Marine DESKEUVRE - Thesis public defence

Marine DESKEUVRE - Medicinal Chemistry (CMFA)

pH Low Insertion Peptides conjugated to fatty acid metabolism inhibitors to prevent cancer cell proliferation

Promotors : Raphaël Frédérick (UCLouvain, LDRI) & Olivier Feron (UCLouvain, IREC)

Related references:

• Marine Deskeuvre, Junjie Lan, Emeline Dierge, Olivier Riant, Cyril Corbet, Olivier Feron, Raphaël Frédérick. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) Insertion Peptides. Int J Pharm. 2022 Aug 25:624:122041. doi: 10.1016/j.ijpharm.2022.122041.
• Marine Deskeuvre, Junjie Lan, Joris Messens, Olivier Riant, Olivier Feron, Raphaël Frédérick. A Novel Approach to pH-Responsive Targeted Cancer Therapy: Inhibition of FaDu Cancer Cell Proliferation with a pH Low Insertion Peptide-Conjugated DGAT1 Inhibitor. Int J Pharm. Submitted

This thesis defence took place on January 12, 2024.