GAEN
Avenue Mounier 53/B1.52.01
1200 Woluwe-Saint-Lambert
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- Isabelle Leclercq
Isabelle Leclercq
Professeure ordinaire
- Diplômes
Année Label Institution 1991 Docteur en médecine, chirurgie et accouchement Université de Liège 2001 Docteur en sciences médicales Université catholique de Louvain
2024
Gillard, Justine ; Roumain, Martin ; Picalausa, Corinne ; Thibaut, Morgane ; Clerbaux, Laure-Alix ; Tailleux, Anne ; Staels, Bart ; Muccioli, Giulio ; Bindels, Laure B. ; Leclercq, Isabelle. A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. In: JHEP Reports, Vol. 6, no. 11, p. 101148 [1-11] (2024). doi:10.1016/j.jhepr.2024.101148 (Accepté/Sous presse).
2024
Ladeiro Domingues, Inês ; Yagoubi, Hafsa ; Zhang, Wunan ; Marotti, Valentina ; Kambale Kavungere, Espoir ; Vints, Kathlijn ; Sliwinska, Malgorzata Alicja ; Leclercq, Isabelle ; Beloqui Garcia, Ana. Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease. In: Drug Delivery and Translational Research, (2024). doi:10.1007/s13346-024-01576-z.
2024
Henin, Guillaume ; Loumaye, Audrey ; Leclercq, Isabelle ; Lanthier, Nicolas. Myosteatosis: diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease. In: JHEP Reports, Vol. 6, no. 2, p. 100963 (2024). doi:10.1016/j.jhepr.2023.100963.
2024
Henin, Guillaume ; Loumaye, Audrey ; Deldicque, Louise ; Leclercq, Isabelle ; Lanthier, Nicolas. Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction-associated steatotic liver disease?. In: Liver International, (2024). doi:10.1111/liv.15938.
2024
De Rudder, Maxime ; Manco, Rita ; Coubeau, Laurent ; Fontaine, Alix ; Claude, Bertrand ; Leclercq, Isabelle ; Dili, Alexandra. Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice.. In: Hepatology (Baltimore, Md.), (2024). doi:10.1097/HEP.0000000000000900 (Accepté/Sous presse).
2023
Nachit, Maxime ; Horsmans, Yves ; Summers, Ronald M ; Leclercq, Isabelle ; Pickhardt, Perry J. AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults.. In: Radiology, Vol. 307, no.5, p. e222008 [1-11] (2023). doi:10.1148/radiol.222008.
2023
Selvais, Camille ; Davis Lopez de Carrizosa, Maria ; Nachit, Maxime ; Versèle, Romain ; Dubuisson, Nicolas ; Noel, Laurence ; Gillard, Justine ; Leclercq, Isabelle ; Brichard, Sonia ; Abou Samra, Michel. AdipoRon enhances healthspan in middle-aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers.. In: Journal of cachexia, sarcopenia and muscle, Vol. 14, no.1, p. 464-478 (2023). doi:10.1002/jcsm.13148.
2023
Gannoun, Lila ; De Schrevel, Catalina ; Belle, Morgane ; Dauguet, Nicolas ; Achouri, Younes ; Loriot, Axelle ; Vanderaa, Christophe ; Cordi, Sabine ; Dili, Alexandra ; Heremans, Yves ; Rooman, Ilse ; Leclercq, Isabelle ; Jacquemin, Patrick ; Gatto, Laurent ; Lemaigre, Frédéric. Axon guidance genes control hepatic artery development.. In: Development, Vol. 150, no. 16, p. dev201642 [1-15] (2023). doi:10.1242/dev.201642.
2023
Gillard, Justine ; Leclercq, Isabelle. Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease.. In: Clinical science, Vol. 137, no.1, p. 65-85 (2023). doi:10.1042/CS20220697.
2023
Ladeiro Domingues, Inês ; Bohns Michalowski, Cecilia ; Marotti, Valentina ; Zhang, Wunan ; Van Hul, Matthias ; Cani, Patrice D. ; Leclercq, Isabelle ; Beloqui Garcia, Ana. Exploiting the biological effect exerted by lipid nanocapsules in non-alcoholic fatty liver disease. In: Journal of Controlled Release, Vol. 356, p. 542-553 (2023). doi:10.1016/j.jconrel.2023.03.012.
2023
Nachit, Maxime ; Montemagno, Christopher ; Clerc, Romain ; Ahmadi, Mitra ; Briand, François ; Bacot, Sandrine ; Devoogdt, Nick ; Serdjebi, Cindy ; Ghezzi, Catherine ; Sulpice, Thierry ; Broisat, Alexis ; Leclercq, Isabelle ; Perret, Pascale. Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody.. In: Nature communications, Vol. 14, no.1, p. 1062 [1-12] (2023). doi:10.1038/s41467-023-36776-7.
2023
Ladeiro Domingues, Inês ; Leclercq, Isabelle ; Beloqui Garcia, Ana. Nonalcoholic fatty liver disease: Current therapies and future perspectives in drug delivery. In: Journal of Controlled Release, Vol. 363, p. 415-434 (2023). doi:10.1016/j.jconrel.2023.09.040 (Accepté/Sous presse).
2023
Maccioni, Luca ; Horsmans, Yves ; Leclercq, Isabelle ; Schnabl, Bernd ; Starkel, Peter. Serum keratin 18-M65 levels detect progressive forms of alcohol-associated liver disease in early noncirrhotic stages.. In: Alcohol, clinical & experimental research, Vol. 47, no.6, p. 1079-1087 (2023). doi:10.1111/acer.15081.
2023
Maccioni, Luca ; Kasavuli, Joyce ; Leclercq, Sophie ; Pirlot, Boris ; Laloux, Géraldine ; Horsmans, Yves ; Leclercq, Isabelle ; Schnabl, Bernd ; Stärkel, Peter. Toll-like receptor 2 activation in monocytes contributes to systemic inflammation and alcohol-associated liver disease in humans.. In: Hepatology communications, Vol. 7, no.5, p. - (2023). doi:10.1097/HC9.0000000000000107.
2022
Serdjebi, Cindy ; Bertotti, Karine ; Huang, Pinzhu ; Wei, Guangyan ; Skelton-Badlani, Disha ; Leclercq, Isabelle ; Barbes, Damien ; Lepoivre, Bastien ; Popov, Yury V ; Julé, Yvon. Automated whole slide image analysis for a translational quantification of liver fibrosis.. In: Scientific reports, Vol. 12, no.1, p. 17935 [1-9] (2022). doi:10.1038/s41598-022-22902-w.
2022
Gillard, Justine ; Clerbaux, Laure-Alix ; Nachit, Maxime Younes ; Sempoux, Christine ; Staels, Bart ; Bindels, Laure B. ; Tailleux, Anne ; Leclercq, Isabelle. Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.. In: JHEP reports, Vol. 4, no. 1, p. 100387 [1-13] (2022). doi:10.1016/j.jhepr.2021.100387.
2022
Maccioni, Luca ; Loriot, Axelle ; Dewulf, Joseph P. ; Bommer, Guido ; Horsmans, Yves ; Lanthier, Nicolas ; Leclercq, Isabelle ; Schnabl, Bernd ; Starkel, Peter. Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol-associated liver disease in humans.. In: Alimentary pharmacology & therapeutics, Vol. 56, no. 6, p. 1055-1070 (2022). doi:10.1111/apt.17177.
2022
Gillard, Justine ; Picalausa, Corinne ; Ullmer, Christoph ; Adorini, Luciano ; Staels, Bart ; Tailleux, Anne ; Leclercq, Isabelle. Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism.. In: Nutrients, Vol. 14, no.13, p. 2707 [1-17] (2022). doi:10.3390/nu14132707.
2022
Etienne, Quentin ; Lebrun, Valérie ; Komuta, Mina ; Navez, Benoît ; Thissen, Jean-Paul ; Leclercq, Isabelle ; Lanthier, Nicolas. Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis.. In: Metabolites, Vol. 12, no. 7, p. 625 [1-16] (2022). doi:10.3390/metabo12070625.
2022
Pichon, Camille ; Nachit, Maxime ; Gillard, Justine ; Vande Velde, Greetje ; Lanthier, Nicolas ; Leclercq, Isabelle. Impact of L-ornithine L-aspartate on non-alcoholic steatohepatitis-associated hyperammonemia and muscle alterations.. In: Frontiers in nutrition, Vol. 9, p. 1051157 [1-15] (2022). doi:10.3389/fnut.2022.1051157.
2022
Lanthier, Nicolas ; Lebrun, Valérie ; Molendi-Coste, Olivier ; van Rooijen, Nico ; Leclercq, Isabelle. Liver Fetuin-A at Initiation of Insulin Resistance. In: Metabolites, Vol. 12, no. 11, p. 1023 [1-10] (2022). doi:10.3390/metabo12111023.
2021
Thibaut, Morgane ; Gillard, Justine ; Dolly, Adeline ; Roumain, Martin ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Bindels, Laure B.. Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. In: Cancers, Vol. 13, no.24, p. 6389 [1-17] (2021). doi:10.3390/cancers13246389.
2021
De Rudder, Maxime ; Dili, Alexandra ; Starkel, Peter ; Leclercq, Isabelle. Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure.. In: International journal of molecular sciences, Vol. 22, no. 15, p. 8053 [1-16] (2021). doi:10.3390/ijms22158053.
2021
Maccioni, Luca ; Leclercq, Isabelle ; Schnabl, Bernd ; Starkel, Peter. Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease.. In: International journal of molecular sciences, Vol. 22, no. 23, p. 12687 [1-14] (2021). doi:10.3390/ijms222312687.
2021
Thibaut, Morgane ; Sboarina, Martina ; Roumain, Martin ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Destrée, Florence ; Gillard, Justine ; Leclercq, Isabelle ; Dachy, Guillaume ; Demoulin, Jean-Baptiste ; Tailleux, Anne ; Lestavel, Sophie ; Rastelli, Marialetizia ; Everard, Amandine ; Cani, Patrice D. ; Porporato, Paolo E ; Loumaye, Audrey ; Thissen, Jean-Paul ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Bindels, Laure B.. Inflammation-induced cholestasis in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 70-20 (2021). doi:10.1002/jcsm.12652.
2021
Nachit, Maxime Younes ; Kwanten, Wilhelmus J ; Thissen, Jean-Paul ; Op De Beeck, Bart ; Van Gaal, Luc ; Vonghia, Luisa ; Verrijken, An ; Driessen, Ann ; Horsmans, Yves ; Francque, Sven ; Leclercq, Isabelle. Muscle fat content is strongly associated with NASH: a longitudinal study in patients with morbid obesity.. In: Journal of hepatology, Vol. 75, no. 2, p. 292-301 (2021). doi:10.1016/j.jhep.2021.02.037.
2021
Nachit, Maxime Younes ; De Rudder, Maxime ; Thissen, Jean-Paul ; Schakman, Olivier ; Bouzin, Caroline ; Horsmans, Yves ; Vande Velde, Greetje ; Leclercq, Isabelle. Myosteatosis rather than sarcopenia associates with non-alcoholic steatohepatitis in non-alcoholic fatty liver disease preclinical models.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 144-158 (2021). doi:10.1002/jcsm.12646.
2021
Minnis-Lyon, Sarah E ; Ferreira-Gonzalez, Sofia ; Aleksieva, Niya ; Man, Tak Yung ; Gadd, Victoria ; Williams, Michael J ; Guest, Rachel V ; Lu, Wei-Yu ; Dwyer, Benjamin J ; Jamieson, Tam ; Nixon, Colin ; Van Hul, Noemi ; Lemaigre, Frédéric ; McCafferty, John ; Leclercq, Isabelle ; Sansom, Owen J ; Boulter, Luke ; Forbes, Stuart J. Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation. In: Science Signaling, Vol. 14, p. eaay9185 (2021). doi:10.1126/scisignal.aay9185.
2021
Nachit, Maxime Younes ; Horsmans, Yves ; Leclercq, Isabelle. Rationale of adding muscle volume to muscle fat infiltration in the definition of an adverse muscle composition is unclear.. In: JHEP reports, Vol. 3, no. 2, p. 100235 [1-2] (2021). doi:10.1016/j.jhepr.2021.100235.
2021
Iesari, Samuele ; Leclercq, Isabelle ; Joudiou, Nicolas ; Komuta, Mina ; Daumerie, Aurélie ; Ambroise, Jérôme ; Dili, Alexandra ; Feza-Bingi, Natacha ; Xhema, Daela ; Bouzin, Caroline ; Gallez, Bernard ; Pisani, Francesco ; Bonaccorsi Riani, Eliano ; Gianello, Pierre. Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection.. In: Clinical Science, Vol. 135, no. 19, p. 2285-2305 (2021). doi:10.1042/CS20210183.
2020
De Rudder, Maxime ; Bouzin, Caroline ; Nachit, Maxime Younes ; Louvegny, Héloïse ; Vande Velde, Greetje ; Julé, Yvon ; Leclercq, Isabelle. Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH.. In: Laboratory investigation, Vol. 100, no. 1, p. 147-160 (2020). doi:10.1038/s41374-019-0315-9.
2020
Courtoy, Guillaume ; Leclercq, Isabelle ; Froidure, Antoine ; Schiano, Guglielmo ; Morelle, Johann ; Devuyst, Olivier ; Huaux, François ; Bouzin, Caroline. Digital Image Analysis of Picrosirius Red Staining: A Robust Method for Multi-Organ Fibrosis Quantification and Characterization.. In: Biomolecules, Vol. 10, no. 11, p. 1585 [1-23] (2020). doi:10.3390/biom10111585.
2020
Duchêne, Gaëtan ; Abarca-Quinones, Jorge ; Feza-Bingi, Natacha ; Leclercq, Isabelle ; Duprez, Thierry ; Peeters, Frank. Double Diffusion Encoding for Probing Radiation-Induced Microstructural Changes in a Tumor Model: A Proof-of-Concept Study With Comparison to the Apparent Diffusion Coefficient and Histology.. In: Journal of magnetic resonance imaging, Vol. 52, no. 3, p. 941-951 (2020). doi:10.1002/jmri.27119.
2020
Lefort, Charlotte ; Roumain, Martin ; Van Hul, Matthias ; Rastelli, Marialetizia ; Manco, Rita ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Di Marzo, Vincenzo ; Flamand, Nicolas ; Luquet, Serge ; Silvestri, Cristoforo ; Muccioli, Giulio ; Cani, Patrice D.. Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. In: Cells, Vol. 9, no. 5, p. 1247 [1-23] (2020). doi:10.3390/cells9051247.
2020
Duchêne, Gaëtan ; Abarca-Quinones, Jorge ; Leclercq, Isabelle ; Duprez, Thierry ; Peeters, Frank. Insights into tissue microstructure using a double diffusion encoding sequence on a clinical scanner: Validation and application to experimental tumor models.. In: Magnetic resonance in medicine, Vol. 83, no. 4, p. 1263-1276 (2020). doi:10.1002/mrm.28012.
2020
Maccioni, Luca ; Gao, Bei ; Leclercq, Sophie ; Pirlot, Boris ; Horsmans, Yves ; de Timary, Philippe ; Leclercq, Isabelle ; Fouts, Derrick ; Schnabl, Bernd ; Starkel, Peter. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans.. In: Gut microbes, Vol. 12, no. 1, p. 1782157 [1-23] (2020). doi:10.1080/19490976.2020.1782157.
2020
Collet, Louis ; Ghurburrun, Elsa ; Meyers, Nora ; Assi, Mohamad ; Pirlot, Boris ; Leclercq, Isabelle ; Couvelard, Anne ; Komuta, Mina ; Cros, Jérôme ; Demetter, Pieter ; Lemaigre, Frédéric ; Borbath, Ivan ; Jacquemin, Patrick. Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells. In: Gut, Vol. 69, no. 4, p. 704-714 (2020). doi:10.1136/gutjnl-2018-318059.
2020
Minsart, Charlotte ; Liefferinckx, Claire ; Lemmers, Arnaud ; Dressen, Cindy ; Quertinmont, Eric ; Leclercq, Isabelle ; Devière, Jacques ; Moreau, Richard ; Gustot, Thierry. New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis.. In: Scientific reports, Vol. 10, no. 1, p. 5557 [1-15] (2020). doi:10.1038/s41598-020-61270-1.
2019
Poekes, Laurence ; Gillard, Justine ; Farrell, Geoffrey C ; Horsmans, Yves ; Leclercq, Isabelle. Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis.. In: Laboratory investigation, Vol. 99, no. 1, p. 4-16 (2019). doi:10.1038/s41374-018-0120-x.
2019
Dili, Alexandra ; Lebrun, Valérie ; Bertrand, Claude ; Leclercq, Isabelle. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): establishment of an innovating animal model with insufficient liver remnant. In: Laboratory Investigation, Vol. 99, no. 5, p. 698-707 (2019). doi:10.1038/s41374-018-0155-z.
2019
Lesaffer, Bram ; Verboven, Elisabeth ; Van Huffel, Leen ; Moya, Ivan M. ; van Grunsven, Leo A. ; Leclercq, Isabelle ; Lemaigre, Frédéric ; Halder, Georg. Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers. In: Cells, Vol. 8, no. 4, p. 380 [1-12] (2019). doi:10.3390/cells8040380.
2019
Stärkel, Peter ; Schnabl, Bernd ; Leclercq, Sophie ; Komuta, Mina ; Bataller, Ramon ; Argemi, Josepmaria ; Palma, Elena ; Chokshi, Shilpa ; Hellerbrand, Claus ; Maccioni, Luca ; Lanthier, Nicolas ; Leclercq, Isabelle. Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis.. In: Hepatology communications, Vol. 3, no.7, p. 867-882 (2019). doi:10.1002/hep4.1364.
2019
van Dievoet, Marie-Astrid ; Leclercq, Isabelle ; Hermans, Cédric ; Lambert, Catherine ; Horsmans, Yves ; Jacquemin, Marc ; Eeckhoudt, Stéphane. Does haemophilia slow down the development of liver fibrosis?. In: Haemophilia, Vol. 25, no. 1, p. e32-e35 (2019). doi:10.1111/hae.13630.
2019
Nachit, Maxime Younes ; Leclercq, Isabelle. Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!. In: Clinical science, Vol. 133, no. 3, p. 465-481 (2019). doi:10.1042/CS20180421.
2019
Dili, Alexandra ; Bertrand, Claude ; Lebrun, Valérie ; Pirlot, Boris ; Leclercq, Isabelle. Hypoxia protects the liver from Small For Size Syndrome: A lesson learned from the associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure in rats.. In: American Journal of Transplantation, Vol. 19, no. 11, p. 2979-2990 (2019). doi:10.1111/ajt.15420.
2019
Czepukojc, Beate ; Abuhaliema, Ali ; Barghash, Ahmad ; Tierling, Sascha ; Naß, Norbert ; Simon, Yvette ; Körbel, Christina ; Cadenas, Cristina ; van Hul, Noemi ; Sachinidis, Agapios ; Hengstler, Jan G ; Helms, Volkhard ; Laschke, Matthias W ; Walter, Jörn ; Haybaeck, Johannes ; Leclercq, Isabelle ; Kiemer, Alexandra K ; Kessler, Sonja M. IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis.. In: Frontiers in medicine, Vol. 6, p. 179 [1-16] (2019). doi:10.3389/fmed.2019.00179.
2019
Clerbaux, Laure-Alix ; Manco, Rita ; Van Hul, Noémi ; Bouzin, Caroline ; Sciarra, Amedeo ; Sempoux, Christine ; Theise, Neil D ; Leclercq, Isabelle. Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans.. In: The American journal of pathology, Vol. 189, no. 8, p. 1569-1581 (2019). doi:10.1016/j.ajpath.2019.04.011.
2019
Farrell, Geoff ; Schattenberg, Jörn M ; Leclercq, Isabelle ; Yeh, Matthew M ; Goldin, Robert ; Teoh, Narci ; Schuppan, Detlef. Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis.. In: Hepatology, Vol. 69, no. 5, p. 2241-2257 (2019). doi:10.1002/hep.30333.
2019
Manco, Rita ; Clerbaux, Laure-Alix ; Verhulst, Stefaan ; Nader, Myriam Bou ; Sempoux, Christine ; Ambroise, Jérôme ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Horsmans, Yves ; van Grunsven, Leo ; Desdouets, Chantal ; Leclercq, Isabelle. Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.. In: Journal of hepatology, Vol. 70, no. 6, p. 1180-1191 (2019). doi:10.1016/j.jhep.2019.02.003.
2019
Dili, Alexandra ; Lebrun, Valérie ; Bertrand, Claude ; Leclercq, Isabelle. Small for size syndrome (SFSS) and hypoxia: lessons learned from the associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure in rats. In: HPB, Vol. 20, no. Suppl 2, p. S448-S449 (2019). doi:10.1016/j.hpb.2018.06.2848.
2018
Delire, Bénédicte ; Henriet, Patrick ; Lemoine, Pascale ; Leclercq, Isabelle ; Starkel, Peter. Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages.. In: Cancer Science, Vol. 109, no. 7, p. 2141-2152 (2018). doi:10.1111/cas.13628.
2018
Manco, Rita ; Leclercq, Isabelle ; Clerbaux, Laure-Alix. Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment.. In: International journal of molecular sciences, Vol. 19, no. 12, p. 4115 [1-18] (2018). doi:10.3390/ijms19124115.
2018
Haczeyni, Fahrettin ; Yeh, Matthew M ; Ioannou, George N ; Leclercq, Isabelle ; Goldin, Robert ; Dan, Yock Young ; Yu, Jun ; Teoh, Narcissus C ; Farrell, Geoffrey C. Mouse models of non-alcoholic steatohepatitis: A reflection on recent literature.. In: Journal of Gatroenterology and hepatology, Vol. 33, no. 7, p. 1312-1320 (2018). doi:10.1111/jgh.14122.
2018
Crespo Yanguas, Sara ; da Silva, Tereza C ; Pereira, Isabel V A ; Willebrords, Joost ; Maes, Michaël ; Sayuri Nogueira, Marina ; Alves de Castro, Inar ; Leclercq, Isabelle ; Romualdo, Guilherme R ; Barbisan, Luís F ; Leybaert, Luc ; Cogliati, Bruno ; Vinken, Mathieu. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice.. In: International Journal of Molecular Sciences, Vol. 19, no. 3, p. E817 (2018). doi:10.3390/ijms19030817.
2018
Ciccarelli, Olga ; Colson, Arthur ; De Saeger, Christine ; Reding, Raymond ; Sempoux, Christine ; Leclercq, Isabelle ; Starkel, Peter. Tumoral response and tumoral phenotypic changes in a rat model of diethylnitrosamine-induced hepatocellular carcinoma after salirasib and sorafenib administration.. In: OncoTargets and Therapy, Vol. 11, p. 7143-7153 (2018). doi:10.2147/OTT.S176903.
2017
Poekes, Laurence ; Legry, Vanessa ; Schakman, Olivier ; Detrembleur, Christine ; Bol, Anne ; Horsmans, Yves ; Farrell, Geoffrey C ; Leclercq, Isabelle. Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice.. In: Clinical Science, Vol. 131, no. 4, p. 285-296 (2017). doi:10.1042/CS20160469.
2017
Willebrords, Joost ; Cogliati, Bruno ; Pereira, Isabel Veloso Alves ; da Silva, Tereza Cristina ; Crespo Yanguas, Sara ; Maes, Michaël ; Govoni, Veronica Mollica ; Lima, Andressa ; Felisbino, Daniele Aparecida ; Decrock, Elke ; Nogueira, Marina Sayuri ; de Castro, Inar Alves ; Leclercq, Isabelle ; Leybaert, Luc ; Rodrigues, Robim Marcelino ; Vinken, Mathieu. Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice.. In: Scientific Reports, Vol. 7, no. 1, p. 8268 (2017). doi:10.1038/s41598-017-08583-w.
2017
Haczeyni, Fahrettin ; Poekes, Laurence ; Wang, Hans ; Mridha, Auvro R ; Barn, Vanessa ; Geoffrey Haigh, W ; Ioannou, George N ; Yeh, Matthew M ; Leclercq, Isabelle ; Teoh, Narcissus C ; Farrell, Geoffrey C. Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice.. In: Obesity : a research journal, Vol. 25, no. 1, p. 155-165 (2017). doi:10.1002/oby.21701.
2017
Wettstein, Guillaume ; Luccarini, Jean-Michel ; Poekes, Laurence ; Faye, Patrick ; Kupkowski, Francine ; Adarbes, Vanessa ; Defrêne, Evelyne ; Estivalet, Céline ; Gawronski, Xavier ; Jantzen, Ingrid ; Philippot, Alain ; Tessier, Julien ; Tuyaa-Boustugue, Pascale ; Oakley, Fiona ; Mann, Derek A ; Leclercq, Isabelle ; Francque, Sven ; Konstantinova, Irena ; Broqua, Pierre ; Junien, Jean-Louis. The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.. In: Hepatology communications, Vol. 1, no.6, p. 524-537 (2017). doi:10.1002/hep4.1057.
2016
Delire, Bénédicte ; Lebrun, Valérie ; Selvais, Charlotte ; Henriet, Patrick ; Bertrand, Amélie ; Horsmans, Yves ; Leclercq, Isabelle. Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling.. In: Aging, Vol. 9, no. 1, p. 98-113 (2016). doi:10.18632/aging.101124.
2016
Bindels, Laure B. ; Leclercq, Isabelle. Colonic acetate in obesity: location matters!. In: Clinical Science, Vol. 130, no.22, p. 2083-2086 (2016). doi:10.1042/CS20160556.
2016
Crespo Yanguas, Sara ; Cogliati, Bruno ; Willebrords, Joost ; Maes, Michaël ; Colle, Isabelle ; van den Bossche, Bert ; de Oliveira, Claudia Pinto Marques Souza ; Andraus, Wellington ; Alves, Venâncio Avancini ; Leclercq, Isabelle ; Vinken, Mathieu. Experimental models of liver fibrosis.. In: Archives of Toxicology, Vol. 90, no. 5, p. 1025–1048 (2016). doi:10.1007/s00204-015-1543-4.
2016
Best, Jan ; Verhulst, Stefaan ; Syn, Wing-Kin ; Lagaisse, Kimberly ; van Hul, Noemi ; Heindryckx, Femke ; Sowa, Jan-Peter ; Peeters, Liesbeth ; Van Vlierberghe, Hans ; Leclercq, Isabelle ; Canbay, Ali ; Dollé, Laurent ; van Grunsven, Leo A. Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies.. In: PLoS One, Vol. 11, no.9, p. e0162286 (2016). doi:10.1371/journal.pone.0162286.
2016
Clerbaux, Laure-Alix ; Manco, Rita ; Leclercq, Isabelle. Upstream regulators of hepatic Wnt/β-catenin activity control liver metabolic zonation, development, and regeneration.. In: Hepatology, Vol. 64, no.4, p. 1361-1363 (2016). doi:10.1002/hep.28763.
2015
Delire, Bénédicte ; Starkel, Peter ; Leclercq, Isabelle. Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development.. In: Journal of clinical and translational hepatology, Vol. 3, no. 1, p. 53-66 (2015). doi:10.14218/JCTH.2014.00035.
2015
Poekes, Laurence ; Lanthier, Nicolas ; Leclercq, Isabelle. Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome.. In: Clinical Science, Vol. 129, no. 11, p. 933-949 (2015). doi:10.1042/CS20150339.
2015
Hubert, C ; Dahrenmoller, C ; Marique, L ; Jabbour, N ; Gianello, P ; Leclercq, Isabelle. Hepatic regeneration in a rat model is impaired by chemotherapy agents used in metastatic colorectal cancer.. In: European Journal of Surgical Oncology, Vol. 41, no.11, p. 1471-8 (2015). doi:10.1016/j.ejso.2015.08.152 (Soumis).
2015
Dusabineza, Ange-Clarisse ; Najimi, Mustapha ; Van Hul, Noémi ; Legry, Vanessa ; Khuu, Ngoc Dung ; van Grunsven, Leo A ; Sokal, Etienne ; Leclercq, Isabelle. Hepatic stellate cells improve engraftment of human primary hepatocytes: A pre-clinical transplantation study in animal model.. In: Cell Transplantation, Vol. 24, no. 12, p. 2557-2571 (2015). doi:10.3727/096368915X686788.
2015
Mu, Xueru ; Español-Suñer, Regina ; Mederacke, Ingmar ; Affò, Silvia ; Manco, Rita ; Sempoux, Christine ; Lemaigre, Frédéric ; Adili, Arlind ; Yuan, Detian ; Weber, Achim ; Unger, Kristian ; Heikenwälder, Mathias ; Leclercq, Isabelle ; Schwabe, Robert F. Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. In: Journal of Clinical Investigation, Vol. 125, no.10, p. 3891-3903 (2015). doi:10.1172/JCI77995.
2015
Dollé, Laurent ; Boulter, Luke ; Leclercq, Isabelle ; van Grunsven, Leo A. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells.. In: A J P: Gastrointestinal and Liver Physiology (Online), Vol. 308, no. 7, p. G573-G578 (2015). doi:10.1152/ajpgi.00420.2014.
2014
Lanthier, Nicolas ; Leclercq, Isabelle. Adipose tissues as endocrine target organs. In: Best Practice & Research: Clinical Gastroenterology, Vol. 28, no. 4, p. 545-558 (August 2014). doi:10.1016/j.bpg.2014.07.002.
2014
Legry, Vanessa ; Van Rooyen, Derrick M ; Lambert, Barbara ; Sempoux, Christine ; Poekes, Laurence ; Espanol Suner, Regina ; Molendi-Coste, Olivier ; Horsmans, Yves ; Farrell, Geoffrey C ; Leclercq, Isabelle. Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice.. In: Clinical Science, Vol. 127, no. 7, p. 507-518 (2014). doi:10.1042/CS20140026.
2014
Lanthier, Nicolas ; Leclercq, Isabelle. Liver and systemic insulin resistance. In: Hepatology, Vol. 60, no. 3, p. 1113–1114 (2014). doi:10.1002/hep.27017.
2014
Laggai, Stephan ; Kessler, Sonja ; Boettcher, Stefan ; Lebrun, Valérie ; Gemperlein, Katja ; Lederer, Eva ; Leclercq, Isabelle ; Mueller, Rolf ; Hartmann, Rolf W. ; Haybaeck, Johannes ; Kiemer, Alexandra K.. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. In: Journal of Lipid Research, Vol. 55, no. 6, p. 1087-1097 (2014). doi:10.1194/jlr.M045500.
2014
Legry, Vanessa. Yin Yang 1 and farnesoid X receptor: a balancing act in non-alcoholic fatty liver disease?, collab. Schaap, Franck G ; Delire, Bénédicte ; Horsmans, Yves. In: Gut, Vol. 63, no. 1, p. 1-2. doi:10.1136/gutjnl-2012-304338.
2013
Lebrun, Valérie ; Molendi-Coste, Olivier ; Lanthier, Nicolas ; Sempoux, Christine ; Cani, Patrice D. ; van Rooijen, Nico ; Starkel, Peter ; Horsmans, Yves ; Leclercq, Isabelle. Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice.. In: Clinical Science, Vol. 125, no.11, p. 501-511 (2013). doi:10.1042/CS20130064.
2013
Leclercq, Isabelle. Non-alcoholic steatohepatitis and the diabetic patient. In: Louvain médical, Vol. 132, no.3, p. 109-111 (2013).
2013
Schaap, Frank G ; Leclercq, Isabelle ; Jansen, Peter L M ; Olde Damink, Steven W. Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth.. In: Journal of Hepatology, Vol. 59, no.5, p. 1121-1123 (2013). doi:10.1016/j.jhep.2013.07.013.
2013
Espanol Suner, Regina ; Lemaigre, Frédéric ; Leclercq, Isabelle. Reply. In: Gastroenterology, Vol. 145, no. 1, p. 255-256 (2013). doi:10.1053/j.gastro.2013.05.037.
2013
Coulon, Stéphanie ; Legry, Vanessa ; Heindryckx, Femke ; Van Steenkiste, Christophe ; Casteleyn, Christophe ; Olievier, Kim ; Libbrecht, Louis ; Carmeliet, Peter ; Jonckx, Bart ; Stassen, Jean-Marie ; Van Vlierberghe, Hans ; Leclercq, Isabelle ; Colle, Isabelle ; Geerts, Anja. Role of vascular endothelial growth factor in the pathophysiology of non-alcoholic steatohepatitis in two mice models. In: Hepatology, Vol. 57, no. 5, p. 1793-1805 (2013). doi:10.1002/hep.26219.
2013
Charette, Nicolas ; De Saeger, Christine ; Horsmans, Yves ; Leclercq, Isabelle ; Starkel, Peter. Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.. In: Cell Death & Disease, Vol. 4, no.epub, p. e471 (2013). doi:10.1038/cddis.2012.200.
2013
Hubert, Catherine ; Sempoux, Christine ; Humblet, Yves ; van den Eynde, Marc ; Zech, Francis ; Leclercq, Isabelle ; Gigot, Jean-François. Sinusoidal obstruction syndrome (SOS) related to chemotherapy for colorectal liver metastases: factors predictive of severe SOS lesions and protective effect of bevacizumab.. In: HPB : the official journal of the International Hepato Pancreato Biliary Association, Vol. 15, no. 11, p. 858-864 (2013). doi:10.1111/hpb.12047.
2012
Rommel, Denis ; Abarca-Quinones, Jorge ; De Saeger, Christine ; Peeters, Frank ; Leclercq, Isabelle ; Duprez, Thierry. Enhanced choline metabolism in a rodent rhabdomyosarcoma model: correlation between RT-PCR and translational 3 T H-MRS.. In: Magnetic Resonance Imaging, Vol. 30, no. 7, p. 1010-1016 (2012). doi:10.1016/j.mri.2012.03.003.
2012
Español Suñer, Regina ; Carpentier, Rodolphe ; Van Hul, Noémi ; Legry, Vanessa ; Achouri, Younes ; Cordi, Sabine ; Jacquemin, Patrick ; Lemaigre, Frédéric ; Leclercq, Isabelle. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. In: Gastroenterology, Vol. 143, no. 6, p. 1564-1575 (2012). doi:10.1053/j.gastro.2012.08.024.
2012
Dusabineza, Ange-Clarisse ; Van Hul, Noémi ; Abarca-Quinones, Jorge ; Starkel, Peter ; Najimi, Mustapha ; Leclercq, Isabelle. Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat model.. In: Laboratory Investigation, Vol. 92, no.1, p. 72-81 (2012). doi:10.1038/labinvest.2011.136.
2012
Leclercq, Isabelle. Pro-oxidants or anti-oxidant defenses? Which one to blame in non-alcoholic steatohepatitis pathogenesis?. In: Journal of gastroenterology and hepatology, Vol. 27, no.11, p. 1651-3 (2012). doi:10.1111/j.1440-1746.2012.07255.x (Soumis).
2012
Starkel, Peter ; Charette, Nicolas ; Borbath, Ivan ; Schneider-Merck, Tanja ; De Saeger, Christine ; Abarca-Quinones, Jorge ; Leclercq, Isabelle ; Horsmans, Yves. Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.. In: Molecular Carcinogenesis, Vol. 51, no. 10, p. 816-825 (2012). doi:10.1002/mc.20849.
2012
Dollé, Laurent ; Best, Jan ; Empsen, Christophe ; Mei, Jie ; Van Rossen, Elke ; Roelandt, Philip ; Snykers, Sarah ; Najimi, Mustapha ; Al Battah, Feras ; Theise, Neil D ; Streetz, Konrad ; Sokal, Etienne ; Leclercq, Isabelle ; Verfaillie, Catherine ; Rogiers, Vera ; Geerts, Albert ; van Grunsven, Leo A. Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice.. In: Hepatology, Vol. 55, no. 2, p. 540-552 (2012). doi:10.1002/hep.24693.
2011
Starkel, Peter ; Leclercq, Isabelle. Animal models for the study of hepatic fibrosis. In: Best Practice & Research: Clinical Gastroenterology, Vol. 25, no. 2, p. 319-333 (2011). doi:10.1016/j.bpg.2011.02.004.
2011
Molendi-Coste, Olivier ; Legry, Vanessa ; Leclercq, Isabelle. Are n-3 PUFA dietary recommendations met in in-hospital and school catering?. In: Acta gastro-enterologica Belgica, Vol. 74, no. 2, p. 281-288 (2011).
2011
Duparc, Thibaut ; Colom, Andre ; Cani, Patrice D. ; Massaly, Nicolas ; Rastrelli, Sophie ; Drougard, Anne ; Le Gonidec, Sophie ; Moulédous, Lionel ; Frances, Bernard ; Leclercq, Isabelle ; Llores-Cortes, Catherine ; Pospisilik, J. Andrew ; Delzenne, Nathalie M. ; Valet, Philippe ; Castan-Laurell, Isabelle ; Knauf, Claude. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. In: Antioxidants & Redox Signaling, Vol. 15, no. 6, p. 1477-1496 (2011). doi:10.1089/ars.2010.3454.
2011
Carpentier, Rodolphe ; Espanol Suner, Regina ; Van Hul, Noémi ; Kopp, Janel L ; Beaudry, Jean-Bernard ; Cordi, Sabine ; Antoniou, Aline ; Raynaud, Peggy ; Lepreux, Sébastien ; Jacquemin, Patrick ; Leclercq, Isabelle ; Sander, Maike ; Lemaigre, Frédéric. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. In: Gastroenterology, Vol. 141, no. 4, p. 1432-8, 1438.e1-4 (2011). doi:10.1053/j.gastro.2011.06.049.
2011
Leclercq, Isabelle ; Van Rooyen, Derrick M ; Farrell, Geoffrey C. Hepatic endoplasmic reticulum stress in obesity : Deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?. In: Hepatology, Vol. 54, no. 6, p. 2260-2265 (2011). doi:10.1002/hep.24661.
2011
Pachikian, Barbara D. ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Neyrinck, Audrey M. ; Catry, Emilie ; De Backer, Fabienne ; Dejeans, Nicolas ; Dewulf, Evelyne ; Sohet, Florence ; Portois, Laurence ; Deldicque, Louise ; Molendi-Coste, Olivier ; Leclercq, Isabelle ; Francaux, Marc ; Carpentier, Yvon A ; Foufelle, Fabienne ; Muccioli, Giulio ; Cani, Patrice D. ; Delzenne, Nathalie M.. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice : genomic analysis of cellular targets.. In: PLoS One, Vol. 6, no. 8, p. e23365 (2011). doi:10.1371/journal.pone.0023365.
2011
Lanthier, Nicolas ; Molendi-Coste, Olivier ; Cani, Patrice D. ; van Rooijen, Nico ; Horsmans, Yves ; Leclercq, Isabelle. Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet.. In: The FASEB Journal, Vol. 25, no. 12, p. 4301-4311 (2011). doi:10.1096/fj.11-189472.
2011
Van Hul, Noémi ; Lanthier, Nicolas ; Espanol Suner, Regina ; Abarca-Quinones, Jorge ; van Rooijen, Nico ; Leclercq, Isabelle. Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.. In: The American Journal of Pathology : cellular and molecular biology of disease, Vol. 179, no. 4, p. 1839-50 (2011). doi:10.1016/j.ajpath.2011.06.042.
2011
Molendi-Coste, Olivier ; Legry, Vanessa ; Leclercq, Isabelle. Why and How Meet n-3 PUFA Dietary Recommendations?. In: Gastroenterology research and practice, Vol. 2011, p. 364040 (2011). doi:10.1155/2011/364040.
2010
Da Silva Morais, Alain ; Abarca-Quinones, Jorge ; Guigas, Bruno ; Viollet, Benoit ; Starkel, Peter ; Horsmans, Yves ; Leclercq, Isabelle. Development of hepatic fibrosis occurs normally in AMPK-deficient mice. In: Clinical Science, Vol. 118, no. 6, p. 411-420 (2010). doi:10.1042/CS20090293.
2010
Molendi-Coste, Olivier ; Legry, Vanessa ; Leclercq, Isabelle. Dietary lipids and NAFLD : suggestions for improved nutrition.. In: Acta gastro-enterologica Belgica, Vol. 73, no. 4, p. 431-436 (2010).
2010
Borbath, Ivan ; Leclercq, Isabelle ; Sempoux, Christine ; Abarca-Quinones, Jorge ; Desaeger, Christine ; Horsmans, Yves. Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in rats.. In: Chemico-Biological Interactions, Vol. 183, no. 1, p. 238-248 (2010). doi:10.1016/j.cbi.2009.10.011.
2010
Gerin, Isabelle ; Clerbaux, Laure-Alix ; Haumont, Olivier ; Lanthier, Nicolas ; Das, Arun K ; Burant, Charles F ; Leclercq, Isabelle ; MacDougald, Ormond A. ; Bommer, Guido. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. In: Journal of Biological Chemistry, Vol. 285, no. 44, p. 33652-33661 (2010). doi:10.1074/jbc.M110.152090.
2010
Lanthier, Nicolas ; Molendi-Coste, Olivier ; Horsmans, Yves ; van Rooijen, Nico ; Cani, Patrice D. ; Leclercq, Isabelle. Kupffer cell activation is a causal factor for hepatic insulin resistance. In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 298, no. 1, p. G107-116 (2010). doi:10.1152/ajpgi.00391.2009.
2010
Starkel, Peter ; De Saeger, Christine ; Strain, Alastair J. ; Leclercq, Isabelle ; Horsmans, Yves. NF kappa B, cytokines, TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease. In: European Journal of Clinical Investigation, Vol. 40, no. 7, p. 575-584 (2010). doi:10.1111/j.1365-2362.2010.02295.x.
2010
Non-alcoholic fatty liver disease.. In: Bulletin et mémoires de l'Académie royale de médecine de Belgique, Vol. 165, no. 3-4, p. 147-55; discussion 155-8 (2010).
2010
Charette, Nicolas ; Horsmans, Yves ; Starkel, Peter ; De Saeger, Christine ; Lannoy, Valerie ; Leclercq, Isabelle. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. In: Molecular Cancer, Vol. 9, p. 256 (2010). doi:10.1186/1476-4598-9-256.
2010
Charette, N ; Leclercq, Isabelle. Why should the gastroenterologist bother about obesity? An oncologic point of view. : n/a. In: Acta gastro-enterologica Belgica, Vol. 73, no. 4, p. 504-9 (2010).
2009
Lanthier, Nicolas ; Leclercq, Isabelle. Adiponectin in non-alcoholic steatohepatitis: an ideal culprit, but what are the proofs of its guilt?. In: Journal of gastroenterology and hepatology, Vol. 24, no.10, p. 1584-6 (2009). doi:10.1111/j.1440-1746.2009.06087.x.
2009
Lanthier, Nicolas ; Horsmans, Yves ; Leclercq, Isabelle. Clodronate liposomes: All sites of injection are not equal.. In: Hepatology (Baltimore, Md.), Vol. 51, no. 2, p. 721-2; author reply 722 (2010). doi:10.1002/hep.23455.
2009
Salameh, Najat ; Larrat, Benoît ; Abarca-Quinones, Jorge ; Pallu, Stéphane ; Dorvillius, Mylène ; Leclercq, Isabelle ; Fink, Mathias ; Sinkus, Ralph ; Van Beers, Bernard. Early Detection of Steatohepatitis in Fatty Rat Liver by Using MR Elastography.. In: Radiology, Vol. 253, no. 1, p. 90-97 (2009). doi:10.1148/radiol.2523081817.
2009
Wang, Jianhua ; Leclercq, Isabelle ; Brymora, Joanne M. ; Xu, Ning ; Ramezani-Moghadam, Mehdi ; London, Roslyn M. ; Brigstock, David ; George, Jacob. Kupffer Cells Mediate Leptin-Induced Liver Fibrosis. In: Gastroenterology, Vol. 137, no. 2, p. 713-23 (2009). doi:10.1053/j.gastro.2009.04.011.
2009
Da Silva Morais, Alain ; Lebrun, Valérie ; Abarca-Quinones, Jorge ; Brichard, Sonia ; Hue, Louis ; Guigas, Bruno ; Viollet, Benoit ; Leclercq, Isabelle. Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.. In: Journal of hepatology, Vol. 50, no. 3, p. 489-500 (2009). doi:10.1016/j.jhep.2008.10.027.
2009
Phung, Nghi ; Pera, Natasha ; Farrell, Geoffrey ; Leclercq, Isabelle ; Hou, Jing Yun ; George, Jacob. Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis. In: International Journal of Molecular Medicine, Vol. 24, no. 2, p. 171-180 (2009). doi:10.3892/ijmm_00000220.
2009
Schneider-Merck, T ; Borbath, Ivan ; Charette, Nicolas ; De Saeger, Christine ; Abarca-Quinones, Jorge ; Leclercq, Isabelle ; Horsmans, Yves ; Starkel, Peter. The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats.. In: European journal of cancer (Oxford, England : 1990), Vol. 45, no. 11, p. 2050-60 (2009). doi:10.1016/j.ejca.2009.04.014.
2009
Lanthier, Nicolas ; Horsmans, Yves ; Leclercq, Isabelle. The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fibrosis.. In: Current opinion in clinical nutrition and metabolic care, Vol. 12, no. 4, p. 404-11 (2009). doi:10.1097/MCO.0b013e32832c7819.
2008
Da Silva Morais, Alain ; Saliez, Alain ; Leclercq, Isabelle ; Horsmans, Yves ; Starkel, Peter. Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats.. In: Clinical science, Vol. 114, no. 1, p. 73-83 (2008). doi:10.1042/CS20070152.
2008
Leclercq, Isabelle ; Horsmans, Yves. Nonalcoholic fatty liver disease: the potential role of nutritional management.. In: Current opinion in clinical nutrition and metabolic care, Vol. 11, no. 6, p. 766-73 (2008). doi:10.1097/MCO.0b013e328312c353.
2008
Rahier, Jean-François ; Rahier, Jacques ; Leclercq, Isabelle ; Geubel, André. Severe acute cholestatic hepatitis with prolonged cholestasis and bile-duct injury following atorvastatin therapy: a case report.. In: Acta gastro-enterologica Belgica, Vol. 71, no. 3, p. 318-20 (2008).
2007
Kesteloot, Frédéric ; Desmoulière, Alexis ; Leclercq, Isabelle ; Thiry, Marc ; Arrese, Jorge E ; Prockop, Darwin J ; Lapière, Charles M ; Nusgens, Betty V ; Colige, Alain. ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.. In: Hepatology, Vol. 46, no.5, p. 1620-31 (2007). doi:10.1002/hep.21868.
2007
Annet, Laurence ; Peeters, Frank ; Abarca-Quinones, Jorge ; Leclercq, Isabelle ; Moulin, Pierre ; Van Beers, Bernard. Assessment of diffusion-weighted MR imaging in liver fibrosis.. In: Journal of magnetic resonance imaging : JMRI, Vol. 25, no. 1, p. 122-8 (2007). doi:10.1002/jmri.20771.
2007
Salameh, Najat ; Peeters, Frank ; Sinkus, Ralph ; Abarca-Quinones, Jorge ; Annet, Laurence ; Ter Beek, Leon C ; Leclercq, Isabelle ; Van Beers, Bernard. Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.. In: Journal of magnetic resonance imaging : JMRI, Vol. 26, no. 4, p. 956-62 (2007). doi:10.1002/jmri.21099.
2007
Leclercq, Isabelle ; Desager, J P ; Horsmans, Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress.. In: Clinical pharmacology and therapeutics, Vol. 64, no. 2, p. 144-9 (1998). doi:10.1016/S0009-9236(98)90147-3.
2007
Borbath, Ivan ; Leclercq, Isabelle ; Abarca-Quinones, Jorge ; Desaeger, Christine ; Lebrun, Valérie ; Moulin, Pierre ; Sempoux, Christine ; Horsmans, Yves. Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide.. In: Cancer science, Vol. 98, no. 12, p. 1831-9 (2007). doi:10.1111/j.1349-7006.2007.00626.x.
2007
Leclercq, Isabelle ; Da Silva Morais, Alain ; Schroyen, Ben ; Van Hul, Noémi ; Geerts, Albert. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences.. In: Journal of hepatology, Vol. 47, no. 1, p. 142-56 (2007). doi:10.1016/j.jhep.2007.04.002.
2007
Leclercq, Isabelle ; Lebrun, Valérie ; Starkel, Peter ; Horsmans, Yves. Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone.. In: Laboratory investigation; a journal of technical methods and pathology, Vol. 87, no. 1, p. 56-65 (2007). doi:10.1038/labinvest.3700489.
2007
dela Pena, Aileen ; Leclercq, Isabelle ; Williams, Jacqueline ; Farrell, Geoffrey C.. NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis. In: Journal of Hepatology, Vol. 46, no. 2, p. 304-13 (2007). doi:10.1016/j.jhep.2006.08.025.
2007
Gonzalez Ramos, Reinaldo Rodrigo ; Donnez, Jacques ; Defrere, Sylvie ; Leclercq, Isabelle ; Squifflet, Jean-Luc ; Lousse, Jean-Christophe ; Van Langendonckt, Anne. Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis.. In: Molecular human reproduction, Vol. 13, no. 7, p. 503-509 (2007). doi:10.1093/molehr/gam033.
2007
Leclercq, Isabelle. Pathogenesis of steatohepatitis: insights from the study of animal models.. In: Acta gastro-enterologica Belgica, Vol. 70, no. 1, p. 25-31 (2007).
2007
Da Silva Morais, Alain ; Abarca-Quinones, Jorge ; Horsmans, Yves ; Starkel, Peter ; Leclercq, Isabelle. Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.. In: International journal of molecular medicine, Vol. 19, no. 1, p. 105-12 (2007).
2007
Starkel, Peter ; Saeger, Christine De ; Leclercq, Isabelle ; Horsmans, Yves. Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients.. In: Laboratory investigation; a journal of technical methods and pathology, Vol. 87, no. 2, p. 173-81 (2007). doi:10.1038/labinvest.3700496.
2007
Borbath, Ivan ; Leclercq, Isabelle ; Moulin, Pierre ; Sempoux, Christine ; Horsmans, Yves. The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.. In: European journal of cancer (Oxford, England : 1990), Vol. 43, no. 11, p. 1755-63 (2007). doi:10.1016/j.ejca.2007.05.005.
2006
Yu, J ; Ip, E ; dela Pena, A ; Hou, JY ; Sesha, J ; Pera, N ; Hall, Peter ; Kirsch, R ; Leclercq, Isabelle ; Farrell, GC. COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. In: Hepatology, Vol. 43, no. 4, p. 826-836 (2006). doi:10.1002/hep.21108.
2006
Leclercq, Isabelle ; Vansteenberghe, Matthieu ; Lebrun, Valérie ; Van Hul, Noémi ; Abarca-Quinones, Jorge ; Sempoux, Christine ; Picard, Christian ; Starkel, Peter ; Horsmans, Yves. Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin.. In: Laboratory Investigation, Vol. 86, no. 11, p. 1161-1171 (2006). doi:10.1038/labinvest.3700474.
2006
Nollevaux, Marie-Cécile ; Guiot, Yves ; Horsmans, Yves ; Leclercq, Isabelle ; Rahier, Jacques ; Geubel, André ; Sempoux, Christine. Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption.. In: Liver international : official journal of the International Association for the Study of the Liver, Vol. 26, no. 2, p. 182-6 (2006). doi:10.1111/j.1478-3231.2005.01207.x.
2006
Leclercq, Isabelle ; Sempoux, Christine. Hépatopathie non alcoolique: de la stéatose à la cirrhose. In: Acta Endoscopica, Vol. 36, no. 3, p. 299-314 (2006). doi:10.1007/BF03006037.
2006
Leclercq, Isabelle ; Sempoux, Christine ; Starkel, Peter ; Horsmans, Yves. Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats.. In: Gut, Vol. 55, no. 7, p. 1020-1029 (2006). doi:10.1136/gut.2005.079194.
2005
Starkel, Peter ; De Saeger, Christine ; Sempoux, Christine ; Legrand, Eric ; Leclercq, Isabelle ; Horsmans, Yves. Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver.. In: Laboratory investigation; a journal of technical methods and pathology, Vol. 85, no. 4, p. 562-71 (2005). doi:10.1038/labinvest.3700245.
2005
Starkel, Peter ; De Saeger, Christine ; Leclercq, Isabelle ; Strain, Alastair ; Horsmans, Yves. Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis.. In: Journal of hepatology, Vol. 43, no. 4, p. 687-695 (2005). doi:10.1016/j.jhep.2005.03.024.
2005
Laurent, Stéphanie ; Horsmans, Yves ; Starkel, Peter ; Leclercq, Isabelle ; Sempoux, Christine ; Lambotte, Luc. Disrupted NF- kappa B activation after partial hepatectomy does not impair hepatocyte proliferation in rats.. In: World Journal of Gastroenterology, Vol. 11, no. 46, p. 7345-7350 (2005). doi:10.3748/wjg.v11.i46.7345.
2005
Becker, TM ; Rizos, H ; de la Pena, A ; Leclercq, Isabelle ; Woodruff, S ; Kefford, RF ; Mann, GJ. Impaired inhibition of NF-kappa B activity by melanoma-associated p16INK4a mutations. In: Biochemical and Biophysical Research Communications, Vol. 332, no. 3, p. 873-879 (2005). doi:10.1016/j.bbrc.2005.05.032.
2005
LAURENT, Sidonie ; Starkel, Peter ; Leclercq, Isabelle ; Lambotte, Luc ; Maiter, Dominique ; Horsmans, Yves. Molecular events associated with accelerated proliferative response in rat livers when partial hepatectomy is preceded by a sham operation.. In: European Journal of Clinical Investigation, Vol. 35, no. 2, p. 140-147 (2005). doi:10.1111/j.1365-2362.2005.01449.x.
2005
Dela Pena, A ; Leclercq, Isabelle ; Field, J ; George, J. ; Jones, B. ; Farrell, G. NF-kappa B activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. In: Gastroenterology, Vol. 129, no. 5, p. 1663-1674 (2005). doi:10.1053/j.gastro.2005.09.004.
2005
Barbarin, Virginie ; Nihoul, Aurélie ; Misson, Pierre-Damien ; Arras, Mohammed ; Delos, Monique ; Leclercq, Isabelle ; Lison, Dominique ; Huaux, François. The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis.. In: Respiratory research, Vol. 6, p. 112 (2005). doi:10.1186/1465-9921-6-112.
2004
Ip, Emilia ; Farrell, Geoff ; Hall, Pauline ; Robertson, Graham ; Leclercq, Isabelle. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice.. In: Hepatology, Vol. 39, no. 5, p. 1286-1296 (2004). doi:10.1002/hep.20170.
2004
Leclercq, Isabelle. Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis?. In: Clinical science (London, England : 1979), Vol. 106, no. 3, p. 235-237 (2004). doi:10.1042/CS20030368.
2004
Leclercq, Isabelle ; Farrell, Geoffrey C. ; Sempoux, Christine ; dela Peña, Aileen ; Horsmans, Yves. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.. In: Journal of Hepatology, Vol. 41, no. 6, p. 926-934 (2004). doi:10.1016/j.jhep.2004.08.010.
2003
Ip, Emilia ; Farrell, Geoffrey C ; Robertson, Graham ; Hall, Pauline ; Kirsch, Richard ; Leclercq, Isabelle. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.. In: Hepatology, Vol. 38, no.1, p. 123-32 (2003). doi:10.1053/jhep.2003.50307.
2003
Leclercq, Isabelle ; Field, Jacqueline ; Farrell, Geoffrey C. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.. In: Gastroenterology, Vol. 124, no. 5, p. 1451-1464 (2003). doi:10.1016/S0016-5085(03)00270-1.
2003
George, Jacob ; Pera, Natasha ; Phung, Nghi ; Leclercq, Isabelle ; Yun Hou, Jing ; Farrell, Geoffrey. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.. In: Journal of Hepatology, Vol. 39, no. 5, p. 756-764 (2003). doi:10.1016/S0168-8278(03)00376-3.
2003
Teoh, Narci ; Leclercq, Isabelle ; Pena, Aileen Dela ; Farrell, Geoffrey. Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning.. In: Hepatology, Vol. 37, no. 1, p. 118-128 (2003). doi:10.1053/jhep.2003.50009.
2003
Starkel, Peter ; Sempoux, Christine ; Leclercq, Isabelle ; Herin, Michel ; Deby, C. ; Desager, Jean-Pierre ; Horsmans, Yves. Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats.. In: Journal of hepatology, Vol. 39, no. 4, p. 538-546 (2003). doi:10.1016/S0168-8278(03)00360-X.
2002
Leclercq, Isabelle ; Farrell, Geoffrey C ; Schriemer, Rixt ; Robertson, Graham R. Leptin is essential for the hepatic fibrogenic response to chronic liver injury.. In: Journal of Hepatology, Vol. 37, no. 2, p. 206-213 (2002). doi:10.1016/S0168-8278(02)00102-2.
2002
Farrell, Geoffrey C. ; Robertson, Graham R ; Leclercq, Isabelle ; Horsmans, Yves. Liver regeneration in obese mice with fatty livers: does the impairment have relevance for other types of fatty liver disease?. In: Hepatology (Baltimore, Md.), Vol. 35, no. 3, p. 731-2 (2002). doi:10.1053/jhep.2002.31786.
2001
Eeckhoudt, S L ; Desager, Jean-Pierre ; Robert, Annie ; Leclercq, Isabelle ; Verbeeck, Roger-K. ; Horsmans, Yves. Midazolam and cortisol metabolism before and after CYP3A induction in humans.. In: International Journal of Clinical Pharmacology and Therapeutics, Vol. 39, no. 7, p. 293-299 (2001). doi:10.5414/CPP39293.
2001
Robertson, G ; Leclercq, Isabelle ; Farrell, G C. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress.. In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 281, no.5, p. G1135-9 (2001).
2000
Leclercq, Isabelle ; Farrell, G C ; Field, J ; Bell, D R ; Gonzalez, F J ; Robertson, G R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.. In: Journal of Clinical Investigation, Vol. 105, no.8, p. 1067-75 (2000). doi:10.1172/JCI8814.
2000
Leclercq, Isabelle ; Field, J ; Enriquez, A ; Farrell, G C ; Robertson, G R. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.. In: Biochemical and Biophysical Research Communications, Vol. 268, no.2, p. 337-44 (2000). doi:10.1006/bbrc.2000.2125.
2000
Lambotte, Luc ; Li, B. ; Leclercq, Isabelle ; Sempoux, Christine ; Saliez, Alain ; Horsmans, Yves. The compensatory hyperplasia (liver regeneration) following ligation of a portal branch is initiated before the atrophy of the deprived lobes.. In: Journal of hepatology, Vol. 32, no. 6, p. 940-5 (2000). doi:10.1016/S0168-8278(00)80098-7.
1999
Enriquez, A ; Leclercq, Isabelle ; Farrell, G C ; Robertson, G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.. In: Biochemical and Biophysical Research Communications, Vol. 255, no.2, p. 300-6 (1999). doi:10.1006/bbrc.1999.0202.
1999
Leclercq, Isabelle ; Horsmans, Yves ; Desager, Jean-Pierre ; Pauwels, Stanislas ; Geubel, André. Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity. In: British Journal of Nutrition, Vol. 82, no. 4, p. 257-262 (1999). doi:10.1017/S0007114599001452.
1999
Leclercq, Isabelle ; Horsmans, Yves ; De Bruyère, Marc ; Geubel, André. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors.. In: Acta Gastro-Enterologica Belgica (Multilingual Edition), Vol. 62, no. 1, p. 16-20 (1999).
1998
Leclercq, Isabelle ; Horsmans, Yves ; Desager, Jean-Pierre. Estimation of chlorzoxazone hydroxylase activity in liver microsomes and of the plasma pharmacokinetics of chlorzoxazone by the same high-performance liquid chromatographic method.. In: Journal of chromatography. A, Vol. 828, no. 1-2, p. 291-6 (1998). doi:10.1016/S0021-9673(98)00588-3.
1998
Leclercq, Isabelle ; Horsmans, Yves ; Desager, Jean-Pierre. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. In: Clinical Pharmacology and Therapeutics, Vol. 64, no. 2, p. 144-149 (1998).
1998
Leclercq, Isabelle ; Horsmans, Yves ; Desager, Jean-Pierre ; Delzenne, Nathalie M. ; Geubel, André. Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation.. In: Journal of hepatology, Vol. 28, no. 3, p. 410-6 (1998).
1997
Leclercq, Isabelle ; Saliez, Alain ; Wallemacq, Pierre ; Horsmans, Yves ; Lambotte, Luc. The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat. In: Hepatology, Vol. 26, no. 5, p. 1182-1188 (1997). doi:10.1002/hep.510260515.
1996
Leclercq, Isabelle ; Desager, Jean-Pierre ; Vandenplas, C. ; Horsmans, Yves. Fast determination of low-level cytochrome P-450 1A1 activity by high-performance liquid chromatography with fluorescence or visible absorbance detection.. In: Journal of Chromatography. B, Biomedical Applications, Vol. 681, no. 2, p. 227-232 (1996).
2018
Leclercq, Isabelle ; Sempoux, Christine. Histophysiologie du foie. In: Encyclopédie Médico-Chirurgicale, Elsevier Masson SAS: Paris, 2018, p. 7-005-A-10. 9782842990312. doi:10.1016/S1155-1976(18)54296-0.
2018
Clerbaux, Laure-Alix ; Van Hul, Noemi ; Gauw, ASH ; Manco, Rita ; Espanol-Suner, Regina ; Leclercq, Isabelle. Relevance of the CDE and DDC mouse models to study ductular reaction in chronic human liver diseases. In: Ibeh Bartholoneuw, Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy, IntechOpen: London, UK, 2018. 978-1--78923-165-6. doi:10.5772/66030.
2018
Clerbaux, Laure-Alix ; Van Hul, Noemi ; Gouw, ASH ; Manco, Rita ; Espanol-Sune, Regina ; Leclercq, Isabelle. Relevance of the CDE and DDC mouse models to study ductular reaction in chronic human liver diseases. In: Bartholomew Ibeh (eds), Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy, IntechOpen: London, UK, 2018. 978-1-78923-165-6. doi:10.5772/intechopen.69533.
2013
Leclercq, Isabelle. Emerging concepts on pathogenesis of NASH. In: Geoffrey C. Farrell, Arthur J. McCullough, Christopher P. Day, Non-Alcoholic Fatty Liver Disease: A Practical Guide, Wiley-Blackwell: (United States) Hoboken, NJ, 2013. 978-0-470-67317-1.
2005
Leclercq, Isabelle ; Horsmans, Yves. Cell Biology of NASH: Fibrosis and cell proliferation. In: Fatty liver disease - NASH and related disorders, 2005. 1-4051-1292-1.