Two thesis defences in September: Arina KOZLOVA and Hervé POILVACHE

September 1st, 2021

Arina KOZLOVA- Medicinal Chemistry (CMFA)

Design, Synthesis and Evaluation of Original 1-H-indol-3-yl Heterocyclic Derivatives as Tryptophan 2,3-Dioxygenase Inhibitors

Director : Raphaël Frédérick, co-director : Benoît Van den Eynde.

Related publications :

• Kozlova A, Frédérick R. Current State on Tryptophan 2,3-Dioxygenase Inhibitors: A Patent Review. Expert Opin. Ther. Pat. 2019, 29 (1), 11–23. doi: 10.1080/13543776.2019.1556638
• Kozlova A, Thabault L, Liberelle M, Klaessens S, Prévost JRC, Mathieu C, Pilotte L, Stroobant V, Van den Eynde B, Frédérick R. Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. J Med Chem. 2021 Aug 2. doi: 10.1021/acs.jmedchem.1c00323.
• Kozlova A, Thabault L, Dauguet N, Stroobant V, Pilotte L, Liberelle M, Van den Eynde B, Frédérick R. Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase. Eur J Med Chem 2021. Under revision.

September 20, 2021

Hervé POILVACHE – NMSK-IREC and TFAR-Cellular and Molecular Pharmacology (FACM)

In-vitro and in-vivo study of biofilm disruption strategies for the treatment of Prosthetic Joint Infections

Directors: Olivier Cornu (NMSK - IREC) et Françoise Van Bambeke (TFAR - FACM)

Related publications:

• Poilvache, H., et al. (2020). "Synergistic Effects of Pulsed Lavage and Antimicrobial Therapy Against Staphylococcus aureus Biofilms in an in-vitro Model." Front Med (Lausanne) 7(527): 527
• Poilvache, H., et al. (2021). "In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model." Antimicrob Agents Chemother 65(4)