Mammalian Development & Cell Biology (MACE Lab)
ions | Bruxelles Woluwe, Louvain-la-Neuve
Research
The mammalian cerebral cortex plays key roles in learning and memory, the control of sensory and motor functions or of our emotions. The proper execution of these tasks depends on a long process of embryonic and postnatal development which relies on the production by neural stem cells of the appropriate number of neurons with proper identities that migrate to their specific location and make connections with each other. Defective signaling pathways during development are the causes of human brain disorders such as lissencephalies and heterotopias, mental retardation, dyslexia, schizophrenia, autism, epilepsy and many others. The goal of our laboratory is to better define the mechanisms of neural cell proliferation, migration, differentiation and synaptogenesis.
A better understanding of how the brain develops in normal conditions and in disease will provide new concepts for therapeutic approaches to improve diagnosis and to treat and prevent neurodevelopmental disorders.
video MACE
Publications
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Article de journalCalvo-Jiménez, E., Stam, K., Jossi, A., & Jossin, Y. (2025). GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis. Communications Biology, 8(1), 1-14. https://doi.org/10.1038/s42003-025-08014-x (Original work published 2025)
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Boucherie, C., Alkailani, M., Jossin, Y., Ruiz Reig, N., Mahdi, A., Aldaalis, A., Aittaleb, M., & Tissir, F. (2025). Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex. Journal of advanced research, 72, 151-163. https://doi.org/10.1016/j.jare.2024.07.012 (Original work published 2025)
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Article de journalCossard, A., Stam, K., Smets, A., & Jossin, Y. (2023). MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. Science advances, 9(46), eadd0676 [1-20]. https://doi.org/10.1126/sciadv.add0676 (Original work published 2023)
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Article de journalLau, E. O.-C., Damiani, D., Chehade, G., Ruiz-Reig, N., Saade, R., Jossin, Y., Aittaleb, M., Schakman, O., Tajeddine, N., Gailly, P., & Tissir, F. (2021). DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. eLife, 10(10), 61974. https://doi.org/10.7554/eLife.61974 (Original work published 2021)
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Article de journalJossin, Y. (2020). Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons. Molecular and Cellular Neuroscience, 106, 103503 [1-23]. https://doi.org/10.1016/j.mcn.2020.103503 (Original work published 2020)
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Jossin, Y. (2020). Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules, 10(6), 964. (Original work published 2020)
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Na, Y., Calvo Jimenez, E., Kon, E., Cao, H., Jossin, Y., & Cooper, J. A. (2020). Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain development. Molecular and Cellular Biology, 40(14), e00539-19. https://doi.org/10.1128/MCB.00539-19 (Original work published 2020)
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Article de journalKon, E., Calvo Jimenez, E., Cossard, A., Na, Y., Cooper, J. A., & Jossin, Y. (2019). N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. eLife, 8. https://doi.org/10.7554/eLife.47673 (Original work published 2019)
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Article de journalBoucherie, C., Boutin, C., Jossin, Y., Schakman, O., Goffinet, A., Ris, L., Gailly, P., & Tissir, F. (2018). Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. Molecular Psychiatry, 23(3), 723-734. https://doi.org/10.1038/mp.2017.236 (Original work published 2018)
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Article de journalKon, E., Cossard, A., & Jossin, Y. (2017). Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex. Frontiers in Cellular Neuroscience, 11. https://doi.org/10.3389/fncel.2017.00163 (Original work published 2017)
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Jossin, Y., Lee, M., Klezovitch, O., Kon, E., Cossard, A., Lien, W.-H., Fernandez, T. E., Cooper, J. A., & Vasioukhin, V. (2017). Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells. Developmental Cell, 41(5), 481-495. https://doi.org/10.1016/j.devcel.2017.05.002 (Original work published 2017)
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Article de journalWang, W., Jossin, Y., Chai, G., Lien, W.-H., Tissir, F., & Goffinet, A. (2016). Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nature Communications, 7, 10936. https://doi.org/10.1038/ncomms10936 (Original work published 2016)
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Article de journalDimidschstein, J., Passante, L., Dufour, A., van den Ameele, J., Tiberi, L., Hrechdakian, T., Adams, R., Klein, R., Lie, D., Jossin, Y., & Vanderhaeghen, P. (2013). Ephrin-B1 Controls the Columnar Distribution of Cortical Pyramidal Neurons by Restricting Their Tangential Migration. Neuron, 79(6), 1123-1135. https://doi.org/10.1016/j.neuron.2013.07.015 (Original work published 2013)
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Article de journalJossin, Y. (2011). Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway. Small GTPases, 2(6), 322-328. https://doi.org/10.4161/sgtp.18283 (Original work published 2011)
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Jossin, Y., & Cooper, J. A. (2011). Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nature Neuroscience, 14(6), 697-703 (2011 juin). https://doi.org/10.1038/nn.2816 (Original work published 2011)
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Article de journalSimo, S., Jossin, Y., & Cooper, J. (2010). Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration. The Journal of Neuroscience, 30(16), 5668-5676. https://doi.org/10.1523/JNEUROSCI.0035-10.2010 (Original work published 2010)
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Chapitre de livreJossin, Y. (2008). Chemistry of Reelin. In S.H. Fatemi (ed.), Reelin glycoprotein: structure, biology and roles in health and disease. Springer.
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Article de journalAndrade, N., Komnenovic, V., Blake, S. M., Jossin, Y., Howell, B., Goffinet, A., Schneider, W. J., & Nimpf, J. (2007). ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proceedings of the National academy of sciences of the United States of America, 104(20), 8508-8513. https://doi.org/10.1073/pnas.0611391104 (Original work published 2007)
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Jossin, Y., & Goffinet, A. (2007). Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Molecular and Cellular Biology, 27(20), 7113-7124. https://doi.org/10.1128/MCB.00928-07 (Original work published 2007)
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Zhou, L., Jossin, Y., & Goffinet, A. (2007). Identification of small molecules that interfere with radial neuronal migration and early cortical plate development. Cerebral Cortex, 17(1), 211-220. https://doi.org/10.1093/cercor/bhj139 (Original work published 2007)
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Jossin, Y., Gui, L., & Goffinet, A. (2007). Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons. The Journal of Neuroscience, 27(16), 4243-4252. https://doi.org/10.1523/JNEUROSCI.0023-07.2007 (Original work published 2007)
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Article de journalFörster, E., Jossin, Y., Zhao, S., Chai, X., Frotscher, M., & Goffinet, A. (2006). Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. European Journal of Neuroscience, 23(4), 901-909. https://doi.org/10.1111/j.1460-9568.2006.04612.x (Original work published 2006)
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Servais, H., Jossin, Y., Van Bambeke, F., Tulkens, P. M., & Mingeot-Leclercq, M.-P. (2006). Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrobial Agents and Chemotherapy, 50(4), 1213-1221. https://doi.org/10.1128/AAC.50.4.1213-1221.2006 (Original work published 2006)
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Price, D. J., Kennedy, H., Dehay, C., Zhou, L., Mercier, M., Jossin, Y., Goffinet, A., Tissir, F., Blakey, D., & Molnár, Z. (2006). The development of cortical connections. European Journal of Neuroscience, 23(4), 910-920. https://doi.org/10.1111/j.1460-9568.2006.04620.x (Original work published 2006)
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Article de journalTissir, F., Bar, I., Jossin, Y., & Goffinet, A. (2005). Protocadherin Celsr3 is crucial in axonal tract development. Nature Neuroscience, 8(4), 451-457. https://doi.org/10.1038/nn1428 (Original work published 2005)
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Article de journalJossin, Y., Ignatova, N., Hiesberger, T., Herz, J., Lambert de Rouvroit, C., & Goffinet, A. (2004). The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development. The Journal of Neuroscience, 24(2), 514-521. https://doi.org/10.1523/JNEUROSCI.3408-03.2004 (Original work published 2004)
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Bock, H., Jossin, Y., May, P. J., Bergner, O., & Herz, J. (2004). Apolipoprotein E receptors are required for Reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. Journal of Biological Chemistry, 279(32), 33471-33479. https://doi.org/10.1074/jbc.M401770200 (Original work published 2004)
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Jossin, Y. (2004). Neuronal migration and the role of reelin during early development of the cerebral cortex. Molecular Neurobiology : a review journal, 30(3), 225-251. https://doi.org/10.1385/MN:30:3:225 (Original work published 2004)
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Article de journalBock, H. H., Jossin, Y., Liu, P., Förster, E., May, P., Goffinet, A., & Herz, J. (2003). Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Journal of Biological Chemistry, 278(40), 38772-38779. https://doi.org/10.1074/jbc.M306416200 (Original work published 2003)
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Jossin, Y., Bar, I., Ignatova, N., Tissir, F., De Rouvroit, C. L., & Goffinet, A. (2003). The reelin signaling pathway: some recent developments. Cerebral cortex (New York, N.Y. : 1991), 13(6), 627-633. https://doi.org/10.1093/cercor/13.6.627 (Original work published 2003)
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Jossin, Y., Ogawa, M., Metin, C., Tissir, F., & Goffinet, A. (2003). Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development. The Journal of Neuroscience, 23(30), 9953-9959. (Original work published 2003)
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Article de journalJossin, Y., & Goffinet, A. (2001). Reelin does not directly influence axonal growth. The Journal of Neuroscience, 21(23), RC183. (Original work published 2001)
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Article de journalGilot, P., Jossin, Y., & Content, J. (2000). Cloning, sequencing and characterisation of a Listeria monocytogenes gene encoding a fibronectin-binding protein. Journal of Medical Microbiology, 49(10), 887-896. (Original work published 2000)
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