Yves Jossin

Chercheur qualifié FNRS
Professeur

SSS/MEDE -- Faculty of Medicine and Dentistry

SSS/IONS -- Institute Of NeuroScience (IONS)

SSS/IONS/CEMO -- Pôle Cellulaire et moléculaire

Postmail address

IONS
Avenue Mounier 53/B1.53.18
1200 Woluwe-Saint-Lambert

yves.jossin@uclouvain.be

IONS

Phone

+32 2 764 55 26

Boucherie C, Alkailani M, Jossin Y, Ruiz-Reig N, Mahdi A, Aldaalis A, Aittaleb M, Tissir F. Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex. J Adv Res. 2024 Jul 14; S2090-1232(24)00296-0. doi: 10.1016/jare.2024.07.012.
Cossard A, Stam K, Smets A, Jossin Y. MKL/SRF and Bcl6 mutual transcription repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. Science Advances. 2023 Nov 17;9(46): eadd0676. doi: 10.1126/sciadv.add0676.
On-Chai Lau E , Damiani D, Chehade G, Ruiz-Reig N, Saade R, Jossin Y, Aittaleb M, Schakman O, Tajeddine N, Gailly P, Tissir F. DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. eLife 2021 Apr 26;10:e61974. doi: 10.7554/eLife.61974.
Jossin Y. Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules 2020 June 26 10(6), 964. doi: 10.3390/biom10060964
Jossin Y. Molecular Mechanisms of Cell Polarity in a Range of Model Systems and in Migrating Neurons. Mol Cell Neurosci. 2020 May 30;103503. doi: 10.1016/j.mcn.2020.103503.
Na Y, Calvo Jiménez E, Kon E, Cao H, Jossin Y,*, Cooper JA*. Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-cadherin and Regulates Neuron Migration During Brain Development. Mol Cell Biol. 2020 Apr 27;MCB.00539-19. doi: 10.1128/MCB.00539-19 (* authors contributed equally)
Kon E, Calvo-Jimenez E, Cossard A, Na Y, Cooper JA, Jossin Y. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. eLife. 2019 Oct 2;8: e47673. doi: 10.7554/eLife.47673.
Boucherie C., Boutin C., Jossin Y., Schakman O., Goffinet AM., Ris L, Gailly P, Tissir F. Neural progenitor fate decision defects, cortical hypoplasia, and behavioral impairment in Celsr1-deficient mice. Mol Psychiatry. 2018 Mar;23(3):723-734. doi: 10.1038/mp.2017.236.
Kon E, Cossard A and Jossin Y. Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex. Front. Cell. Neurosci. 2017 June 16;11:163
Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V. Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells. Dev Cell. 2017 Jun 5;41(5):481-495.e5.

(Recommended by the Faculty of 1000 Prime: 6*)
Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet A. Feedback regulation of apical progenitor fate by immature neurons through Wnt7, Celsr3 and Fzd3 signaling. Nat Commun. 2016 Mar 4;7:10936
Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Chichung Lie D, Jossin Y, and Vanderhaeghen P. Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron, 2013; 79:1123-35.
Jossin Y. Polarization of migrating cortical neurons by Rap1 and N-cadherin : Revisiting the model for the Reelin signaling pathway. Small GTPases. 2011; 2(6):322-328. (Cover Article)
Jossin Y & Cooper JA. Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nat Neurosci. 2011 14(6):697-703.

(Highlighted by the Faculty of 1000. FFa score :8, Must read).
Simó S, Jossin Y, Cooper JA. Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration. J Neurosci. 2010; 30(16):5668-76.
Jossin Y. Chemistry of Reelin. (2008) Reelin glycoprotein: structure, biology and roles in health and disease. (Ed S.H. Fatemi. Springer, New-York, NY).
Jossin Y & Goffinet AM. Reelin signals through PI3K and Akt to control cortical development, and through mTor to regulate dendritic growth. Mol Cell Biol. 2007 27(20):7113-24.
Jossin Y, Gui L, Goffinet AM. Processing of Reelin by embryonic neurons is important for function in tissue, but not in dissociated cultured neurons. J Neurosci. 2007; 27(16):4243-52.
Zhou L, Jossin Y, Goffinet AM. Identification of Small Molecules That Interfere with Radial Neuronal Migration and Early Cortical Plate Development. Cereb Cortex. 2007; 17(1):211-20.
Andrade N, Komnenovic V, Blake S, Jossin Y, Howell B, Goffinet A, Schneider WJ, Nimpf J. ApoER2/ VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci USA. 2007; 104(20):8508-13.
Forster E*, Jossin Y*, Zhao S, Chai X, Frotscher M, Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur J Neurosci. 2006; 23(4):901-9. (* authors contributed equally)
Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP. Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK1 Cells Subjected to Electroporation. Antimicrob Agents Chemother. 2006; 50(4):1213-21.
Price DJ, Kennedy H, Dehay C, Zhou L, Mercier M, Jossin Y, Goffinet AM, Tissir F, Blakey D, Molnar Z. The development of cortical connections. Eur J Neurosci. 2006; 23(4):910-20.
Tissir F, Bar I, Jossin Y, De Backer O., Goffinet AM. Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005; 8(4):451-7.

(Highlighted by the Faculty of 1000, FFa score:8; Must Read).
Jossin Y. Neuronal migration and the role of Reelin during early development of the cerebral cortex. Mol Neurobiol. 2004; 30(3):225-52.
Jossin Y, Ignatova N, Hiesberger T, Herz J, Lambert de Rouvroit C, Goffinet AM. The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development. J Neurosci. 2004; 24(2):514-21.
Bock HH, Jossin Y, May P, Bergner O, Herz J. Apolipoprotein E receptors are required for Reelin-induced proteasomal degradation of the neuronal adaptor protein disabled-1. J Biol Chem. 2004; 279(32):33471-9.
Jossin Y, Ogawa M, Metin C, Tissir F, Goffinet AM. Inhibition of Src family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development. J Neurosci. 2003; 23(30): 9953-9.
Jossin Y, Bar I, Ignatova N, Tissir F, De Rouvroit CL, Goffinet AM. The reelin signaling pathway: some recent developments. Cereb Cortex. 2003; 13(6):627-33.
Bock HH, Jossin Y, Liu P, Forster E, May P, Goffinet AM, Herz J. PI3-Kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem. 2003; 278(40):38772-9.
Jossin Y & Goffinet AM. Reelin does not directly influence axonal growth. J Neurosci. 2001; 21(23):RC183.
Gilot P, Jossin Y, Content J. Cloning, sequencing and characterisation of a Listeria monocytogenes gene encoding a fibronectin-binding protein. J Med Microbiol. 2000; 49(10):887-96.