Publications

Pricolo, M. R., López-Unzu, M. A., Vicente, N., Morales-López, C., Huerta-López, C., Pérez-Franco, W., Dumitru, A.-C., Jorge Peña-Peña, Espinosa, F. M., Sanchez, M. I., Garcia, R., Silva-Rojas, R., Miguel Torres, Herrero-Galán, E., Alegre-Cebollada, J., & et al. (2026). Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation. Journal of Biological Chemistry, 302(7), 113167. https://doi.org/10.1016/j.jbc.2026.113167 (Original work published 2026)

Bak, A., Dumitru, A.-C., Clemente-Manteca, A., Calvo, E., Silva-Rojas, R., Vicente, N., Sánchez-Ortiz, D., Martínez-Martín, I., Velázquez-Carreras, D., Pricolo, M., Espinosa, F., Almeida-Coelho, J., Pérez-Medina, C., Garcia, R., Vázquez, J., Falcão-Pires, I., Herrero-Galán, E., Adrover, M., & Alegre-Cebollada, J. (2026). Pathological stiffening by crosslinking glycation of titin. Submitted. https://doi.org/10.64898/2026.02.13.705744 (Original work published 2026)

Vicanolo, T., Özcan, A., Li, J. L., Huerta-López, C., Ballesteros, I., Rubio-Ponce, A., Dumitru, A.-C., Nicolás-Ávila, J. Á., Molina-Moreno, M., Reyes-Gutierrez, P., Johnston, A. D., Martone, C., Greto, E., Quílez-Alvarez, A., Calvo, E., Bonzon-Kulichenko, E., Álvarez-Velez, R., Chooi, M. Y., Kwok, I., et al. (2025). Matrix-producing neutrophils populate and shield the skin. Nature, 641(8063), 740-748. https://doi.org/10.1038/s41586-025-08741-5 (Original work published 2025)

Silva-Rojas, R., Vicente, N., Gavilán-Herrera, M., Labrador-Cantarero, V., Sicilia, J., Giménez-Sáez, O., Dumitru, A.-C., Sánchez, M. I., Gato-Vilaseca, M., Velázquez-Carreras, D., López, J. A., Vázquez, J., Herrero-Galán, E., López-Unzu, M. A., Pricolo, M. R., & Alegre-Cebollada, J. (2025). Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease. Nature Biomedical Engineering, 1(1), 1. https://doi.org/10.1038/s41551-025-01403-x (Original work published 2025)

Stommen, A., Ghodsi, M., Cloos, A.-S., Conrard, L., Dumitru, A.-C., Henriet, P., Pierreux, C., Alsteens, D., & Tyteca, D. (2024). Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte–Discocyte–Echinocyte Transformation. Biomolecules, 14(1), 51 [1-27]. https://doi.org/10.3390/biom14010051 (Original work published 2024)

dos Santos Natividade, R., Dumitru, A.-C., Nicoli, A., Strebl, M., Sutherland, D. M., Welsh, O. L., Ghulam, M., Stehle, T., Dermody, T. S., Di Pizio, A., Koehler, M., & Alsteens, D. (2024). Viral capsid structural assembly governs the reovirus binding interface to NgR1. Nanoscale Horizons : the home for rapid reports of exceptional significance in nanoscience and nanotechnology, 9(11), 1925-1937. https://doi.org/10.1039/d4nh00315b (Original work published 2024)

Dumitru, A.-C., Köhler, M., & et al. (2023). Recent advances in the application of atomic force microscopy to structural biology. Journal of Structural Biology, 2(215), 107963. https://doi.org/10.1016/j.jsb.2023.107963 (Original work published 2023)

Lo Giudice, M., Yang, J., Poncin, M. A., Adumeau, L., Delguste, M., Koehler, M., Evers, K., Dumitru, A.-C., Dawson, K. A., & Alsteens, D. (2022). Nanophysical Mapping of Inflammasome Activation by Nanoparticles via Specific Cell Surface Recognition Events. ACS Nano, 16(1), 306-316. https://doi.org/10.1021/acsnano.1c06301 (Original work published 2021)

Maja, M., Mohammed, D., Dumitru, A.-C., Verstraeten, S., Lingurski, M., Mingeot-Leclercq, M.-P., Alsteens, D., & Tyteca, D. (2022). Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation. Cellular and Molecular Life Sciences, 79(8), 417 [1-20]. https://doi.org/10.1007/s00018-022-04426-8 (Original work published 2022)

Koehler, M., Petitjean, S., Yang, J., Aravamudhan, P., Somoulay, X., Lo Giudice, M., Poncin, M., Dumitru, A.-C., Dermody, T. S., & Alsteens, D. (2021). Reovirus directly engages integrin to recruit clathrin for entry into host cells. Nature Communications, 12(1), 1-15. https://doi.org/10.1038/s41467-021-22380-0 (Original work published 2021)

Cloos, A.-S., Daenen, L. G. M., Maja, M., Stommen, A., Vanderroost, J., Van Der Smissen, P., Rab, M., Westerink, J., Mignolet, E., Larondelle, Y., Terrasi, R., Muccioli, G., Dumitru, A.-C., Alsteens, D., van Wijk, R., & Tyteca, D. (2021). Impaired Cytoskeletal and Membrane Biophysical Properties of Acanthocytes in Hypobetalipoproteinemia – A Case Study. Frontiers in Physiology, 12(2), 638027 [1-22]. https://doi.org/10.3389/fphys.2021.638027 (Original work published 2021)

Mohammed, D., Koehler, M., Dumitru, A.-C., Aravamudhan, P., Sutherland, D. M., Dermody, T. S., & Alsteens, D. (2021). Altered Glycan Expression on Breast Cancer Cells Facilitates Infection by T3 Seroptype Oncolytic Reovirus. Nano Letters : a journal dedicated to nanoscience and nanotechnology, 21(22), 9720-9728. https://doi.org/10.1021/acs.nanolett.1c03608 (Original work published 2021)

Dumitru, A.-C., Stommen, A., Koehler, M., Cloos, A.-S., Yang, J., Leclercqz, A., Tyteca, D., & Alsteens, D. (2021). Probing PIEZO1 Localization upon Activation Using High-Resolution Atomic Force and Confocal Microscopy. Nano Letters : a journal dedicated to nanoscience and nanotechnology, 21(12), 4950-4958. https://doi.org/10.1021/acs.nanolett.1c00599 (Original work published 2021)

Koehler, M., Petitjean, S., Yang, J., Aravamudhan, P., Somoulay, X., Lo Giudice, M., Poncin, M., Dumitru, A.-C., Dermody, T. S., & Alsteens, D. (2021). Author Correction: Reovirus directly engages integrin to recruit clathrin for entry into host cells. Nature Communications, 12(1), 2946. https://doi.org/10.1038/s41467-021-23537-7 (Original work published 2021)

Yang, J., Petitjean, S., Koehler, M., Zhang, Q., Dumitru, A.-C., Chen, W., Derclaye, S., Vincent, S. P., Soumillion, P., & Alsteens, D. (2021). Author Correction: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor. Nature Communications, 12(1), 2996. https://doi.org/10.1038/s41467-021-23498-x (Original work published 2021)

Müller, D. J., Dumitru, A.-C., Lo Giudice, M., Gaub, H. E., Hinterdorfer, P., Hummer, G., De Yoreo, J. J., Dufrêne, Y., & Alsteens, D. (2021). Atomic Force Microscopy-Based Force Spectroscopy and Multiparametric Imaging of Biomolecular and Cellular Systems. Chemical Reviews, 121, 11701-11725. https://doi.org/10.1021/acs.chemrev.0c00617 (Original work published 2020)

Dumitru, A.-C., Deepak, R. N. V. K., Liu, H., Koehler, M., Zhang, C., Fan, H., & Alsteens, D. (2020). Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism. Communications Biology, 3(1), 786. https://doi.org/10.1038/s42003-020-01518-8 (Original work published 2020)

Lecordier, L., Uzureau, S., Vanwalleghem, G., Deleu, M., Crowet, J.-M., Barry, P., Moran, B., Voorheis, P., Dumitru, A.-C., Yamaryo-Botté, Y., Dieu, M., Tebabi, P., Vanhollebeke, B., Lins, L., Botté, C. Y., Alsteens, D., Dufrêne, Y., Pérez-Morga, D., Nolan, D. P., & Pays, E. (2020). The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity. iScience, 23(9), 101476. https://doi.org/10.1016/j.isci.2020.101476 (Original work published 2020)

Dumitru, A.-C., Mohammed, D., Maja, M., Yang, J., Verstraeten, S., del Campo, A., Mingeot-Leclercq, M.-P., Tyteca, D., & Alsteens, D. (2020). Label‐Free Imaging of Cholesterol Assemblies Reveals Hidden Nanomechanics of Breast Cancer Cells. Advanced Science, 2002643. https://doi.org/10.1002/advs.202002643 (Original work published 2020)

Yang, J., Petitjean, S., Koehler, M., Zhang, Q., Dumitru, A.-C., Chen, W., Derclaye, S., Vincent, S. P., Soumillion, P., & Alsteens, D. (2020). Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor. Nature Communications, 11(1), 4541. https://doi.org/10.1038/s41467-020-18319-6 (Original work published 2020)

Valotteau, C., Dumitru, A.-C., Lecordier, L., Alsteens, D., Pays, E., Pérez-Morga, D., & Dufrêne, Y. (2020). Multiparametric Atomic Force Microscopy Identifies Multiple Structural and Physical Heterogeneities on the Surface of Trypanosoma brucei. ACS Omega, 5(33), 20953-20959. https://doi.org/10.1021/acsomega.0c02416 (Original work published 2020)