Motor skill learning and intensive neurorehabilitation Lab (MSL-IN)
ions | Bruxelles Woluwe, Louvain-la-Neuve
Description
The Motor Skill Learning and Intensive Neurorehabilitation (MSL-IN) laboratory has been investigating the optimal parameters of intensive rehabilitation for brain-damaged patients for several years.
Since 2011, our team has developed an innovative method combining upper and lower limb rehabilitation within the same window of opportunity: Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE). This therapy is based on the principles of motor learning and has already demonstrated its ability to deliver significant functional improvements in children with cerebral palsy, linked to cortical reorganization processes that reflect the brain's ability to adapt and strengthen certain structures in response to stimuli.
Our main research projects aim to evaluate the effects of intensive interventions at different levels in various populations of individuals with brain lesions, and to define the optimal modalities of training.
Assessment methods
Multidimensional approach combining functional assessments, advanced analyses of brain plasticity (MRI, DTI) and spinal cord plasticity, pain, muscle mass (ultrasound), cognitive and visual-spatial abilities, etc.
Creation and validation of questionnaires to assess activity and social participation.
Target populations
Our work focuses on intensive neurorehabilitation in pathologies resulting from cerebral lesions or alterations.
To date, our research has focused on different populations:
Babies and children with cerebral palsy (CP)
Stroke patients
Patients with acquired/traumatic brain injuries
Current projects focus on adult patients with bilateral cerebral palsy.
By combining clinical expertise and fundamental research, our laboratory aims to refine intensive rehabilitation protocols to optimize motor and functional recovery in adults with cerebral palsy.
MSL-IN video
Publications
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Article de journalFerron, A., Robert, M. T., Fortin, W., Bau, O., Cardinal, M.-C., Desgagné, J., Saussez, G., Bleyenheuft, Y., & Levac, D. (2024). Virtual Reality and Active Video Game Integration within an Intensive Bimanual Therapy Program for Children with Hemiplegia. Physical & Occupational Therapy in Pediatrics : a quarterly journal of developmental therapy, 44(3), 410-426. https://doi.org/10.1080/01942638.2023.2259462 (Original work published 2024)
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Carton de Tournai, A., Herman, E., Ebner Karestinos, D. S., Gathy, E., Araneda Oyaneder, R., Renders, A., De Clerck, C., Kilcioglu, S., Dricot, L., Macq, B., Vandermeeren, Y., & Bleyenheuft, Y. (2024). Hand-Arm Bimanual Intensive Therapy Including Lower Extremities in Infants With Unilateral Cerebral Palsy: A Randomized Clinical Trial. JAMA Network Open, 7(11), e2445133 [1-14]. https://doi.org/10.1001/jamanetworkopen.2024.45133 (Original work published 2024)
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Papier de conférenceGathy, E., Ebner Karestinos, D. S., Carton de Tournai, A., Herman, E., Araneda Oyaneder, R., Roselli, Z., Someville, M., Lauricella, L., Dricot, L., Macq, B., Vandermeeren, Y., & Bleyenheuft, Y. (2024). Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in chronic stroke: clinical changes. 24th Congress of the European Society for Physical and Rehabilitation Medicine (ESPRM2024), Ljubljana, Slovenia.
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Article de journalSogbossi, E. S., Arnould, C., Kpadonou, T. G., Batcho, C. S., & Bleyenheuft, Y. (2022). Measuring global activity performance in children with cerebral palsy in West Africa: validation of an adapted version of the ACTIVLIM-CP questionnaire. Disability and Rehabilitation, 1-10. https://doi.org/10.1080/09638288.2022.2154083 (Original work published 2022)
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Philippot, A., Dubois, V., Lambrechts, K., Grogna, D., Robert, A., Jonckheer, U., Chakib, W., Beine, A., Bleyenheuft, Y., & De Volder, A. (2022). Data on the impact of physical exercise treatment on depression and anxiety in a psychiatric hospital for adolescents. Data in Brief, 42, 108165 [1-7]. https://doi.org/10.1016/j.dib.2022.108165 (Original work published 2022)
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Article de journalSantamaria, V., Rachwani, J., Saussez, G., Bleyenheuft, Y., Dutkowsky, J., Gordon, A. M., & Woollacott, M. H. (2020). The Seated Postural & Reaching Control Test in Cerebral Palsy: A Validation Study. Physical & Occupational Therapy in Pediatrics : a quarterly journal of developmental therapy, 40(4), 441-469. https://doi.org/10.1080/01942638.2019.1705456 (Original work published 2020)
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Article de journalChabrier, S., Pouyfaucon, M., Chatelin, A., Bleyenheuft, Y., Fluss, J., Gautheron, V., Newman, C. J., Sébire, G., Van Bogaert, P., Vuillerot, C., Brochard, S., & Dinomais, M. (2019). From congenial paralysis to post-early brain injury developmental condition: Where does cerebral palsy actually stand? Annals of physical and rehabilitation medicine, ##(##), ##. https://doi.org/10.1016/j.rehab.2019.07.003 (Original work published 2019)
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Sogbossi, S. E., Houekpetodji, D., Kpadonou, T. G., & Bleyenheuft, Y. (2019). A Cross-sectional Study of the Clinical Profile of Children With Cerebral Palsy in Benin, a West African Low-Income Country. Journal of Child Neurology, 34(13), 842-850. https://doi.org/10.1177/0883073819864516 (Original work published 2019)
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Papier de conférencePhilippot, A., Dubois, V., Lambrechts, K., Grogna, D., Robert, A., Jonckheer, U., Chakib, W., Beine, A., Bleyenheuft, Y., & De Volder, A. (2019). L’activité physique chez les jeunes en santé mentale: un outil préventif et thérapeutique ? Projet T4T « Together for Teens ». Projet T4T « Together for Teens ». Sport et Psychiatrie. Société royale de médecine mentale de Belgique, Beauvallon, Belgique.
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Article de journalIckx, G., Hatem, S. M., Riquelme, I., Friel, K. M., Henne, C., Araneda, R., Gordon, A. M., & Bleyenheuft, Y. (2018). Impairments of Visuospatial Attention in Children with Unilateral Spastic Cerebral Palsy. Neural Plasticity, 2018, 1435808 [1-14]. https://doi.org/10.1155/2018/1435808 (Original work published 2018)
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Gillick, B. T., Gordon, A. M., Feyma, T., Krach, L. E., Carmel, J., Rich, T. L., Bleyenheuft, Y., & Friel, K. (2018). Non-Invasive Brain Stimulation in Children With Unilateral Cerebral Palsy: A Protocol and Risk Mitigation Guide. Frontiers in Pediatrics, ecollection2018(6), 1-9. https://doi.org/10.3389/fped.2018.00056 (Original work published 2018)
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Article de journalSmorenburg, A. R. P., Gordon, A. M., Kuo, H.-C., Ferre, C. L., Brandao, M., Bleyenheuft, Y., Carmel, J. B., & Friel, K. M. (2017). Does Corticospinal Tract Connectivity Influence the Response to Intensive Bimanual Therapy in Children With Unilateral Cerebral Palsy? Neurorehabilitation and Neural Repair, 31(3), 250-260. https://doi.org/10.1177/1545968316675427 (Original work published 2017)
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Saussez, G., Brandão, M. B., Gordon, A. M., & Bleyenheuft, Y. (2017). Including a Lower-Extremity Component during Hand-Arm Bimanual Intensive Training does not Attenuate Improvements of the Upper Extremities: A Retrospective Study of Randomized Trials. Frontiers in Neurology, 8, epages. https://doi.org/10.3389/fneur.2017.00495 (Original work published 2017)
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Ickx, G., Bleyenheuft, Y., & Hatem, S. M. (2017). Development of Visuospatial Attention in Typically Developing Children. Frontiers in Psychology, 8, epages. https://doi.org/10.3389/fpsyg.2017.02064 (Original work published 2017)
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Article de journalMarneweck, M., Kuo, H., Smorenburg, A., Flamand, V., Ferre, C., Bleyenheuft, Y., Gordon, A. M., & Friel, K. M. (2016). Searching for the neural correlates of hand function in unilateral spastic cerebral palsy: does size, strength, and overlap of movement representations matter? Developmental Medicine and Child Neurology. https://doi.org/10.1111/dmcn.16_13224
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Friel, K. M., Kuo, H.-C., Fuller, J., Ferre, C. L., Brandão, M., Carmel, J. B., Bleyenheuft, Y., Gowatsky, J. L., Stanford, A. D., Rowny, S. B., Luber, B., Bassi, B., Murphy, D. L. K., Lisanby, S. H., & Gordon, A. M. (2016). Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy. Neurorehabilitation and Neural Repair, 30(9), 834-844. https://doi.org/10.1177/1545968315625838 (Original work published 2016)
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Article de journalBleyenheuft, Y., Dricot, L., Gilis, N., Kuo, H.-C., Grandin, C., Bleyenheuft, C., Gordon, A. M., & Friel, K. M. (2015). Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study. Research in Developmental Disabilities, 43-44, 136-149. https://doi.org/10.1016/j.ridd.2015.06.014 (Original work published 2015)
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Riquelme, I., Henne, C., Flament, B., Legrain, V., Bleyenheuft, Y., & Hatem, S. (2015). Use of prism adaptation in children with unilateral brain lesion: Is it feasible? Research in Developmental Disabilities, 43-44, 61-71. https://doi.org/10.1016/j.ridd.2015.06.009 (Original work published 2015)
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Papier de conférenceBleyenheuft, Y., Gordon, A. M., Rameckers, E., Thonnard, J.-L., & Arnould, C. (2015). Measuring manual ability changes with ABILHAND-Kids during intensive training for children with cerebral palsy: a responsiveness study. Developmental Medicine and Child Neurology, 57(Suppl 4), 32. https://doi.org/10.1111/dmcn.12780_16 (Original work published 2015)
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Article de journalArnould, C., Bleyenheuft, Y., & Thonnard, J.-L. (2014). Hand Functioning in Children with Cerebral Palsy. Frontiers in Neurology, 5, 48 [1-10]. https://doi.org/10.3389/fneur.2014.00048 (Original work published 2014)
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Article de journalBleyenheuft, C., Bleyenheuft, Y., Hanson, P., & Deltombe, T. (2010). Treatment of genu recurvatum in hemiparetic adult patients: A systematic literature review. Annals of Physical and Rehabilitation Medicine, 53(3), 189-199. https://doi.org/10.1016/j.rehab.2010.01.001 (Original work published 2010)
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