Post-translational regulation of proteins

Teacher(s)

Bertrand Luc (coordinator); Bommer Guido; Collet Jean-François; Demoulin Jean Baptiste;

Language

French
> English-friendly

Prerequisites

It is the perfect follow-up of sbim2115, protein structure and function. 

Main themes

This course aims to deepen the knowledge on post-translational modifications. 

Content

General introduction on the importance of post-translational modifications of proteins in their regulation and function 
- Mechanisms of disulfide bond formation in prokaryotes and eukaryotes
- Protein phosphorylations 
- The new world of post-translational modifications resulting from metabolism (Acetylation, O-GlcNacylation)
- Mechanisms of targeted proteolysis, protein ubiquitination and related post-translational modifications
- Protein repair mechanisms (isoaspartates, glycation/deglycation) and role of rare post-translationnal modifications

Teaching methods

The different parts of the course will be given by lecturers who are specialists in their domains using powerpoint slides. The slides will be available for the students.

Evaluation methods

Written exam on all parts of the course

Online resources

There is no formal syllabus ! PDF versions of slides presented in the course, which cover the subject in a comprehensive way, will be made available on MoodleUCL (https://moodleucl.uclouvain.be/). In addition, a tablet will be used to explain certain aspects of the course. The "Tablet" PDF versions of the PowerPoint files will also be made available to students via MoodleUCL.

Faculty or entity

> SBIM