Romain MARTEAU - Thesis public defense

Romain MARTEAU - Medicinal Chemistry (CMFA)

Investigating the acyl-CoA synthetase long-chain family member 4 (ACSL4) inhibition and substrate specificity: a pathway to targeting ferroptosis-related diseases and cancer

Promotor: Raphaël Frédérick - Co-promotor: Séverine Ravez (Université de Lille)

Related publications:

• Marteau Romain*, Ravez Séverine*, Mazhari Dorooee Darius, Bouchaoui Hind, Porte Karine, Devedjian Jean Christophe, Melnyk Patricia, Devos David, Frédérick Raphaël°, El Bakali Jamal°. Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis (2022) Biochemical Pharmacology, 204: 115239
• Mazhari Dorooee Darius, Ravez Séverine, Vertommen Didier, Renault Nicolas, Papadopoulos Nicolas, Marteau Romain, Charnelle Emeline, Porte Karine, Gobert Alexandre, Hennuyer Nathalie, Herinckx Gaetan, Pautric Maëla, Jonneaux Aurélie, Devedjian Jean Christophe, Devos David, Staels Bart, Melnyk Patricia, Constantinescu Stefan N, Frédérick Raphaël°, El Bakali Jamal°. LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode (2025) Angewandte Chemie - International Edition, e202500518.
• Charnelle Emeline*, Gobert Alexandre*, Marteau Romain, Pautric Maëla, Renault Nicolas, Jonneaux Aurélie, Mazhari Dorooee Darius, Laversin Amélie, Devedjian Jean-christophe, Melnyk Patricia, Yous Saïd, Devos David, Frédérick Raphaël, Ravez Séverine°, El Bakali Jamal°. Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties (2025) Journal of Medicinal Chemistry.

This thesis defense took place on August 19, 2025.