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Photo of Frédéric Clotman

Frédéric Clotman

Professeur, Directeur de recherche FNRS
frederic.clotman@uclouvain.be

SST/SC Faculté des sciences (SC)

SST/SC/BIOL Ecole de biologie (BIOL)

SST/IBST Louvain Institute of Biomolecular Science and Technology (LIBST)

  • Mécanismes moléculaires et cellulaires contrôlant la diversification neuronale dans la moelle épinière en développement
  • Caractérisation des sous-populations d'interneurones médullaires V2 au cours du développement et de la vie adulte
  • Transfert inter-cellulaire des protéines Onecut au cours du développement de la moelle épinière
  • Transfert inter-cellulaire d'homéoprotéines dans les cancers du système nerveux
  • Contribution des interneurones médullaires à l'initiation et à la progression de la Sclérose Latérale Amyotrophique (SLA)
2026
Article de journal

Glibert, H., Bridoux, L., Moens, C., Olivier, S., Jeannotte, L., Clotman, F., & Gofflot, F. (2026). Postnatal relevance of HOXA5 transcription factor in cerebellum-associated behaviors and disorders. Behavioral and Brain Functions. Published. https://doi.org/10.1186/s12993-026-00343-z (Original work published 2026)

https://research.dial.uclouvain.be/handle/2078.5/278528


2025
Article de journal

Glibert, H., Bridoux, L., Palate, M., Piget, C., Ahn, M.-T., Gualdani, R., Dominguez Bajo, A., Clotman, F., Rijli, F. M., & Gofflot, F. (2025). Primary Cell Cultures in Neurobiology: Optimized Protocol for Culture of Mouse Fetal Hindbrain Neurons. Cells, 14(11), 758. https://doi.org/10.3390/cells14110758 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/246491


Vigneul, E., Krins, F., & Clotman, F. (2025). Of travelling homeoproteins and medulloblastomas. Oncogene : including Oncogene Reviews, 44(34), 3043-3051. https://doi.org/10.1038/s41388-025-03523-9 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/271859


2024
Article de journal

Zupančič, M., Keimpema, E., Tretiakov, E. O., Eder, S. J., Lev, I., Englmaier, L., Bhandari, P., Fietz, S. A., Härtig, W., Renaux, E., Villunger, A., Hökfelt, T., Zimmer, M., Clotman, F., & Harkany, T. (2024). Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3. Nature Communications, 15(1), Published online. https://doi.org/10.1038/s41467-024-52762-z (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/233910


Goffin, L., Lemoine, D., & Clotman, F. (2024). Potential contribution of spinal interneurons to the etiopathogenesis of amyotrophic lateral sclerosis. Frontiers in Neuroscience, 18(None), Published online. https://doi.org/10.3389/fnins.2024.1434404 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/233902


Renaux, E., Baudouin, C., Marchese, D., Clovis, Y., Lee, S.-K., Gofflot, F., Rezsohazy, R., & Clotman, F. (2024). Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons. Cellular and Molecular Life Sciences, 81(1), Published online. https://doi.org/10.1007/s00018-024-05316-x (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/233904


Dominguez Bajo, A., & Clotman, F. (2024). Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults. Cells, 13(8), 652. https://doi.org/10.3390/cells13080652 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/216877


Renaux, E., Baudouin, C., Schakman, O., Gay, O., Martin, M., Marchese, D., Achouri, Y., Rezsohazy, R., Gofflot, F., & Clotman, F. (2024). Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Frontiers in Cellular Neuroscience, 18(None), Published online. https://doi.org/10.3389/fncel.2024.1466056 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/233907


2023
Article de journal

Zupančič, M., Tretiakov, E., Máté, Z., Erdélyi, F., Szabó, G., Clotman, F., Hökfelt, T., Harkany, T., & Keimpema, E. (2023). Brain‐wide mapping of efferent projections of glutamatergic (Onecut3<sup>+</sup>) neurons in the lateral mouse hypothalamus. Acta Physiologica, 238(3), 1. https://doi.org/10.1111/apha.13973 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/103948


2021
Article de journal

Baudouin, C., Pelosi, B., Courtoy, G. E., Achouri, Y., & Clotman, F. (2021). Generation and characterization of a tamoxifen-inducible Vsx1-CreER line to target V2 interneurons in the mouse developing spinal cord. Genesis: The Journal of Genetics and Development, 59(7-8), e23435. https://doi.org/10.1002/dvg.23435 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/109656


2020
Article de journal

Debrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Pelosi, B., Francius, C., Rucchin, V., Ronellenfitch, K., Chow, R. L., Tissir, F., Lee, S.-K., & Clotman, F. (2020). Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cellular and Molecular Life Sciences, 77(20), 4117-4131. https://doi.org/10.1007/s00018-019-03408-7 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/123508


Romanov, R. A., Tretiakov, E. O., Kastriti, M. E., Zupancic, M., Häring, M., Korchynska, S., Popadin, K., Benevento, M., Rebernik, P., Lallemend, F., Nishimori, K., Clotman, F., Andrews, W. D., Parnavelas, J. G., Farlik, M., Bock, C., Adameyko, I., Hökfelt, T., Keimpema, E., & Harkany, T. (2020). Molecular design of hypothalamus development. Nature, 582(7811), 246-252. https://doi.org/10.1038/s41586-020-2266-0 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/119385


Toch, M., Harris, A., Schakman, O., Kondratskaya, E., Boulland, J.-L., Dauguet, N., Debrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Gow, A., Glover, J. C., Tissir, F., & Clotman, F. (2020). Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. Scientific Reports, 10(1), 996 [1-17]. https://doi.org/10.1038/s41598-020-57945-4 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/122592


Gray de Cristoforis, A., Ferrari, F., Clotman, F., & Vogel, T. (2020). Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Molecular Brain, 13(1), 85. https://doi.org/10.1186/s13041-020-00623-3 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/98183


2019
Article de journal

Masgutova, G., Harris, A., Jacob, B., Corcoran, L. M., & Clotman, F. (2019). Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord. Frontiers in Molecular Neuroscience, 12, 263. https://doi.org/10.3389/fnmol.2019.00263 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/123513


Harris, A., Masgutova, G., Collin, A., Toch, M., Hidalgo-Figueroa, M., Jacob, B., Corcoran, L. M., Francius, C., & Clotman, F. (2019). Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord. Frontiers in Cellular Neuroscience, 13(184), 1. https://doi.org/10.3389/fncel.2019.00184 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/55992


Toch, M., & Clotman, F. (2019). CBP and p300 coactivators contribute to the maintenance of Isl1 expression by the Onecut transcription factors in embryonic spinal motor neurons. Molecular and Cellular Neuroscience, 101, 103411. https://doi.org/10.1016/j.mcn.2019.103411 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/123515


2018
Article de journal

Clotman, F., & Tissir, F. (2018). Guidance of motor axons: where do we stand? Current Opinion in Physiology, 4, 76-81. https://doi.org/10.1016/j.cophys.2018.06.004 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/59858


2017
Article de journal

Kabayiza, U. K., Masgutova, G., Harris, A., Rucchin, V., Jacob, B., & Clotman, F. (2017). The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development. Frontiers in Molecular Neuroscience, 10. https://doi.org/10.3389/fnmol.2017.00157 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/56261


2016
Article de journal

Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., Hsueh, B., Crow, A. K., Martens, H., Schwindling, C., Calvigioni, D., Bains, J. S., Máté, Z., Szabó, G., Yanagawa, Y., et al. (2016). Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nature Neuroscience, 20(2), 176-188. https://doi.org/10.1038/nn.4462 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/56612


Stanga, S., Zanou, B. N., TASIAUX, B., Contino, S., Clotman, F., Gailly, P., Dewachter, I., Octave, J.-N., & Kienlen-Campard, P. (2016). APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation. The FASEB Journal, 30(5), 1696-1711. https://doi.org/10.1096/fj.15-278739 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/63623


Francius, C., Hidalgo Figueroa, M., Debrulle, S., Pelosi, B., Rucchin, V., Ronellenfitch, K., Panayiotou, E., Makrides, N., Misra, K., Harris, A., Hassani, H., Schakman, O., Parras, C., Xiang, M., Malas, S., Chow, R. L., & Clotman, F. (2016). Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Frontiers in Molecular Neuroscience, 9, 145 [1-15]. https://doi.org/10.3389/fnmol.2016.00145 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/57177


2015
Article de journal

Pirson, M., Debrulle, S., Clippe, A., Clotman, F., & Knoops, B. (2015). Thioredoxin-2 modulates neuronal programmed cell death in the embryonic chick spinal cord in basal and target-deprived conditions. PLoS One, 1-21. https://doi.org/10.1371/journal.pone.0142280 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/187691


2014
Article de journal

Chai, G., Zhou, L., Manto, M., Helmbacher, F., Clotman, F., Goffinet, A., & Tissir, F. (2014). Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience, 17(9), 1171-1179. https://doi.org/10.1038/nn.3784 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/62456


Francius, C., Ravassard, P., Hidalgo Figueroa, M., Mallet, J., Clotman, F., & Nardelli, J. (2014). Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord. Developmental Neurobiology. Published. https://doi.org/10.1002/dneu.22244 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/193564


des Rieux, A., De Berdt, P., Ansorena Artieda, E., Ucakar, B., Jacobs, D., Schakman, O., Audouard, E., Bouzin, C., Auhl, D., Simón-Yarza, T., Feron, O., Blanco-Prieto, M. J., Carmeliet, P., Bailly, C., Clotman, F., & Préat, V. (2014). Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord. Journal of Biomedical Materials Research. Part A, 102(7), 2345-2355. https://doi.org/10.1002/jbm.a.34915 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/203789


Francius, C., & Clotman, F. (2014). Generating spinal motor neuron diversity: a long quest for neuronal identity. Cellular and Molecular Life Sciences, 71(5), 813-829. https://doi.org/10.1007/s00018-013-1398-x (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/57173


2013
Article de journal

Hermant, P., Francius, C., Clotman, F., & Michiels, T. (2013). IFN-ε Is Constitutively Expressed by Cells of the Reproductive Tract and Is Inefficiently Secreted by Fibroblasts and Cell Lines. PLoS One, 8(8), e71320. https://doi.org/10.1371/journal.pone.0071320 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/56585


Francius, C., Harris, A., Rucchin, V., Hendricks, T. J., Stam, F. J., Barber, M., Kurek, D., Grosveld, F. G., Pierani, A., Goulding, M., & Clotman, F. (2013). Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord. PLoS One, 8(8), e70325. https://doi.org/10.1371/journal.pone.0070325 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/56273


Panayiotou, E., Panayi, E., Lapathitis, G., Francius, C., Clotman, F., Kessaris, N., Richardson, W. D., & Malas, S. (2013). Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice. Gene Expression Patterns, 13(8), 328-334. https://doi.org/10.1016/j.gep.2013.06.004 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/63859


Audouard, E., Schakman, O., Ginion, A., Bertrand, L., Gailly, P., & Clotman, F. (2013). The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development. Molecular and Cellular Neuroscience, 56, 159-168. https://doi.org/10.1016/j.mcn.2013.05.001 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/56592


Papier de conférence

Stanga, S., Tasiaux, B., Clotman, F., & Kienlen-Campard, P. (2013). APP-dependent regulation of GDNF expression and its involvement in neuromuscular junction. BELSPO IAP NEUROBRAINNET, VIB Antwerpen, Belgium.

https://research.dial.uclouvain.be/handle/2078.5/56614


2012
Article de journal

Chakrabarty, K., Von Oerthel, L., Hellemons, A., Clotman, F., Espana-Bessy, A., Groot Koerkamp, M., Holstege, F. C. P., Pasterkamp, R. J., & Smidt, M. P. (2012). Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biology Open, 1(8), 693-704. https://doi.org/10.1242/bio.20121230 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/56878


Roy, A., Francius, C., Rousso, D. L., Seuntjens, E., Debruyn, J., Luxenhofer, G., Huber, A. B., Huylebroeck, D., Novitch, B. G., & Clotman, F. (2012). Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (Cambridge, England), 139(17), 3109-3119. https://doi.org/10.1242/dev.078501 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/56284


Espana-Bessy, A., & Clotman, F. (2012). Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Molecular and Cellular Neuroscience, 50(1), 93-102. https://doi.org/10.1016/j.mcn.2012.04.002 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/63863


Audouard, E., Schakman, O., René, F., Huettl, R.-E., Huber, A. B., Loeffler, J.-P., Gailly, P., & Clotman, F. (2012). The Onecut Transcription Factor HNF-6 Regulates in Motor Neurons the Formation of the Neuromuscular Junctions. PLoS One, 7(12), e50509. https://doi.org/10.1371/journal.pone.0050509 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/57187


2011
Article de journal

Espana-Bessy, A., & Clotman, F. (2011). Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. The Journal of Comparative Neurology, 520(7), 1424-1441. https://doi.org/10.1002/cne.22803 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/56873


Stam, F. J., Hendricks, T. J., Zhang, J., Geiman, E. J., Francius, C., Labosky, P. A., Clotman, F., & Goulding, M. (2011). Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development, 139(1), 179-190. https://doi.org/10.1242/dev.071134 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/57193


2010
Article de journal

Francius, C., & Clotman, F. (2010). Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience, 165(1), 116-129. https://doi.org/10.1016/j.neuroscience.2009.09.076 (Original work published 2010)

https://research.dial.uclouvain.be/handle/2078.5/56574


2009
Article de journal

Antoniou, A., Raynaud, P., Cordi, S., Zong, Y., Tronche, F., Stanger, B., Jacquemin, P., Pierreux, C., Clotman, F., & Lemaigre, F. (2009). Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9. Gastroenterology, 136(7), 2325-2333. https://doi.org/10.1053/j.gastro.2009.02.051 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/58888


2008
Papier de conférence

Espana, A., & Clotman, F. (2008). Roles of the onecut transcription factors in catecholaminergic neuron differentiation. International Journal of Developmental Neuroscience, 26(8), 875. https://doi.org/10.1016/j.ijdevneu.2008.09.151 (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/63865


Article de journal

Margagliotti, S., Clotman, F., Pierreux, C., Lemoine, P., Rousseau, G., Henriet, P., & Lemaigre, F. (2008). Role of metalloproteinases at the onset of liver development. Development, Growth and Differentiation, 50(5), 331-338. https://doi.org/10.1111/j.1440-169X.2008.01031.x (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/135974


Clotman, F., Libbrecht, L., Killingsworth, M. C., Loo, C. C. K., Roskams, T., & Lemaigre, F. (2008). Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome. Liver International, 28(3), 377-384. https://doi.org/10.1111/j.1478-3231.2007.01617.x (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/99138


2007
Article de journal

Margagliotti, S., Clotman, F., Pierreux, C., Beaudry, J.-B., Jacquemin, P., Rousseau, G., & Lemaigre, F. (2007). The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Developmental Biology Journal, 311(2), 579-589. https://doi.org/10.1016/j.ydbio.2007.09.013 (Original work published 2007)

https://research.dial.uclouvain.be/handle/2078.5/133824


2006
Article de journal

Veiga da Cunha, M., Jacquemin, P., Delpierre, G., Théate, I., Vertommen, D., Clotman, F., Lemaigre, F., Devuyst, O., & Van Schaftingen, E. (2006). Increased protein glycation in fructosamine 3-kinase-deficient mice. The Biochemical Journal, 399(2), 257-264. https://doi.org/10.1042/BJ20060684 (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/97173


Pierreux, C., Poll, A. V., Kemp, C. R., Clotman, F., Maestro, M. A., Cordi, S., Ferrer, J., Leyns, L., Rousseau, G., & Lemaigre, F. (2006). The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology, 130(2), 532-541. https://doi.org/10.1053/j.gastro.2005.12.005 (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/97176


Clotman, F., & Lemaigre, F. (2006). Control of hepatic differentiation by activin/TGFbeta signaling. Cell Cycle, 5(2), 168-171. https://doi.org/10.4161/cc.5.2.2341 (Original work published 2006)

https://research.dial.uclouvain.be/handle/2078.5/95906


2005
Article de journal

Clotman, F., Courtoy, P., Jacquemin, P., Plumb-Rudewiez, N., Pierreux, C., Van Der Smissen, P., Dietz, H. C., Rousseau, G., & Lemaigre, F. (2005). Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes & Development, 19(16), 1849-1854. https://doi.org/10.1101/gad.340305 (Original work published 2005)

https://research.dial.uclouvain.be/handle/2078.5/130185


2004
Article de journal

Plumb-Rudewiez, N., Clotman, F., Strick-Marchand, H., Pierreux, C., Weiss, M. C., Rousseau, G., & Lemaigre, F. (2004). Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology (Baltimore, Md.), 40(6), 1266-1274. https://doi.org/10.1002/hep.20459 (Original work published 2004)

https://research.dial.uclouvain.be/handle/2078.5/95982


Briançon, N., Bailly, A., Clotman, F., Jacquemin, P., Lemaigre, F., & Weiss, M. C. (2004). Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver. Journal of biological chemistry, 279(32), 33398-33408. https://doi.org/10.1074/jbc.M405312200 (Original work published 2004)

https://research.dial.uclouvain.be/handle/2078.5/97437


2003
Article de journal

Clotman, F., Libbrecht, L., Gresh, L., Yaniv, M., Roskams, T., Rousseau, G., & Lemaigre, F. (2003). Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development. Journal of Hepatology, 39(5), 686-692. https://doi.org/10.1016/S0168-8278(03)00409-4 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/95698


Bouzin, C., Clotman, F., Renauld, J.-C., Lemaigre, F., & Rousseau, G. (2003). The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. Journal of Immunology, 171(3), 1297-1303. https://doi.org/10.4049/jimmunol.171.3.1297 (Original work published 2003)

https://research.dial.uclouvain.be/handle/2078.5/131931


2002
Article de journal

Clotman, F., Lannoy, V. J., Reber, M., Cereghini, S., Cassiman, D., Jacquemin, P., Roskams, T., Rousseau, G., & Lemaigre, F. (2002). The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development (Cambridge, England), 129(8), 1819-1828. (Original work published 2002)

https://research.dial.uclouvain.be/handle/2078.5/96841


2000
Article de journal

Clotman, F., De Backer, O., Boon, T., De Plaen, E., & Picard, J. (2000). Cell- and stage-specific expression of mage genes during mouse spermatogenesis. Mammalian Genome, 11(8), 696-699. https://doi.org/10.1007/s003350010116 (Original work published 2000)

https://research.dial.uclouvain.be/handle/2078.5/57203


1999
Article de journal

Carmeliet, P., Moons, L., Lampugnani, M. G., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M., Zanetti, A., Angellilo, A., Mattot, V., Nuyens, D., Lutgens, E., Clotman, F., de Ruiter, M. C., Gittenberger-de Groot, A., Poelmann, R., et al. (1999). Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell, 98(2), 147-157. (Original work published 1999)

https://research.dial.uclouvain.be/handle/2078.5/56888


Gofflot, F., Kolf-Clauw, M., Clotman, F., Roux, C., & Picard, J. (1999). Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome. American Journal of Medical Genetics, 87(3), 207-216. https://doi.org/10.1002/(SICI)1096-8628(19991126)87:3<207::AID-AJMG3>3.0.CO;2-5 (Original work published 1999)

https://research.dial.uclouvain.be/handle/2078.5/130693


1998
Article de journal

Clotman, F., Van Maele, G., Chu-Wu, L., & Picard, J. (1998). Structural and gene expression abnormalities induced by retinoic acid in the forebrain. Reproductive Toxicology, 12(2), 169-176. https://doi.org/10.1016/S0890-6238(97)00151-2 (Original work published 1998)

https://research.dial.uclouvain.be/handle/2078.5/56638


Clotman, F., Van Maele, G., & Picard, JJ. (1998). All-trans-retinoic acid upregulates the expression of COUP-TFI in early-somite mouse embryos cultured in vitro. Neurotoxicology and Teratology, 20(6), 591-599. https://doi.org/10.1016/S0892-0362(98)00018-X (Original work published 1998)

https://research.dial.uclouvain.be/handle/2078.5/56628


1997
Article de journal

Rosen, E., Chan, J., Idusogie, E., Clotman, F., Vlasuk, G., Luther, T., Jalbert, L., Albrecht, S., Zhong, L., Lissens, A., Schoonjans, L., Moons, L., Collen, D., Castellino, F., & Carmeliet, P. (1997). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature : international weekly journal of science, 390(6657), 290-294. https://doi.org/10.1038/36862 (Original work published 1997)

https://research.dial.uclouvain.be/handle/2078.5/57162


Clotman, F., Van Maele, G., & Picard, J. (1997). Retinoic acid induces a tissue-specific deletion in the expression domain of Otx2. Neurotoxicology and Teratology, 19(3), 163-169. https://doi.org/10.1016/S0892-0362(97)00017-2 (Original work published 1997)

https://research.dial.uclouvain.be/handle/2078.5/132296


Landry, C., Clotman, F., Hioki, T., Oda, H., Picard, J., Lemaigre, F., & Rousseau, G. (1997). HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Developmental Biology Journal, 192(2), 247-257. https://doi.org/10.1006/dbio.1997.8757 (Original work published 1997)

https://research.dial.uclouvain.be/handle/2078.5/130209


Van Maele, G., Clotman, F., Gofflot, F., Bosschaert, J., & Picard, J. (1997). Postimplantation mouse embryos cultured in vitro : Assessment with whole-mount immunostaining and in situ hybridization. The International Journal of Developmental Biology, 41(2), 365-374. (Original work published 1997)

https://research.dial.uclouvain.be/handle/2078.5/132305


Papier de conférence

Clotman, F., Vanmaelefabry, G., & Picard, JJ. (1997). Deletion of a specific region of the expression domain of Otx2 in early mouse embryos exposed in vitro to AT-retinoic acid. Developmental Biology, 186(2), B185-B185. (Original work published 1997)

https://research.dial.uclouvain.be/handle/2078.5/56891


1996
Article de journal

Van Maele, G., Clotman, F., & Picard, J. (1996). Exogenously added retinoic acid effects on expression of Otx2 and on morphology in early mouse embryos. Hunan Shifan Daxue Xuebao (Ziran Kexue Ban), 19(3), 47-53. (Original work published 1996)

https://research.dial.uclouvain.be/handle/2078.5/110353


Thèse

Clotman, F. (1996). Modifications des domaines d’expression de gènes du développement induites par l’acide rétinoïque sous la forme all-trans chez des embryons de souris cultivés in vitro.

https://research.dial.uclouvain.be/handle/2078.5/57594


1995
Article de journal

Van Maele, G., Gofflot, F., Clotman, F., & Picard, J. (1995). Alterations of mouse embryonic branchial nerves and ganglia induced by ethanol. Neurotoxicology and Teratology, 17(4), 497-506. https://doi.org/10.1016/0892-0362(95)00009-G (Original work published 1995)

https://research.dial.uclouvain.be/handle/2078.5/132373


Unités d'enseignement pour 2026

Libellé Code
Animal and human cellular physiology LBBMC2111
Biologie animale intégrée : coordination, perception et locomotion LBIO1236
Neurobiologie LBIO1349
Année Libellé Établissement
1996 Docteur en sciences UCLouvain | Université catholique de Louvain (Belgique)
1994 Diplômé d'études approfondies en biologie UCLouvain | Université catholique de Louvain (Belgique)
1991 Licencie en sciences (groupe des sciences zoologiques) UCLouvain | Université catholique de Louvain (Belgique)
1989 Candidat en sciences pour le groupe des sciences biologiques UCLouvain | Université catholique de Louvain (Belgique)