Raphaël Robiette

Maître de recherche FNRS, Professeur

raphael.robiette@uclouvain.be

SST/SC Faculty of Science (SC)

SST/SC/CHIM Ecole de chimie (CHIM)

SST/IMCN Institute of Condensed Matter and Nanosciences (IMCN)

SST/IMCN/MOST Molecular Chemistry, Materials and Catalysis (MOST)

Postal address

MOST - Lavoisier
L4.01.02
Place Louis Pasteur 1
1348 Louvain-la-Neuve

MOST

SC08 - Lavoisier
Floor 02 Office A 257
1348 Louvain-la-Neuve

Phone : 010479176

Secretary Phone : 010472740

Fax : 010474168

2026

Journal article

Verlaine, O., Amoroso, A., Remy, M., Wautier, S., Robiette, R., Joris, B., & Gilet, T. (2026). Enzymatic assay in a lab-on-a-disk format to measure free piperacillin concentration in serum. Biomedical Microdevices, 28(2). https://doi.org/10.1007/s10544-026-00807-z (Original work published 2026)

https://research.dial.uclouvain.be/handle/2078.5/277136

Rodrigues, S., Chelly, S., Ha, J., Pedussaut, L., Lakhdar, S., Robiette, R., Vincent, S., & Berionni, G. (2026). Mapping the Reactivity of the C=C bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals. Angewandte Chemie (International Edition). Submitted. (Original work published 2026)

https://research.dial.uclouvain.be/handle/2078.5/266119

Morelle, A., Dechenne, J., Caruano, J., Vander Auwera, O., Barozzino‐Consiglio, G., Michaux, C., Muccioli, G., & Robiette, R. (2026). Toward a Better Understanding of Fatty Acid Amide Hydrolase Inhibition by β‐Lactams. Chemistry & Biodiversity, e02705. https://doi.org/10.1002/cbdv.202502705 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267991

2025

Journal article

Cope, C. J., Zanini, M., George, M. R. P., Otero, D., Sendra, J., Noble, A., Lefranc, J., Robiette, R., & Aggarwal, V. K. (2025). Intramolecular Lithiation‐Borylation for the Stereoselective Synthesis of Cyclopentyl and Cyclobutyl Bis‐Boronic Esters. Angewandte Chemie (International Edition), 64(38), e202512896. https://doi.org/10.1002/anie.202512896 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267984

Fuksová, M., Hrubá, K., Horák, A., De Dobbeleer, C., Robiette, R., & Pospíšil, J. (2025). Modular Synthesis of Dihydropyranones through Cyclization and Organometallic Functionalization. European Journal of Organic Chemistry, e202500848. https://doi.org/10.1002/ejoc.202500848 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267985

Gilbert, U., Mu, X., Lam, Y. Y. S., De Leener, G., Schoenauen, M., Bottin, M., Robeyns, K., Luhmer, M., Robiette, R., & Singleton, M. (2025). Influence of imidazole functionalization on the properties of small molecule models of the LPMO active site. Dalton Transactions, 54(15), 6174-6187. https://doi.org/10.1039/d4dt03424d (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267982

Christiaens, R., Simon, M., Robiette, R., & Collin, S. (2025). Evidence in Lager Yeasts of β-Lyase Activity Breaking Down γ-GluCys-Conjugates More Efficiently Than Cys-Conjugates to Odorant Beer Polyfunctional Thiols. Molecules, 30(2), 325. https://doi.org/10.3390/molecules30020325 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/248279

Janssens, J., Berionni, G., & Robiette, R. (2025). Synthesis of Vinyl Boronates from Aldehydes and Ketones by Peterson Olefination: Investigation of the Peterson/Boron‐Wittig Chemoselectivity. European Journal of Organic Chemistry, 28, e202500033. https://doi.org/10.1002/ejoc.202500033 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267978

Book chapter

Robiette, R. (2025). Formation of Four-Membered Heterocycles. In Knochel, Paul (ed.), Comprehensive Organic Synthesis,3rd Edition. Elsevier Ltd. https://doi.org/10.1016/B978-0-08-097742-3.00503-6

https://research.dial.uclouvain.be/handle/2078.5/266089

2024

Journal article

Hu, L., Chakraborty, S., Tumanov, N., Wouters, J., Robiette, R., & Berionni, G. (2024). Regulating iminophosphorane PN bond reactivity through geometric constraints with cage-shaped triarylphosphines. Chemical Communications, 60, 7073-7076. https://doi.org/10.1039/d4cc01868k (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/241377

Janssens, J., De Roose, M., Jacquemin, A., Vanhosmael, T., Delbrassinne, A., Collard, L., & Robiette, R. (2024). One-Carbon Homologation of Knoevenagel Adducts: Enantioselective Access to Benzhydryl Derivatives. The Journal of Organic Chemistry, 89(10), 7270-7274. https://doi.org/10.1021/acs.joc.4c00057 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/241378

Vogl, L. S., Mayer, P., Robiette, R., & Waser, M. (2024). Chiral Isochalcogenourea‐Catalysed Enantioselective (4+2) Cycloadditions of Allenoates. Angewandte Chemie (International Edition), 63(2), e202315345. https://doi.org/10.1002/anie.202315345 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/241382

Bensaida, A., Mahaut, D., Tumanov, N., Wouters, J., Champagne, B., Vanthuyne, N., Robiette, R., & Berionni, G. (2024). Reactivity and Steric Parameters from 2D to 3D Bulky Pyridines : Increasing Steric Demand at Nitrogen with Chiral Azatriptycenes. Angewandte Chemie (International Edition), 63, e202407503. https://doi.org/10.1002/anie.202407503 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/241381

2023

Journal article

Delbrassinne, A., Takam Mba, B. J., Collard, L., & Robiette, R. (2023). One‐Carbon Homologation of α,β‐Unsaturated Aldehydes: Access to α‐Tertiary β,γ‐Unsaturated Aldehydes. European Journal of Organic Chemistry, 26(40), e2023007. https://doi.org/10.1002/ejoc.202300765 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/241383

2022

Journal article

Chenot, C., Robiette, R., & Collin, S. (2022). First evidence of the glutathione S-conjugate of 3-sulfanylheptanol in green malt: discrepancy with the ubiquitous 5- and 6-C analogues. Institute of Brewing & Distilling. Brewing & Distilling Directory, 128(2), 43-51. https://doi.org/10.1002/jib.690 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/105490

Chenot, C., Haest, S., Robiette, R., Collin, S., & et al. (2022). Thiol S-Conjugate Profiles: A Comparative Investigation on Dual Hop and Grape Must with Focus on Sulfanylalkyl Aldehydes and Acetates Adducts. American Society of Brewing Chemists. Journal, 1, 1-11. https://doi.org/10.1080/03610470.2021.2015560 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/218104

2021

Journal article

Hu, L., Mahaut, D., Tumanov, N., Wouters, J., Collard, L., Robiette, R., & Berionni, G. (2021). Sterically hindered ortho-substituted phosphatriptycenes as configurationally stable P-chirogenic triarylphosphines. Dalton Transactions, 50(14), 4772-4777. https://doi.org/10.1039/d1dt00816a (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/241386

Caillé, J., & Robiette, R. (2021). Cycloaddition of Cyclopropanes for the Elaboration of Medium-sized Carbocycles. Organic & Biomolecular Chemistry. Accepted/in-press. https://doi.org/10.1039/d1ob00838b (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/110501

Kassin, V.-E. H., Morodo, R., Toupy, T., Jacquemin, I., Van Hecke, K., Robiette, R., & Monbaliu, J.-C. M. (2021). A modular, low footprint and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones. Green Chemistry, 23(6), 2336-2351. https://doi.org/10.1039/d0gc04395h (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/114279

Delbrassinne, A., Richald, M., Janssens, J., & Robiette, R. (2021). Divergent Rearrangements of Vinylcyclopropane into Skipped Diene and Cyclopentene: Mechanism, Scope, and Limitations. European Journal of Organic Chemistry, 2021(20), 2862-2868. https://doi.org/10.1002/ejoc.202100430 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/112712

2020

Journal article

Morelle, A., Caruano, J., Feledziak, M., Michaux, C., Perpète, E., Muccioli, G., Marchand-Brynaert, J., & Robiette, R. (2020). β-lactams to act on the endocannabinoid system. Chimie Nouvelle, 134, 41. (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/119801

2019

Journal article

Scheinok, S., Driesschart, B., d’Hose, D., Sonveaux, P., Robiette, R., & Gallez, B. (2019). Synthesis and characterization of a 5-membered ring cyclic hydroxylamine coupled to triphenylphosphonium to detect mitochondrial superoxide by EPR spectrometry. Free Radical Research, 53(11-12), 1135-1143. https://doi.org/10.1080/10715762.2019.1692137 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/95958

Hu, L., Mahaut, D., Tumanov, N., Wouters, J., Robiette, R., & Berionni, G. (2019). Complementary Synthetic Approaches toward 9-Phosphatriptycene and Structure–Reactivity Investigations of Its Association with Sterically Hindered Lewis Acids. The Journal of Organic Chemistry, 84(17), 11268-11274. https://doi.org/10.1021/acs.joc.9b01570 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/61967

Richald, M., Delbrassinne, A., & Robiette, R. (2019). Unexpected Vinylcyclopropane Rearrangement: New Strategies toward Skipped Dienes Using Sulfonium Ylides : Unexpected Vinylcyclopropane Rearrangement: New Strategies toward Skipped Dienes Using Sulfonium Ylides. European Journal of Organic Chemistry, 2019(23), 3779-3782. https://doi.org/10.1002/ejoc.201900720 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/123013

Chenot, C., Robiette, R., & Collin, S. (2019). First Evidence of the Cysteine and Glutathione Conjugates of 3-Sulfanylpentan-1-ol in Hop (Humulus lupulus L.). Journal of Agricultural and Food Chemistry, 67(14), 4002-4010. https://doi.org/10.1021/acs.jafc.9b00225 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/123015

2018

Journal article

Frédéric, C. J.-M., Cornil, J., Vandamme, M., Dumitrescu, L., Tikad, A., Robiette, R., & Vincent, S. P. (2018). Highly (Z)-Diastereoselective Synthesis of Trifluoromethylated exo-Glycals via Photoredox and Copper Catalysis. Organic Letters, 20(21), 6769-6773. https://doi.org/10.1021/acs.orglett.8b02891 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/124746

Fan, Y., Tiffner, M., Schörgenhumer, J., Robiette, R., Waser, M., & Kass, S. R. (2018). Synthesis of Cyclic Organic Carbonates Using Atmospheric Pressure CO2 and Charge-Containing Thiourea Catalysts. The Journal of Organic Chemistry, 83(17), 9991-10000. https://doi.org/10.1021/acs.joc.8b01374 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/125028

Clergue, S., Rousseau, O., Delaunay, T., Dequirez, G., Tran, T.-V., El Aakchioui, S., Barozzino Consiglio, G., & Robiette, R. (2018). Asymmetric Sulfur-Ylide-Mediated Formal [4+1]-Annulation Reaction: Scope and Mechanism. Chemistry: A European Journal, 24(44), 11417-11425. https://doi.org/10.1002/chem.201801874 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/173530

Eitzinger, A., Zielke, K., Widhalm, M., Robiette, R., & Waser, M. (2018). Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates. Asian Journal of Organic Chemistry, 7(8), 1620-1625. https://doi.org/10.1002/ajoc.201800275 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/215258

Kankolongo Ntumba, J., Tshiongo, C., Mifundu, M., Robiette, R., & Taba, K. (2018). Effective Antimalarial Activities of α-Hydroxy Diynes Isolated from Ongokea gore. Planta Medica, 84(11), 806-812. https://doi.org/10.1055/s-0043-124974 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/238043

2017

Journal article

Meisinger, N., Roiser, L., Monkowius, U., Himmelsbach, M., Robiette, R., & Waser, M. (2017). Asymmetric Synthesis of 2,3-Dihydrobenzofurans by a [4+1] Annulation Between Ammonium Ylides and In Situ Generatedo-Quinone Methides. Chemistry: A European Journal, 23(21), 5137-5142. https://doi.org/10.1002/chem.201700171 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/215261

Ntumba, J. K., Mulula, A., Kashishi, K. T., Mifundu, M. N., Robiette, R., & Taba, K. M. (2017). Physicochemical Properties of Diacetylenic Light Fuel Oil from Congolese Oleaginous PlantOngokea gore(Hua) Pierre. Journal of Applied Chemistry, 2017, 1-6. https://doi.org/10.1155/2017/7176317 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/179338

Depré, D., Vermeulen, W. A. A., Lang, Y., Dubois, J., Vandevivere, J., Vandermeersch, J., Huang, L., & Robiette, R. (2017). Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α-Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α-Alkoxy Aldehydes. Organic Letters, 19(6), 1414-1417. https://doi.org/10.1021/acs.orglett.7b00344 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/215599

Novacek, J., Robiette, R., & Waser, M. (2017). On the origin of the stereoselectivity in chiral amide-based ammonium ylide-mediated epoxidations. Monatshefte für Chemie : an international journal of chemistry, 148(1), 77-81. https://doi.org/10.1007/s00706-016-1866-8 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/182401

Cibaka, M.-L. K., Tran, T. T. H., Gros, J., Robiette, R., & Collin, S. (2017). Investigation of 2-Sulfanylethyl Acetate Cysteine-S-Conjugate as a Potential Precursor of Free Thiols in Beer. American Society of Brewing Chemists. Journal, 75(3), 228-235. https://doi.org/10.1094/asbcj-2017-3276-01 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/127770

2016

Journal article

Novacek, J., Roiser, L., Zielke, K., Robiette, R., & Waser, M. (2016). Towards a General Understanding of Carbonyl-Stabilised Ammonium Ylide-Mediated Epoxidation Reactions. Chemistry: A European Journal, 22(32), 11422-11428. https://doi.org/10.1002/chem.201602052 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/215526

Caruano, J., Muccioli, G., & Robiette, R. (2016). Biologically active γ-lactams: synthesis and natural sources. Organic & Biomolecular Chemistry, 14(43), 10134-10156. https://doi.org/10.1039/C6OB01349J (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/181568

Kankolongo Cibaka, M.-L., Decourrière, L., Lorenzo-Alonso, C. j., Bodart, E., Robiette, R., & Collin, S. (2016). 3‐Sulfanyl-4-methylpentan-1-ol in Dry-Hopped beers: first evidence of glutathione S‐Conjugates in hop (Humulus lupulus L.). Journal of Agricultural and Food Chemistry, 64(45), 8572-8582. https://doi.org/10.1021/acs.jafc.6b03788 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/180551

Roiser, L., Robiette, R., & Waser, M. (2016). Benzylic Ammonium Ylide Mediated Epoxidations. Synlett : accounts and rapid communications in synthetic organic chemistry, 27(13), 1963-1968. https://doi.org/10.1055/s-0035-1562344 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/185019

Robiette, R., Tran, T.-V., Aggarwal, V. K., & Harvey, J. N. (2016). Activation of the SN2 Reaction by Adjacent π Systems: The Critical Role of Electrostatic Interactions and of Dissociative Character. Journal of the American chemical society, 138(3), 734-737. https://doi.org/10.1021/jacs.5b11402 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/215540

2015

Journal article

Pichler, M., Novacek, J., Robiette, R., Poscher, V., Himmelsbach, M., Monkowius, U., Müller, N., & Waser, M. (2015). Asymmetric Syntheses of Three-Membered Heterocycles Using Chiral Amide-Based Ammonium Ylides. Organic & Biomolecular Chemistry, 13, 2092-2099. https://doi.org/10.1039/C4OB02318H (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/238050

Rousseau, O., Delaunay, T., Dequirez, G., Tran, T.-V., Robeyns, K., & Robiette, R. (2015). Formal Asymmetric (4+1) Annulation Reaction between Sulfur Ylides and 1,3-Dienes. Chemistry: A European Journal, 21(37), 12899-12902. https://doi.org/10.1002/chem.201502579 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/238052

Ntumba Kankolongo, J., Collard, L., Taba, K., & Robiette, R. (2015). Isolation of a Series of Fatty Acid Components of Ongokea Gore Seed (Isano) Oil and Their Detailed Structural Analysis. Lipids. Accepted/in-press. https://doi.org/10.1007/s11745-014-3984-6 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/193310

2014

Journal article

Caruano, J., Feledziak, M., Labar, G., Michaux, C., Perpete, E., Muccioli, G., Robiette, R., & Marchand-Brynaert, J. (2014). (S)-1-(Pent-4’-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling. Journal of Enzyme Inhibition and Medicinal Chemistry, 29, 654-662. https://doi.org/10.3109/14756366.2013.837900 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/203062

Ntumba Kankolongo, J., Taba, K., & Robiette, R. (2014). L’huile d’Ongokea Gore (isano) : Analyse de sa composition chimique et valorisation par dérivatisation. Chimie Nouvelle, 2014(117), 12-20. (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/194071

Rousseau, O., Delaunay, T., & Robiette, R. (2014). Synthesis of Monosubstituted 1,1-Dicarbonyl Ester 1,3-Dienes. Synlett : accounts and rapid communications in synthetic organic chemistry, 2014, 519-522. https://doi.org/10.1055/s-0033-1340468 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/238055

Book chapter

Robiette, R., & Marchand-Brynaert, J. (2014). Formation of four-membered heterocycles. In Paul Knochel et Gary A. Molander (ed.), Comprehensive Organic Synthesis, 2nd Edition, Vol. 5 (p. 85-128 p.). Elsevier. https://doi.org/10.1016/B978-0-08-097742-3.00503-6

https://research.dial.uclouvain.be/handle/2078.5/257894

2013

Journal article

Nizet, S., Gros, J., Peeters, F., Chaumont, S., Robiette, R., & Collin, S. (2013). First Evidence of the Production of Odorant Polyfunctional Thiols by Bottle Refermentation. American Society of Brewing Chemists. Journal, 71(1), 15-22. https://doi.org/10.1094/ASBCJ-2013-0117-01 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/207919

Robiette, R., & Pospíšil, J. (2013). On the Origin of E/Z Selectivity in the Modified Julia Olefination - Importance of the Elimination Step. European Journal of Organic Chemistry, 2013(5), 836-840. https://doi.org/10.1002/ejoc.201201634 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/238065

Van Den Berge, E., & Robiette, R. (2013). Development of a Regioselective N-Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer. The Journal of Organic Chemistry, 78(23), 12220-12223. https://doi.org/10.1021/jo401978b (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/238063

Robiette, R., Caruano, J., Van Den Berge, E., Rousseau, O., & Tran, T.-V. (2013). Comprendre les réactions pour mieux les développer et les utiliser. Chimie Nouvelle, 113([2]), 18-20. (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/204284

Mathieu, V., Van Den Berge, E., Ceusters, J., Konopka, T., Cops, A., Bruyère, C., Pirker, C., Tran, T.-V., Kiss, R., Robiette, R., Berger, W., Serteyn, D., & et al. (2013). New 5-aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting. Journal of Medicinal Chemistry, 56, 6626-6637. https://doi.org/10.1021/jm400287v (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/205886

Villemin, E., Robeyns, K., Robiette, R., Herent, M.-F., & Marchand-Brynaert, J. (2013). Polycyclic phosphonic acid derivatives obtained by a [4+2] cycloaddition strategy using phosphonodienes. Tetrahedron, 69(3), 1138-1147. https://doi.org/10.1016/j.tet.2012.11.059 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/238062

2012

Journal article

Dive, G., Robiette, R., Ahenel, A., Ndong, M., Meier, C., & Desouter-Lecomte, M. (2012). Laser control in open quantum systems: Preliminary analysis towards the Cope rearrangement control in methyl-cyclopentadienylcarboxylate dimer. Theoretical Chemistry Accounts, 131(1), 1236. https://doi.org/10.1007/s00214-012-1236-5 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/203063

Billard, F., Robiette, R., & Pospisil, J. (2012). Julia-Kocienski Reaction-Based 1,3-Diene Synthesis: Aldehyde-Dependent (E,E/E,Z)-Selectivity. The Journal of Organic Chemistry, 77(14), 6358-6364. https://doi.org/10.1021/jo300929a (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/268514

Pospisil, J., Robiette, R., Sato, H., & Debrus, K. (2012). Practical synthesis of β-oxo benzo[d]thiazolyl sulfones: Scope and limitations. Organic & Biomolecular Chemistry, 10(6), 1225-1234. https://doi.org/10.1039/C1OB06510F (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/159597

Driesschaert, B., Robiette, R., Le Duff, C. S., Collard, L., Robeyns, K., Gallez, B., & Marchand-Brynaert, J. (2012). Configurationally stable tris(tetrathioaryl)methyl molecular propellers. European Journal of Organic Chemistry, 2012(33), 6517-6525. https://doi.org/10.1002/ejoc.201200801 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/163332

2011

Journal article

Driesschaert, B., Robiette, R., Lucaccioni, F., Gallez, B., & Marchand-Brynaert, J. (2011). Chiral properties of tetrathiatriarylmethyl spin probes. Chemical Communications, 47(16), 4793-4795. https://doi.org/10.1039/c1cc10988j (Original work published 2011)

https://research.dial.uclouvain.be/handle/2078.5/238056

Van Den Berge, E., Pospisil, J., trieu-van, t., Collard, L., & Robiette, R. (2011). Planar Chirality of Imidazole-Containing Macrocycles - Understanding and Tuning Atropisomerism. European Journal of Organic Chemistry, 2011, 6649-6655. https://doi.org/10.1002/ejoc.201100805 (Original work published 2011)

https://research.dial.uclouvain.be/handle/2078.5/268150

Villemin, E., Elias, B., Robiette, R., Robeyns, K., Herent, M.-F., Habib Jiwan, J.-L., & Marchand-Brynaert, J. (2011). Novel phosphonated bicyclic frameworks from Diets-Alder reaction as chelating agents of di- and trivalent metal cations. Tetrahedron Letters, 52(40), 5140-5144. https://doi.org/10.1016/j.tetlet.2011.07.116 (Original work published 2011)

https://research.dial.uclouvain.be/handle/2078.5/155172

2010

Journal article

Robiette, R., Tran, T.-V., Cordi, A., Tinant, B., & Marchand-Brynaert, J. (2010). A Practical Synthesis of 1,2-Nitroamines by Michael Addition of N-Nucleophiles to Nitroalkenes. Synthesis : journal of synthetic organic chemistry, 18, 3138-3142. https://doi.org/10.1055/s-0030-1258176 (Original work published 2010)

https://research.dial.uclouvain.be/handle/2078.5/131963

Nshimyumukiza, P., Van Den Berge, E., Delest, B., Mijatovic, T., Kiss, R., Marchand-Brynaert, J., & Robiette, R. (2010). Synthesis and biological evaluation of novel imidazole-containing macrocycles. Tetrahedron, 66(25), 4515-4520. https://doi.org/10.1016/j.tet.2010.04.070 (Original work published 2010)

https://research.dial.uclouvain.be/handle/2078.5/131498

Robert, F., Naik, A., Hidara, F., Tinant, B., Robiette, R., Wouters, J., & Garcia, Y. (2010). Engineering Solid-State Molecular Switches: N-Salicylidene N-Heterocycle Derivatives. European Journal of Organic Chemistry, 4, 621-637. https://doi.org/10.1002/ejoc.200901175 (Original work published 2010)

https://research.dial.uclouvain.be/handle/2078.5/131796

2009

Journal article

Robert, F., Naik, A., Tinant, B., Robiette, R., & Garcia, Y. (2009). Insights into the Origin of Solid-State Photochromism and Thermochromism of N-Salicylideneanils: The Intriguing Case of Aminopyridines. Chemistry: A European Journal, 15(17), 4327-4342. https://doi.org/10.1002/chem.200801932 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/130599

Monbaliu, J.-C., Robiette, R., Peeters, D., & Marchand-Brynaert, J. (2009). (R)-4-phenyloxazolidin-2-thione: an efficient chiral auxiliary for [4+2] cycloaddition of 1-aminodiene and activated phosphonodienophiles. Tetrahedron Letters, 50(12), 1314-1317. (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/132952

2008

Journal article

Robiette, R., & Marchand-Brynaert, J. (2008). Diastereoselective synthesis of vinylcyclopropanes from dienes and sulfur ylides. Synlett : accounts and rapid communications in synthetic organic chemistry, 4, 517-520. https://doi.org/10.1055/s-2008-1032080 (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/133879

Howells, D., Robiette, R., Fang, G. Y., Knowles, L. S., Woodrow, M. D., Harvey, J., & Aggarwal, V. K. (2008). Reactions of silyl-stabilised sulfur ylides with organoboranes: enantioselectivity, mechanism, and understanding. Organic & Biomolecular Chemistry, 6(7), 1185-1189. https://doi.org/10.1039/b718496d (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/133861

Delest, B., Nshimyumukiza, P., Fasbender, O., Tinant, B., Marchand-Brynaert, J., Darro, F., & Robiette, R. (2008). Divergent and regioselective synthesis of 1,2,4- and 1,2,5-trisubstituted imidazoles. The Journal of Organic Chemistry, 73(17), 6816-6823. https://doi.org/10.1021/jo801256b (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/130756

2007

Journal article

Robiette, R., Aggarwal, V. K., & Harvey, J. (2007). Mechanism of the Morita-Baylis-Hillman reaction: A computational investigation. Journal of the American chemical society, 129(50), 15513-15525. https://doi.org/10.1021/ja0717865 (Original work published 2007)

https://research.dial.uclouvain.be/handle/2078.5/154472

Broustal, G., Ariza, X., Campagne, J.-M., Garcia, J., Georges, Y., Marinetti, A., & Robiette, R. (2007). A stereoselective approach to 1,3-amino alcohols protected as cyclic carbamates: Kinetic vs. thermodynamic control. European Journal of Organic Chemistry, 26, 4293-4297. https://doi.org/10.1002/ejoc.200700503 (Original work published 2007)

https://research.dial.uclouvain.be/handle/2078.5/134478

2006

Journal article

Harvey, J., Aggarwal, V. K., Bathelt, C. M., Carreon-Macedo, J. L., Gallagher, T., Holzmann, N., Mulholland, A. J., & Robiette, R. (2006). QM and QM/MM studies of selectivity in organic and bioorganic chemistry. Journal of Physical Organic Chemistry, 19(8-9), 608-615. https://doi.org/10.1002/poc.1030 (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/154681

Robiette, R., Fang, G. Y., Harvey, J. N., & Aggarwal, V. K. (2006). Is phenyl a good migrating group in the rearrangement of organoborates generated from sulfur ylides? Chemical Communications, 1(7), 741-743. https://doi.org/10.1039/b514987h (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/154689

Aggarwal, V. K., Charmant, J. P. H., Fuentes, D., Harvey, J., Hynd, G., Ohara, D., Picoul, W., Robiette, R., Vasse, J.-L., & Winn, C. L. (2006). Highly enantioselective synthesis of glycidic amides using camphor-derived sulfonium salts. Mechanism and applications in synthesis. Journal of the American chemical society, 128(6), 2105-2114. https://doi.org/10.1021/ja0568345 (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/154690

Robiette, R., Conza, M., & Aggarwal, V. K. (2006). Delineation of the factors governing reactivity and selectivity in epoxide formation from ammonium ylides and aldehydes. Organic & Biomolecular Chemistry, 4(4), 621-623. https://doi.org/10.1039/b516926g (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/154686

Robiette, R., Richardson, J., Aggarwal, V. K., & Harvey, J. (2006). Reactivity and selectivity in the Wittig reaction: A computational study. Journal of the American chemical society, 128(1), 2394-2409. https://doi.org/10.1021/ja056650q (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/154683

Robiette, R. (2006). Mechanism and diastereoselectivity of aziridine formation from sulfur ylides and imines: a computational study. The Journal of Organic Chemistry, 71(7), 2726-2734. https://doi.org/10.1021/jo052559t (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/132964

2005

Journal article

Aggarwal, V. K., Harvey, J. N., & Robiette, R. (2005). On the importance of leaving group ability in reactions of ammonium, oxonium, phosphonium, and sulfonium ylides. Angewandte Chemie (International Edition), 44(34), 5468-5471. https://doi.org/10.1002/anie.200501526 (Original work published 2005)

https://research.dial.uclouvain.be/handle/2078.5/238058

Robiette, R., Richardson, J., Aggarwal, V., & Harvey, J. (2005). On the origin of high E selectivity in the Wittig reaction of stabilized ylides: Importance of dipole-dipole interactions. Journal of the American chemical society, 127(39), 13468-13469. https://doi.org/10.1021/ja0539589 (Original work published 2005)

https://research.dial.uclouvain.be/handle/2078.5/238061

Robiette, R., Defacqz, N., Peeters, D., & Marchand-Brynaert, J. (2005). A novel strategy towards aminophosphonic derivatives based on the Diels-Alder cycloaddition: Experimental and theoretical approaches. Current Organic Synthesis, 2(4), 453-477. https://doi.org/10.2174/157017905774322668 (Original work published 2005)

https://research.dial.uclouvain.be/handle/2078.5/238064

Boulanger, M., Leyssens, T., Robiette, R., & Peeters, D. (2005). Theoretical approach of steric effects in the Diels-Alder reaction. Journal of Molecular Structure: THEOCHEM, 731(1-3), 101-106. https://doi.org/10.1016/j.theochem.2005.07.005 (Original work published 2005)

https://research.dial.uclouvain.be/handle/2078.5/136281

2004

Journal article

Tinant, B., Defacqz, N., Robiette, R., Touillaux, R., & Marchand-Brynaert, J. (2004). Stereochemistry and conformation of amido-phosphonocyclohexene derivatives, assigned by NMR and X-ray diffraction analyses. Phosphorus, Sulfur and Silicon and the Related Elements, 179(2), 389-402. https://doi.org/10.1080/10426500490262522 (Original work published 2004)

https://research.dial.uclouvain.be/handle/2078.5/136486

2003

Journal article

Robiette, R., Dekoker-Malengreau, A., & Marchand-Brynaert, J. (2003). A study of the alkylation and rearrangement products of chiral 1,3-oxazolidine- and thiazolidine-2-thiones. Heterocycles, 60(3), 523-+. https://doi.org/10.3987/COM-02-9653 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/238045

Robiette, R., Defacqz, N., Stofferis, J., & Marchand-Brynaert, J. (2003). [4+2] Cycloaddition of 1-aminodienes and 2-substituted vinylphosphonates: application to asymmetric synthesis of 3-amino-5-phosphono-1-cyclohexene derivatives. Tetrahedron, 59(23), 4167-4175. https://doi.org/10.1016/S0040-4020(03)00580-5 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/137088

Robiette, R., Cheboub-Benchaba, K., Peeters, D., & Marchand-Brynaert, J. (2003). Design of a new and highly effective chiral auxiliary for Diels-Alder reaction of 1-aminodiene. The Journal of Organic Chemistry, 68(25), 9809-9812. https://doi.org/10.1021/jo0302049 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/238060

Peeters, D., Leyssens, T., & Robiette, R. (2003). Analyse de la réorganisation électronique dans les molécules en réaction. Chimie Nouvelle, 82, 91-95. (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/156614

Tinant, B., Robiette, R., & Marchand-Brynaert, J. (2003). Crystal structure of (S)-3-(Z-1 ‘,3 ’-butadienyl)-4-phenylthiazoline-2-one, C13H13NOS, a chiral 1-amino-diene useful in Diels-Alder cycloaddition reactions. Zeitschrift fuer Kristallographie - New Crystal Structures, 218(4), 475-476. https://doi.org/10.1524/ncrs.2003.218.4.475 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/238053

Dissertation

Robiette, R. (2003). Développement d’une voie générale d’accès aux dérivés β- et γ-aminophosphoniques par réaction Diels-Alder : approches expérimentale et théorique.

https://research.dial.uclouvain.be/handle/2078.5/124230

2002

Journal article

Robiette, R., Marchand-Brynaert, J., & Peeters, D. (2002). Theoretical study of the influence of phosphonate substituents on Diels-Alder reactions. Journal of Molecular Structure: THEOCHEM, 587(1-3), 159-169. https://doi.org/10.1016/S0166-1280(02)00113-6 (Original work published 2002)

https://research.dial.uclouvain.be/handle/2078.5/238102

Robiette, R., Marchand-Brynaert, J., & Peeters, D. (2002). Influence of diene substitution on transition state stabilization in Diels-Alder reaction. The Journal of Organic Chemistry, 67(19), 6823-6826. https://doi.org/10.1021/jo025796u (Original work published 2002)

https://research.dial.uclouvain.be/handle/2078.5/238051

2001

Book chapter

Marchand-Brynaert, J., Defacqz, N., & Robiette, R. (2001). [4+2] Cycloaddition of phosphoryl-substituted dienes and dienophiles with a view of preparing aminophosphonic acid derivatives. In Pandalai S.G. (ed.), Recent Research Developments in Organic Chemistry. vol 5. Transworld Research Network.

https://research.dial.uclouvain.be/handle/2078.5/203028

Journal article

Robiette, R., & Marchand-Brynaert, J. (2001). Asymmetric synthesis of beta- and gamma-amidophosphonates by Diels-Alder reaction using chiral aminodiene: theoretical and experimental study of the facial selectivity of chiral N-dienyl lactam. Royal Chemical Society. Journal. Perkin Transactions 2, 11, 2155-2158. https://doi.org/10.1039/b105070m (Original work published 2001)

https://research.dial.uclouvain.be/handle/2078.5/238101

1998 - 2003	Ph.D. Doctorate in chemistry at the Université catholique de Louvain. Advisors: Profs J. Marchand-Brynaert (experimental) and D. Peeters (theory),
2003 - 2004	Postdoctoral position at the University of California, Los Angeles (U.C.L.A., U.S.A.), with a Fulbright research fellowship. Advisor: Prof. M. E. Jung
2004 - 2005	Postdoctoral position at the University of Bristol (U.K.), with a FSR fellowship from UCLouvain. Advisors: Prof. V. K. Aggarwal (organic synthesis) and Prof. J. N. Harvey (computational chemistry)
2005 - 2009	Chargé de recherches F.R.S.-FNRS at the Université catholique de Louvain (Belgium)
2009 to date	F.R.S.-FNRS Research Fellow and Professor at the Université catholique de Louvain (Belgium).
2017 - 2023	Head of the Molecular Chemistry, Materials and Catalysis (MOST) Division of the Université catholique de Louvain (Belgium).

Year	Label	School
2003	Docteur en sciences	UCLouvain \| Université catholique de Louvain (Belgique)
1999	Diplômé d'études approfondies en chimie moléculaire	UCLouvain \| Université catholique de Louvain (Belgique)
1998	Licencié en sciences chimiques	UCLouvain \| Université catholique de Louvain (Belgique)
1996	Candidat en sciences chimiques	UCLouvain \| Université catholique de Louvain (Belgique)

Learning units for 2026

Label	Code
Spectroscopic methods of analysis Organic analysis II	LBIRC2102
Organic chemistry III	LCHM1341
Exercises in organic chemistry I	LCHM1342
Project	LCHM1391
Physical organic chemistry	LCHM2143

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Raphaël Robiette

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Learning units for 2026