08/05/2026 - 16:00 - ISBA C.115 + Online 
 

Erwin Dreesen

(KULeuven)

Will give a presentation on : 

Why Precision Dosing Fails (and How Statistics Could Fix It)

Model-informed precision dosing uses statistical models to individualize therapy, but real-world performance often suffers from model mismatch, prior miscalibration, and overconfidence in single-model forecasts. This talk shows how to make MIPD more reliable using practical tools from applied statistics: controlling prior informativeness (including prior flattening), robust Bayesian updating, and multimodel/ensemble approaches to address model uncertainty. I will illustrate these ideas with case studies across different disease areas and drugs, and I will discuss how to validate performance using calibration and prediction-focused metrics that matter in clinical practice.

Teams Link: https://teams.microsoft.com/meet/325074107501257?p=T7gDATOIXe5s01DMsU