DDUV
Avenue Hippocrate 74/B1.74.03
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Jean-Philippe Defour
Jean-Philippe Defour
Chef de laboratoire associé Saint-Luc
Professeur
- Diplômes
Année Label Institution 2003 Licencié en pharmacie Université catholique de Louvain 2008 DES en biologie clinique Université catholique de Louvain 2016 Docteur en sciences biomédicales et pharmaceutiques Université catholique de Louvain
- Les cours
Nom ID Prestations techniques de base en biologie clinique : en routine et en garde WBCMM2101 Séminaires de biologie clinique WBCMM2102 Hémopathies : de l'hémogramme à la moléculaire. Approche biologique multidisciplinaire. WBCMM2201 Revues de cas en hématologie et journal club WBCMM2202 Séminaires de biologie clinique postgradués WBCMM2204 Complément d'hématologie WBICL2109 Biochimie médicale WFARM1303
Levy, Gabriel ; Carillo, Serge ; Papoular, Benjamin ; Cassinat, Bruno ; Zini, Jean Marc ; Leroy, Emilie ; Varghese, Leila ; Chachoua, Ilyas ; Defour, Jean-Philippe ; Smith, Steven O ; Constantinescu, Stefan N.. MPL Mutations in Essential Thrombocythemia Uncover A Common Path of Activation with Eltrombopag Dependent on W491.. In: Blood, Vol. ., no.., p. . (2020). doi:10.1182/blood.2019003240.
Froidure, Antoine ; Mahieu, Manon ; Hoton, Delphine ; Laterre, Pierre-François ; Yombi, Jean Cyr ; Koenig, Sandra ; Ghaye, Benoit ; Defour, Jean-Philippe ; Decottignies, Anabelle. Short telomeres increase the risk of severe COVID-19.. In: Aging, Vol. 12, no.20, p. 19911-19922 (2020). doi:10.18632/aging.104097.
Favresse, Julien ; Boland, Lidvine ; Schellen, Marie ; Fervaille, Caroline ; Wuestenberghs, Fabien ; Camboni, Alessandra ; Chatelain, Bernard ; Mullier, François ; Defour, Jean-Philippe ; JACQMIN, Hugues. Two-site evaluation of a new workflow for the detection of malignant cells on the Sysmex XN-1000 body fluid analyzer.. In: International journal of laboratory hematology, (2020). doi:10.1111/ijlh.13187 (Soumis).
Pecquet, Christian ; Chachoua, Ilyas ; Roy, Anita ; Balligand, Thomas ; Vertenoeil, Gaëlle ; Leroy, Emilie ; Albu, Roxana-Irina ; Defour, Jean-Philippe ; Nivarthi, Harini ; Hug, Eva ; Xu, Erica ; Ould-Amer, Yasmine ; Mouton, Céline ; Colau, Didier ; Vertommen, Didier ; Shwe, Myat Marlar ; Marty, Caroline ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Constantinescu, Stefan N.. Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants. In: Blood, Vol. 133, no.25, p. blood-2018-09-874578 (2019). doi:10.1182/blood-2018-09-874578.
Paridaens, Henry ; Sabor, Lina ; Simar, Joanna ; Ronez, Emily ; Cornet, Edouard ; Defour, Jean-Philippe. Can the 72-hour rule based on "Blast/Abn Lymph" flag on Sysmex XN-10 optimize the workflow in hematology laboratory?. In: Annales de biologie clinique, Vol. 77, no.4, p. 422-428 (2019). doi:10.1684/abc.2019.1462.
Dheur, Marie-Sophie ; Poirel, Hélène ; Ameye, Geneviève ; Tilman, Gaëlle ; Saussoy, Pascale ; Defour, Jean-Philippe ; Camboni, Alessandra ; Van Den Neste, Eric ; Coulie, Pierre ; van Baren, Nicolas. Characterization of two new high-grade B-cell lymphoma cell lines with MYC and BCL2 rearrangements that are suitable for in vitro drug sensitivity studies. In: Leukemia & lymphoma, Vol. 60, no. 4, p. 1043-1052 (2019). doi:10.1080/10428194.2018.1508663.
Veiga da Cunha, Maria ; Chevalier, Nathalie ; Stéphenne, Xavier ; Defour, Jean-Philippe ; Paczia, Nicole ; Ferster, Alina ; Achouri, Younes ; Dewulf, Joseph ; Linster, Carole L ; Bommer, Guido ; Van Schaftingen, Emile. Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, no. 4, p. 1241-1250 (2019). doi:10.1073/pnas.1816143116.
Balligand, Thomas ; Achouri, Younes ; Pecquet, Christian ; Gaudray, Gilles ; Colau, Didier ; Hug, Eva ; Rahmani, Yacine ; Stroobant, Vincent ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Van den Eynde, Benoit ; Defour, Jean-Philippe ; Constantinescu, Stefan N.. Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development. In: Leukemia, Vol. 34, no. 2, p. 510-521 (2020). doi:10.1038/s41375-019-0538-1.
Defour, Jean-Philippe ; Levy, Gabriel ; Leroy, Emilie ; Smith, Steven O ; Constantinescu, Stefan N.. The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.. In: Leukemia, Vol. 33, no.2, p. 563-564 (2019). doi:10.1038/s41375-018-0356-x.
Schillinger, Françoise ; Sourdeau, Elise ; Boubaya, Marouane ; Baseggio, Lucile ; Clauser, Sylvain ; Cornet, Edouard ; Debord, Camille ; Defour, Jean-Philippe ; Dubois, Frédérique ; Eveillard, Marion ; Galoisy, Anne-Cécile ; Geay, Marie-Odile ; Mullier, François ; Nivaggioni, Vanessa ; Soenen, Valérie ; Morel, Pascal ; Garnache-Ottou, Francine ; Ronez, Emily ; Bardet, Valérie ; Deconinck, Eric. A new approach for diagnosing chronic myelomonocytic leukemia using structural parameters of Sysmex XNTM analyzers in routine laboratory practice.. In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 78, no. 3, p. 159-164 (2018). doi:10.1080/00365513.2018.1423702.
Favresse, Julien ; van Dievoet, Marie-Astrid ; De Wolf, Hélène ; Rodriguez-Villalobos, Hector ; Defour, Jean-Philippe. Characterization of Candida spp. interference on the Sysmex XN-1000 body fluid mode. In: International Journal of Laboratory Hematology, Vol. 40, no. 2, p. e28-e32 (2018). doi:10.1111/ijlh.12780.
Mambet, Cristina ; Babosova, Olga ; Defour, Jean-Philippe ; Leroy, Emilie ; Necula, Laura ; Stanca, Oana ; Tatic, Aurelia ; Berbec, Nicoleta ; Coriu, Daniel ; Belickova, Monika ; Kralova, Barbora ; Lanikova, Lucie ; Vesela, Jitka ; Pecquet, Christian ; Saussoy, Pascale ; Havelange, Violaine ; Diaconu, Carmen C ; Divoky, Vladimir ; Constantinescu, Stefan N.. Cooccurring V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms.. In: Blood, Vol. 132, no. 25, p. 2695-2699 (2018). doi:10.1182/blood-2018-04-843060.
Defour, Jean-Philippe ; Hoade, Yvette ; Reuther, A-M ; Callaway, Alison ; Ward, Daniel ; Chen, Frederick ; Constantinescu, Stefan N. ; Cross, Nicholas C.P.. An unusual, activating insertion/deletion MPL mutant in primary myelofibrosis.. In: Leukemia, Vol. 31, no. 8, p. 1838-1839 (2017). doi:10.1038/leu.2017.153.
Moussaoui , Samira ; Saussoy, Pascale ; Ambroise, Jérôme ; Defour, Jean-Philippe ; Zouitene, Raouf ; Sifi, Karima ; Abadi, Noureddine. Genetic Risk Factors of Venous Thromboembolism in the East Algerian Population. In: Clinical and Applied Thrombosis / Hemostasis, Vol. 23, no. 2, p. 105-115 (2017). doi:10.1177/1076029615600789.
Varghese, Leila ; Defour, Jean-Philippe ; Pecquet, Christian ; Constantinescu, Stefan N.. The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.. In: Frontiers in Endocrinology, Vol. 8, p. 59 [1-13] (2017). doi:10.3389/fendo.2017.00059.
Forget, Patrice ; Khalifa, Céline ; Defour, Jean-Philippe ; Latinne, Dominique ; Van Pel, Marie-Cécile ; De Kock, Marc. What is the normal value of the neutrophil-to-lymphocyte ratio?. In: BMC Research Notes, Vol. 10, p. 12 (2017). doi:10.1186/s13104-016-2335-5 (Soumis).
Favale, Fabrizia ; Messaoudi, Kahia ; Varghese, Leila ; Boukour, Siham ; Pecquet, Christian ; Gryshkova, Vitalina ; Defour, Jean-Philippe ; Albu, Roxana-Irina ; Bluteau, Olivier ; Ballerini, Paola ; Leverger, Guy ; Plo, Isabelle ; Debili, Najet ; Raslova, Hana ; Favier, Remi ; Constantinescu, Stefan N. ; Vainchenker, William. An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.. In: Blood, Vol. 128, no. 26, p. 3146-3158 (2016). doi:10.1182/blood-2016-06-722058.
Cabagnols, Xénia ; Favale, Fabrizia ; Pasquier, Florence ; Messaoudi, Kahia ; Defour, Jean-Philippe ; Ianotto, Jean Christophe ; Marzac, Christophe ; Le Couédic, Jean Pierre ; Droin, Nathalie ; Chachoua, Ilyas ; Favier, Remi ; Diop, M'boyba Khadija ; Ugo, Valérie ; Casadevall, Nicole ; Debili, Najet ; Raslova, Hana ; Bellanne-Chantelot, Christine ; Constantinescu, Stefan N. ; Bluteau, Olivier ; Plo, Isabelle ; Vainchenker, William. Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients.. In: Blood, Vol. 127, no. 3, p. 333-342 (2016). doi:10.1182/blood-2015-07-661983.
Chachoua, Ilyas ; Pecquet, Christian ; El-Khoury, Mira ; Nivarthi, Harini ; Albu, Roxana-Irina ; Marty, Caroline ; Gryshkova, Vitalina ; Defour, Jean-Philippe ; Vertenoeil, Gaëlle ; Ngo, Anna ; Koay, Ann ; Raslova, Hana ; Courtoy, Pierre J. ; Choong, Meng Ling ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Constantinescu, Stefan N.. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.. In: Blood, Vol. 127, no. 10, p. 1325-35 (2016). doi:10.1182/blood-2015-11-681932.
Cabagnols, X ; Defour, Jean-Philippe ; Ugo, V ; Ianotto, J C ; Mossuz, P ; Mondet, J ; Girodon, F ; Alexandre, J H ; Mansier, O ; Viallard, J F ; Lippert, E ; Murati, A ; Mozziconacci, M J ; Saussoy, P ; Vekemans, Marie-Christiane ; Knoops, Laurent ; Pasquier, F ; Ribrag, V ; Solary, E ; Plo, I ; Constantinescu, Stefan N. ; Casadevall, N ; Vainchenker, W ; Marzac, C ; Bluteau, O. Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution.. In: Leukemia, Vol. 29, no. 1, p. 249-252 (2014). doi:10.1038/leu.2014.270.
Leroy, Emilie ; Defour, Jean-Philippe ; Sato, Takeshi ; Dass, Sharmila ; Gryshkova, Vitalina ; Shwe, Myat Marlar ; Staerk, Judith ; Constantinescu, Stefan N. ; Smith, Steven O. His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.. In: Journal of Biological Chemistry, Vol. 291, no. 6, p. 1317-1324 (2015). doi:10.1074/jbc.M115.696534.
André, Emmanuel ; Belkhir, Leïla ; Goeminne, Léonie ; Colmant, Alexandre ; Sottiaux, Jean-Yves ; Yildiz, Halil ; Ruelle, Jean ; Delmée, Michel ; Vandercam, Bernard ; Defour, Jean-Philippe. Immune reconstitution inflammatory syndrome due to Mycobacterium genavense in an HIV-infected patient: Impact of rapid species identificationby rpoB sequencing on clinical management. In: JMM Case Reports, Vol. 2, no. 6, p. [1-5] (2015). doi:10.1099/jmmcr.0.005007.
Defour, Jean-Philippe ; Chachoua, Ilyas ; Pecquet, Christian ; Constantinescu, Stefan N.. Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms.. In: Leukemia, Vol. 30, no. 5, p. 1214-1216 (2015). doi:10.1038/leu.2015.271.
Depoorter, Maxime ; Goletti, Sylvie ; Latinne, Dominique ; Defour, Jean-Philippe. Optimal flagging combinations for best performance of five blood cell analyzers. In: International Journal of Laboratory Hematology (Print), Vol. 37, no. 1, p. 63-70 (2015). doi:10.1111/ijlh.12238.
Dewulf, Joseph ; Dermine, Alexandre ; Defour, Jean-Philippe ; Vekemans, Marie-Christiane. Une anémie de Biermer se dissimulant sous les traits d’une anémie normocytaire. In: Louvain médical, Vol. 134, no.7, p. 381-388 (2015).
Choong, Meng Ling ; Pecquet, Christian ; Pendharkar, Vishal ; Diaconu, Carmen C ; Yong, Jacklyn Wei Yan ; Tai, Shi Jing ; Wang, Si Fang ; Defour, Jean-Philippe ; Sangthongpitag, Kanda ; Villeval, Jean-Luc ; Vainchenker, William ; Constantinescu, Stefan N. ; Lee, May Ann. Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.. In: Journal of Cellular and Molecular Medicine (Print) : a journal of translational medicine, Vol. 17, no.11, p. 1397-1409 (2013). doi:10.1111/jcmm.12156.
Defour, Jean-Philippe ; Itaya, Miki ; Gryshkova, Vitalina ; Brett, Ian C ; Pecquet, Christian ; Sato, Takeshi ; Smith, Steven O ; Constantinescu, Stefan N.. Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.7, p. 2540-5 (2013). doi:10.1073/pnas.1211560110.
Pecquet, Christian ; Diaconu, Carmen C ; Staerk, Judith ; Girardot, Michael ; Marty, Caroline ; Royer, Yohan ; Defour, Jean-Philippe ; Dusa, Alexandra ; Besancenot, Rodolphe ; Giraudier, Stephane ; Villeval, Jean-Luc ; Knoops, Laurent ; Courtoy, Pierre J. ; Vainchenker, William ; Constantinescu, Stefan N.. Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.. In: Blood, Vol. 119, no. 20, p. 4625-4635 (2012). doi:10.1182/blood-2011-08-372524.
Staerk, Judith ; Defour, Jean-Philippe ; Pecquet, Christian ; Leroy, Emilie ; Poirel, Hélène ; Brett, Ian ; Itaya, Miki ; Smith, Steven O ; Vainchenker, William ; Constantinescu, Stefan N.. Orientation-specific signalling by thrombopoietin receptor dimers.. In: The EMBO journal, Vol. 30, no.21, p. 4398-413 (2011). doi:10.1038/emboj.2011.315.
Balligand, Thomas ; Achouri, Younes ; Chachoua, Ilyas ; Pecquet, Christian ; Defour, Jean-Philippe ; Constantinescu, Stefan N.. Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis. 58th meeting of the American Society of Hematology (San Diego, du 03/12/2016 au 06/12/2016). In: Blood, Vol. 128, no.22, p. 4274 (1 Dec 2016).
Defour, Jean-Philippe ; André, Emmanuel ; Olivier, Pierre-Alexandre ; Boeras, Anca ; Grimmelprez, Alexandre ; Huang, Te-Din ; Delmée, Michel. Redox potential as a diagnostic tool to investigate growth of various clinical pathogens. International Symposiuem - Clinical Biology (Bruxelles, du 15/5/2008 au 17/5/2008).
Defour, Jean-Philippe. Thrombopoietin receptor : regulation, dimerization, oncogenic activation and bimodal signaling, prom. : Constantinescu, Stefan, 12/01/2016.