Isolation and Structural Analysis of Natural Products

Teacher(s)

Muccioli Giulio; Spillier Quentin;

Language

French
> English-friendly

Main themes

- Extraction, fractionation and purification methods of compounds from complex media: advantages and limits of the different methods. - Mass spectrometry: ionisation techniques, ions analyses and main fragmentations. - Nuclear Magnetic Resonance (NMR): basic principles - Use of spectral data for structure determination of organic drugs

Learning outcomes

At the end of this learning unit, the student is able to :
1	At the end of this course, the students should be able to propose a method of extraction and purification for different types of organic molecules in complex media and identify the structure of simple compounds from spectroscopic data.

Content

several important aspects related to the isolation and structural analysis of natural products will be covered:
- methods of extraction, fractionation and purification of organic molecules from complex extracts
- mass spectrometry 
- the essential principles underlying NMR, enabling students to use the information contained in 1D NMR spectra of hydrogen and carbon. 2D NMR is also briefly covered

Teaching methods

theoretical courses and exercises

Evaluation methods

oral exam

Online resources

slides on Moodle

Bibliography

•  "identification spectrométrique des composés organiques (Silverstein, 2 ème édition, De Boek éd.)

Teaching materials

• dias sur Moodle, "identification spectrométrique des composés organiques (Silverstein, 2 ème édition, De Boek éd.)

Faculty or entity

> FARM