Gwenaëlle MAHIEU - Thesis public defense

Gwenaëlle MAHIEU - TFAR FACM and PMGK

An integrated pharmacokinetic, pharmacogenomic and pharmacodynamic study of fluoroquinolones in the context of intracellular infections

Promotor: Prof. Françoise Van Bambeke.

Co-promotor: Prof. Laure Elens

Related publications: 

• Mahieu, G., Elens, L., Prebonnaud, N., Chauzy, A., & Van Bambeke, F. (2025). A hollow fiber infection model to study intracellular and extracellular antibiotic activity against Staphylococcus aureus. iScience, 28(3), 112076.
• Mahieu, G., Haufroid, V., Van Bambeke, F., & Elens, L. (2025). In vitro assessment of ATP-binding cassette transporters and their functional genetic polymorphisms on fluoroquinolone accumulation in human embryonic kidney 293 recombinant cell lines. Drug Metabolism and Disposition, 100063.
• Mahieu, G., Sennesael, A.-L., Pochet, L., Haufroid, V., Van Bambeke, F., Spinewine, A., & Elens, L. (2024). In vitro assessment of the risk of ABCB1-mediated drug–drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines. Research and Practice in Thrombosis and Haemostasis, 8(5), 102521. (Collaborative work)

This thesis defense took place on April 22, 2025.