Jean-Philippe Defour

Levy, Gabriel ; Carillo, Serge ; Papoular, Benjamin ; Cassinat, Bruno ; Zini, Jean Marc ; Leroy, Emilie ; Varghese, Leila ; Chachoua, Ilyas ; Defour, Jean-Philippe ; Smith, Steven O ; Constantinescu, Stefan N.. MPL Mutations in Essential Thrombocythemia Uncover A Common Path of Activation with Eltrombopag Dependent on W491.. In: Blood, Vol. ., no.., p. . (2020). doi:10.1182/blood.2019003240.

http://hdl.handle.net/2078.1/227719

Froidure, Antoine ; Mahieu, Manon ; Hoton, Delphine ; Laterre, Pierre-François ; Yombi, Jean Cyr ; Koenig, Sandra ; Ghaye, Benoit ; Defour, Jean-Philippe ; Decottignies, Anabelle. Short telomeres increase the risk of severe COVID-19.. In: Aging, Vol. 12, no.20, p. 19911-19922 (2020). doi:10.18632/aging.104097.

http://hdl.handle.net/2078.1/237426

Favresse, Julien ; Boland, Lidvine ; Schellen, Marie ; Fervaille, Caroline ; Wuestenberghs, Fabien ; Camboni, Alessandra ; Chatelain, Bernard ; Mullier, François ; Defour, Jean-Philippe ; JACQMIN, Hugues. Two-site evaluation of a new workflow for the detection of malignant cells on the Sysmex XN-1000 body fluid analyzer.. In: International journal of laboratory hematology, (2020). doi:10.1111/ijlh.13187 (Soumis).

http://hdl.handle.net/2078.1/228464

Pecquet, Christian ; Chachoua, Ilyas ; Roy, Anita ; Balligand, Thomas ; Vertenoeil, Gaëlle ; Leroy, Emilie ; Albu, Roxana-Irina ; Defour, Jean-Philippe ; Nivarthi, Harini ; Hug, Eva ; Xu, Erica ; Ould-Amer, Yasmine ; Mouton, Céline ; Colau, Didier ; Vertommen, Didier ; Shwe, Myat Marlar ; Marty, Caroline ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Constantinescu, Stefan N.. Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants. In: Blood, Vol. 133, no.25, p. blood-2018-09-874578 (2019). doi:10.1182/blood-2018-09-874578.

http://hdl.handle.net/2078.1/216385

Paridaens, Henry ; Sabor, Lina ; Simar, Joanna ; Ronez, Emily ; Cornet, Edouard ; Defour, Jean-Philippe. Can the 72-hour rule based on "Blast/Abn Lymph" flag on Sysmex XN-10 optimize the workflow in hematology laboratory?. In: Annales de biologie clinique, Vol. 77, no.4, p. 422-428 (2019). doi:10.1684/abc.2019.1462.

http://hdl.handle.net/2078.1/224103

Dheur, Marie-Sophie ; Poirel, Hélène ; Ameye, Geneviève ; Tilman, Gaëlle ; Saussoy, Pascale ; Defour, Jean-Philippe ; Camboni, Alessandra ; Van Den Neste, Eric ; Coulie, Pierre ; van Baren, Nicolas. Characterization of two new high-grade B-cell lymphoma cell lines with MYC and BCL2 rearrangements that are suitable for in vitro drug sensitivity studies. In: Leukemia & lymphoma, Vol. 60, no. 4, p. 1043-1052 (2019). doi:10.1080/10428194.2018.1508663.

http://hdl.handle.net/2078.1/213376

Veiga da Cunha, Maria ; Chevalier, Nathalie ; Stéphenne, Xavier ; Defour, Jean-Philippe ; Paczia, Nicole ; Ferster, Alina ; Achouri, Younes ; Dewulf, Joseph ; Linster, Carole L ; Bommer, Guido ; Van Schaftingen, Emile. Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, no. 4, p. 1241-1250 (2019). doi:10.1073/pnas.1816143116.

http://hdl.handle.net/2078.1/211478

Balligand, Thomas ; Achouri, Younes ; Pecquet, Christian ; Gaudray, Gilles ; Colau, Didier ; Hug, Eva ; Rahmani, Yacine ; Stroobant, Vincent ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Van den Eynde, Benoit ; Defour, Jean-Philippe ; Constantinescu, Stefan N.. Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development. In: Leukemia, Vol. 34, no. 2, p. 510-521 (2020). doi:10.1038/s41375-019-0538-1.

http://hdl.handle.net/2078.1/220787

Defour, Jean-Philippe ; Levy, Gabriel ; Leroy, Emilie ; Smith, Steven O ; Constantinescu, Stefan N.. The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.. In: Leukemia, Vol. 33, no.2, p. 563-564 (2019). doi:10.1038/s41375-018-0356-x.

http://hdl.handle.net/2078.1/213451

Schillinger, Françoise ; Sourdeau, Elise ; Boubaya, Marouane ; Baseggio, Lucile ; Clauser, Sylvain ; Cornet, Edouard ; Debord, Camille ; Defour, Jean-Philippe ; Dubois, Frédérique ; Eveillard, Marion ; Galoisy, Anne-Cécile ; Geay, Marie-Odile ; Mullier, François ; Nivaggioni, Vanessa ; Soenen, Valérie ; Morel, Pascal ; Garnache-Ottou, Francine ; Ronez, Emily ; Bardet, Valérie ; Deconinck, Eric. A new approach for diagnosing chronic myelomonocytic leukemia using structural parameters of Sysmex XNTM analyzers in routine laboratory practice.. In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 78, no. 3, p. 159-164 (2018). doi:10.1080/00365513.2018.1423702.

http://hdl.handle.net/2078.1/192606

Favresse, Julien ; van Dievoet, Marie-Astrid ; De Wolf, Hélène ; Rodriguez-Villalobos, Hector ; Defour, Jean-Philippe. Characterization of Candida spp. interference on the Sysmex XN-1000 body fluid mode. In: International Journal of Laboratory Hematology, Vol. 40, no. 2, p. e28-e32 (2018). doi:10.1111/ijlh.12780.

http://hdl.handle.net/2078.1/196529

Mambet, Cristina ; Babosova, Olga ; Defour, Jean-Philippe ; Leroy, Emilie ; Necula, Laura ; Stanca, Oana ; Tatic, Aurelia ; Berbec, Nicoleta ; Coriu, Daniel ; Belickova, Monika ; Kralova, Barbora ; Lanikova, Lucie ; Vesela, Jitka ; Pecquet, Christian ; Saussoy, Pascale ; Havelange, Violaine ; Diaconu, Carmen C ; Divoky, Vladimir ; Constantinescu, Stefan N.. Cooccurring V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms.. In: Blood, Vol. 132, no. 25, p. 2695-2699 (2018). doi:10.1182/blood-2018-04-843060.

http://hdl.handle.net/2078.1/222160

Defour, Jean-Philippe ; Hoade, Yvette ; Reuther, A-M ; Callaway, Alison ; Ward, Daniel ; Chen, Frederick ; Constantinescu, Stefan N. ; Cross, Nicholas C.P.. An unusual, activating insertion/deletion MPL mutant in primary myelofibrosis.. In: Leukemia, Vol. 31, no. 8, p. 1838-1839 (2017). doi:10.1038/leu.2017.153.

http://hdl.handle.net/2078.1/191444

Moussaoui , Samira ; Saussoy, Pascale ; Ambroise, Jérôme ; Defour, Jean-Philippe ; Zouitene, Raouf ; Sifi, Karima ; Abadi, Noureddine. Genetic Risk Factors of Venous Thromboembolism in the East Algerian Population. In: Clinical and Applied Thrombosis / Hemostasis, Vol. 23, no. 2, p. 105-115 (2017). doi:10.1177/1076029615600789.

http://hdl.handle.net/2078.1/175966

Varghese, Leila ; Defour, Jean-Philippe ; Pecquet, Christian ; Constantinescu, Stefan N.. The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.. In: Frontiers in Endocrinology, Vol. 8, p. 59 [1-13] (2017). doi:10.3389/fendo.2017.00059.

http://hdl.handle.net/2078.1/191425

Forget, Patrice ; Khalifa, Céline ; Defour, Jean-Philippe ; Latinne, Dominique ; Van Pel, Marie-Cécile ; De Kock, Marc. What is the normal value of the neutrophil-to-lymphocyte ratio?. In: BMC Research Notes, Vol. 10, p. 12 (2017). doi:10.1186/s13104-016-2335-5 (Soumis).

http://hdl.handle.net/2078.1/192506

Favale, Fabrizia ; Messaoudi, Kahia ; Varghese, Leila ; Boukour, Siham ; Pecquet, Christian ; Gryshkova, Vitalina ; Defour, Jean-Philippe ; Albu, Roxana-Irina ; Bluteau, Olivier ; Ballerini, Paola ; Leverger, Guy ; Plo, Isabelle ; Debili, Najet ; Raslova, Hana ; Favier, Remi ; Constantinescu, Stefan N. ; Vainchenker, William. An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.. In: Blood, Vol. 128, no. 26, p. 3146-3158 (2016). doi:10.1182/blood-2016-06-722058.

http://hdl.handle.net/2078.1/180993

Cabagnols, Xénia ; Favale, Fabrizia ; Pasquier, Florence ; Messaoudi, Kahia ; Defour, Jean-Philippe ; Ianotto, Jean Christophe ; Marzac, Christophe ; Le Couédic, Jean Pierre ; Droin, Nathalie ; Chachoua, Ilyas ; Favier, Remi ; Diop, M'boyba Khadija ; Ugo, Valérie ; Casadevall, Nicole ; Debili, Najet ; Raslova, Hana ; Bellanne-Chantelot, Christine ; Constantinescu, Stefan N. ; Bluteau, Olivier ; Plo, Isabelle ; Vainchenker, William. Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients.. In: Blood, Vol. 127, no. 3, p. 333-342 (2016). doi:10.1182/blood-2015-07-661983.

http://hdl.handle.net/2078.1/166233

Chachoua, Ilyas ; Pecquet, Christian ; El-Khoury, Mira ; Nivarthi, Harini ; Albu, Roxana-Irina ; Marty, Caroline ; Gryshkova, Vitalina ; Defour, Jean-Philippe ; Vertenoeil, Gaëlle ; Ngo, Anna ; Koay, Ann ; Raslova, Hana ; Courtoy, Pierre J. ; Choong, Meng Ling ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Constantinescu, Stefan N.. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.. In: Blood, Vol. 127, no. 10, p. 1325-35 (2016). doi:10.1182/blood-2015-11-681932.

http://hdl.handle.net/2078.1/168151

Cabagnols, X ; Defour, Jean-Philippe ; Ugo, V ; Ianotto, J C ; Mossuz, P ; Mondet, J ; Girodon, F ; Alexandre, J H ; Mansier, O ; Viallard, J F ; Lippert, E ; Murati, A ; Mozziconacci, M J ; Saussoy, P ; Vekemans, Marie-Christiane ; Knoops, Laurent ; Pasquier, F ; Ribrag, V ; Solary, E ; Plo, I ; Constantinescu, Stefan N. ; Casadevall, N ; Vainchenker, W ; Marzac, C ; Bluteau, O. Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution.. In: Leukemia, Vol. 29, no. 1, p. 249-252 (2014). doi:10.1038/leu.2014.270.

http://hdl.handle.net/2078.1/155936

Leroy, Emilie ; Defour, Jean-Philippe ; Sato, Takeshi ; Dass, Sharmila ; Gryshkova, Vitalina ; Shwe, Myat Marlar ; Staerk, Judith ; Constantinescu, Stefan N. ; Smith, Steven O. His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.. In: Journal of Biological Chemistry, Vol. 291, no. 6, p. 1317-1324 (2015). doi:10.1074/jbc.M115.696534.

http://hdl.handle.net/2078.1/169706

André, Emmanuel ; Belkhir, Leïla ; Goeminne, Léonie ; Colmant, Alexandre ; Sottiaux, Jean-Yves ; Yildiz, Halil ; Ruelle, Jean ; Delmée, Michel ; Vandercam, Bernard ; Defour, Jean-Philippe. Immune reconstitution inflammatory syndrome due to Mycobacterium genavense in an HIV-infected patient: Impact of rapid species identificationby rpoB sequencing on clinical management. In: JMM Case Reports, Vol. 2, no. 6, p. [1-5] (2015). doi:10.1099/jmmcr.0.005007.

http://hdl.handle.net/2078.1/166743

Defour, Jean-Philippe ; Chachoua, Ilyas ; Pecquet, Christian ; Constantinescu, Stefan N.. Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms.. In: Leukemia, Vol. 30, no. 5, p. 1214-1216 (2015). doi:10.1038/leu.2015.271.

http://hdl.handle.net/2078.1/166234

Depoorter, Maxime ; Goletti, Sylvie ; Latinne, Dominique ; Defour, Jean-Philippe. Optimal flagging combinations for best performance of five blood cell analyzers. In: International Journal of Laboratory Hematology (Print), Vol. 37, no. 1, p. 63-70 (2015). doi:10.1111/ijlh.12238.

http://hdl.handle.net/2078.1/164352

Dewulf, Joseph ; Dermine, Alexandre ; Defour, Jean-Philippe ; Vekemans, Marie-Christiane. Une anémie de Biermer se dissimulant sous les traits d’une anémie normocytaire. In: Louvain médical, Vol. 134, no.7, p. 381-388 (2015).

http://hdl.handle.net/2078.1/176615

Choong, Meng Ling ; Pecquet, Christian ; Pendharkar, Vishal ; Diaconu, Carmen C ; Yong, Jacklyn Wei Yan ; Tai, Shi Jing ; Wang, Si Fang ; Defour, Jean-Philippe ; Sangthongpitag, Kanda ; Villeval, Jean-Luc ; Vainchenker, William ; Constantinescu, Stefan N. ; Lee, May Ann. Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.. In: Journal of Cellular and Molecular Medicine (Print) : a journal of translational medicine, Vol. 17, no.11, p. 1397-1409 (2013). doi:10.1111/jcmm.12156.

http://hdl.handle.net/2078.1/137917

Defour, Jean-Philippe ; Itaya, Miki ; Gryshkova, Vitalina ; Brett, Ian C ; Pecquet, Christian ; Sato, Takeshi ; Smith, Steven O ; Constantinescu, Stefan N.. Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.7, p. 2540-5 (2013). doi:10.1073/pnas.1211560110.

http://hdl.handle.net/2078.1/124118

Pecquet, Christian ; Diaconu, Carmen C ; Staerk, Judith ; Girardot, Michael ; Marty, Caroline ; Royer, Yohan ; Defour, Jean-Philippe ; Dusa, Alexandra ; Besancenot, Rodolphe ; Giraudier, Stephane ; Villeval, Jean-Luc ; Knoops, Laurent ; Courtoy, Pierre J. ; Vainchenker, William ; Constantinescu, Stefan N.. Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.. In: Blood, Vol. 119, no. 20, p. 4625-4635 (2012). doi:10.1182/blood-2011-08-372524.

http://hdl.handle.net/2078/120319

Staerk, Judith ; Defour, Jean-Philippe ; Pecquet, Christian ; Leroy, Emilie ; Poirel, Hélène ; Brett, Ian ; Itaya, Miki ; Smith, Steven O ; Vainchenker, William ; Constantinescu, Stefan N.. Orientation-specific signalling by thrombopoietin receptor dimers.. In: The EMBO journal, Vol. 30, no.21, p. 4398-413 (2011). doi:10.1038/emboj.2011.315.

http://hdl.handle.net/2078.1/137930

Balligand, Thomas ; Achouri, Younes ; Chachoua, Ilyas ; Pecquet, Christian ; Defour, Jean-Philippe ; Constantinescu, Stefan N.. Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis. 58th meeting of the American Society of Hematology (San Diego, du 03/12/2016 au 06/12/2016). In: Blood, Vol. 128, no.22, p. 4274 (1 Dec 2016).

http://hdl.handle.net/2078.1/182491

Defour, Jean-Philippe ; André, Emmanuel ; Olivier, Pierre-Alexandre ; Boeras, Anca ; Grimmelprez, Alexandre ; Huang, Te-Din ; Delmée, Michel. Redox potential as a diagnostic tool to investigate growth of various clinical pathogens. International Symposiuem - Clinical Biology (Bruxelles, du 15/5/2008 au 17/5/2008).

http://hdl.handle.net/2078.1/123950

Defour, Jean-Philippe. Thrombopoietin receptor : regulation, dimerization, oncogenic activation and bimodal signaling, prom. : Constantinescu, Stefan, 12/01/2016.

http://hdl.handle.net/2078.1/171096