Laure Bindels

Professeure

SSS/FASB Faculté de pharmacie et des sciences biomédicales (FASB)

SSS/LDRI Louvain Drug Research Institute (LDRI)

Dr. Laure Bindels obtained the title of pharmacist and completed her PhD training as an FNRS fellow at the Université catholique de Louvain in Belgium. Her PhD research established the therapeutic potential of prebiotics and probiotics in managing tumor progression and associated cachexia. During her postdoctoral tenure at the University of Nebraska-Lincoln in the USA, she demonstrated that resistant starches can enhance insulin sensitivity independently of the gut microbiota. During this time, she trained herself in bioinformatics and biostatistics.

Currently, Dr. Bindels serves as an Associate Professor at the Université catholique de Louvain and is a WELRI investigator. She is an internationally recognized expert in the mechanisms linking the gut microbiota with cancer cachexia and metabolic and inflammatory disorders, a research focus she is exploring with her team. She is also a lecturer at the Faculty of Pharmaceutical and Biomedical Sciences where her current teaching topics include toxicology, nutrition, cancer, analytical chemistry and drug metabolism.

Dr. Bindels has received numerous accolades, including the Collen-Francqui Research Professor Mandate (2022-2025), the Galien Prize (2024), the Bekales Prize (2024), the Dr. Maes Prize (2023) and the Pharmabiotics Young Investigators Award (2018). Additionally, she holds editorial positions as an Associate Editor for JCSM and Senior Editor for Microbiome and acts as a Board Director for the Cancer Cachexia Society. More information on her research can be found in the CV and Research projects tabs.

Adresse postale

LDRI - Van Helmont
B1.73.11
Avenue Mounier 73
1200 Woluwe-Saint-Lambert

LDRI

73 - Van Helmont
Étage 03 Bureau 6038
Avenue Mounier 73
1200 Woluwe-Saint-Lambert

Téléphone : 024362185

CURRENT POSITION & TITLES

Associate Professor in Pharmaceutical and Biomedical Sciences & PI in the Metabolism and Nutrition Research Group (UCLouvain, tenured since 2020)

Louvain Drug Research Institute. August 2016 – ongoing. “Harnessing the therapeutic potential of the gut microbiota for cancer and cachexia: beyond the usual suspects”

Welbio Investigator (Wel Research Institute). May 2022 - ongoing

Collen-Francqui Research Professor. September 2022 - ongoing

PREVIOUS POSITIONS

FNRS Post-doctoral Researcher (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. July 2014 – August 2016. “Gut microbiota as a causative factor for cancer-related cachexia: involvement of the gut barrier function”

Post-doctoral Research Associate (University of Nebraska-Lincoln, NE, USA) in the Mucosal Immunology Lab, Prof Amanda Ramer-Tait and in the Gastrointestinal Microbiology Lab, Prof Jens Walter. July 2013 – June 2014. “Role of the gut microbiota in the metabolic improvements induced by resistant starches in obese mice”

Post-doctoral Researcher (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. April 2013 - June 2013. Walloon Region-funded project (NutriGUTior) dedicated to the investigation of nutritional compounds to improve intestinal health in the elderly

FNRS fellow (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. October 2008 - March 2013. “Gut-immunity relationship in the control of cachexia associated with tumour development: role of the gut microbiota.”

EDUCATION

UCLouvain leadership program. Since 2022.
Roo programming and package development. A one-day intensive workshop. October 2019.
MixOmics workshop (20h). A two-day intensive workshop on multi -omics data integration. November 17.
15.071x The Analytics Edge (MITx-edX) (90h). A course for multivariate and logistic analyses of large datasets organized by the Massachusetts Institute of Technology, Massachusetts, MA, USA. February – May 2015.
European Nutrition Leadership Program (ENLP). April 2015.
Intercultural Leadership skills workshop for postdocs supported by Prins Filip Fonds. September 2014.
Perl Programming for Biological Applications (UNL, 3 credits, 75h). September-December 2013.
Intensive one-week workshop: “Next-generation sequencing technologies and bioinformatics analyses” with Dr Ines Martinez, University of Nebraska-Lincoln, NE, USA. August 2013.
PhD in Biomedical and Pharmaceutical Sciences (UCLouvain). Role of gut microbiota modulation in the control of cancer progression and associated cachexia. Thesis director: Prof. Nathalie Delzenne, Université catholique de Louvain (UCLouvain), Belgium. Mars 2013.
First Nutrimetabonomics Workshop (University of Reading, UK). April 2012.
Master in Animal Experimentation (UCLouvain). June 2009.
Pharmacist (UCLouvain). June 2008.

PRIZES & AWARDS

Fondation Bekales Prize (Académie royale de Médecine de Belgique) (2025)
Galien Prize for best pharmacological project (2024)
Prize Dr Jean-Oscar Maes (triennal prize from the UCLouvain) (2023)
Collen-Francqui Research Professorship Mandate (2022-2025)
Pharmabiotics Young Investigators Award (2018), to fund future research
Prize Docteur Maurice Godin-Maria Savelkoul (Académie royale de Médecine de Belgique) (2016)
Scholarship for the Next Gen Immunology 2016 meeting sponsored by the Weizmann Systems Biology initiative (2016)
Award Danone Institute for the best popular article in nutrition (2015)
Young Investigator Award from the Society on Cachexia and Wasting Disorders (2015)
Nebraska Gateway to Nutrigenomics Research Award (2014)
Honorary Fellowship from the B.A.E.F. (Belgian American Education Foundation) (2014)
Early Career Investigator Travel Fellowship from the New York Academy of Sciences (2013)
Keystone Symposium Scholarship, grant from the NIH, Colorado, USA (2012)
Prize of Excellence for the research activities conducted as undergrad student, UCL, Belgium (2008)
“Pharmacist & Doctor Nedeljkovitch” Award, Belgian Society of Pharmaceutical Sciences, Belgium (2008)

Last updated: July 2025

RESEARCH TOPIC

My current research team is dedicated to the development of novel therapies for cancer cachexia based on our mechanistic exploration of the gut microbiota-host crosstalk. Cancer cachexia is a multifactorial syndrome characterized by body weight loss, anorexia, muscle atrophy, fat depletion and systemic inflammation. Clinically, cancer cachexia results in increased morbidity and mortality rates as well as reduced tolerance to anti-cancer treatments. The gut microbiota consists of the trillions of microbes that reside in the gastrointestinal tract of mammals, and has a vast impact on host physiology and metabolism. Studying the gut microbiota as a therapeutic target constitutes an innovative approach to this pathology, an approach currently followed by my team. Additional projects focus on the role of bacterial and microbial metabolites in various metabolic disorders, including kidney-related cachexia, and in the modulation of drug pharmacokinetics.

A summary of our key research results regarding the gut microbiota-host crosstalk in cancer cachexia can be found here. The video abstract of our publication on the gut microbiota and drug pharmacokinetics can be seen here. Recorded presentations can be found here (Cancer Cachexia Seminars, April 2021) and here (44^th ESPEN Congress, September 2022).

We are always looking for highly motivated PhD and master students to perform their thesis or project work in our group. If you are interested, please reach out and let us know about your motivations.

CURRENT LAB MEMBERS UNDER MY SUPERVISION

Dr Audrey Neyrinck, qualified researcher
Dr Xiaolin Li, Posdoctoral fellow
Sophie Lecop, PhD fellow (Thesis director)
Alice Barbé, PhD fellow (Thesis co-director)
Dr Inès Dufour, PhD fellow (Thesis director)
Edwie Piron, PhD fellow (Thesis director)
Stéphanie Delieux, technician in medical biology
Bouazza Es Saadi, technician in medical biology
Marine Olivier, technician in medical biology
Luc Gesche, technician assistant
Hoang Nguyen, financial account manager

A full list of our group with shared technical and logistical expertise can be found here.

SELECTED INVITATIONS TO INTERNATIONAL CONFERENCES AND SYMPOSIUMS

IS: invited speaker; SA: selected abstract for oral communication.

2024 (IS) 5th Self-care Dialysis Symposium, Brussels, Belgium.

2024 (IS) Keystone Symposium, Novato, CA, USA.

2023 (IS) Cachexia Conference, CCS, Edinburgh, UK.

2023 (IS) 45^th ESPEN Congress, Lyon France.

2023 (IS) Berchtesgarden Microbiome Science Days, Berchtesgaden, Germany.

2023 (IS) Cachexia conference, SCWD, Stockholm, Sweden.

2023 (IS) Microbiota INSERM Workshop, Bordeaux, France.

2022 (IS) Conference of the JIRU-MicroMeNu, Rome, Italy.

2022 (IS) CRC1382 International Symposium, Aachen, Germany.

2022 (IS) London Microbiome Meeting, online meeting.

2020 (IS) 44^th ESPEN Congress, Vienne, Austria.

2022 (IS) Cachexia Conference, SCWD, Lisbon, Portugal.

2022 (IS) ISAPP meeting, Barcelona, Spain.

2022 (IS) Frontiers in Host-Microbiota Symbiotic Interactions Symposium, Berlin, Germany.

2021 (IS) Nature Conference, online meeting, initially planned in San Diego, California, USA.

2021 (IS) Ag & Health Summit, online meeting, initially planned in Lincoln, Nebraska, USA.

2021 (IS) New York Academy of Science Conference, online meeting.

2020 (IS) 42^st ESPEN Congress, online meeting. Muscle modulation by the gut microbiota.

2019 (IS) International Symposium DeSève chair, Brussels, Belgium.

2019 (IS) EHMSG Workshop, Innsbruck, Austria.

2019 (IS) 41^st ESPEN Congress, ESPEN Research fellow, Krakow, Poland.

2019 (IS) CDDF multi-stakeholder workshop, Munich, Germany.

2018 (SA) Cachexia Conference, SCWD, Maastricht, the Netherlands.

2018 (IS) Pharmabiotics, Paris, France. Pharmabiotics Investigator Award.

2018 (IS) Keystone Symposium, Banff, Canada.

2017 (IS) Beneficial Microbes Conference, Amsterdam, the Netherlands. Keynote topic.

2017 (IS) Berchtesgaden Microbiome Science Days, Berchtesgaden, Germany.

2017 (IS) Wellcome Trust Scientific Conference, Hinxton, UK.

2016 (IS) NuGO week, Copenhagen, Denmark.

2016 (IS) Annual Meeting of the American Society for Microbiology (ASM), Boston, USA. Plenary session.

2015 (IS) International Society of Cancer Metabolism, Venice, Italy. Keynote speaker.

2015 (IS) Physiology, Cardiff, UK.

2015 (SA) Cachexia Conference, SCWD, Paris, France. Young Investigators Award (265 abstracts).

2014 (SA) Targeting Microbiota, Paris, France.

2012 (SA) ISAPP meeting, Cork, Ireland.

Invited speaker in international and national events (26/11), local seminars (17) and educational seminars (9). A full list of my oral communications is available here.

Last updated: July 2025.

Année	Libellé	Établissement
2013	Docteur en sciences biomédicales et pharmaceutiques	Université catholique de Louvain (Belgique)
2008	Pharmacienne	Université catholique de Louvain (Belgique)

SELECTED RESEARCH ARTICLES

• Thibaut MM, Roumain M, Piron E, Gillard J, Loriot A, Neyrinck AM, Rodriguez J, Massart I, Thissen JP, Huot JR, Pin F, Bonetto A, Delzenne NM, Muccioli GG, Bindels LB. The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia. Gut Microbes 2025.

• Pötgens SA, Havelange V, Lecop S, Li F, Neyrinck AM, Bindels F, Neveux N, Demoulin JB, Moors I, Kerre T, Maertens J, Walter J, Schoemans H, Delzenne NM, Bindels LB. Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia. Haematologica 2024.

• Lefevre C, Thibaut MM, Loumaye A, Thissen JP, Neyrinck AM, Navez B, Delzenne NM, Feron O, Bindels LB. Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis, Mol Metab 2024.

• Degraeve A, Haufroid V, Loriot A, Gatto L, Andries V, Vereecke L, Elens L*, Bindels LB*. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1, Microbiome 2023 (cited 31 times).

• Dolly A, Pötgens SA*, Thibaut MM*, Neyrinck AM, de Castro GS, Galbert C, Lefevre C, Wyart E, Gomes SP, Gonçalves DC, Lanthier N, Baldin P, Huot JR, Bonetto A, Seelaender M, Delzenne NM, Sokol H, Bindels LB. Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia. J Cach Sarc Muscle 2023.

• Pötgens SA, Thibaut MM, Joudiou N, Sboarina M, Neyrinck AM, Cani PD, Claus SP, Delzenne NM, Bindels LB. Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice, J Cach Sarc Muscle 2021 (cited 44 times).

• Bindels LB, Segura Munoz R, Gomes Neto JC, Mutemberezi V, Martínez I, Salazar N, Cody EA, Quintero-Villegas MI, Kittana H, de los Reyes-Gavilán CG, Schmaltz RJ, Muccioli GG, Walter J, Ramer-Tait AE. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome 2017 (cited 122 times).

• Bindels LB, Neyrinck AM, Claus SP, Le Roy CI, Grangette C, Pot B, Martinez I, Walter J, Cani PD, Delzenne NM. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia, The ISME J 2016 (cited 163 times).

• Bindels LB, Porporato P, Dewulf EM, Verrax J, Neyrinck AM, Martin JC, Scott KP, Buc CP, Feron O, Muccioli GG, Sonveaux P, Cani PD, Delzenne NM. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver, Br J Cancer 2012 (cited 247 times).

• Bindels LB, Beck R, Schakman O, Martin JC, De Backer FC, Sohet FM, Dewulf EM, Pachikian BD, Neyrinck AM, Thissen JP, Verrax J, Buc Calderon P, Pot B, Grangette C, Cani PD, Delzenne NM. Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model, PLoS One 2012 (cited 218 times).

SELECTED REVIEWS, COMMENTARIES & EDITORIALS

• Bindels LB, Watts JEM, Theis KR, Carrion VJ, Ossowicki A, Seifert J, Oh J, Shao Y, Hilty M, Kumar P, Hildebrand F, Lovejoy C, Wigley P, Yu K, Zhang M, Zhang T, Walter J, Desai MS, Huws SA, Schriml LM, Ravel J, Fricke WF, Eloe-Fadrosh EA, Lee CK, Clavel T. A blueprint for contemporary studies of microbiomes. Microbiome 2025.

• Dufour I, Bindels LB, Goffin E. Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med 2025.

• Delzenne NM, Bindels LB, Neyrinck AM, Walter J. The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer. Nat Rev Microbiol 2025.

• Thibaut MM, Bindels LB. Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends Mol Med 2022 (cited 100 times).

• Delzenne NM, Bindels LB. Food for thought about manipulating gut bacteria. Nature 2020.

• Bindels LB, Delzenne NM, Cani PD, Walter J. Opinion: towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 2015 (cited 753 times).

Last updated: July 2025

2026

Article de journal

Degraeve, A., Cutignano, A., Piscitelli, F., Villano, R., De Simone, G., Verde, R., Thibaut, M., Bindels, L., & Di Marzo, V. (2026). Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis. BJC reports, 4(1), 7 [1-12]. https://doi.org/10.1038/s44276-026-00208-y (Original work published 2026)

https://research.dial.uclouvain.be/handle/2078.5/273501

Morigny, P., Vondrackova, M., Ji, H., Brejchova, K., Krakovkova, M., Makris, K., Trubacova, R., Samanci, T. F., Kaltenecker, D., Ng, S.-P., Karthikaisamy, V., Chrysostomou, S. E., Bidovec, A., Ponce-de-Leon, M., Krauss, T., Seeliger, C., Prokopchuk, O., Martignoni, M. E., Claussnitzer, M., et al. (2026). Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer. Nature Metabolism, 1-47. https://doi.org/10.1038/s42255-025-01434-3 (Original work published 2026)

https://research.dial.uclouvain.be/handle/2078.5/270638

2025

Article de journal

Thibaut, M., Roumain, M., Piron, E., Gillard, J., Loriot, A., Neyrinck, A., Rodriguez, J., Massart, I., Thissen, J.-P., Huot, J. R., Pin, F., Bonetto, A., Delzenne, N., Muccioli, G., & Bindels, L. (2025). The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia. Gut microbes, 17(1), 2449586 [1-26]. https://doi.org/10.1080/19490976.2025.2449586 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/239170

Delzenne, N., Bindels, L., Neyrinck, A., & Walter, J. (2025). The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer. Nature Reviews. Microbiology, 23(4), 225-238. https://doi.org/10.1038/s41579-024-01108-z (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/246426

Neyrinck, A., Rodriguez, J., Robles Sanchez, C., Autuori, M., Cani, P., Bindels, L., Bindelle, J., & Delzenne, N. (2025). Interest of inulin in obesity: comparison of the prebiotic effect of edible-food sources versus purified inulin from chicory root. European Journal of Nutrition, 64(4), 148 [1-17]. https://doi.org/10.1007/s00394-025-03640-x (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/244144

Chaouki, G., Parry, L., Vituret, C., Jousse, C., Leremboure, M., Bourgne, C., Mosoni, L., Delorme, Y., Djelloul-Mazouz, M., Hermet, J., Averous, J., Bruhat, A., Combaret, L., Taillandier, D., Papet, I., Bindels, L., Fafournoux, P., & Maurin, A.-C. (2025). Pre-cachectic changes in amino acid homeostasis precede activation of eIF2α signaling in the liver at the onset of C26 cancer-induced cachexia. iScience, 28(3), 112030 [1-20]. https://doi.org/10.1016/j.isci.2025.112030 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/242296

Neyrinck, A., Ahmed, H., Leyrolle, Q., Leclercq, S., Amadieu, C., Meuronen, T., Layé, S., Cani, P., Kärkkäinen, O., Bindels, L., Hanhineva, K., & Delzenne, N. (2025). Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health. Scientific Reports, 15(1), 15455 [1-13]. https://doi.org/10.1038/s41598-025-99047-z (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/246281

Bindels, L., Watts, J. E. M., Theis, K. R., Carrion, V. J., Ossowicki, A., Seifert, J., Oh, J., Shao, Y., Hilty, M., Kumar, P., Hildebrand, F., Lovejoy, C., Wigley, P., Yu, K., Zhang, M., Zhang, T., Walter, J., Desai, M. S., Huws, S. A., et al. (2025). A blueprint for contemporary studies of microbiomes. Microbiome, 13(1), 95 [1-9]. https://doi.org/10.1186/s40168-025-02091-0 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/243389

Delzenne, N., & Bindels, L. (2025). The Prebiotic Concept in Nutrition Celebrates its 30th Anniversary. The Journal of Nutrition. Accepted/in-press. https://doi.org/10.1016/j.tjnut.2025.05.046 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/246429

Dufour, I., Bindels, L., & Goffin, E. (2025). Ponsegromab for the Treatment of Cancer Cachexia. The New England journal of medicine, 392(10), 1035. https://doi.org/10.1056/NEJMc2500502 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/267486

Amadieu, C., Ahmed, H., Leclercq, S., Koistinen, V., Leyrolle, Q., Starkel, P., Bindels, L., Layé, S., Neyrinck, A., Kärkkäinen, O., de Timary, P., Hanhineva, K., & Delzenne, N. (2025). Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention. Clinical Nutrition ESPEN, 66, 361-371. https://doi.org/10.1016/j.clnesp.2025.01.046 (Original work published 2025)

https://research.dial.uclouvain.be/handle/2078.5/241698

2024

Article de journal

Berger, M. M., Amrein, K., Barazzoni, R., Bindels, L., Bretón, I., Calder, P. C., Cappa, S., Cuerda, C., D’Amelio, P., de Man, A., Delzenne, N., Forbes, A., Genton, L., Gombart, A. F., Joly, F., Laviano, A., Matthys, C., Phyo, P. P., Ravasco, P., et al. (2024). The science of micronutrients in clinical practice - Report on the ESPEN symposium. Clinical Nutrition, 43(1), 268-283. https://doi.org/10.1016/j.clnu.2023.12.006 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/26649

Simonson, M., Cueff, G., Thibaut, M., Giraudet, C., Salles, J., Chambon, C., Boirie, Y., Bindels, L., Gueugneau, M., & Guillet, C. (2024). Skeletal Muscle Proteome Modifications following Antibiotic-Induced Microbial Disturbances in Cancer Cachexia. Journal of Proteome Research, 23(7), 2452-2473. https://doi.org/10.1021/acs.jproteome.4c00143 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/240000

Pötgens, S., Havelange, V., Lecop, S., Li, F., Neyrinck, A., Bindels, F., Neveux, N., Demoulin, J. B., Moors, I., Kerre, T., Maertens, J., Walter, J., Schoemans, H., Delzenne, N., & Bindels, L. (2024). Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia. Haematologica, 109(10), 3194-3208. https://doi.org/10.3324/haematol.2023.284138 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/214669

Degraeve, A., Bindels, L., Haufroid, V., Moudio Ebosse Timba, M. S., Boland, L., Delongie, K.-A., Dewulf, J., Chaib Eddour, D., Mourad, M., & Elens, L. (2024). Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study. Clinical Pharmacology and Therapeutics, 115(1), 104-115. https://doi.org/10.1002/cpt.3077 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/273085

Van Hul, M., Neyrinck, A., Everard, A., Abot, A., Bindels, L., Delzenne, N., Knauf, C., & Cani, P. (2024). Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities. Clinical Microbiology Reviews, e0004523. https://doi.org/10.1128/cmr.00045-23 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/218134

Muñoz-Fernandez, S. S., Garcez, F. B., Alencar, J. C. G., Bastos, A. A., Morley, J. E., Cederholm, T., Aprahamian, I., de Souza, H. P., Avelino-Silva, T. J., Bindels, L., & Ribeiro, S. M. L. (2024). Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes. Nutrition : an international journal of applied and basic nutritional science, 112369. https://doi.org/10.1016/j.nut.2024.112369 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/29832

Gillard, J., Roumain, M., Picalausa, C., Thibaut, M., Clerbaux, L.-A., Tailleux, A., Staels, B., Muccioli, G., Bindels, L., & Leclercq, I. (2024). A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. JHEP Reports, 6(11), 101148 [1-11]. https://doi.org/10.1016/j.jhepr.2024.101148 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/274828

Moens de Hase, E., Neyrinck, A., Rodriguez, J., Cnop, M., Paquot, N., Thissen, J.-P., Xu, Y., Beloqui Garcia, A., Bindels, L., Delzenne, N., Van Hul, M., & Cani, P. (2024). Impact of metformin and Dysosmobacter welbionis on diet-induced obesity and diabetes: from clinical observation to preclinical intervention. Diabetologia : clinical and experimental diabetes and metabolism, 67(2), 333-345. https://doi.org/10.1007/s00125-023-06032-0 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/30342

Lefevre, C., Thibaut, M., Loumaye, A., Thissen, J.-P., Neyrinck, A., Navez, B., Delzenne, N., Feron, O., & Bindels, L. (2024). Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis. Molecular Metabolism, 83, 101930 [1-18]. https://doi.org/10.1016/j.molmet.2024.101930 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/213070

Massart, I., Kouakou, A.-n., Pelet, N., Lause, P., Schakman, O., Loumaye, A., Abou Samra, M., Deldicque, L., Bindels, L., Brichard, S., & Thissen, J.-P. (2024). Administration of adiponectin receptor agonist AdipoRon relieves cancer cachexia by mitigating inflammation in tumour-bearing mice. Journal of Cachexia, Sarcopenia and Muscle, 1-15. https://doi.org/10.1002/jcsm.13454 (Original work published 2024)

https://research.dial.uclouvain.be/handle/2078.5/242397

2023

Article de journal

Dolly, A., Pötgens, S., Thibaut, M., Neyrinck, A., de Castro, G. S., Galbert, C., Lefevre, C., Wyart, E., Gomes, S. P., Gonçalves, D. C., Lanthier, N., Baldin, P., Huot, J. R., Bonetto, A., Seelaender, M., Delzenne, N., Sokol, H., & Bindels, L. (2023). Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 14(3), 1569-1582. https://doi.org/10.1002/jcsm.13246 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/239047

Cremer, J., Brohée, L., Dupont, L., Lefevre, C., Peiffer, R., Saarinen, A. M., Peulen, O., Bindels, L., Liu, J., Colige, A., & Deroanne, C. F. (2023). Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression. Cancer Letters, 569, 216306 [1-13]. https://doi.org/10.1016/j.canlet.2023.216306 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/29646

Falascina, G., Bindels, L., Di Marzo, V., & Cutignano, A. (2023). Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples. Journal of Pharmaceutical and Biomedical Analysis, 226, 115252 [1-8]. https://doi.org/10.1016/j.jpba.2023.115252 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/101813

Mbusa Kambale, R., Ntagazibwa, J. N., Kasengi, J. B., Zigashane, A. B., Francisca, I. N., Mashukano, B. N., Amani Ngaboyeka, G., Bahizire, E., Zech, F., Bindels, L., & Van der Linden, D. (2023). Probiotics for children with uncomplicated severe acute malnutrition (PruSAM study): A randomized controlled trial in the Democratic Republic of Congo. American Journal of Clinical Nutrition : a journal reporting the practical application of our world-wide knowledge of nutrition, 117(5), 976-984. https://doi.org/10.1016/j.ajcnut.2023.01.019 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/214438

Degraeve, A., Haufroid, V., Loriot, A., Gatto, L., Andries, V., Vereecke, L., Elens, L., & Bindels, L. (2023). Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. Microbiome, 11(1), 138 [1-20]. https://doi.org/10.1186/s40168-023-01578-y (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/214435

Zubiaga, L., Briand, O., Auger, F., Touche, V., Hubert, T., Thevenet, J., Marciniak, C., Quenon, A., Bonner, C., Peschard, S., Raverdy, V., Daoudi, M., Kerr-Conte, J., Pasquetti, G., Koepsell, H., Zdzieblo, D., Mühlemann, M., Thorens, B., Delzenne, N., et al. (2023). Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes. iScience, 26(4), 106057 [1-17]. https://doi.org/10.1016/j.isci.2023.106057 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/100393

Pötgens, S., Lecop, S., Havelange, V., Li, F., Neyrinck, A., Neveux, N., Maertens, J., Walter, J., Schoemans, H., Delzenne, N., & Bindels, L. (2023). Gut microbiota alterations induced by intensive chemotherapy in acute myeloid leukaemia patients are associated with gut barrier dysfunction and body weight loss. Clinical Nutrition, 42(11), 2214-2228. https://doi.org/10.1016/j.clnu.2023.09.021 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/214431

Bilson, J., Oquendo, C. J., Read, J., Scorletti, E., Afolabi, P. R., Lord, J., Bindels, L., Targher, G., Mahajan, S., Baralle, D., Calder, P. C., Byrne, C. D., & Sethi, J. K. (2023). Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD. Metabolism : clinical and experimental, 151, 155759 [1-12]. https://doi.org/10.1016/j.metabol.2023.155759 (Original work published 2023)

https://research.dial.uclouvain.be/handle/2078.5/26753

2022

Article de journal

Le Roy, T., Moens De Hase, E., Van Hul, M., Paquot, A., Pelicaen, R., Régnier, M., Depommier, C., Druart, C., Everard, A., Maiter, D., Delzenne, N., Bindels, L., de Barsy, M., Loumaye, A., Hermans, M., Thissen, J.-P., Vieira-Silva, S., Falony, G., Raes, J., et al. (2022). Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. Gut, 71, 534-543. https://doi.org/10.1136/gutjnl-2020-323778 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/110115

Amadieu, C., Coste, V., Neyrinck, A., Thijssen, V., Leyrolle, Q., Bindels, L., Piessevaux, H., Starkel, P., de Timary, P., Delzenne, N., & Leclercq, S. (2022). Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. Gut Microbes, 14(1), 2007042 [1-20]. https://doi.org/10.1080/19490976.2021.2007042 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/166926

Neyrinck, A., Rodriguez, J., Zhang, Z., Nazare, J.-A., Bindels, L., Cani, P., Maquet, V., Laville, M., Bischoff, S. C., Walter, J., & Delzenne, N. (2022). Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers. EBioMedicine, 80, 104051 [1-13]. https://doi.org/10.1016/j.ebiom.2022.104051 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/106190

Gillard, J., Clerbaux, L.-A., Nachit, M., Sempoux, C., Staels, B., Bindels, L., Tailleux, A., & Leclercq, I. (2022). Bile acids contribute to the development of non-alcoholic steatohepatitis in mice. JHEP Reports, 4(1), 100387 [1-13]. https://doi.org/10.1016/j.jhepr.2021.100387 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/274830

Neyrinck, A., Rodriguez, J., Taminiau, B., Herpin, F., Cani, P., Daube, G., Bindels, L., & Delzenne, N. (2022). Constipation Mitigation by Rhubarb Extract in Middle-Aged Adults Is Linked to Gut Microbiome Modulation: A Double-Blind Randomized Placebo-Controlled Trial. International journal of molecular sciences, 23(23), 14685 [1-15]. https://doi.org/10.3390/ijms232314685 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/106247

Thibaut, M., & Bindels, L. (2022). Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends in Molecular Medicine, 28(3), 223-236. https://doi.org/10.1016/j.molmed.2021.12.006 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/113827

Loumaye, A., Lause, P., Zhong, X., Zimmers, T. A., Bindels, L., & Thissen, J.-P. (2022). Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis. Cells, 11(7), 1119 [1-18]. https://doi.org/10.3390/cells11071119 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/25841

Wyart, E., Hsu, M. Y., Sartori, R., Mina, E., Rausch, V., Pierobon, E. S., Mezzanotte, M., Pezzini, C., Bindels, L., Lauria, A., Penna, F., Hirsch, E., Martini, M., Mazzone, M., Roetto, A., Geninatti Crich, S., Prenen, H., Sandri, M., Menga, A., & Porporato, P. E. (2022). Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia. EMBO reports, 23(4), e53746 [1-18]. https://doi.org/10.15252/embr.202153746 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/109673

Rodriguez, J., Neyrinck, A., Van Kerckhoven, M., Gianfrancesco, M. A., Renguet, E., Bertrand, L., Cani, P., Lanthier, N., Cnop, M., Paquot, N., Thissen, J.-P., Bindels, L., & Delzenne, N. (2022). Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals. BMC Medicine, 20(1), 110 [1-20]. https://doi.org/10.1186/s12916-022-02299-z (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/165988

Leyrolle, Q., Cserjesi, R., Demeure, R., Neyrinck, A., Amadieu, C., Rodriguez, J., Kärkkäinen, O., Hanhineva, K., Paquot, N., Cnop, M., Cani, P., Thissen, J.-P., Bindels, L., Klein, O., Luminet, O., & Delzenne, N. (2022). Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients. Nutrients, 14(1), 147-. https://doi.org/10.3390/nu14010147 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/238899

Aron-Wisnewsky, J., Lefevre, C., & Bindels, L. (2022). Interactions entre les traitements du diabète et le microbiote intestinal : état des connaissances et perspectives. Médecine des Maladies Métaboliques, 16(2), 148-159. https://doi.org/10.1016/j.mmm.2022.01.004 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/28729

Lefevre, C., & Bindels, L. (2022). Role of the Gut Microbiome in Skeletal Muscle Physiology and Pathophysiology. Current Osteoporosis Reports, 20(6), 422-432. https://doi.org/10.1007/s11914-022-00752-9 (Original work published 2022)

https://research.dial.uclouvain.be/handle/2078.5/27125

2021

Article de journal

Neyrinck, A., Rodriguez, J., Zhang, Z., Seethaler, B., Mailleux, F., Vercammen, J., Bindels, L., Cani, P., Nazare, J.-A., Maquet, V., Laville, M., Bischoff, S. C., Walter, J., & Delzenne, N. (2021). Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study. Gut microbes, 13(1), e1862028 [1-16]. https://doi.org/10.1080/19490976.2020.1862028 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/119799

Lanthier, N., Rodriguez, J., Nachit, M., Hiel, S., Trefois, P., Neyrinck, A., Cani, P., Bindels, L., Thissen, J.-P., & Delzenne, N. (2021). Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients. Scientific Reports, 11(1), 659 [1-14]. https://doi.org/10.1038/s41598-020-79718-9 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/167816

Leyrolle, Q., Cserjesi, R., Mulders, M. D. G. H., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Rodriguez, J., Portheault, D., Amadieu, C., Leclercq, S., Bindels, L., Neyrinck, A., Cani, P., Karkkainen, O., Haninheva, K., Lanthier, N., Trefois, P., Paquot, N., Cnop, M., et al. (2021). Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients. Clinical Nutrition, 40, 2035-2044. https://doi.org/10.1016/j.clnu.2020.09.025 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/167610

Neyrinck, A., Rodriguez, J., Taminiau, B., Amadieu, C., Herpin, F., Allaert, F.-A., Cani, P., Daube, G., Bindels, L., & Delzenne, N. (2021). Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial. Scientific Reports, 11(1), 2627 [1-12]. https://doi.org/10.1038/s41598-020-80947-1 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/117490

Thibaut, M., Gillard, J., Dolly, A., Roumain, M., Leclercq, I., Delzenne, N., Muccioli, G., & Bindels, L. (2021). Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. Cancers, 13(24), 6389 [1-17]. https://doi.org/10.3390/cancers13246389 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/216762

Lanthier, N., Rodriguez, J., Nachit, M., Hiel, S., Trefois, P., Neyrinck, A., Cani, P., Bindels, L., Thissen, J.-P., & Delzenne, N. (2021). Publisher Correction: Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients. Scientific Reports, 11(1), 6123. https://doi.org/10.1038/s41598-021-85083-y (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/164767

Nachit, M., Lanthier, N., Rodriguez, J., Neyrinck, A., Cani, P., Bindels, L., Hiel, S., Pachikian, B. D., Trefois, P., Thissen, J.-P., & Delzenne, N. (2021). A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients. JHEP Reports, 3(4), 100323 [1-10]. https://doi.org/10.1016/j.jhepr.2021.100323 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/165910

Bilson, J., Scorletti, E., Bindels, L., Afolabi, P. R., Targher, G., Calder, P. C., Sethi, J. K., & Byrne, C. D. (2021). Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD. Nutrition & diabetes, 11(1), 32 [1-9]. https://doi.org/10.1038/s41387-021-00170-3 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/111066

Leyrolle, Q., Cserjesi, R., D.G.H. Mulders, M., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Portheault, D., Amadieu, C., Bindels, L., Leclercq, S., Rodriguez, J., Neyrinck, A., Cani, P., Lanthier, N., Trefois, P., Bindelle, J., Paquot, N., Cnop, M., Thissen, J.-P., et al. (2021). Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial. Brain, Behavior, and Immunity, 94(May), 289-298. https://doi.org/10.1016/j.bbi.2021.01.014 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/167474

Neyrinck, A., Robles Sanchez, C., Rodriguez, J., Cani, P., Bindels, L., & Delzenne, N. (2021). Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice. Nutrients, 13(5), 1436 [1-13]. https://doi.org/10.3390/nu13051436 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/114334

Amadieu, C., Leclercq, S., Coste, V., Thijssen, V., Neyrinck, A., Bindels, L., Cani, P., Piessevaux, H., Starkel, P., de Timary, P., & Delzenne, N. (2021). Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder. Clinical Nutrition, 40(5), 2673-2682. https://doi.org/10.1016/j.clnu.2021.03.029 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/166583

La, C., de Toeuf, B., Bindels, L., Van Maele, L., Assabban, A., Melchior, M., Smout, J., Köhler, A., Nguyen, M., Thomas, S., Soin, R., Delacourt, N., Li, H., Hu, W., Blackshear, P. J., Kruys, V., Gueydan, C., Oldenhove, G., & Goriely, S. (2021). The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis. Mucosal Immunology, 14(11), 80-91. https://doi.org/10.1038/s41385-020-0302-x (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/118919

Pötgens, S., Thibaut, M., Joudiou, N., Sboarina, M., Neyrinck, A., Cani, P., Claus, S. P., Delzenne, N., & Bindels, L. (2021). Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice. Journal of Cachexia, Sarcopenia and Muscle, 1-20. https://doi.org/10.1002/jcsm.12684 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/272991

Knudsen, C., Neyrinck, A., Leyrolle, Q., Baldin, P., Leclercq, S., Rodriguez, J., Beaumont, M., Cani, P., Bindels, L., Lanthier, N., & Delzenne, N. (2021). Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice. The Journal of Nutrition, 151(6), 1507-1516. https://doi.org/10.1093/jn/nxab032 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/167014

Mbusa Kambale, R., Nancy, F. I., Ngaboyeka, G. A., Kasengi, J. B., Bindels, L., & Van der Linden, D. (2021). Effects of probiotics and synbiotics on diarrhea in undernourished children: Systematic review with meta-analysis. Clinical Nutrition, 40(5), 3158-3169. https://doi.org/10.1016/j.clnu.2020.12.026 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/167822

Neyrinck, A., Rodriguez, J., Zhang, Z., Seethaler, B., Robles Sanchez, C., Roumain, M., Hiel, S., Bindels, L., Cani, P., Paquot, N., Cnop, M., Nazare, J.-A., Laville, M., Muccioli, G., Bischoff, S. C., Walter, J., Thissen, J.-P., & Delzenne, N. (2021). Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial. European Journal of Nutrition, 60(6), 3159-3170. https://doi.org/10.1007/s00394-021-02484-5 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/216768

Thibaut, M., Sboarina, M., Roumain, M., Pötgens, S., Neyrinck, A., Destrée, F., Gillard, J., Leclercq, I., Dachy, G., Demoulin, J. B., Tailleux, A., Lestavel, S., Rastelli, M., Everard, A., Cani, P., Porporato, P. E., Loumaye, A., Thissen, J.-P., Muccioli, G., et al. (2021). Inflammation-induced cholestasis in cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 12(1), 70-20. https://doi.org/10.1002/jcsm.12652 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/265133

Breton, J., Tirelle, P., Hasanat, S., Pernot, A., L’Huillier, C., do Rego, J.-C., Déchelotte, P., Coëffier, M., Bindels, L., & Ribet, D. (2021). Gut microbiota alteration in a mouse model of Anorexia Nervosa. Clinical Nutrition, 40(1), 181-189. https://doi.org/10.1016/j.clnu.2020.05.002 (Original work published 2021)

https://research.dial.uclouvain.be/handle/2078.5/118913

Chapitre de livre

Degraeve, A., & Bindels, L. (2021). Microbiote et médicaments. In Jean-Michel Lecerf, Nathalie Delzenne (ed.), Microbiote intestinal et santé humaine (pp. 56-61). Elsevier Masson.

https://research.dial.uclouvain.be/handle/2078.5/225286

2020

Article de journal

Ducastel, S., Touche, V., Trabelsi, M.-S., Boulinguiez, A., Butruille, L., Nawrot, M., Peschard, S., Chávez-Talavera, O., Dorchies, E., Vallez, E., Annicotte, J.-S., Lancel, S., Briand, O., Bantubungi, K., Caron, S., Bindels, L., Delzenne, N., Tailleux, A., Staels, B., & Lestavel, S. (2020). The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids. Scientific Reports, 10(1), 174 [1-10]. https://doi.org/10.1038/s41598-019-56743-x (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/93956

Delzenne, N., & Bindels, L. (2020). Food for thought about manipulating gut bacteria. Nature, 577(7788), 32-34. https://doi.org/10.1038/d41586-019-03704-z (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/93005

Hiel, S., Gianfrancesco, M. A., Rodriguez, J., Portheault, D., Leyrolle, Q., Bindels, L., Gomes da Silveira Cauduro, C., Mulders, M. D. G. H., Zamariola, G., Azzi, A.-S., Kalala, G., Pachikian, B. D., Amadieu, C., Neyrinck, A., Loumaye, A., Cani, P., Lanthier, N., Trefois, P., Klein, O., et al. (2020). Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial. Clinical Nutrition, 39(12), 3618-3628. https://doi.org/10.1016/j.clnu.2020.04.005 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/168381

Rodriguez, J., Hiel, S., Neyrinck, A., Le Roy, T., Pötgens, S., Leyrolle, Q., Pachikian, B. D., Gianfrancesco, M. A., Cani, P., Paquot, N., Cnop, M., Lanthier, N., Thissen, J.-P., Bindels, L., & Delzenne, N. (2020). Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients. Gut, 69(11), 1975-1987. https://doi.org/10.1136/gutjnl-2019-319726 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/169434

Rodriguez, J., Neyrinck, A., Zhang, Z., Seethaler, B., Nazare, J.-A., Robles Sanchez, C., Roumain, M., Muccioli, G., Bindels, L., Cani, P., Maquet, V., Laville, M., Bischoff, S. C., Walter, J., & Delzenne, N. (2020). Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota. Gut microbes, 12(1), 1810530 [1-15]. https://doi.org/10.1080/19490976.2020.1810530 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/216770

Degraeve, A., Moudio Ebosse Timba, M. S., Haufroid, V., Chaib Eddour, D., Mourad, M., Bindels, L., & Elens, L. (2020). Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives. Expert Opinion on Drug Metabolism & Toxicology, 16(9), 769-782. https://doi.org/10.1080/17425255.2020.1803277 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/268915

Wyart, E., Bindels, L., Mina, E., Menga, A., Stanga, S., & Porporato, P. E. (2020). Cachexia, a Systemic Disease beyond Muscle Atrophy. International journal of molecular sciences, 21(22), 8592 [1-18]. https://doi.org/10.3390/ijms21228592 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/114287

Leclercq, S., Le Roy, T., Furgiuele, S., Coste, V., Bindels, L., Leyrolle, Q., Neyrinck, A., Quoilin, C., Amadieu, C., Petit, G., Dricot, L., Tagliatti, V., Cani, P., Verbeke, K., Colet, J.-M., Starkel, P., de Timary, P., & Delzenne, N. (2020). Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. Cell Reports, 33(2), 108238 [1-24]. https://doi.org/10.1016/j.celrep.2020.108238 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/167612

Segura Munoz, R. R., Quach, T., Gomes-Neto, J. C., Xian, Y., Pena, P. A., Weier, S., Pellizzon, M. A., Kittana, H., Cody, L. A., Geis, A. L., Heck, K., Schmaltz, R. J., Bindels, L., Cahoon, E. B., Benson, A. K., Clemente, T. E., & Ramer-Tait, A. E. (2020). Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila. Molecular Nutrition & Food Research (Print), 64(17), e2000162 [1-10]. https://doi.org/10.1002/mnfr.202000162 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/115972

Massart, I., Paulissen, G., Loumaye, A., Lause, P., Pötgens, S., Thibaut, M., Balan, E., Deldicque, L., Atfi, A., Louis, E., Gruson, D., Bindels, L., Meuwis, M.-A., & Thissen, J.-P. (2020). Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Cancers, 12(11), 3221 [1-24]. https://doi.org/10.3390/cancers12113221 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/118078

Scorletti, E., Afolabi, P. R., Miles, E. A., Smith, D. E., Almehmadi, A., Alshathry, A., Childs, C. E., Del Fabbro, S., Beavis, J., Moyses, H. E., Clough, G. F., Sethi, J. K., Patel, J., Wright, M., Breen, D. J., Peebles, C., Darekar, A., Aspinall, R., Fowell, A. J., et al. (2020). Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology, 158(6), 1597-1610. https://doi.org/10.1053/j.gastro.2020.01.031 (Original work published 2020)

https://research.dial.uclouvain.be/handle/2078.5/122140

2019

Article de journal

Delzenne, N., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A., & Bindels, L. (2019). Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut-liver axis. Nutrition Society. Proceedings, 78(3), 319-328. https://doi.org/10.1017/S0029665118002756 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/124878

Hiel, S., Bindels, L., Pachikian, B. D., Kalala, G., Broers, V., Zamariola, G., Chang, B. P., Kambashi, B., Rodriguez, J., Cani, P., Neyrinck, A., Thissen, J.-P., Luminet, O., Bindelle, J., & Delzenne, N. (2019). Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. American Journal of Clinical Nutrition : a journal reporting the practical application of our world-wide knowledge of nutrition, 109(6), 1683-1695. https://doi.org/10.1093/ajcn/nqz001 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/214436

Milard, M., Laugerette, F., Durand, A., Buisson, C., Meugnier, E., Loizon, E., Louche-Pelissier, C., Sauvinet, V., Garnier, L., Viel, S., Bertrand, K., Joffre, F., Cheillan, D., Humbert, L., Rainteau, D., Plaisancié, P., Bindels, L., Neyrinck, A., Delzenne, N., & Michalski, M.-C. (2019). Milk Polar Lipids in a High-Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids. Molecular Nutrition & Food Research (Print), 63(4), e1801078 [1-13]. https://doi.org/10.1002/mnfr.201801078 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/124886

Salazar, N., Neyrinck, A., Bindels, L., Druart, C., Ruas-Madiedo, P., Cani, P., de los Reyes-Gavilán, C. G., & Delzenne, N. (2019). Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice. Frontiers in Microbiology, 10, 1809 [1-12]. https://doi.org/10.3389/fmicb.2019.01809 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/127056

Olivares Sevilla, M., Rodriguez, J., Pötgens, S., Neyrinck, A., Cani, P., Bindels, L., & Delzenne, N. (2019). The Janus Face of Cereals: Wheat‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High‐Fat/High‐Sucrose Diet. Molecular Nutrition & Food Research (Print), 63(24), 1900632 [1-12]. https://doi.org/10.1002/mnfr.201900632 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/123845

Neyrinck, A., Catry, E., Taminiau, B., Cani, P., Bindels, L., Daube, G., Dessy, C., & Delzenne, N. (2019). Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction. Scientific Reports, 9(1), 14150 [1-12]. https://doi.org/10.1038/s41598-019-50700-4 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/125867

Genton, L., Mareschal, J., Charretier, Y., Lazarevic, V., Bindels, L., & Schrenzel, J. (2019). Targeting the Gut Microbiota to Treat Cachexia. Frontiers in Cellular and Infection Microbiology, 9, 305 [1-8]. https://doi.org/10.3389/fcimb.2019.00305 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/62062

Biver, E., Berenbaum, F., Valdes, A. M., Araujo de Carvalho, I., Bindels, L., Brandi, M. L., Calder, P. C., Castronovo, V., Cavalier, E., Cherubini, A., Cooper, C., Dennison, E., Franceschi, C., Fuggle, N., Laslop, A., Miossec, P., Thomas, T., Tuzun, S., Veronese, N., et al. (2019). Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO). Ageing Research Reviews, 55, 100946 [1-8]. https://doi.org/10.1016/j.arr.2019.100946 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/61754

Bernard, A., Ancel, D., Neyrinck, A., Dastugue, A., Bindels, L., Delzenne, N., & Besnard, P. (2019). A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice. Nutrients, 11(3), 549 [1-13]. https://doi.org/10.3390/nu11030549 (Original work published 2019)

https://research.dial.uclouvain.be/handle/2078.5/57229

2018

Article de journal

Hiel, S., Neyrinck, A., Rodriguez, J., Pachikian, B. D., Bouzin, C., Thissen, J.-P., Cani, P., Bindels, L., & Delzenne, N. (2018). Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine. Nutrients, 10(5), 532 [1-13]. https://doi.org/10.3390/nu10050532 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/127822

Pachikian, B. D., Druart, C., Catry, E., Bindels, L., Neyrinck, A., Larondelle, Y., Cani, P., & Delzenne, N. (2018). Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis. PLoS One, 13(2), e0192447 [1-14]. https://doi.org/10.1371/journal.pone.0192447 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/124003

Olivares Sevilla, M., Schüppel, V., Hassan, A. M., Beaumont, M., Neyrinck, A., Bindels, L., Benítez-Páez, A., Sanz, Y., Haller, D., Holzer, P., & Delzenne, N. (2018). The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. Frontiers in Microbiology, 9, 1900 [1-10]. https://doi.org/10.3389/fmicb.2018.01900 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/56414

Kittana, H., Quintero-Villegas, M. I., Bindels, L., Gomes-Neto, J. C., Schmaltz, R. J., Segura Munoz, R. R., Cody, L. A., Moxley, R. A., Hostetter, J., Hutkins, R. W., & Ramer-Tait, A. E. (2018). Galactooligosaccharide supplementation provides protection against Citrobacter rodentium-induced colitis without limiting pathogen burden. Microbiology, 164(2), 154-162. https://doi.org/10.1099/mic.0.000593 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/48289

Suriano, F., Neyrinck, A., Verspreet, J., Olivares Sevilla, M., Leclercq, S., Van de Wiele, T., Courtin, C. M., Cani, P., Bindels, L., & Delzenne, N. (2018). Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota. Journal of Functional Foods, 41, 155-162. https://doi.org/10.1016/j.jff.2017.12.035 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/177159

Catry, E., Bindels, L., Tailleux, A., Lestavel, S., Neyrinck, A., Goossens, J.-F., Lobysheva, I., Plovier, H., Essaghir, A., Demoulin, J. B., Bouzin, C., Pachikian, B. D., Cani, P., Staels, B., Dessy, C., & Delzenne, N. (2018). Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction. Gut, 67(2), 271-283. https://doi.org/10.1136/gutjnl-2016-313316 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/127865

Kittana, H., Gomes-Neto, J. C., Heck, K., Geis, A. L., Segura Muñoz, R. R., Cody, L. A., Schmaltz, R. J., Bindels, L., Sinha, R., Hostetter, J. M., Benson, A. K., & Ramer-Tait, A. E. (2018). Commensal Escherichia coli Strains Can Promote Intestinal Inflammation via Differential Interleukin-6 Production. Frontiers in Immunology, 9, 2318 [1-13]. https://doi.org/10.3389/fimmu.2018.02318 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/61114

Delzenne, N., & Bindels, L. (2018). Gut microbiota in 2017: Contribution of gut microbiota-host cooperation to drug efficacy. Nature Reviews Gastroenterology & Hepatology, 15(2), 69-70. https://doi.org/10.1038/nrgastro.2017.170 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/63997

Pötgens, S., Sboarina, M., & Bindels, L. (2018). Polyunsaturated fatty acids, polyphenols, amino acids, prebiotics: can they help to tackle cancer cachexia and related inflammation? Current Opinion in Clinical Nutrition and Metabolic Care, 21(6), 458-464. https://doi.org/10.1097/MCO.0000000000000505 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/50186

Pötgens, S., Brossel, H., Sboarina, M., Catry, E., Cani, P., Neyrinck, A., Delzenne, N., & Bindels, L. (2018). Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction. Scientific Reports, 8(1), 12321 [1-12]. https://doi.org/10.1038/s41598-018-30569-5 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/214434

Bindels, L., Neyrinck, A., Loumaye, A., Catry, E., Walgrave, H., Cherbuy, C., Leclercq, S., Van Hul, M., Plovier, H., Pachikian, B. D., Bermúdez-Humarán, L. G., Langella, P., Cani, P., Thissen, J.-P., & Delzenne, N. (2018). Increased gut permeability in cancer cachexia: mechanisms and clinical relevance. OncoTarget, 9(26), 18224-18238. https://doi.org/10.18632/oncotarget.24804 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/127846

Gueugneau, M., d’Hose, D., Barbé, C., de Barsy, M., Lause, P., Maiter, D., Bindels, L., Delzenne, N., Schaeffer, L., Gangloff, Y.-G., Chambon, C., Coudy-Gandilhon, C., Béchet, D., & Thissen, J.-P. (2018). Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy. Journal of Cachexia, Sarcopenia and Muscle, 9(5), 929-946. https://doi.org/10.1002/jcsm.12315 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/94030

Neyrinck, A., Hiel, S., Bouzin, C., Campayo, V. G., Cani, P., Bindels, L., & Delzenne, N. (2018). Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice. Nutrition and Diabetes, 8(1), 15 [1-5]. https://doi.org/10.1038/s41387-018-0019-z (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/127752

Scorletti, E., Afolabi, P. R., Miles, E. A., Smith, D. E., Almehmadi, A., Alshathry, A., Moyses, H. E., Clough, G. F., Wright, M., Patel, J., Bindels, L., Delzenne, N., Calder, P. C., & Byrne, C. D. (2018). Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease. Contemporary Clinical Trials, 71, 113-123. https://doi.org/10.1016/j.cct.2018.05.010 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/56834

Beaumont, M., Neyrinck, A., Olivares Sevilla, M., Rodriguez, J., de Rocca Serra, A., Roumain, M., Bindels, L., Cani, P., Evenepoel, P., Muccioli, G., Demoulin, J. B., & Delzenne, N. (2018). The gut microbiota metabolite indole alleviates liver inflammation in mice. The FASEB Journal, 32(12), fj201800544 [1-13]. https://doi.org/10.1096/fj.201800544 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/236207

Olivares Sevilla, M., Neyrinck, A., Pötgens, S., Beaumont, M., Salazar, N., Cani, P., Bindels, L., & Delzenne, N. (2018). The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice. Diabetologia : clinical and experimental diabetes and metabolism, 61(8), 1838-1848. https://doi.org/10.1007/s00125-018-4647-6 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/127269

Delzenne, N., & Bindels, L. (2018). Microbiome metabolomics reveals new drivers of human liver steatosis. Nature Medicine, 24(7), 906-907. https://doi.org/10.1038/s41591-018-0126-3 (Original work published 2018)

https://research.dial.uclouvain.be/handle/2078.5/63745

2017

Article de journal

Neyrinck, A., Taminiau, B., Walgrave, H., Daube, G., Cani, P., Bindels, L., & Delzenne, N. (2017). Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota? Nutrients, 9(6), 633 [1-13]. https://doi.org/10.3390/nu9060633 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/178784

Leclercq, S., Mian, F. M., Stanisz, A. M., Bindels, L., Cambier, E., Ben-Amram, H., Koren, O., Forsythe, P., & Bienenstock, J. (2017). Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. Nature Communications, 8, 15062 ^1-12]. https://doi.org/10.1038/ncomms15062 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/91324

Bindels, L., Porporato, P., Ducastel, S., Sboarina, M., Neyrinck, A., Dewulf, E., Feron, O., Lestavel, S., Cani, P., Staels, B., Sonveaux, P., & Delzenne, N. (2017). Ffar2 expression regulates leukaemic cell growth in vivo. The British journal of cancer, 117(9), 1336-1340. https://doi.org/10.1038/bjc.2017.307 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/175964

Gomes-Neto, J. C., Kittana, H., Mantz, S., Segura Munoz, R. R., Schmaltz, R. J., Bindels, L., Clarke, J., Hostetter, J. M., Benson, A. K., Walter, J., & Ramer-Tait, A. E. (2017). A gut pathobiont synergizes with the microbiota to instigate inflammatory disease marked by immunoreactivity against other symbionts but not itself. Scientific Reports, 7, 17707. https://doi.org/10.1038/s41598-017-18014-5 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/177259

Neyrinck, A., Etxeberria, U., Taminiau, B., Daube, G., Van Hul, M., Everard, A., Cani, P., Bindels, L., & Delzenne, N. (2017). Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota. Molecular Nutrition & Food Research (Print), 61(1), 1500899 [1-12]. https://doi.org/10.1002/mnfr.201500899 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/182883

Bindels, L., Segura Munoz, R. R., Gomes-Neto, J. C., Mutemberezi, V., Martínez, I., Salazar, N., Cody, E. A., Quintero-Villegas, M. I., Kittana, H., de Los Reyes-Gavilán, C. G., Schmaltz, R. J., Muccioli, G., Walter, J., & Ramer-Tait, A. E. (2017). Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome, 5(1), 12 [1-16]. https://doi.org/10.1186/s40168-017-0230-5 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/51119

Reid, G., Abrahamsson, T. R., Bailey, M., Bindels, L., Bubnov, R., Ganguli, K., Martoni, C., O’Neill, C., Savignac, H. M., Stanton, C., Ship, N., Surette, M., Tuohy, K., & van Hemert, S. (2017). How do probiotics and prebiotics function at distant sites? Beneficial Microbes, 8(4), 521-533. https://doi.org/10.3920/BM2016.0222 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/175124

Suriano, F., Bindels, L., Verspreet, J., Courtin, C. M., Verbeke, K., Cani, P., Neyrinck, A., & Delzenne, N. (2017). Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity. Scientific Reports, 7(1), 5621 [1-13]. https://doi.org/10.1038/s41598-017-05698-y (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/214654

Neyrinck, A., Bindels, L., Geurts, L., Van Hul, M., Cani, P., & Delzenne, N. (2017). A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice. The Journal of Nutritional Biochemistry, 49, 15-21. https://doi.org/10.1016/j.jnutbio.2017.07.008 (Original work published 2017)

https://research.dial.uclouvain.be/handle/2078.5/175132

2016

Article de journal

Bindels, L., & Thissen, J.-P. (2016). Nutrition in cancer patients with cachexia: A role for the gut microbiota? Clinical Nutrition Experimental, 6(2016), 74-82. https://doi.org/10.1016/j.yclnex.2015.11.001 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/57891

Neyrinck, A., Pachikian, B. D., Taminiau, B., Daube, G., Frédérick, R., Cani, P., Bindels, L., & Delzenne, N. (2016). Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics. PLoS One, 11(8), e0160488 [1-13]. https://doi.org/10.1371/journal.pone.0160488 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/216382

Hutkins, R. W., Krumbeck, J. A., Bindels, L., Cani, P., Fahey, G., Goh, Y. J., Hamaker, B., Martens, E. C., Mills, D. A., Rastal, R. A., Vaughan, E., & Sanders, M. E. (2016). Prebiotics: why definitions matter. Current Opinion in Biotechnology, 37, 1-7. https://doi.org/10.1016/j.copbio.2015.09.001 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/190181

Bindels, L., & Leclercq, I. (2016). Colonic acetate in obesity: location matters! Clinical Science, 130(22), 2083-2086. https://doi.org/10.1042/CS20160556 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/61337

Bindels, L., Neyrinck, A., Claus, S. P., Le Roy, C. I., Grangette, C., Pot, B., Martinez, I., Walter, J., Cani, P., & Delzenne, N. (2016). Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia. The I S M E Journal : multidisciplinary journal of microbial ecology, 10(6), 1456-1470. https://doi.org/10.1038/ismej.2015.209 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/188651

Yang, J., Bindels, L., Segura Munoz, R. R., Martínez, I., Walter, J., Ramer-Tait, A. E., & Rose, D. J. (2016). Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota. PLoS One, 11(1), e0146144. https://doi.org/10.1371/journal.pone.0146144 (Original work published 2016)

https://research.dial.uclouvain.be/handle/2078.5/187393

2015

Article de journal

Simon, M.-C., Strassburger, K., Nowotny, B., Kolb, H., Nowotny, P., Burkart, V., Zivehe, F., Hwang, J.-H., Stehle, P., Pacini, G., Hartmann, B., Holst, J. J., MacKenzie, C., Bindels, L., Martinez, I., Walter, J., Henrich, B., Schloot, N. C., & Roden, M. (2015). Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose tolerant humans: a proof of concept. Diabetes Care, 38(10), 1827-1834. https://doi.org/10.2337/dc14-2690 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/40753

Delzenne, N., Cani, P., Everard, A., Neyrinck, A., & Bindels, L. (2015). Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia : clinical and experimental diabetes and metabolism, 58(10), 2206-2217. https://doi.org/10.1007/s00125-015-3712-7 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/189966

Bindels, L., Neyrinck, A., Salazar Garzo, N., Taminiau, B., Druart, C., Muccioli, G., François, E., Blecker, C., Richel, A., Daube, G., Mahillon, J., de Los Reyes-Gavilán, C. G., Cani, P., & Delzenne, N. (2015). Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. PLoS One, 10(6), e0131009 [1-16]. https://doi.org/10.1371/journal.pone.0131009 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/214751

Neyrinck, A., Catry, E., Sohet, F. M., Cani, P., Pachikian, B. D., Bindels, L., & Delzenne, N. (2015). Lack of anti-inflammatory effect of coenzyme Q10 supplementation in the liver of rodents after lipopolysaccharide challenge. Clinical Nutrition Experimental, 1, 10-18. https://doi.org/10.1016/j.yclnex.2015.07.002 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/187350

Druart, C., Bindels, L., Schmaltz, R., Neyrinck, A., Cani, P., Walter, J., Ramer-Tait, A. E., & Delzenne, N. (2015). Ability of the gut microbiota to produce PUFA-derived bacterial metabolites: Proof of concept in germ-free versus conventionalized mice. Molecular Nutrition & Food Research (Print), 59(8), 1603-1613. https://doi.org/10.1002/mnfr.201500014 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/214599

Bindels, L., Walter, J., & Ramer-Tait, A. E. (2015). Resistant starches for the management of metabolic diseases. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), 559-565. https://doi.org/10.1097/MCO.0000000000000223 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/186893

Bindels, L., Delzenne, N., Cani, P., & Walter, J. (2015). Towards a more comprehensive concept for prebiotics. Nature Reviews Gastroenterology & Hepatology, 12(5), 303-310. https://doi.org/10.1038/nrgastro.2015.47 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/190671

Salazar Garzo, N., Dewulf, E. M., Neyrinck, A., Bindels, L., Cani, P., Mahillon, J., de Vos, W. M., Thissen, J.-P., Gueimonde, M., de los Reyes-Gavilan, C. G., & Delzenne, N. (2015). Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women. Clinical Nutrition, 34(3), 501-507. https://doi.org/10.1016/j.clnu.2014.06.001 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/190398

Delzenne, N., & Bindels, L. (2015). Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity? Nature Reviews Gastroenterology & Hepatology, 12(10), 553-554. https://doi.org/10.1038/nrgastro.2015.137 (Original work published 2015)

https://research.dial.uclouvain.be/handle/2078.5/56446

2014

Article de journal

Everard, A., Geurts, L., Caesar, R., Van Hul, M., Matamoros, S., Duparc, T., Denis, R. G. P., Cochez, P., Pierard, F., Castel, J., Bindels, L., Plovier, H., Robine, S., Muccioli, G., Renauld, J.-C., Dumoutier, L., Delzenne, N., Luquet, S., Bäckhed, F., & Cani, P. (2014). Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nature Communications, 5(1), 5648 [1-12]. https://doi.org/10.1038/ncomms6648 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/193213

Sheridan, P. O., Bindels, L., Saulnier, D. M., Reid, G., Nova, E., Holmgren, K., O’Toole, P. W., Bunn, J., Delzenne, N., & Scott, K. P. (2014). Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals? Gut Microbes, 5(1), 74-82. https://doi.org/10.4161/gmic.27252 (Original work published 2014)

https://research.dial.uclouvain.be/handle/2078.5/64009

2013

Article de journal

Dewulf, E., Cani, P., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A., Bindels, L., de Vos, W. M., Gibson, G. R., Thissen, J.-P., & Delzenne, N. (2013). Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut, 62(8), 1112-1121. https://doi.org/10.1136/gutjnl-2012-303304 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/158706

Bindels, L., Dewulf, E. M., & Delzenne, N. (2013). GPR43/FFA2: physiopathological relevance and therapeutic prospects. Trends in Pharmacological Sciences, 34(4), 226-232. https://doi.org/10.1016/j.tips.2013.02.002 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/214603

Bindels, L., & Delzenne, N. (2013). Muscle wasting: the gut microbiota as a new therapeutic target? The International Journal of Biochemistry & Cell Biology, 45(10), 2186-2190. https://doi.org/10.1016/j.biocel.2013.06.021 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/57084

Dewulf, E. M., Ge, Q., Bindels, L., Sohet, F. M., Cani, P., Brichard, S., & Delzenne, N. (2013). Evaluation of the relationship between GPR43 and adiposity in human. Nutrition & Metabolism, 10(1), 11 [1-5]. https://doi.org/10.1186/1743-7075-10-11 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/160948

Neyrinck, A., Van Hee, V. F., Bindels, L., De Backer, F., Cani, P., & Delzenne, N. (2013). Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. British Journal of Nutrition, 109(5), 802-809. https://doi.org/10.1017/S0007114512002206 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/158689

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L., Guiot, Y., Derrien, M., Muccioli, G., Delzenne, N., de Vos, W. M., & Cani, P. (2013). Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proceedings of the National academy of sciences of the United States of America, 110(22), 9066-9071. https://doi.org/10.1073/pnas.1219451110 (Original work published 2013)

https://research.dial.uclouvain.be/handle/2078.5/204909

2012

Article de journal

Bindels, L., Beck, R., Schakman, O., Martin, J. C., De Backer, F., Sohet, F. M., Dewulf, E., Pachikian, B. D., Neyrinck, A., Thissen, J.-P., Verrax, J., Buc Calderon, P., Pot, B., Grangette, C., Cani, P., Scott, K. P., & Delzenne, N. (2012). Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model. PLoS One, 7(6), e37971 [1-10]. https://doi.org/10.1371/journal.pone.0037971 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/158681

Bindels, L., Porporato, P., Dewulf, E., Verrax, J., Neyrinck, A., Martin, J. C., Scott, K. P., Buc Calderon, P., Feron, O., Muccioli, G., Sonveaux, P., Cani, P., & Delzenne, N. (2012). Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. The British journal of cancer, 107(8), 1337-1344. https://doi.org/10.1038/bjc.2012.409 (Original work published 2012)

https://research.dial.uclouvain.be/handle/2078.5/93456

2011

Article de journal

Dewulf, E., Cani, P., Neyrinck, A., Possemiers, S., Van Holle, A., Muccioli, G., Deldicque, L., Bindels, L., Pachikian, B. D., Sohet, F., Mignolet, E., Francaux, M., Larondelle, Y., & Delzenne, N. (2011). Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry, 22(8), 712-722. https://doi.org/10.1016/j.jnutbio.2010.05.009 (Original work published 2011)

https://research.dial.uclouvain.be/handle/2078.5/210117

2010

Article de journal

Pachikian, B. D., Neyrinck, A., Deldicque, L., De Backer, F., Catry, E., Dewulf, E., Sohet, F., Bindels, L., Everard, A., Francaux, M., Guiot, Y., Cani, P., & Delzenne, N. (2010). Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. The Journal of Nutrition, 140(3), 509-514. https://doi.org/10.3945/jn.109.117374 (Original work published 2010)

https://research.dial.uclouvain.be/handle/2078.5/131763

2009

Article de journal

Neyrinck, A., Bindels, L., De Backer, F., Pachikian, B. D., Cani, P., & Delzenne, N. (2009). Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice : a phenomenon linked to its lipid-lowering action. International Immunopharmacology, 9(6), 767-773. https://doi.org/10.1016/j.intimp.2009.02.015 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/214571

Neyrinck, A., Cani, P., Dewulf, E., De Backer, F., Bindels, L., & Delzenne, N. (2009). Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. Biochemical and Biophysical Research Communications, 385(3), 351-356. https://doi.org/10.1016/j.bbrc.2009.05.070 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/99020

Sohet, F., Neyrinck, A., Dewulf, E., Bindels, L., Portois, L., Malaisse, W. J., Carpentier, Y. A., Cani, P., & Delzenne, N. (2009). Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice. British Journal of Nutrition, 102(3), 462-469. https://doi.org/10.1017/S0007114508191243 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/129823

Sohet, F., Neyrinck, A., Pachikian, B. D., De Backer, F., Bindels, L., Niklowitz, P., Menke, T., Cani, P., & Delzenne, N. (2009). Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochemical Pharmacology, 78(11), 1391-1400. https://doi.org/10.1016/j.bcp.2009.07.008 (Original work published 2009)

https://research.dial.uclouvain.be/handle/2078.5/131697

2008

Article de journal

Neyrinck, A., De Backer, F., Cani, P., Bindels, L., Stroobants, A., Portetelle, D., & Delzenne, N. (2008). Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet. International Immunopharmacology, 8(10), 1423-1432. https://doi.org/10.1016/j.intimp.2008.05.015 (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/138416

Pachikian, B. D., Neyrinck, A., Cani, P., Portois, L., Deldicque, L., De Backer, F., Bindels, L., Sohet, F., Malaisse, W. J., Francaux, M., Carpentier, Y. A., & Delzenne, N. (2008). Hepatic steatosis in n-3 fatty acid depleted mice : focus on metabolic alterations related to tissue fatty acid composition. BMC physiology, 8(21), 1-11. https://doi.org/10.1186/1472-6793-8-21 (Original work published 2008)

https://research.dial.uclouvain.be/handle/2078.5/130745

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Causes and risk factors for cancer	WSBIM2143
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