1128/AAC.49.4.1279-1288.2005.

http://hdl.handle.net/2078.1/10145

Mesaros, Narcisa ; Van Bambeke, Françoise ; Avrain, Laetitia ; Glupczynski, Gerald ; Vanhoof, Raymond ; Tulkens, Paul M.. Actieve efflux van antibiotica en bactériële resistentie: stand van zake en implicaties. In: Belgisch Tijdschrift voor Geneeskunde, Vol. 61, no.20, p. 1407-1417 (2005).

http://hdl.handle.net/2078/124274

Lemaire, Sandrine ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Activity of three {beta}-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus. In: Journal of Antimicrobial Chemotherapy, Vol. 55, no. 6, p. 897-904 (2005). doi:10.1093/jac/dki094.

http://hdl.handle.net/2078.1/10173

Seral, Cristina ; Barcia Macay, Maritza ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages. In: Journal of Antimicrobial Chemotherapy, Vol. 55, no. 4, p. 511-517 (2005). doi:10.1093/jac/dki059.

http://hdl.handle.net/2078.1/10113

Servais, Hélène ; Van Der Smissen, Patrick ; Thirion, Gaëtan ; Van Der Essen, Gauthier ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. In: Toxicology and Applied Pharmacology : for those working in the fields of toxicology, pharmacology, biochemistry, nutrition, veterinary medicine, Vol. 206, no. 3, p. 321-333 (2005). doi:10.1016/j.taap.2004.11.024.

http://hdl.handle.net/2078.1/10264

Michot, Jean-Michel ; Seral, Cristina ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 6, p. 2429-2437 (2005). doi:10.1128/AAC.49.6.2429-2437.2005.

http://hdl.handle.net/2078.1/10202

Mesaros, Narcisa ; Van Bambeke, Françoise ; Avrain, Laetitia ; Glupczynski, Gerald ; Vanhoof, Raymond ; Plésiat, Patrick ; Tulkens, Paul M.. L'efflux actif des antibiotiques et la résistance bactérienne: état de la question et implications. In: La Lettre de l'Infectiologue : de la microbiologie à la clinique, Vol. 20, p. 117-126 (2005).

http://hdl.handle.net/2078.1/124284

Mesaros, Narcisa ; Van Bambeke, Françoise ; Glupczynski, Gerald ; Vanhoof, Raymond ; Tulkens, Paul M.. L'efflux des antibiotiques: un mécanisme ubiquitaire conduisant à la résistance. État de la question et implications microbiologiques et cliniques. In: Louvain médical, Vol. 124, no.8, p. 308-320 (2005).

http://hdl.handle.net/2078.1/124272

Van Bambeke, Françoise ; Saffran, Jennifer ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation. In: Antimicrobial Agents and Chemotherapy, Vol. 49, no. 5, p. 1695-1700 (2005). doi:10.1128/AAC.49.5.1695-1700.2005.

http://hdl.handle.net/2078.1/10171

Piret, Jocelyne ; Schanck, André ; Delfosse, Sylvie ; Van Bambeke, Françoise ; Kishore, Bellamkonda K ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids. In: Chemistry and Physics of Lipids, Vol. 133, no. 1, p. 1-15 (2005). doi:10.1016/j.chemphyslip.2004.08.002.

http://hdl.handle.net/2078/114050

Van Bambeke, Françoise ; Michot, Jean-Michel ; Van Eldere, Johan ; Tulkens, Paul M.. Quinolones in 2005: an update.. In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 11, no. 4, p. 256-80 (2005). doi:10.1111/j.1469-0691.2005.01131.x.

http://hdl.handle.net/2078.1/23953

Michot, Jean-Michel ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter. In: Antimicrobial Agents and Chemotherapy, Vol. 48, no. 7, p. 2673-2682 (2004). doi:10.1128/AAC.48.7.2673-2682.2004.

http://hdl.handle.net/2078.1/9886

Van Bambeke, Françoise ; Carryn, Stéphane ; Seral, Cristina ; Chanteux, Hugues ; Tyteca, Donatienne ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 48, no. 8, p. 2853-2860 (2004). doi:10.1128/AAC.48.8.2853-2860.2004.

http://hdl.handle.net/2078.1/9902

Nassogne, Marie-Cécile ; Lizarraga, Chantal ; N'Kuli, Francisca ; Van Bambeke, Françoise ; Van Binst, Roger ; Wallemacq, Pierre ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Levade, Thierry ; Courtoy, Pierre J.. Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1. In: Toxicology and Applied Pharmacology, Vol. 194, no. 2, p. 101-110 (2004). doi:10.1016/j.taap.2003.09.026.

http://hdl.handle.net/2078.1/22987

Van Bambeke, Françoise ; Van Laethem, Yves ; Courvalin, Patrice ; Tulkens, Paul M.. Glycopeptide antibiotics: from conventional molecules to new derivatives.. In: Drugs, Vol. 64, no. 9, p. 913-936 (2004). doi:10.2165/00003495-200464090-00001.

http://hdl.handle.net/2078.1/9811

Van Bambeke, Françoise. Glycopeptides in clinical development: pharmacological profile and clinical perspectives.. In: Current opinion in pharmacology, Vol. 4, no. 5, p. 471-478 (2004). doi:10.1016/j.coph.2004.04.006.

http://hdl.handle.net/2078.1/25037

Carryn, Stéphane ; Van de Velde, Sébastien ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide. In: The Journal of Infectious Diseases, Vol. 189, no. 11, p. 2101-2109 (2004). doi:10.1086/420848.

http://hdl.handle.net/2078.1/9841

Ben Abdelaziz, Halim ; Lemaire, Sandrine ; Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria. In: Journal of Antimicrobial Chemotherapy, Vol. 54, no. 1, p. 288-289 (2004). doi:10.1093/jac/dkh288.

http://hdl.handle.net/2078.1/22986

Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model. In: Journal of Antimicrobial Chemotherapy, Vol. 51, no. 4, p. 1051-1052 (2003). doi:10.1093/jac/dkg189.

http://hdl.handle.net/2078.1/22989

Van Bambeke, Françoise ; Michot, J-M ; Tulkens, Paul M.. Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.. In: The Journal of antimicrobial chemotherapy, Vol. 51, no. 5, p. 1067-77 (2003). doi:10.1093/jac/dkg225.

http://hdl.handle.net/2078.1/9430

Van Bambeke, Françoise ; Glupczynski, Gerald ; Plésiat, P ; Pechère, J C ; Tulkens, Paul M.. Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy.. In: Journal of Antimicrobial Chemotherapy, Vol. 51, no. 5, p. 1055-1065 (2003). doi:10.1093/jac/dkg224.

http://hdl.handle.net/2078.1/9431

Seral, Cristina ; Carryn, Stéphane ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.. In: The Journal of antimicrobial chemotherapy, Vol. 51, no. 5, p. 1167-73 (2003). doi:10.1093/jac/dkg223.

http://hdl.handle.net/2078.1/9432

Seral, Cristina ; Michot, Jean-Michel ; Chanteux, Hugues ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M. ; Van Bambeke, Françoise. Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 47, no. 3, p. 1047-1051 (2003). doi:10.1128/AAC.47.3.1047-1051.2003.

http://hdl.handle.net/2078.1/9383

Chanteux, Hugues ; Mingeot-Leclercq, Marie-Paule ; Sonveaux, Etienne ; Van Bambeke, Françoise ; Tulkens, Paul M.. Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages. In: Journal of Antimicrobial Chemotherapy, Vol. 52, no. 4, p. 610-615 (2003). doi:10.1093/jac/dkg431.

http://hdl.handle.net/2078.1/22988

Carryn, Stéphane ; Chanteux, Hugues ; Seral, Cristina ; Mingeot-Leclercq, Marie-Paule ; Van Bambeke, Françoise ; Tulkens, Paul M.. Intracellular pharmacodynamics of antibiotics. In: Infectious Disease Clinics of North America, Vol. 17, no. 3, p. 615-634 (2003). doi:10.1016/S0891-5520(03)00066-7.

http://hdl.handle.net/2078.1/9707

Mingeot-Leclercq, Marie-Paule ; Lins, Laurence ; Bensliman, Mariam ; Thomas, Annick ; Van Bambeke, Françoise ; Peuvot, Jacques ; Schanck, André ; Brasseur, Robert. Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. In: BBA - Biomembranes, Vol. 1609, no. 1, p. 28-38 (2003). doi:10.1016/S0005-2736(02)00654-5.

http://hdl.handle.net/2078.1/9343

Seral, Cristina ; Van Bambeke, Françoise ; Tulkens, Paul M.. Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages. In: Antimicrobial Agents and Chemotherapy, Vol. 47, no. 7, p. 2283-2292 (2003). doi:10.1128/aac.47.7.2283-2292.2003.

http://hdl.handle.net/2078.1/9497

Tyteca, Donatienne ; Van Der Smissen, Patrick ; Mettlen, Marcel ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule ; Courtoy, Pierre J.. Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages. In: Experimental Cell Research, Vol. 281, no. 1, p. 86-100 (2002). doi:10.1006/excr.2002.5613.

http://hdl.handle.net/2078.1/9307

Carryn, Stéphane ; Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Tulkens, Paul M.. Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations. In: Antimicrobial Agents and Chemotherapy, Vol. 46, no. 7, p. 2095-2103 (2002). doi:10.1128/AAC.46.7.2095-2103.2002.

http://hdl.handle.net/2078.1/9180

Mingeot-Leclercq, Marie-Paule ; Lins, Laurence ; Bensliman, Mariam ; Van Bambeke, Françoise ; Van Der Smissen, Patrick ; Peuvot, Jacques ; Schanck, André ; Brasseur, Robert. Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus. In: Chemistry and Physics of Lipids, Vol. 120, no. 1-2, p. 57-74 (2002). doi:10.1016/S0009-3084(02)00108-1.

http://hdl.handle.net/2078.1/9299

Tyteca, Donatienne ; Van Der Smissen, Patrick ; Van Bambeke, Françoise ; Leys, Karin ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts. In: European Journal of Cell Biology, Vol. 80, no. 7, p. 466-478 (2001). doi:10.1078/0171-9335-00180.

http://hdl.handle.net/2078.1/8914

Van Bambeke, Françoise ; Verhaegen, Jacques ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine en de huidige neomacroliden: klinisch gebruik en perspectieven. In: Tijdschrift voor Geneeskunde, Vol. 57, no. 5, p. 382-395 (2001). doi:10.2143/TVG.57.5.5000995.

http://hdl.handle.net/2078.1/111763

Van Bambeke, Françoise ; Verhaegen, J. ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine et néomacrolides actuels, usages cliniques et perspectives. In: Medecine et Hygiene, Vol. 59, no. 2369, p. 2316-2323 (2001).

http://hdl.handle.net/2078.1/111766

Van Bambeke, Françoise ; Verhaegen, J. ; Tulkens, Paul M.. Erythromycine, autres macrolides et kétolides: usages cliniques actuels et perspectives. In: La Lettre de l&apos;Infectiologue : de la microbiologie à la clinique, Vol. 57, p. 382-395 (2001).

http://hdl.handle.net/2078.1/111769

Mingeot-Leclercq, Marie-Paule ; Gallet, Xavier ; Flore, Chistrel ; Van Bambeke, Françoise ; Peuvot, Jacques ; Brasseur, Robert. Experimental and conformational analyses of interactions between butenafine and lipids. In: Antimicrobial Agents and Chemotherapy, Vol. 45, no. 12, p. 3347-3354 (2001). doi:10.1128/AAC.45.12.3347-3354.2001.

http://hdl.handle.net/2078.1/8990

Van Bambeke, Françoise ; Tulkens, Paul M.. Macrolides: pharmacokinetics and pharmacodynamics.. In: International journal of antimicrobial agents, Vol. 18 Suppl 1, p. S17-23 (2001).

http://hdl.handle.net/2078.1/8951

Gholizadeh, Y ; Prevost, M ; Van Bambeke, Françoise ; Casadewall, B ; Tulkens, Paul M. ; Courvalin, P.. Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.. In: Protein science : a publication of the Protein Society, Vol. 10, no. 4, p. 836-44 (2001). doi:10.1110/ps.39101.

http://hdl.handle.net/2078.1/25038

Van Bambeke, Françoise ; Balzi, E. ; Tulkens, Paul M.. Antibiotic efflux pumps.. In: Biochemical pharmacology, Vol. 60, no. 4, p. 457-70 (2000). doi:10.1016/S0006-2952(00)00291-4.

http://hdl.handle.net/2078.1/8560

Tyteca, Donatienne ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Azythomycin, a lysosomotropic antibiotic impairs endocytosis in cultured macrophages. In: Chemistry and Physics of Lipids, Vol. 107, p. 58-59 (2000).

http://hdl.handle.net/2078.1/114779

Van Bambeke, Françoise ; Kerkhofs, Anne ; Schanck, André ; Remacle, Claude ; Sonveaux, Etienne ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Biophysical studies and intracellular destabilization of pH-sensitive liposomes. In: Lipids, Vol. 35, no. 2, p. 213-223 (2000). doi:10.1007/BF02664772.

http://hdl.handle.net/2078.1/22604

Van Bambeke, Françoise ; Verhaegen, Jacques ; Tyteca, Donatienne ; Auckenthaler, R. ; Tulkens, Paul M.. Erythromycine et némacrolides actuels: usages cliniques et perspectives. In: Louvain médical, Vol. 119, p. 259-286 (2000).

http://hdl.handle.net/2078.1/111771

Prévost, M ; Van Belle, D ; Tulkens, Paul M. ; Courvalin, P. ; Van Bambeke, Françoise. Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.. In: Journal of molecular microbiology and biotechnology, Vol. 2, no. 3, p. 321-30 (2000).

http://hdl.handle.net/2078.1/25039

Montenez, Jean-Pierre ; Van Bambeke, Françoise ; Piret, Jocelyne ; Brasseur, Robert ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. In: Toxicology and Applied Pharmacology : for those working in the fields of toxicology, pharmacology, biochemistry, nutrition, veterinary medicine, Vol. 156, no. 2, p. 129-140 (1999). doi:10.1006/taap.1999.8632.

http://hdl.handle.net/2078.1/8256

Van Bambeke, Françoise ; Tulkens, Paul M.. Optimisation des traitements antibactériens sur base de propriétés pharmacodynamiques des antibiotiques. In: Médisphère, Vol. 93, p. 21-24 (1999).

http://hdl.handle.net/2078/124283

Van Bambeke, Françoise ; Tyteca, Donatienne ; Ouadrhiri, Youssef ; Tulkens, Paul M.. Optimisation des traitements antibactériens sur base des propriétés pharmacodynamiques des antibiotiques. In: Louvain médical, Vol. 118, p. 43-63 (1999).

http://hdl.handle.net/2078/124275

Van Bambeke, Françoise ; Chauvel, M ; Reynolds, P E ; Fraimow, H S ; Courvalin, P.. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants.. In: Antimicrobial agents and chemotherapy, Vol. 43, no. 1, p. 41-7 (1999).

http://hdl.handle.net/2078.1/25041

Van Bambeke, Françoise ; Bigaignon, Geoffroy ; Ninane, Jacques ; Tulkens, Paul M.. La maladie de Lyme: diagnostic et thérapeutique rationnels. In: Louvain médical, Vol. 117, p. 375-388 (1998).

http://hdl.handle.net/2078.1/124277

Van Bambeke, Françoise ; Gerbaux, C ; Michot, Jean-Michel ; d'Yvoire, M B ; Montenez, J P ; Tulkens, Paul M.. Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.. In: The Journal of antimicrobial chemotherapy, Vol. 42, no. 6, p. 761-7 (1998). doi:10.1093/jac/42.6.761.

http://hdl.handle.net/2078.1/25040

Nachega, Jean ; Van Bambeke, Françoise ; Vandercam, Bernard ; Tulkens, Paul M.. Usages cliniques actuels et raisonnables des glycopeptides. In: Louvain médical, Vol. 116, no. 6, p. 162-174 (1997).

http://hdl.handle.net/2078.1/124278

Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Brasseur, Robert ; Tulkens, Paul M. ; Schanck, André. Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents. In: Chemistry and Physics of Lipids, Vol. 79, no. 2, p. 123-135 (1996). doi:10.1016/0009-3084(95)02520-0.

http://hdl.handle.net/2078.1/12173

Gerbaux, C ; Van Bambeke, Françoise ; Montenez, J P ; Piret, J. ; Morlighem, G ; Tulkens, Paul M.. Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.. In: FEBS letters, Vol. 394, no. 3, p. 307-10 (1996). doi:10.1016/0014-5793(96)00975-1.

http://hdl.handle.net/2078.1/12222

Van Bambeke, Françoise ; Montenez, Jean-Pierre ; Piret, Jocelyne ; Tulkens, Paul M. ; Courtoy, Pierre J. ; Mingeot-Leclercq, Marie-Paule. Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity. In: European Journal of Pharmacology, Vol. 314, no. 1-2, p. 203-214 (1996). doi:10.1016/S0014-2999(96)00552-3.

http://hdl.handle.net/2078.1/22991

Montenez, Jean-Pierre ; Van Bambeke, Françoise ; Piret, Jocelyne ; Schanck, André ; Brasseur, Robert ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies. In: European Journal of Pharmacology, Vol. 314, no. 1-2, p. 215-227 (1996). doi:10.1016/S0014-2999(96)00553-5.

http://hdl.handle.net/2078.1/12266

Van Bambeke, Françoise ; Nachega, Jean ; Tulkens, Paul M.. Traitement des infections à Herpes simplex, Varicella zoster et cytomegalovirus. In: Louvain médical, Vol. 115, p. 735-744 (1996).

http://hdl.handle.net/2078.1/124280

Van Bambeke, Françoise ; Tulkens, Paul M. ; Brasseur, Robert ; Mingeot-Leclercq, Marie-Paule. Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.. In: European Journal of Pharmacology, Vol. 289, no. 2, p. 321-333 (1995). doi:10.1016/0922-4106(95)90110-8.

http://hdl.handle.net/2078.1/11872

Mingeot-Leclercq, Marie-Paule ; Schanck, André ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Lins, Laurence ; Brasseur, Roger. Molecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.. In: Pharmacology : international journal of experimental and clinical pharmacology, Vol. 14, p. 71-98 (1995).

http://hdl.handle.net/2078.1/132020

Van Bambeke, Françoise ; Mingeot-Leclercq, Marie-Paule ; Schanck, André ; Brasseur, Robert ; Tulkens, Paul M.. Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells. In: European Journal of Pharmacology, Vol. 247, no. 2, p. 155-168 (1993). doi:10.1016/0922-4106(93)90073-I.

http://hdl.handle.net/2078.1/12052