Mandy Grootaert
Professeure
2023
Simmonds, Steven J ; Grootaert, Mandy ; Cuijpers, Ilona ; Carai, Paolo ; Geuens, Nadeche ; Herwig, Melissa ; Baatsen, Pieter ; Hamdani, Nazha ; Luttun, Aernout ; Heymans, Stephane ; Jones, Elizabeth A V ; FJ Ketelhuth, Daniel. Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction. In: European Heart Journal Open, Vol. 4, no.1, p. 13 (2023). doi:10.1093/ehjopen/oead129.
2023
Bonacina, Fabrizia ; Di Costanzo, Alessia ; Genkel, Vadim ; Kong, Xiang Yi ; Kroon, Jeffrey ; Stimjanin, Ena ; Tsiantoulas, Dimitrios ; Grootaert, Mandy. The heterogeneous cellular landscape of atherosclerosis: Implications for future research and therapies. A collaborative review from the EAS young fellows. In: Atherosclerosis, Vol. 372, no.372, p. 48-56 (2023). doi:10.1016/j.atherosclerosis.2023.03.021.
2022
Grootaert, Mandy ; Bennett, Martin R.. Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets. In: Nature Reviews Cardiology, Vol. 19, no.10, p. 668-683 (2022). doi:10.1038/s41569-022-00685-x.
2021
Coornaert, Isabelle ; Puylaert, Pauline ; Marcasolli, Giullia ; Grootaert, Mandy ; Vandenabeele, Peter ; De Meyer, Guido R.Y. ; Martinet, Wim. Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice. In: Atherosclerosis, Vol. 322, p. 51-60 (2021). doi:10.1016/j.atherosclerosis.2021.02.021.
2021
Grootaert, Mandy ; Finigan, Alison ; Figg, Nichola L. ; Uryga, Anna K. ; Bennett, Martin R.. SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis. In: Circulation Research, Vol. 128, no.4, p. 474-491 (2021). doi:10.1161/circresaha.120.318353.
2021
Uryga, Anna K. ; Grootaert, Mandy ; Garrido, Abel M. ; Oc, Sebnem ; Foote, Kirsty ; Chappell, Joel ; Finigan, Alison ; Rossiello, Francesca ; d’Adda di Fagagna, Fabrizio ; Aravani, Dimitra ; Jorgensen, Helle F. ; Bennett, Martin R.. Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury. In: Communications Biology, Vol. 4, no.1, p. 16 (2021). doi:10.1038/s42003-021-02123-z.
2021
Grootaert, Mandy ; Bennett, Martin R. Vascular smooth muscle cells in atherosclerosis: time for a re-assessment. In: Cardiovascular Research, Vol. 117, no.11, p. 2326-2339 (2021). doi:10.1093/cvr/cvab046.
2018
Grootaert, Mandy ; Roth, Lynn ; Schrijvers, Dorien M. ; De Meyer, Guido R. Y. ; Martinet, Wim ; Pająk, Beata. Defective Autophagy in Atherosclerosis: To Die or to Senesce?. In: Oxidative Medicine and Cellular Longevity, Vol. 2018, no.1 (2018). doi:10.1155/2018/7687083.
2018
Grootaert, Mandy ; Moulis, Manon ; Roth, Lynn ; Martinet, Wim ; Vindis, Cécile ; Bennett, Martin R ; De Meyer, Guido R Y. Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis. In: Cardiovascular Research, Vol. 114, no.4, p. 622-634 (2018). doi:10.1093/cvr/cvy007.
2017
Rombouts, Miche ; Cools, Nathalie ; Grootaert, Mandy ; de Bakker, Flore ; Van Brussel, Ilse ; Wouters, An ; De Meyer, Guido R. Y. ; De Winter, Benedicte Y. ; Schrijvers, Dorien M. ; Lutgens, Esther. Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model. In: PLOS ONE, Vol. 12, no.1, p. e0169608 (2017). doi:10.1371/journal.pone.0169608.
2016
Grootaert, Mandy ; Schrijvers, Dorien M. ; Hermans, Marthe ; Van Hoof, Viviane O. ; De Meyer, Guido R. Y. ; Martinet, Wim ; Kevil, Chris. Caspase‐3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice. In: Oxidative Medicine and Cellular Longevity, Vol. 2016, no.1, p. 11 (2016). doi:10.1155/2016/3087469.
2016
Cleenewerck, Matthias ; Grootaert, Mandy ; Gladysz, Rafaela ; Adriaenssens, Yves ; Roelandt, Ria ; Joossens, Jurgen ; Lambeir, Anne-Marie ; De Meyer, Guido R.Y. ; Declercq, Wim ; Augustyns, Koen ; Martinet, Wim ; Van der Veken, Pieter. Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay. In: European Journal of Medicinal Chemistry, Vol. 123, no.123, p. 631-638 (2016). doi:10.1016/j.ejmech.2016.07.073.
2016
Grootaert, Mandy ; Schrijvers, Dorien M. ; Van Spaendonk, Hanne ; Breynaert, Annelies ; Hermans, Nina ; Van Hoof, Viviane O. ; Takahashi, Nozomi ; Vandenabeele, Peter ; Kim, Soon Ha ; De Meyer, Guido R.Y. ; Martinet, Wim. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. In: Atherosclerosis, Vol. 252, no.252, p. 166-174 (2016). doi:10.1016/j.atherosclerosis.2016.06.045.
2015
De Meyer, Guido R.Y. ; Grootaert, Mandy ; Michiels, Cédéric F. ; Kurdi, Ammar ; Schrijvers, Dorien M. ; Martinet, Wim. Autophagy in Vascular Disease. In: Circulation Research, Vol. 116, no.3, p. 468-479 (2015). doi:10.1161/circresaha.116.303804.
2015
Grootaert, Mandy ; da Costa Martins, Paula A ; Bitsch, Nicole ; Pintelon, Isabel ; De Meyer, Guido RY ; Martinet, Wim ; Schrijvers, Dorien M. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. In: Autophagy, Vol. 11, no.11, p. 2014-2032 (2015). doi:10.1080/15548627.2015.1096485.
2016
Grootaert, Mandy ; Kurdi, Amar ; De munck, Dorien ; Martinet, Wim ; De Meyer, Guido. Autophagy in Atherosclerosis. In: M. A. Hayat, Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging, 2016. 9780128054208.