Juhans DECHENNE - Thesis public defence

Juhans DECHENNE - CMFA  

Deciphering and Targeting Arginase-1 Oligomerization: A New Strategy for Enzyme Inhibition

Promotor: Raphaël Frédérick

Related publication :
Dechenne, J.; Wierzbicka, M.; Krimou, R.; El Aakchioui, A.; Malo Pueyo, J.; Messens, J.; Fillet, M.; Spillier, Q.; Frédérick, R. Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition. Journal of Medicinal Chemistry 2025, 68 (2), 1433-1445.
Dechenne, J.; Cobraiville, G.; Briois, V.; Fillet, M.; Spillier, Q.; Frédérick, R. Allosteric inhibition of Arginase-1 via acetylation-driven trimer disruption. Submitted in European Journal of Medicinal Chemistry.

This thesis defence took place on September 8, 2026