Wednesday, February 21, 2024 – 4:30pm – Auditoire Maisin

Emilia HOSTE – Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics - PMGK

Etude du transport cellulaire de l'atorvastatine : d'une approche fondamentale à une approche translationnelle

Promotor: Prof. Laure Elens – Copromotor: Prof. Vincent Haufroid

Related references:

• Hoste E, Paquot A, Panin N, Horion S, El Hamdaoui H, Muccioli GG, Haufroid V, Elens L. Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. Therapeutic Drug Monitoring, 2023 Jun 1;45(3):400-408.
• Hoste E, Haufroid V, Deldicque L, Balligand J-L, Elens L. Atorvastatin-associated myotoxicity: a toxicokinetic review of pharmacogenetic associations to evaluate the fesability of precision pharmacotherapy. Clinical Biochemistry, 2024 Jan 3:124:110707.
• Hoste E, Deldicque L, Muccioli GG, Panin N, Terrasi R, Paquot A, Lingurski M, Pyr dit Ruys S, Haufroid V, Elens L. Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics. Submitted in British Journal of Pharmacology (2024).

Info: laure.elens@uclouvain.be