We are pleased to announce the next CEMO seminar on Wednesday, the 7th of May, at the Maisin Auditorium, from noon to 2 pm.
Kirsten Stam (Mammalian Development & Cell Biology lab (Yves JOSSIN))
Understanding the underlying molecular pathway causing the Van Maldergem syndrome
Abstract: The organization of the six-layered cerebral cortex is dependent on a tight coordination and regulation of the proliferation, differentiation of the neural stem cells and migration of the neurons. Disruptions in these processes can lead to malformations of the cortex. In the Van Maldergem syndrome, mutations in Dchs1 or Fat4 genes result in intellectual disabilities and neuronal heterotopia. While the defect was described as partially resulting from a defect in cortical progenitor proliferation, the mechanism leading to this malformation is still unclear. Indeed, Fat4 and Dchs1 are also expressed in the cortical migration zone. But their functions in postmitotic neurons and migration in the cerebral cortex are not known, and could be one of the main causes of neuronal heterotopias found in the Van Maldergem syndrome. Using in vivo gain and loss of function in a mouse model, combined with molecular and cellular approaches, we discovered a molecular and signaling link between Fat4, Dchs1 and RhoA for the control of excitatory neurons migration in the developing neocortex.
In order to have an estimation of the people having a sandwich, please do not forget to fill out the survey (deadline Monday May 5th at noon):
We keep the online version of the seminar on teams.
Contact: Roberta Gualdani or Nuria Ruiz Reig