October 4 – 1-2pm – Auditoire 51B

Prof. Charles PILETTE, IREC/PNEU

Mucosal immunity in chronic obstructive pulmonary disease: focus on the airway epithelium

Related publications:

• Gohy S, Detry B, Lecocq M, Bouzin C, Weynand B, Sibille Y, and Pilette C. Polymeric immunoglobulin receptor downregulation in COPD: persistence in the cultured epithelium and role of transforming growth factor-b. Am J Respir Crit Care Med 2014; 190:509-521. https://pubmed.ncbi.nlm.nih.gov/25078120/
• Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P, Polette M, Pilette C. Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition. Eur Respir J 2015; 45: 1258-1272. https://pubmed.ncbi.nlm.nih.gov/25745049/
• Ladjemi MZ, Gras D, Detry B, Lecocq M, Dupasquier S, Garulli C, Fremmilicka C, Bouzin C, Gohy S, Chanez P, Pilette C. Bronchial epithelial IgA secretion is impaired in asthma: role of IL-4/IL-13. Am J Respir Crit Care Med 2018; 197(11):1396-1409. https://pubmed.ncbi.nlm.nih.gov/29652177/
• Carlier FM, Dupasquier S, Ambroise J, Detry B, Lecocq M, Biétry-Claudet C, Boukala Y, Gala JL, Bouzin C, Verleden SE, Hoton D, Gohy S, Bearzatto B, Pilette C. Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease. EBioMed 2020 Nov; 61:103034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559244/
• Carlier FM, de Fays C, Pilette C. Epithelial barrier dysfunction in chronic respiratory diseases. Frontiers Physiol 2021 Jun 24;12:691227. https://www.frontiersin.org/articles/10.3389/fphys.2021.691227/full

Info: rita.vanbever@uclouvain.be