Friday, October 23, 2020 -  4pm -  Auditoire Maisin

Léopold Thabault

Medicinal Chemistry (CMFA) - LDRI

Interrogating the Lactate Dehydrogenase Tetrameric Interface Using (Stapled) Peptides and Short Proteins: An Original Approach to Protein Inhibition

Event Teams : https://teams.microsoft.com/l/meetup-join/19%3ameeting_MmM4NzVjZmMtMTczYi00YjcyLWExMDctNjNjMzQwMTdjMDE5%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%2234e84350-e4dc-4ccf-a85d-22195e1fa0f9%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Promotors: Raphaël Frédérick and Pierre Sonveaux

Related publications :

• Thabault, L., Brisson, L., Brustenga, C., Gache, S. A. M., Kozlova, A., Spillier, Q., Liberelle, M., Benyahia, Z., Messens, J., Copetti, T., Sonveaux, P., and Frédérick, R. (2020) Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides. J. Med. Chem. 63, 4628–4643.
• Thabault, L., Liberelle, M., Frédérick, R. Targeting Proteins Self-Association in Drug Design. Drug Discov. Today. provisionnally accepted
• Thabault, L., Liberelle, M., Koruza, K., Yildiz, E., Messens, J., Wouters, J., Sonveaux, P., Frédérick, R. Exploration of Lactate dehydrogenase Tetrameric Interface Unravels a New Tetrameric Site with Related Peptide Ligands. Under preparation.

Info: raphael.frederick@uclouvain.be