Tuesday Septembre 8 - 5pm - Auditoire Maisin

Juhans DECHENNE - CMFA 

Deciphering and Targeting Arginase-1 Oligomerization: A New Strategy for Enzyme Inhibition

Promoteur : Prof. Raphaël Frédérick

Publications :
•    Dechenne, J.; Wierzbicka, M.; Krimou, R.; El Aakchioui, A.; Malo Pueyo, J.; Messens, J.; Fillet, M.; Spillier, Q.; Frédérick, R. Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition. Journal of Medicinal Chemistry 2025, 68 (2), 1433-1445.
•    Dechenne, J.; Cobraiville, G.; Briois, V.; Fillet, M.; Spillier, Q.; Frédérick, R. Allosteric inhibition of Arginase-1 via acetylation-driven trimer disruption. Submitted in European Journal of Medicinal Chemistry.

Info: raphael.frederick@uclouvain.be