LDRI
Avenue Mounier 72/B1.72.02
1200 Woluwe-Saint-Lambert
Laure Elens
Professeure
- Diploma
Year Label Educational Organization 2004 Candidate en sciences biomédicales Université catholique de Louvain 2006 Licenciée en sciences biomédicales, orientation toxicologie Université catholique de Louvain 2007 Diplômée d'études approfondies en sciences de la santé Université catholique de Louvain 2008 DEA en sciences de la santé publique Université catholique de Louvain 2010 Docteur en sciences biomédicales et pharmaceutiques Université catholique de Louvain
- Courses
Name ID Analyse des médicaments WFARI2104 Pharmacokinetics and metabolism of xenobiotics WFARM1300 Compléments de pharmacocinétique WFARM1339 Seminary and practical exercises integred of pharmaceutical sciences WFARM2135 Pharmacocinetic, genomics and toxicology WFARM2139 Biostatistics WFARM2177 Biologie clinique et monitoring thérapeutique WFARM2244 Formes pharmaceutiques et biodisponibilité WFARM2506 Pharmacocinétique approfondie WFARM2513 Applications cliniques en pharmacocinétique et pharmacogénomique WHOPI2108 Pharmacologie générale WMDS1237 Introduction to toxicology WSBIM1205 Research and sustainable development : Green lab project WSBIM2139 Clinical toxicology WSBIM2246 Toxicants in Ecosystems and Humans: Exposure and Accumulation WSBIM2252
2024
Hoste, Emilia ; Haufroid, Vincent ; Deldicque, Louise ; Balligand, Jean-Luc ; Elens, Laure. Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy. In: Clinical Biochemistry, Vol. 124, no. 1, p. 110707 (2024). doi:10.1016/j.clinbiochem.2024.110707.
2024
Delvau, N. ; Elens, Laure ; Penaloza, A. ; Liistro, G. ; Thys, F. ; Roy, P.M. ; Gianello, P. ; Hantson, P.. Carboxyhemoglobin half-life toxicokinetic profiles during and after normobaric oxygen therapy: on a swine model. In: Toxicology Reports, Vol. 12, no.June 2024, p. 271-279 (2024). doi:10.1016/j.toxrep.2024.02.005.
2024
Ward, Bradley ; Pyr dit Ruys, Sébastien ; Balligand, Jean-Luc ; Belkhir, Leïla ; Cani, Patrice D. ; Collet, Jean-François ; De Greef, Julien ; Dewulf, Joseph P. ; Gatto, Laurent ; Haufroid, Vincent ; Jodogne, Sébastien ; Kabamba-Mukadi, Benoît ; Lingurski, Maxime ; Yombi, Jean Cyr ; Vertommen, Didier ; Elens, Laure. Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort.. In: Journal of proteome research, Vol. 23, no. 9, p. 3806-3822 (2024). doi:10.1021/acs.jproteome.4c00104.
2024
De Greef, Julien ; Akue, Mathilde ; Panin, Nadtha ; Delongie, Kévin-Alexandre ; Andre, Marina ; Mahieu, Gwenaëlle ; Hoste, Emilia ; Elens, Laure ; Belkhir, Leïla ; Haufroid, Vincent. Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines.. In: Scientific reports, Vol. 14, no.1, p. 16290 (2024). doi:10.1038/s41598-024-66809-0.
2024
Degraeve, Alexandra ; Bindels, Laure B. ; Haufroid, Vincent ; Moudio Ebosse Timba, Moussinga Serge ; Boland, Lidvine ; Delongie, Kévin-Alexandre ; Dewulf, Joseph P. ; Chaib Eddour, Djamila ; Mourad, Michel ; Elens, Laure. Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study. In: Clinical pharmacology and therapeutics, Vol. 115, no. 1, p. 104-115 (2024). doi:10.1002/cpt.3077.
2024
Mahieu, Gwenaëlle ; Sennesael, Anne-Laure ; Pochet, Lionel ; Haufroid, Vincent ; Van Bambeke, Françoise ; Spinewine, Anne ; Elens, Laure. assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines.. In: Research and practice in thrombosis and haemostasis, Vol. 8, no.5, p. 102521 (2024). doi:10.1016/j.rpth.2024.102521.
2023
Hoste, Emilia ; Paquot, Adrien ; Panin, Nadtha ; Horion, Shaleena ; El-Hamdaoui, Halima ; Muccioli, Giulio ; Haufroid, Vincent ; Elens, Laure. Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. In: Therapeutic drug monitoring, Vol. 45, no. 3, p. 400-408 (2023). doi:10.21203/rs.3.rs-1520877/v1 (Accepté/Sous presse).
2023
Degraeve, Alexandra ; Haufroid, Vincent ; Loriot, Axelle ; Gatto, Laurent ; Andries, Vanessa ; Vereecke, Lars ; Elens, Laure ; Bindels, Laure B.. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. In: Microbiome, Vol. 11, no. 1, p. 138 [1-20] (2023). doi:10.1186/s40168-023-01578-y.
2023
Lagreula, Juliette ; Ferraiolo, Mattia ; de Timary, Philippe ; Delatte, Benoit ; Elens, Laure ; Hermans, Emmanuel ; Dalleur, Olivia. Impact of a Caffeine Restriction Policy on Inpatients With Schizophrenia- A Pre-Post Comparison Using Electronic Health Records. In: Journal of Clinical Psychopharmacology, Vol. 43, no.2, p. 167-170 (2023). doi:10.1097/JCP.0000000000001670.
2023
Lagreula, Juliette ; Vincent Dagenais-Beaulé ; de Timary, Philippe ; Elens, Laure ; Dalleur, Olivia. Prescribing and deprescribing trends in schizophrenia : An overview of inpatients in Belgium and in the Canadian province of Québec. In: Basic & Clinical Pharmacology & Toxicology, p. 1-12 (2023). doi:10.1111/bcpt.13867.
2023
Lemaitre, Florian ; Budde, Klemens ; Van Gelder, Teun ; Bergan, Stein ; Lawson, Roland ; Noceti, Ofelia ; Venkataramanan, Raman ; Elens, Laure ; Moes, Dirk Jan A. R. ; Hesselink, Dennis A. ; Pawinski, Tomasz ; Johnson-Davis, Kamisha L. ; De Winter, Brenda C. M. ; Pattanaik, Smita ; Brunet, Mercè ; Masuda, Satohiro ; Langman, Loralie J.. Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19. In: Therapeutic Drug Monitoring, Vol. 45, no.2, p. 191-199 (2023). doi:10.1097/ftd.0000000000001014.
2022
Lagreula, Juliette ; de Timary, Philippe ; Elens, Laure ; Dalleur, Olivia. Antipsychotic polypharmacy and clozapine prescribing patterns: evolution and correlates before and after a psychiatric hospitalisation. In: Therapeutic advances in psychopharmacology, Vol. 12, p. [1-12] (2022). doi:10.1177/20451253221112587.
2022
Ward, Bradley ; Yombi, Jean Cyr ; Balligand, Jean-Luc ; Cani, Patrice D. ; Collet, Jean-François ; De Greef, Julien ; Dewulf, Joseph P. ; Gatto, Laurent ; Haufroid, Vincent ; Jodogne, Sébastien ; Kabamba-Mukadi, Benoît ; Pyr dit Ruys, Sébastien ; Vertommen, Didier ; Elens, Laure ; Belkhir, Leïla. HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach. In: Viruses, Vol. 14, no. 7, p. 1373 [1-17] (2022). doi:10.3390/v14071373.
2022
Ngougni Pokem, Perrin ; Wittebole, Xavier ; Collienne, Christine ; Rodriguez-Villalobos, Hector ; Tulkens, Paul M. ; Elens, Laure ; Van Bambeke, Françoise ; Laterre, Pierre-François. Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. In: Antibiotics, Vol. 11, no. 7, p. 898 [1-19] (2022). doi:10.3390/antibiotics11070898.
2021
Stillemans, Gabriel ; Paquot, Adrien ; Muccioli, Giulio ; Hoste, Emilia ; Panin, Nadtha ; Åsberg, Anders ; Balligand, Jean-Luc ; Haufroid, Vincent ; Elens, Laure. Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response. In: Clinical and Translational Science, (2021). doi:10.1111/cts.13185.
2021
Mulder, Tessa A. M. ; van Eerden, Ruben A. G. ; de With, Mirjam ; Elens, Laure ; Hesselink, Dennis A. ; Matic, Maja ; Bins, Sander ; Mathijssen, Ron H. J. ; van Schaik, Ron H. N.. CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?. In: Frontiers in Genetics, Vol. 12, no. 12, p. 711943 (2021). doi:10.3389/fgene.2021.711943.
2021
Stillemans, Gabriel ; Djokoto, Happy Phanio ; Delongie, Kévin-Alexandre ; El-Hamdaoui, Halima ; Panin, Nadtha ; Haufroid, Vincent ; Elens, Laure. Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines. In: Scientific Reports, Vol. 11, no. 1, p. 9000 [1-7] (2021). doi:10.1038/s41598-021-88365-7.
2021
Stillemans, Gabriel ; Belkhir, Leïla ; Vandercam, Bernard ; Vincent, Anne ; Haufroid, Vincent ; Elens, Laure. Exploration of reduced doses and short cycle therapy for darunavir/cobicistat in HIV patients using population pharmacokinetic modeling and simulations. In: Clinical Pharmacokinetics, Vol. 60, no. 2, p. 177-189 (2021). doi:10.1007/s40262-020-00920-z.
2021
Stillemans, Gabriel ; Belkhir, Leïla ; Vandercam, Bernard ; Vincent, Anne ; Haufroid, Vincent ; Elens, Laure. Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model. In: European Journal of Clinical Pharmacology, Vol. 77, no. 4, p. 607-616 (2021). doi:10.1007/s00228-020-03036-2.
2021
Bergan, Stein ; Brunet, Mercè ; Hesselink, Dennis A. ; Johnson-Davis, Kamisha L. ; Kunicki, Paweł K. ; Lemaitre, Florian ; Marquet, Pierre ; Molinaro, Mariadelfina ; Noceti, Ofelia ; Pattanaik, Smita ; Pawinski, Tomasz ; Seger, Christoph ; Shipkova, Maria ; Swen, Jesse J. ; van Gelder, Teun ; Venkataramanan, Raman ; Wieland, Eberhard ; Woillard, Jean-Baptiste ; Zwart, Tom C. ; Barten, Markus J. ; Budde, Klemens ; Dieterlen, Maja-Theresa ; Elens, Laure ; Haufroid, Vincent ; Masuda, Satohiro ; Millan, Olga ; Mizuno, Tomoyuki ; Moes, Dirk J. A. R. ; Oellerich, Michael ; Picard, Nicolas ; Salzmann, Linda ; Tönshoff, Burkhard ; van Schaik, Ron H. N. ; Vethe, Nils Tore ; Vinks, Alexander A. ; Wallemacq, Pierre ; Åsberg, Anders ; Langman, Loralie J.. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. In: Therapeutic drug monitoring, Vol. 43, no. 2, p. 150-200 (2021). doi:10.1097/ftd.0000000000000871.
2020
Elens, Laure ; Langman, Loralie J. ; Hesselink, Dennis A. ; Bergan, Stein ; Moes, Dirk Jan A.R. ; Molinaro, Mariadelfina ; Venkataramanan, Raman ; Lemaitre, Florian. Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2 : Considerations Regarding Therapeutic Drug Monitoring and Drug–Drug Interactions. In: Therapeutic Drug Monitoring, Vol. 42, no. 3, p. 360-368 (2020). doi:10.1097/ftd.0000000000000761.
2020
Lemaitre, Florian ; Solas, Caroline ; Grégoire, Matthieu ; Lagarce, Laurence ; Elens, Laure ; Polard, Elisabeth ; Saint‐Salvi, Béatrice ; Sommet, Agnès ; Tod, Michel ; Barin‐Le Guellec, Chantal. Potential drug‐drug interactions associated with drugs currently proposed for COVID‐19 treatment in patients receiving other treatments. In: Fundamental & Clinical Pharmacology, Vol. 34, no. 5, p. 530-547 (2020). doi:10.1111/fcp.12586.
2020
Degraeve, Alexandra ; Moudio Ebosse Timba, Moussinga Serge ; Haufroid, Vincent ; Chaib Eddour, Djamila ; Mourad, Michel ; Bindels, Laure B. ; Elens, Laure. Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.. In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 16, no. 9, p. 769-782 (2020). doi:10.1080/17425255.2020.1803277.
2020
De Greef, Julien ; Doyen, Louise ; Henrard, Séverine ; Elens, Laure ; Vandercam, Bernard ; Belkhir, Leïla. Should we treat bacteremic prostatitis for 7 days?. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 70, no. 2, p. 351 (2020). doi:10.1093/cid/ciz392.
2020
Francke, Marith I. ; de Winter, Brenda C.M. ; Elens, Laure ; Lloberas, Nuria ; Hesselink, Dennis A.. The pharmacogenetics of tacrolimus and its implications for personalized therapy in kidney transplant recipients. In: Expert Review of Precision Medicine and Drug Development, Vol. 5, no.5, p. 313-316 (2020). doi:10.1080/23808993.2020.1776107.
2019
Andrews, L.M. ; Hesselink, D.A. ; Schaik, R.H.N. ; Gelder, T. ; Fijter, J.W. ; Lloberas, N. ; Elens, Laure ; Moes, D.J.A.R. ; Winter, B.C.M.. A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients. In: British Journal of Clinical Pharmacology, (2018). doi:10.1111/bcp.13838.
2019
Brunet, Mercè ; van Gelder, Teun ; Åsberg, Anders ; Haufroid, Vincent ; Hesselink, Dennis A ; Langman, Loralie ; Lemaitre, Florian ; Marquet, Pierre ; Seger, Christoph ; Shipkova, Maria ; Vinks, Alexander ; Wallemacq, Pierre ; Wieland, Eberhard ; Woillard, Jean Baptiste ; Barten, Markus J ; Budde, Klemens ; Colom, Helena ; Dieterlen, Maja-Theresa ; Elens, Laure ; Johnson-Davis, Kamisha L ; Kunicki, Paweł K ; MacPhee, Iain ; Masuda, Satohiro ; Mathew, Binu S ; Millán, Olga ; Mizuno, Tomoyuki ; Moes, Dirk-Jan A R ; Monchaud, Caroline ; Noceti, Ofelia ; Pawinski, Tomasz ; Picard, Nicolas ; van Schaik, Ron ; Sommerer, Claudia ; Vethe, Nils Tore ; de Winter, Brenda ; Christians, Uwe ; Bergan, Stein. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report.. In: Therapeutic drug monitoring, Vol. 41, no.3, p. 261-307 (2019). doi:10.1097/FTD.0000000000000640.
2018
Ekhart, Corine ; Matic, Maja ; Kant, Agnes ; Elens, Laure ; Puijenbroek, Eugène van ; Schaik, Ron van. Cytochrome P450 genotype and aggressive behavior on selective serotonin reuptake inhibitors. In: Pharmacogenomics, Vol. 19, no. 14, p. 1097-1099 (2018). doi:10.2217/pgs-2018-0122.
2018
Lloberas, Nuria ; Hesselink, Dennis A ; van Schaik, Ron Hn ; Grinyò, Josep M ; Colom, Helena ; Gelder, Teun van ; Elens, Laure. Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype.. In: Pharmacogenomics, Vol. 19, no.4, p. 305-310 (2018). doi:10.2217/pgs-2017-0301.
2018
Sennesael, Anne-Laure ; Panin, Nadtha ; Vancraeynest, Christelle ; Pochet, Lionel ; Spinewine, Anne ; Haufroid, Vincent ; Elens, Laure. Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines. In: Scientific Reports, Vol. 8, no. 1, p. 10514 [1-6] (2018). doi:10.1038/s41598-018-28622-4.
2018
Belkhir, Leïla ; Seguin-Devaux, Carole ; Elens, Laure ; Pauly, Caroline ; Gengler, Nicolas ; Schneider, Serge ; Ruelle, Jean ; Haufroid, Vincent ; Vandercam, Bernard. Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients.. In: Scientific Reports, Vol. 8, no.1, p. 7359 [1-8] (2018). doi:10.1038/s41598-018-25803-z.
2018
Stillemans, Gabriel ; Belkhir, Leïla ; Hesselink, Dennis A ; Haufroid, Vincent ; Elens, Laure. Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?. In: Expert opinion on drug metabolism & toxicology, Vol. 14, no. 6, p. 601-611 (2018). doi:10.1080/17425255.2018.1478964.
2018
Sennesael, Anne-Laure ; Larock, Anne-Sophie ; Douxfils Jonathan ; Elens, Laure ; Stillemans, Gabriel ; Wiesen, Martin ; Taubert, Max ; Dogné, Jean-Michel ; Spinewine, Anne ; Mullier, François. Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study.. In: Thrombosis journal, Vol. 16, p. 28 (2018). doi:10.1186/s12959-018-0183-3.
2017
Andreu, Franc ; Colom, Helena ; Elens, Laure ; van Gelder, Teun ; van Schaik, Ronald H N ; Hesselink, Dennis A ; Bestard, Oriol ; Torras, Joan ; Cruzado, Josep M ; Grinyó, Josep M ; Lloberas, Nuria. A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach.. In: Clinical Pharmacokinetics, Vol. 56, p. 963-975 (2017). doi:10.1007/s40262-016-0491-3.
2017
Matic, Maja ; Jongen, Joost Lm ; Elens, Laure ; de Wildt, Saskia N ; Tibboel, Dick ; Sillevis Smitt, Peter Ae ; van Schaik, Ron Hn. Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.. In: Pharmacogenomics, Vol. 18, no.12, p. 1133-1142 (2017). doi:10.2217/pgs-2017-0060.
2017
Elens, Laure ; Haufroid, Vincent. Genotype-based tacrolimus dosing guidelines: with or without CYP3A4*22?. In: Pharmacogenomics, Vol. 18, p. 1473-1480 (2017). doi:10.2217/pgs-2017-0131.
2017
Woillard, Jean-Baptiste ; Mourad, Michel ; Neely, Michael ; Capron, Arnaud ; van Schaik, Ron H ; van Gelder, Teun ; Lloberas, Nuria ; Hesselink, Dennis A ; Marquet, Pierre ; Haufroid, Vincent ; Elens, Laure. Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.. In: Frontiers in Pharmacology, Vol. 8, p. 358 [1-14] (2017). doi:10.3389/fphar.2017.00358.
2017
Lloberas, Nuria ; Elens, Laure ; Llaudó, Ines ; Padullés, Ariadna ; van Gelder, Teun ; Hesselink, Dennis A ; Colom, Helena ; Andreu, Franc ; Torras, Joan ; Bestard, Oriol ; Cruzado, Josep M ; Gil-Vernet, Salvador ; van Schaik, Ron ; Grinyó, Josep M. The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation.. In: Pharmacogenetics and Genomics, Vol. 27, p. 313-322 (2017). doi:10.1097/FPC.0000000000000296.
2016
Dessilly, Géraldine ; Elens, Laure ; Panin, Nadtha ; Karmani, Linda ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib.. In: Pharmacogenomics, Vol. 17, no. 8, p. 883-890 (2016). doi:10.2217/pgs-2016-0012.
2016
Elens, Laure ; Elisabeth, Norman ; Maja, Matic ; Rane, Anders ; Fellman, Vineta ; van Schaik, Ron Hn. Genetic predisposition to poor opioid response in preterm infants: Impact of KCNJ6 and COMT polymorphisms on pain relief after endotracheal intubation.. In: Therapeutic Drug Monitoring, Vol. 38, no. 4, p. 525-33 (2016). doi:10.1097/FTD.0000000000000301.
2016
Dessilly, Géraldine ; Panin, Nadtha ; Elens, Laure ; Haufroid, Vincent ; Demoulin, Jean-Baptiste. Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib.. In: Scientific Reports, Vol. 6, p. 29559 [1-9] (2016). doi:10.1038/srep29559.
2016
Belkhir, Leïla ; Elens, Laure ; Zech, Francis ; Panin, Nadtha ; Vincent, Anne ; Yombi, Jean Cyr ; Vandercam, Bernard ; Haufroid, Vincent. Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism.. In: PLoS One, Vol. 11, no. 10, p. e0165631 [1-13] (2016). doi:10.1371/journal.pone.0165631.
2016
Belkhir, Leïla ; de Laveleye, Morgane ; Vandercam, Bernard ; Zech, Francis ; Delongie, Kévin-Alexandre ; Capron, Arnaud ; Yombi, Jean Cyr ; Vincent, Anne ; Elens, Laure ; Haufroid, Vincent. Quantification of darunavir and etravirine in human peripheral blood mononuclear cells using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS), clinical application in a cohort of 110 HIV-1 infected patients and evidence of a potential drug-drug interaction. In: Clinical Biochemistry, Vol. 49, no. 7-8, p. 580-586 (2016). doi:10.1016/j.clinbiochem.2015.12.011.
2016
Matic, Maja ; de Wildt, Saskia N ; Elens, Laure ; de Hoon, Jan N ; Annaert, Pieter ; Tibboel, Dick ; van Schaik, Ron Hn ; Allegaert, Karel. SLC22A1 /OCT1 genotype affects O-desmethyltramadol exposure in new-born infants.. In: Therapeutic Drug Monitoring, Vol. EPub, no.AOP, p. 1 (2016). doi:10.1097/FTD.0000000000000307.
2015
Traynor, Carol ; Conlon, Peter ; Phelan, Paul J ; O'Kelly, Patrick ; Elens, Laure ; McCormack, Mark ; Cavalleri, Gianpiero ; Comber, Harry ; van Schaik, R H N ; Conlon, Peter J. Association of CYP3A variants with kidney transplant outcomes.. In: Renal Failure, Vol. 37, no. 4, p. 562-566 (2015). doi:10.3109/0886022X.2015.1007013.
2015
De Berdt, Pauline ; Vanacker, Julie ; Ucakar, Bernard ; Elens, Laure ; Diogenes, Anibal ; Leprince, Julian ; Deumens, Ronald ; des Rieux, Anne. Dental Apical Papilla as Therapy for Spinal Cord Injury. In: Journal of Dental Research, Vol. 94, no.11, p. 1575-1581 (2015). doi:10.1177/0022034515604612.
2015
Ragia, Georgia ; Kolovou, Vana ; Tavridou, Anna ; Elens, Laure ; Tselepis, Alexandros D ; Elisaf, Moses ; Van Schaik, Ron H N ; Kolovou, Genovefa ; Manolopoulos, Vangelis G. No effect of CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) on lipid-lowering response to statins in Greek patients with primary hypercholesterolemia. In: Drug metabolism and personalized therapy, Vol. 30, no. 1, p. 43-48 (2015). doi:10.1515/dmdi-2014-0021.
2015
de Jonge, H. ; Elens, Laure ; de Loor, H. ; van Schaik, R. H. ; Kuypers, D. R. J.. The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients.. In: The Pharmacogenomics Journal, Vol. 15, no. 2, p. 144-152 (2015).
2014
Dessilly, Géraldine ; Elens, Laure ; Panin, Nadtha ; Capron, Arnaud ; Decottignies, Anabelle ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. In: PLoS One, Vol. 9, no. 3, p. e91555 [1-11] (2014). doi:10.1371/journal.pone.0091555.
2014
Ragia, Georgia ; Tavridou, Anna ; Elens, Laure ; Van Schaik, Ron H. N. ; Manolopoulos, Vangelis G.. CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas. In: Experimental and Clinical Endocrinology and Diabetes, Vol. 122, no. 1, p. 60-63 (2014). doi:10.1055/s-0033-1361097.
2014
Elens, Laure ; Bouamar, Rachida ; Shuker, Nauras ; Hesselink, Dennis A. ; Van Gelder, Teun ; Van Schaik, Ron H. N.. Clinical implementation of pharmacogenetics in kidney transplantation: Calcineurin inhibitors in the starting blocks. In: British Journal of Clinical Pharmacology, Vol. 77, no. 4, p. 715-728 (2014). doi:10.1111/bcp.12253.
2014
Matic, Maja ; Norman, Elisabeth ; Rane, Anders ; Beck, Olof ; Andersson, Maria ; Elens, Laure ; Tibboel, Dick ; Fellman, Vineta ; van Schaik, Ron H N. Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.. In: Pharmacogenomics, Vol. 15, no. 12, p. 1589-1597 (2014).
2014
Matic, Maja ; Norman, Elisabeth ; Rane, Anders ; Beck, Olof ; Andersson, Maria ; Elens, Laure ; Tibboel, Dick ; Fellman, Vineta ; Van Schaik, Ron H.N.. Effect of UGT2B7-900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: Results from a pilot cohort. In: Pharmacogenomics, Vol. 15, no. 12, p. 1589-1597 (2014). doi:10.2217/pgs.14.115.
2014
Elens, Laure ; Hesselink, Dennis A ; Bouamar, Rachida ; Budde, Klemens ; de Fijter, Johannes W ; De Meyer, Martine ; Mourad, Michel ; Kuypers, Dirk R J ; Haufroid, Vincent ; van Gelder, Teun ; van Schaik, Ron H N. Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. In: Therapeutic Drug Monitoring, Vol. 36, no. 1, p. 71-79 (2014). doi:10.1097/FTD.0b013e31829da6dd.
2014
Guy-Viterbo, Vanessa ; Baudet, Henry ; Elens, Laure ; Haufroid, Vincent ; Lacaille, Florence ; Girard, Muriel ; Debray, Dominique ; Chardot, Christophe ; Reding, Raymond ; Wallemacq, Pierre ; Musuamba, Flora. Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. In: Pharmacogenomics, Vol. 15, no. 9, p. 1207-1221 (2014). doi:10.2217/pgs.14.75.
2014
Ragia, Georgia ; Kolovou, Vana ; Tavridou, Anna ; Elens, Laure ; Tselepis, Alexandros D. ; Elisaf, Moses ; Van Schaik, Ron H. N. ; Kolovou, Genovefa ; Manolopoulos, Vangelis G.. Lack of association of the P450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients. In: Molecular Diagnosis and Therapy, Vol. 18, no. 3, p. 323-331 (2014). doi:10.1007/s40291-013-0082-z.
2014
Drogari, Euridiki ; Ragia, Georgia ; Mollaki, Vasiliki ; Elens, Laure ; Van Schaik, Ron H N ; Manolopoulos, Vangelis G. POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia. In: Pharmacogenomics, Vol. 15, no. 16, p. 1963-1972 (2014). doi:10.2217/pgs.14.138.
2014
Matic, Maja ; Simons, Sinno H.P. ; Van Lingen, Richard A. ; Van Rosmalen, Joost ; Elens, Laure ; De Wildt, Saskia N. ; Tibboel, Dick ; Van Schaik, Ron H.N.. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. In: Pharmacogenomics, Vol. 15, no. 10, p. 1287-1295 (2014). doi:10.2217/pgs.14.100.
2014
Hesselink, Dennis A. ; Bouamar, Rachida ; Elens, Laure ; Van Schaik, Ron H. N. ; Van Gelder, Teun. The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. In: Clinical Pharmacokinetics, Vol. 53, no. 2, p. 123-139 (2014). doi:10.1007/s40262-013-0120-3.
2013
de Graan, Anne-Joy M ; Elens, Laure ; Smid, Marcel ; Martens, John W ; Sparreboom, Alex ; Nieuweboer, Annemieke J M ; Friberg, Lena E ; Elbouazzaoui, Samira ; Wiemer, Erik A C ; van der Holt, Bronno ; Verweij, Jaap ; van Schaik, Ron H N ; Mathijssen, Ron H J. A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.. In: Clinical Cancer Research, Vol. 19, no.18, p. 5210-5217 (2013). doi:10.1158/1078-0432.CCR-13-0487.
2013
Elens, Laure ; Nieuweboer, Annemieke ; Clarke, Stephen J ; Charles, Kellie A ; de Graan, Anne-Joy ; Haufroid, Vincent ; Mathijssen, Ron H J ; van Schaik, Ron H N. CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.. In: Pharmacogenomics, Vol. 14, no.2, p. 137-149 (2013). doi:10.2217/pgs.12.202.
2013
Gijsen, Violette Mgj ; Van Schaik, Ron Hn ; Elens, Laure ; Soldin, Offie P ; Soldin, Steven J ; Koren, Gideon ; De Wildt, Saskia N. CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. In: Pharmacogenomics, Vol. 14, no. 9, p. 1027-1036 (2013). doi:10.2217/pgs.13.80.
2013
de Graan, Anne-Joy M ; Elens, Laure ; Sprowl, Jason A ; Sparreboom, Alex ; Friberg, Lena E ; van der Holt, Bronno ; de Raaf, Pleun J ; de Bruijn, Peter ; Engels, Frederike K ; Eskens, Ferry A L M ; Wiemer, Erik A C ; Verweij, Jaap ; Mathijssen, Ron H J ; van Schaik, Ron H N. CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.. In: Clinical Cancer Research, Vol. 19, no.12, p. 3316-3324 (2013). doi:10.1158/1078-0432.CCR-12-3786.
2013
Elens, Laure ; van Gelder, Teun ; Hesselink, Dennis A ; Haufroid, Vincent ; van Schaik, Ron H N. CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy. In: Pharmacogenomics, Vol. 14, no. 1, p. 47-62 (2013). doi:10.2217/pgs.12.187.
2013
Becker, M L ; Elens, Laure ; Visser, L E ; Hofman, A ; Uitterlinden, A G ; van Schaik, R H N ; Stricker, B H. Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy.. In: The Pharmacogenomics Journal, Vol. 13, no.3, p. 251-256 (2011). doi:10.1038/tpj.2011.59.
2013
De Keyser, Catherine E ; Becker, Matthijs L ; Uitterlinden, André G ; Hofman, Albert ; Lous, Jan J ; Elens, Laure ; Visser, Loes E ; Van Schaik, Ron Hn ; Stricker, Bruno H. Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. In: Pharmacogenomics, Vol. 14, no. 11, p. 1295-1304 (2013). doi:10.2217/pgs.13.112.
2013
Elens, Laure ; Capron, Arnaud ; van Schaik, Ron H N ; De Meyer, Martine ; De Pauw, Luc ; Eddour, Djamila C ; Latinne, Dominique ; Wallemacq, Pierre ; Mourad, Michel ; Haufroid, Vincent. Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines. In: Therapeutic Drug Monitoring, Vol. 35, no. 5, p. 608-616 (2013). doi:10.1097/FTD.0b013e318296045b.
2013
Elens, Laure ; Nieuweboer, Annemieke J M ; Clarke, Stephen J ; Charles, Kellie A ; de Graan, Anne-Joy M ; Haufroid, Vincent ; van Gelder, Teun ; Mathijssen, Ron H J ; van Schaik, Ron H N. Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.. In: Pharmacogenetics and Genomics, Vol. 23, no.3, p. 148-155 (2013). doi:10.1097/FPC.0b013e32835dc113.
2013
Elens, Laure ; Sombogaard, Ferdi ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus.. In: Pharmacogenetics and Genomics, Vol. 23, no.12, p. 649-657 (2013). doi:10.1097/FPC.0000000000000001.
2013
Elens, Laure ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations. In: British Journal of Clinical Pharmacology, Vol. 75, no. 6, p. 1545-1547 (2013). doi:10.1111/bcp.12038.
2013
Ahlers, Sabine J G M ; Elens, Laure ; van Gulik, Laura ; van Schaik, Ron H ; van Dongen, Eric P A ; Bruins, Peter ; Tibboel, Dick ; Knibbe, Catherijne A J. The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.. In: British Journal of Clinical Pharmacology, Vol. 75, no.6, p. 1506-1515 (2013). doi:10.1111/bcp.12052.
2012
De Meyer, Martine ; Haufroid, Vincent ; Elens, Laure ; Fusaro, Fabio ; Patrono , Damiano ; De Pauw, Luc ; Kanaan, Nada ; Goffin, Eric ; Mourad, Michel. Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation.. In: Journal of Surgical Research, Vol. 178, no.2, p. 988-95 (2012). doi:10.1016/j.jss.2012.06.070.
2012
de Graan, Anne-Joy M ; Lancaster, Cynthia S ; Obaidat, Amanda ; Hagenbuch, Bruno ; Elens, Laure ; Friberg, Lena E ; de Bruijn, Peter ; Hu, Shuiying ; Gibson, Alice A ; Bruun, Gitte H ; Corydon, Thomas J ; Mikkelsen, Torben S ; Walker, Aisha L ; Du, Guoqing ; Loos, Walter J ; van Schaik, Ron H N ; Baker, Sharyn D ; Mathijssen, Ron H J ; Sparreboom, Alex. Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.. In: Clinical Cancer Research, Vol. 18, no. 16, p. 4433-4440 (2012). doi:10.1158/1078-0432.CCR-12-0761.
2012
Bouamar, Rachida ; Elens, Laure ; Shuker, Nauras ; van Schaik, Ron H N ; Weimar, Willem ; Hesselink, Dennis A ; van Gelder, Teun. Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8.. In: Transplantation, Vol. 93, no.10, p. e39-40; author reply e41-2 (2012). doi:10.1097/TP.0b013e3182488bb4.
2012
Elens, Laure ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. Pharmacogenetics in kidney transplantation: recent updates and potential clinical applications. In: Molecular Diagnosis and Therapy, Vol. 16, no. 6, p. 331-345 (2012). doi:10.1007/s40291-012-0012-5.
2012
Elens, Laure ; Bouamar, Rachida ; Hesselink, Dennis A ; Haufroid, Vincent ; van Gelder, Teun ; van Schaik, Ron H N. The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.. In: Pharmacogenetics and genomics, Vol. 22, no.5, p. 373-80 (2012). doi:10.1097/FPC.0b013e328351f3c1.
2011
Elens, Laure ; Bouamar, Rachida ; Hesselink, Dennis A ; Haufroid, Vincent ; van der Heiden, Ilse P ; van Gelder, Teun ; van Schaik, Ron H N. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.. In: Clinical Chemistry : international journal of molecular diagnostics and laboratory medicine, Vol. 57, no. 11, p. 1574-83 (2011). doi:10.1373/clinchem.2011.165613.
2011
Elens, Laure ; van Schaik, Ron H. ; Panin, Nadtha ; De Meyer, Martine ; Wallemacq, Pierre ; Lison, Dominique ; Mourad, Michel ; Haufroid, Vincent. Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients. In: Pharmacogenomics, Vol. 12, no. 10, p. 1383-1396 (2011). doi:10.2217/pgs.11.90.
2011
Elens, Laure ; Tyteca, Donatienne ; Panin, Nadtha ; Courtoy, Pierre J. ; Lison, Dominique ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. Functional defect caused by the 4544G>A SNP in ABCC2 : potential impact for drug cellular disposition.. In: Pharmacogenetics and Genomics, Vol. 21, no. 12, p. 884-893 (2011). doi:10.1097/FPC.0b013e32834d672b.
2011
Elens, Laure ; Vandercam, Bernard ; Yombi, Jean Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Haufroid, Vincent. Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.. In: Pharmacogenomics, Vol. 11, no. 9, p. 1223-1234 (2010). doi:10.2217/pgs.10.94.
2011
Elens, Laure ; Becker, Matthijs L ; Haufroid, Vincent ; Hofman, Albert ; Visser, Loes E ; Uitterlinden, André G ; Stricker, Bruno Ch ; van Schaik, Ron H N. Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in The Rotterdam Study.. In: Pharmacogenetics and Genomics, Vol. 21, no. 12, p. 861-6 (2011). doi:10.1097/FPC.0b013e32834c6edb.
2010
Capron, Arnaud ; Mourad, Michel ; De Meyer, Martine ; De Pauw, Luc ; Eddour, Djamila Chaib ; Latinne, Dominique ; Elens, Laure ; Haufroid, Vincent ; Wallemacq, Pierre. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation.. In: Pharmacogenomics, Vol. 11, no. 5, p. 703-714 (2010). doi:10.2217/pgs.10.43.
2009
Elens, Laure ; Haufroid, Vincent ; Doyen, Chantal ; Vandercam, Bernard ; Yombi, Jean Cyr. Acute intoxication with nevirapine in an HIV-1-infected patient : clinical and pharmacokinetic follow up.. In: AIDS (London, England), Vol. 23, no. 10, p. 1291-1293 (2009). doi:10.1097/QAD.0b013e328325d61f.
2009
Elens, Laure ; Yombi, Jean Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. In: Pharmacogenomics, Vol. 10, no. 10, p. 1589-1597 (2009). doi:10.2217/PGS.09.88.
2009
Elens, Laure ; Yombi, Jean-Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.. In: Pharmacogenomics, Vol. 10, no.10, p. 1589-1597 (2009). doi:10.2217/pgs.09.88.
2009
Elens, Laure ; Veriter, Sophie ; Yombi, Jean Cyr ; Di Fazio, V ; Vanbinst, R ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, B ; Haufroid, Vincent. Validation and Clinical Application of a High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantitative Determination of 10 Antiretrovirals in Human Peripheral Blood Mononuclear Cells. In: Therapeutic drug monitoring, Vol. 31, no. 5, p. 19 - (2009).
2009
Elens, Laure ; Veriter, Sophie ; Yombi, Jean Cyr ; Di Fazio, V. ; Vanbinst, R. ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Validation and clinical application of a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 10 anti-retrovirals in human peripheral blood mononuclear cells.. In: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Vol. 877, no. 20-21, p. 1805-14 (2009). doi:10.1016/j.jchromb.2009.04.046.
2008
Elens, Laure ; Veriter, Sophie ; Di Fazio, Vincent ; Vanbinst, Roger ; Boesmans, Daniel ; Wallemacq, Pierre ; Haufroid, Vincent. Quantification of 8 HIV-Protease Inhibitors and 2 Nonnucleoside Reverse Transcriptase Inhibitors by Ultra-Performance Liquid Chromatography with Diode Array Detection.. In: Clinical chemistry, Vol. 55, no. 1, p. 170-174 (2009). doi:10.1373/clinchem.2008.108647.
2007
Elens, Laure ; Capron, Arnaud ; Kerckhove, Valérie Van ; Lerut, Jan ; Mourad, Michel ; Lison, Dominique ; Wallemacq, Pierre ; Haufroid, Vincent. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation.. In: Pharmacogenetics and Genomics, Vol. 17, no. 10, p. 873-883 (2007). doi:10.1097/FPC.0b013e3282e9a533.
2006
Haufroid, Vincent ; De Meyer, Martine ; Wallemacq, Pierre ; Van Kerckhove, Valérie ; Elens, Laure ; Eddour, D C ; Malaise, Jacques ; Lison, Dominique ; Mourad, Michel. CYP3A5 and ABCB1 polymorphisms and tacrolimus pharmacokinetics in renal transplant candidates: guidelines from an experimental study.. In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 6, no. 11, p. 2706-13 (2006). doi:10.1111/j.1600-6143.2006.01518.x.
2022
Lagreula, Juliette ; Elens, Laure ; de Timary, Philippe ; Dalleur, Olivia. Antipsychotics deprescribing in schizophrenia: trends and associated characteristics in Belgium and Québec. International Conference on Deprescribing ICOD (Kolding, Denmark, du 05/09/2022 au 07/09/2022).
2022
Lagreula, Juliette ; Elens, Laure ; de Timary, Philippe ; Dalleur, Olivia. Characterising the evolution of antipsychotic polypharmacy and clozapine prescribing patterns in schizophrenia patients during psychiatric hospitalisations. European Psychiatric Association (du 04/06/2022 au 07/06/2022). In: European psychiatry, Vol. 65, no.S1, p. 98 (2022). doi:10.1192/j.eurpsy.2022.284.
2021
Lagreula, Juliette ; de Timary, Philippe ; Elens, Laure ; Dalleur, Olivia. Antipsychotic polypharmacy- Evolution of prescribing patterns between admission and discharge of 5 Belgian hospitals. World Congress of Psychiatry (du 18/10/2021 au 21/10/2021).
2017
Belkhir, Leïla ; Vandercam, Bernard ; Haufroid, Vincent ; Elens, Laure. Effect of ABCB1 Polymorphisms on Darunavir Plasma and Intracellular Concentrations. 16th European AIDS conference ((Italy) Minalo, du 25/10/2017 au 27/10/2017).
2017
Belkhir, Leïla ; Elens, Laure ; Zech, Francis ; Panin, Nadtha ; Yombi, Jean Cyr ; Vandercam, Bernard ; Haufroid, Vincent. Interaction Between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism. 15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology ((Japan) Kyoto, du 24/9/2017 au 27/09/2017).
2016
De Berdt, Pauline ; Vanacker, Julie ; Leprince, Julian ; Ucakar, Bernard ; Elens, Laure ; Schakman, Olivier ; Elens, Laure ; Deumens, Ronald ; des Rieux, Anne. Apical papilla implantation promotes functional recovery after rat spinal cord injury. SCI and neurotrauma summer school (Hattingen (Germany), 28/06/2016).
2016
Belkhir, Leïla ; Elens, Laure ; Zech, Francis ; Vandercam, Bernard ; Haufroid, Vincent. Impact of CYP3A5 polymorphism on trough plasma concentrations of darunavir when co-administred with etravirine in a cohort of HIV-1 infected patients. IREC 3rd PhD Day ((Belgium) Bruxelles, du 04/03/2016 au 04/03/2016).
2015
De Berdt, Pauline ; Vanacker, Julie ; Leprince, Julian ; Ucakar, Bernard ; Schakman, Olivier ; Elens, Laure ; Deumens, Ronald ; des Rieux, Anne. Apical papilla from human teeth promotes functional recovery after rat spinal cord injury. Cribio 29/01/2015 (UCL (Woluwé) (Belgium), 29/01/2015).
2015
Belkhir, Leïla ; Elens, Laure ; Pauly, C. ; Devaux, C. ; Schneider, S. ; Yombi, Jean Cyr ; Vincent, Anne ; Vandercam, Bernard ; Haufroid, Vincent. Impact of UGT1A1*28 Polymorphism on Raltegravir Metabolism. 15th European AIDS Conference ((Spain) Barcelona, du 21/10/2015 au 24/10/2015).
2015
Belkhir, Leïla ; Elens, Laure ; Pauly, C. ; Devaux, C. ; Schneider, S. ; Yombi, Jean Cyr ; Vincent, Anne ; Vandercam, Bernard ; Haufroid, Vincent. Impact of UGT1A1*28 Polymorphism on Raltegravir Metabolism. 4th BREACH : "What's going on in Belgium in the field of HIV / AIDS?" ((Belgium) Antwerp, 27/11/2015).
2015
Personalizing Immunosuppressive therapy.. European Society of organ transplantation (ESOT) congress (Brussels, du 13/09/2015 au 16/09/2015). In: , collab. Elens, Laure, 2015.
2015
Elens, Laure. Pharmacogenetics of ABC transporters: consequences on tissue distribution and clinical outcomes. 2015 Annual French-Belgian Meeting on ABC proteins and other transporters (Paris, du 08/10/2015 au 09/10/2015). In: , 2015.
2015
Elens, Laure. Pharmacogenetics of Opioids. 14th International Congress of Therapeutic Drug monitoring and Clinical Toxicology (IATDMCT) (Rotterdam, The Netherlands, du 11/10/2015 au 15/10/2015). In: , 2015.
2014
Belkhir, Leïla ; de Laveleye, Morgane ; Elens, Laure ; Zech, Francis ; Capron, Arnaud ; Vincent, Anne ; Yombi, Jean Cyr ; Vandercam, Bernard ; Haufroid, Vincent. Development, validation and clinical application of a high performance liquid chromatography method with tandem mass spectrometry (LC-MS/MS) for the quantification of Darunavir in Peripheral blood mononuclear cells in 104 HIV-positive patients. IREC 2d PhD Day ((Belgium) Bruxelles, 09/2014).
2014
Elens, Laure. European Society of Pharmacogenomics and Personalised Therapy (ESPT) congress. European Society of Pharmacogenomics and Personalised Therapy (ESPT) congress. (Santorini, du 25/09/2014 au 27/09/2014). In: , 2014.
2014
Elens, Laure. SNiPer. Mission : Tailoring tacrolimus therapy in renal transplantation. Target: ABC and CYP genes. Is it impossble?. GMP/DMDG (Paris, du 22/10/2014 au 24/10/2014).
2014
Elens, Laure. « From new diagnosis to new therapeutics ». European society of organ transplantation + American association for transplantation Joint meeting (Madrid, du 17/10/2014 au 19/10/2014).
2013
Elens, Laure. A pharmacogenetic model predicting low paclitaxel clearance based on the DMET platform. . Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) (Chicago, USA, du 31/05/2013 au 04/06/2013). In: Journal of Clinical Oncology, Vol. 31, no.15, p. 1 (mai 2013).
2013
Elens, Laure. Companion diagnostics: Clinical significance of Pharmacogenetics, the concept of personalized therapy. xSample Luminex Congress (Rotterdam, The Netherlands, 12/06/2013).
2013
Elens, Laure. EARLY TACROLIMUS DOSING IN PEDIATRIC LIVER TRANSPLANTATION DEPENDS ON RECIPIENT CYP3A5 AND ABCB1 (or MDR1) GENOTYPES: EXPERIENCE IN LIVING DONOR RECIPIENTS. International Pediatric Transplant Association (Mont Laurel, USA, du 13/07/2013 au 16/07/2013). In: Pediatric Transplantation, Vol. 17, no.S1, p. 1-118 (Aug 2013).
2013
Elens, Laure. Early Tacrolimus Dosing in Pediatric Liver Transplantation Depends on Recipient CYP3A5 and ABCB1 (or MDR1) Genotypes: Experience in Living Donor Recipients . 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Salt lake city, USA, du 22/09/2013 au 26/09/2013). In: Therapeutic Drug Monitoring, Vol. 35, no.5, p. 709 (octobre 2013).
2013
Elens, Laure. GENETIC PREDISPOSITIONS FOR THE DEVELOPMENT OF NEW-ONSET OF DIABETES AFTER KIDNEY TRANSPLANTATION . 16th ESOT Congress (Austria, du 08/09/2013 au 11/09/2013). In: Transplant International, Vol. 26, no.S3, p. 1-33 (Novembre 2013).
2013
Elens, Laure. Genetic Variation in the PPARA Gene Is Associated with Simvastatin-Mediated Cholesterol Reduction in the Rotterdam Study . 29th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (Montréal, Canada, du 25/08/2013 au 28/08/2013). In: Pharmacoepidemiology and Drug Safety : an international journal, Vol. 22, no.S1, p. 23-24 (Octobre 2013).
2013
Elens, Laure. Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: Towards updated genotype-based dosing guidelines. 13th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) (Salt Lake City, USA, du 22/09/2013 au 26/09/2013).
2013
Elens, Laure. Impact of POR*28 on the Clinical Pharmacokinetics of CYP3A Phenotyping Probes Midazolam and Erythromycin . 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Salt Lake City, USA, du 22/09/2013 au 26/09/2013). In: Therapeutic Drug Monitoring, Vol. 35, no.5, p. 686 (octobre 2013).
2013
Elens, Laure. Impact of POR*28 on the Pharmacokinetics of Tacrolimus and Cyclosporine A in Renal Transplant Patients . 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Salt lake city usa, du 22/09/2013 au 26/09/2013). In: Therapeutic Drug Monitoring, Vol. 35, no.5, p. 709 (octobre 2013).
2013
Elens, Laure. Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin. 13th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) (Salt Lake city, USA, du 22/09/2013 au 26/09/2013).
2013
Elens, Laure. Pharmacogenetics of statins: Are we ready for the clinic?. the Royal Belgian Society of Clinical Chemistry annual symposium (Brussels, Belgium, 12/04/2013).
2013
Elens, Laure. Single-nucleotide polymorphisms in P450 Oxidoreductase and Peroxisome Proliferator-Activated Receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus.. European Society for Organ transplantation (ESOT) annual Congress (Vienna, Austria, du 15/09/2013 au 18/09/2013).
2013
Elens, Laure. TACROLIMUS FIRST DOSE DEPENDS ON RECIPIENT CYP3A5 AND ABCB1 (OR MDR1) GENOTYPES IN PEDIATRIC LIVER TRANSPLANTATION: EXPERIENCE IN LIVING DONOR RECIPIENTS . 13th ESOT (Austria, du 08/09/2013 au 11/09/2013). In: Transplant International, Vol. 26, no.S2, p. 199 (sept 2013).
2012
Elens, Laure. A NEW FUNCTIONAL CYP3A4 POLYMORPHISM (CYP3A4*22) IS ASSOCIATED WITH INCREASED RISK OF DELAYED GRAFT FUNCTION AND WORSE RENAL FUNCTION IN CYCLOSPORIN-TREATED KIDNEY TRANSPLANT RECIPIENTS. . 113th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) (Washington, USA, du 14/03/2012 au 17/03/2012). In: Clinical Pharmacology and Therapeutics, Vol. 91, no.S1, p. S107 (mars 2012).
2012
Elens, Laure. ASSOCIATION BETWEEN THE CYP3A4*22 ALLELE AND THE PHARMACOKINETICS OF THE CYP3A4 PHENOTYPING PROBES MIDAZOLAM AND ERYTHROMYCIN IN CANCER PATIENTS. . 113th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) (Washington, USA, du 14/03/2012 au 17/03/2012). In: Clinical Pharmacology and Therapeutics, Vol. 91, no.S1, p. S107 (mars 2012).
2012
Elens, Laure. Association between the CYP3A4*22 allele and the pharmacokinetics of the CYP3=a4 phenotyping probes Midazolam and erythromycin in cancer patients. Annual meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) (Washington, USA, du 11/03/2012 au 14/03/2012).
2012
Elens, Laure. INFLUENCE OF DRUG EXPOSURE AND GENETIC VARIATION ON PACLITAXEL-INDUCED NEUROTOXICITY . 37th Congress of the European-Society-for-Medical-Oncology (ESMO) (Vienna, Austria, du 28/09/2012 au 02/10/2012). In: Annals of Oncology, Vol. 23, no.9, p. 534 (septembre 2012).
2012
Elens, Laure. Pharmacogenetic aspects of taxanen therapy toxicity . 48th Congress of the European-Societies-of-Toxicology (EUROTOX) (Staocholm, Sweden, du 17/06/2012 au 20/06/2012). In: Toxicology Letters, Vol. 211, no.S, p. S20-S21 (juin 2012).
2012
Elens, Laure. THE NEW CYP3A4 INTRON 6 POLYMORPHISM (CYP3A4*22) IS SIGNIFICANTLY ASSOCIATED WITH DECREASED TACROLIMUS METABOLISM. . 113th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) (Washington, USA, du 14/03/2012 au 17/03/2012). In: Clinical Pharmacology and Therapeutics, Vol. 91, no.S1, p. S107 (mars 2012).
2012
Elens, Laure. The new CYP3A4 intron 6 SNP significantly affects drug metabolism of midazolam, erythromycin and tacrolimus. 16th Molecular medicine Day (Rotterdam, The Netherlands, 10/02/2012).
2011
Elens, Laure. A new CYP3A4 polymorphism is associated with an increased risk of renal toxicity in cyclosporin-treated kidney transplant recipients. 12th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) (Stuttgart, Germany, du 16/10/2011 au 19/10/2011).
2011
Elens, Laure. A new CYP3A4 polymorphism is associated with an increased risk of renal toxicity in cyclosporin-treated kidney transplant recipients . 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Stuttgart, Germany, du 02/10/2011 au 06/10/2011). In: Therapeutic Drug Monitoring, Vol. 33, no.4, p. 480 (aout 2011).
2011
Elens, Laure. A new functional CYP3A4 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Stuttgart, Germany, du 02/10/2011 au 06/10/2011). In: Therapeutic Drug Monitoring, Vol. 33, no.4, p. 507 (aout 2011).
2011
Elens, Laure. Effect of a new functional CYP3A4 polymorphism on cyclosporine dose requirement and trough blood levels in stable renal transplant patients . 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Stuttgart, Germany, du 02/10/2011 au 06/10/2011). In: Therapeutic Drug Monitoring, Vol. 33, no.4, p. 506-507 (aout 2011).
2011
Elens, Laure. Effect of a new functional CYP3A4 polymorphism on tacrolimus dose requirement and trough blood levels in stable renal transplant patients . 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Stuttgart, Germany, du 02/10/2011 au 06/10/2011). In: Therapeutic Drug Monitoring, Vol. 33, no.4, p. 507 (aout 2011).
2009
Elens, Laure ; Yombi, Jean Cyr ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent ; Lison, Dominique. ABCC2 4544G > A Polymorphism is Associated with Lopinavir Accumulation in Peripheral Blood Mononuclear Cells of HIV-Infected Patients. 11th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Montreal (Canada), Oct 03-08, 2009). In: Therapeutic Drug Monitoring, Vol. 31, no. 5, p. 622-622 (2009).
2009
Elens, Laure. ABCC2 4544G>A polymorphism is associated with Lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) (Montréal, Canada, du 04/10/2009 au 08/10/2009).
2009
Elens, Laure. Validation and Clinical Application of a High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantitative Determination of 10 Antiretrovirals in Human Peripheral Blood Mononuclear Cells . 11th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Montréal, Canada, du 03/10/2009 au 08/10/2009). In: Therapeutic Drug Monitoring, Vol. 31, no.5, p. 609 (octobre 2009).
2009
Elens, Laure. Validation and clinical application of a LC-MS/MS method for the quantitative determination of 10 anti-retrovirals in human peripheral blood mononuclear cells.. 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) (Montréal, Canada, du 04/10/2009 au 08/10/2009).
2008
Elens, Laure. Validation and clinical application of a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method with isotopic dilution for the quantitative determination of 10 anti-retrovirals in human peripheral blood mononuclear cells. Belgian and Luxembourg Society of Toxicology (BLT) (Brussels, 01/11/2008).
2007
Elens, Laure. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently influence tacrolimus concentration in hepatic tissue after liver transplantation.. Belgian Society of Toxicology and Ecotoxicology (Beltox) (Namur, 01/11/2007).
2007
Elens, Laure. Tacrolimus concentrations in liver biopsies after hepatic transplantation: Correlation with histopathologic staging of rejection, time post-transplantation and genetic polymorphism . 10th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (Nice, France, du 09/09/2007 au 14/09/2007). In: Therapeutic Drug Monitoring, Vol. 29, no.4, p. 484-485 (aout 2007).
2010
Elens, Laure. Pharmacogenetic determinants of antiretroviral therapy : the case of lopinavir, prom. : Haufroid, Vincent, 29/10/2010.