Theses

THESES IN PROGRESS

Bastin Amandine
Beyond metabolism: Disrupting PHGDH protein–protein interactions as a therapeutic strategy in colorectal cancer
Director: Quentin Spillier

Beghin Lou-Anne
Exploiting tumor metabolic vulnerabilities to develop innovative anticancer drugs
Director: Quentin Spillier

Dubois Rachel
Design, synthesis and in vitro pharmacological evaluation of new inhibitors of the CX- system, the cystine/gutamate exchanger
Director: Didier Lambert

Hubeau Sarah
Study of the activity, regulation, and selective inhibition of human pyruvate kinase M1 as a new therapeutic target in pancreatic cancer
Director: Raphaël Frédérick

Jijon-Vergara Ariana
Inhibition of the TSPYL5-USP7 interaction and its relation with the viability of ALT-positive cells
Director: Raphaël Frédérick

Lacour Séraphin
Design, synthesis and evaluation of new pharmacological tools to study tryptophan-2,3-dioxygenase (TDO2) in cancer immunotherapy
Director: Raphaël Frédérick

Martou Marie-Sophie
Creating anti-angiogenic miniproteins targeting protein-protein interactions as a new strategy in anticancer therapy
Director: Quentin Spillier

Mathieu Caroline
Inhibition of tryptophan 2,3-dioxygenase (TDO2) by targeting its self-assembly: from the development of analytical methodologies to the identification of new potential disrupters
Director: Raphaël Frédérick; Co-director: Marianne Fillet (ULiège)

Ronco Camilla
Targetting the protein-protein interactions between SLC7A11 and SLC3A2 for designing  novel inhibitors of the system xc-
Director: Didier Lambert

Savoyen Perrine
Design and synthesis of peptide macrocycles as inhibitors of lactate dehydrogenase.
Director: Raphaël Frédérick; Co-director: Pierre Sonveaux

Van Oppens Manon
Development of potent and selective ACSL4 inhibitors derived from LIBX-A401 as anti-ferroptotic agents for cancer treatment
Director: Raphaël Fédérick