LDRI
Avenue Mounier 72/B1.72.01
1200 Woluwe-Saint-Lambert
Giulio Muccioli
Professeur ordinaire
- Diploma
Year Label Educational Organization 1998 Candidat en sciences pharmaceutiques Université catholique de Louvain 2001 Pharmacien Université catholique de Louvain 2003 Diplômé d'études approfondies en sciences de la santé Université catholique de Louvain 2005 Docteur en sciences pharmaceutiques Université catholique de Louvain
- Courses
Name ID Design of the drug WFARM1008 Introduction à la chimie analytique WFARM1243 Travaux pratiques d'introduction à la chimie analytique WFARM1244 Internschips in the pharmaceutical world WFARM1309 Instrumental analysis applied to pharmaceutical sciences WFARM1312 Travaux pratiques d'analyse instrumentale WFARM1313 Advanced instrumental analysis WFARM1329 Integrated Seminar in Pharmaceutical Sciences WFARM1349 Analyse et contrôle de qualité des médicaments WFARM2117 Chimie médicinale WFARM2118 Seminary and practical exercises integred of pharmaceutical sciences WFARM2135 Etude critique d'un article de recherche en sciences pharmaceutiques WFARM2175 Présentation d'un travail de recherche en sciences pharmaceutiques WFARM2176 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 Analysis of biotechnology drugs WFARM2266 Exercice de communication scientifique WFARM2275 Chimie pharmaceutique avancée et drug design WFARM2501 Isolation and Structural Analysis of Natural Products WFARM2508 Biomedical instrumental analysis and radiation protection WSBIM1200
2024
Gillard, Justine ; Roumain, Martin ; Picalausa, Corinne ; Thibaut, Morgane ; Clerbaux, Laure-Alix ; Tailleux, Anne ; Staels, Bart ; Muccioli, Giulio ; Bindels, Laure B. ; Leclercq, Isabelle. A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. In: JHEP Reports, , p. 101148 (2024). doi:10.1016/j.jhepr.2024.101148 (Accepté/Sous presse).
2024
Marotti, Valentina ; Xu, Yiqing ; Bohns Michalowski, Cecilia ; Zhang, Wunan ; Ladeiro Domingues, Inês ; Ameraoui, Hafsa ; Moreels, Tom ; Baatsen, Pieter ; Van Hul, Matthias ; Muccioli, Giulio ; Cani, Patrice D. ; Al Houayek, Mireille ; Malfanti, Alessio ; Beloqui Garcia, Ana. A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment. In: Bioactive Materials, Vol. 32, p. 206-221 (2024). doi:10.1016/j.bioactmat.2023.09.014.
2024
Muccioli, Giulio ; Bannenberg, Gerard. Editorial – Special issue of the 8th European Workshop on Lipid Mediators. In: Prostaglandins & Other Lipid Mediators, Vol. 172, no., p. 106835 (2024). doi:10.1016/j.prostaglandins.2024.106835.
2024
Paone, Paola ; Latousakis, Dimitris ; Terrasi, Romano ; Vertommen, Didier ; Jian, Ching ; Borlandelli, Valentina ; Suriano, Francesco ; Johansson, Malin E V ; Puel, Anthony ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Salonen, Anne ; Juge, Nathalie ; Florea, Bogdan I ; Muccioli, Giulio ; Overkleeft, Herman ; Van Hul, Matthias ; Cani, Patrice D.. Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.. In: Gut, Vol. X, no.1, p. 18 (2024). doi:10.1136/gutjnl-2023-330301.
2024
Mwema, Ariane ; Gratpain, Viridiane ; Ucakar, Bernard ; Vanvarenberg, Kevin ; Perdaens, Océane ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination. In: Drug Delivery and Translational Research, (2024). doi:10.1007/s13346-024-01535-8.
2024
Gratpain, Viridiane ; Loriot, Axelle ; Bottemanne, Pauline ; d'Auria, Ludovic ; Terrasi, Romano ; Payen, Valéry L ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation.. In: Heliyon, Vol. 10, no.5, p. e27025 (2024). doi:10.1016/j.heliyon.2024.e27025.
2024
Labrak, Y ; Al Houayek, Mireille ; Mwema, Ariane ; d'Auria, L ; Ucakar, Bernard ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration.. In: International journal of pharmaceutics, Vol. 659, p. 124237 (2024). doi:10.1016/j.ijpharm.2024.124237 (Accepté/Sous presse).
2023
Romano, Adele ; Friuli, Marzia ; Eramo, Barbara ; Gallelli, Cristina Anna ; Koczwara, Justyna Barbara ; Azari, Elnaz Karimian ; Paquot, Adrien ; Arnold, Myrtha ; Langhans, Wolfgang ; Muccioli, Giulio ; Lutz, Thomas Alexander ; Gaetani, Silvana. "To brain or not to brain": evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system.. In: Frontiers in endocrinology, Vol. 14, p. 1158287 [1-12] (2023). doi:10.3389/fendo.2023.1158287.
2023
van Dijk, Myrthe J ; van Oirschot, Brigitte A ; Harrison, Alexander N ; Recktenwald, Steffen M ; Qiao, Min ; Stommen, Amaury ; Cloos, Anne-Sophie ; Vanderroost, Juliette ; Terrasi, Romano ; Dey, Kuntal ; Bos, Jennifer ; Rab, Minke A E ; Bogdanova, Anna ; Minetti, Giampaolo ; Muccioli, Giulio ; Tyteca, Donatienne ; Egée, Stéphane ; Kaestner, Lars ; Molday, Robert S ; van Beers, Eduard J ; van Wijk, Richard. A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia.. In: American journal of hematology, , p. [1-11] (2023). doi:10.1002/ajh.27088 (Accepté/Sous presse).
2023
Moens de Hase, Emilie ; Petitfils, Camille ; Al Houayek, Mireille ; Depommier, Clara ; Le Faouder, Pauline ; Delzenne, Nathalie M. ; Van Hul, Matthias ; Muccioli, Giulio ; Cenac, Nicolas ; Cani, Patrice D.. Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids. In: Journal of lipid research, Vol. 64, no. 10, p. 100437 [1-14] (2023). doi:10.1016/j.jlr.2023.100437.
2023
Ruiz, Florian ; Peter, Benjamin ; Rebeaud, Jessica ; Vigne, Solenne ; Bressoud, Valentine ; Roumain, Martin ; Wyss, Tania ; Yersin, Yannick ; Wagner, Ingrid ; Kreutzfeldt, Mario ; Pimentel Mendes, Marisa ; Kowalski, Camille ; Boivin, Gael ; Roth, Leonard ; Schwaninger, Markus ; Merkler, Doron ; Muccioli, Giulio ; Hugues, Stephanie ; Petrova, Tatiana V ; Pot, Caroline. Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis.. In: EMBO reports, Vol. 24, no.3, p. e55328 [1-20] (2023). doi:10.15252/embr.202255328.
2023
Hoste, Emilia ; Paquot, Adrien ; Panin, Nadtha ; Horion, Shaleena ; El-Hamdaoui, Halima ; Muccioli, Giulio ; Haufroid, Vincent ; Elens, Laure. Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. In: Therapeutic drug monitoring, Vol. 45, no. 3, p. 400-408 (2023). doi:10.21203/rs.3.rs-1520877/v1 (Accepté/Sous presse).
2023
Roumain, Martin ; Guillemot-Legris, Owein ; Ameraoui, Hafsa ; Al Houayek, Mireille ; Muccioli, Giulio. Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol. In: The Journal of Steroid Biochemistry and Molecular Biology, Vol. 234, p. 106376 (2023). doi:10.1016/j.jsbmb.2023.106376.
2023
Mwema, Ariane ; Muccioli, Giulio ; des Rieux, Anne. Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 364, p. 435-457 (2023). doi:10.1016/j.jconrel.2023.10.052.
2023
Régnier, Marion ; Van Hul, Matthias ; Roumain, Martin ; Paquot, Adrien ; de Wouters d’Oplinter, Alice ; Suriano, Francesco ; Everard, Amandine ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Cani, Patrice D.. Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota. In: Gut Microbes, Vol. 15, no.1, p. 20 (2023). doi:10.1080/19490976.2023.2178796.
2023
Mwema, Ariane ; Bottemanne, Pauline ; Paquot, Adrien ; Ucakar, Bernard ; Vanvarenberg, Kevin ; Al Houayek, Mireille ; Muccioli, Giulio ; des Rieux, Anne. Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD-G.. In: Nanomedicine : nanotechnology, biology, and medicine, Vol. 48, p. 102633 (2023). doi:10.1016/j.nano.2022.102633.
2023
Karemera, Manon ; Verce, Marko ; Roumain, Martin ; Muccioli, Giulio ; Cani, Patrice D. ; Everard, Amandine ; Stéphenne, Xavier ; Sokal, Etienne. Pediatric Autoimmune or Primary Sclerosing Cholangitis: Metronidazole Effectiveness on Biochemical Data, Bile Acid Profile, and Gut Microbiota: A Pilot Study. In: JPGN reports, Vol. 4, no. 3, p. e334 [1-8] (2023). doi:10.1097/pg9.0000000000000334.
2023
Cloos, Anne-Sophie ; Rab, Minke AE ; Van Der Smissen, Patrick ; van Oirschot, Brigitte A ; Mignolet, Eric ; van der Net, Jeroen B ; Koster, Ad ; Kleinen, Kelly ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; van Wijk, Richard ; Tyteca, Donatienne. Red blood cells from patients with sitosterolemia exhibit impaired membrane lipid composition and distribution and decreased deformability. In: Frontiers in Hematology. Red Cells, Iron and Erythropoiesis, Vol. 2, p. 055086 [1-14] (2023). doi:10.3389/frhem.2023.1055086.
2023
van Doorslaer de ten Ryen, Sophie ; Dalle, Sebastiaan ; Terrasi, Romano ; Koppo, Katrien ; Muccioli, Giulio ; Deldicque, Louise. Regulation of the endocannabinoid system by endurance and resistance exercise in hypoxia in human skeletal muscle.. In: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 134, no.3, p. 569-580 (2023). doi:10.1152/japplphysiol.00645.2022.
2023
Paquot, Adrien ; Bestard-Escalas, Juan ; Muccioli, Giulio. Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors.. In: Prostaglandins & other lipid mediators, , p. 106763 (2023). doi:10.1016/j.prostaglandins.2023.106763 (Accepté/Sous presse).
2022
Abdul Khaliq, Hafiz ; Al Houayek, Mireille ; Quetin-Leclercq, Joëlle ; Muccioli, Giulio. 5'AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases.. In: Critical reviews in food science and nutrition, , p. [1-26] (2022). doi:10.1080/10408398.2022.2145264 (Accepté/Sous presse).
2022
Ranaivo, Harimalala ; Zhang, Zhengxiao ; Alligier, Maud ; Van Den Berghe, Laurie ; Sothier, Monique ; Lambert-Porcheron, Stéphanie ; Feugier, Nathalie ; Cuerq, Charlotte ; Machon, Christelle ; Neyrinck, Audrey M. ; Seethaler, Benjamin ; Rodriguez, Julie ; Roumain, Martin ; Muccioli, Giulio ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M. ; Nazare, Julie-Anne. Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial.. In: Scientific reports, Vol. 12, no.1, p. 8830 [1-14] (2022). doi:10.1038/s41598-022-12920-z.
2022
Mozaheb, Negar ; Van Der Smissen, Patrick ; Opsomer, Tomas ; Mignolet, Eric ; Terrasi, Romano ; Paquot, Adrien ; Larondelle, Yvan ; Dehaen, Wim ; Muccioli, Giulio ; Mingeot-Leclercq, Marie-Paule. Contribution of Membrane Vesicle to Reprogramming of Bacterial Membrane Fluidity in Pseudomonas aeruginosa.. In: mSphere, Vol. 7, no. 3, p. e0018722 [1-13] (2022). doi:10.1128/msphere.00187-22.
2022
Abdul Khaliq, Hafiz ; Ortiz Aguirre, Sergio Enrique ; Al Houayek, Mireille ; Muccioli, Giulio ; Quetin-Leclercq, Joëlle. Dereplication and Quantification of Major Compounds of L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages.. In: Molecules (Basel, Switzerland), Vol. 27, no.3, p. 963 [1-19] (2022). doi:10.3390/molecules27030963.
2022
Bozzato, Elia ; Tsakiris, Nikolaos ; Paquot, Adrien ; Muccioli, Giulio ; Bastiancich, Chiara ; Préat, Véronique. Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells.. In: International journal of pharmaceutics, Vol. 628, p. 122341 [1-12] (2022). doi:10.1016/j.ijpharm.2022.122341.
2022
Le Roy, Tiphaine ; Moens De Hase, Emilie ; Van Hul, Matthias ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Depommier, Clara ; Druart, Céline ; Everard, Amandine ; Maiter, Dominique ; Delzenne, Nathalie M. ; Bindels, Laure B. ; de Barsy, Marie ; Loumaye, Audrey ; Hermans, Michel ; Thissen, Jean-Paul ; Vieira-Silva, Sara ; Falony, Gwen ; Raes, Jeroen ; Muccioli, Giulio ; Cani, Patrice D.. Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. In: Gut, Vol. 71, p. 534–543 (2022). doi:10.1136/gutjnl-2020-323778.
2022
Copperi, Francesca ; Schleis, Inna ; Roumain, Martin ; Muccioli, Giulio ; Casola, Stefano ; Klingenspor, Martin ; Pfeifer, Alexander ; Gnad, Thorsten. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.. In: Communications biology, Vol. 5, no.1, p. 280 [1-9] (2022). doi:10.1038/s42003-022-03201-6.
2022
Abdul Khaliq, Hafiz ; Ortiz Aguirre, Sergio Enrique ; Al Houayek, Mireille ; Neyts, Tanguy ; Muccioli, Giulio ; Quetin-Leclercq, Joëlle. Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. In: Toxicology Reports, Vol. 9, p. 1742-1753 (2022). doi:10.1016/j.toxrep.2022.09.004.
2022
Barington, Line ; Christensen, Liv von Voss ; Pedersen, Kristian Kåber ; Niss Arfelt, Kristine ; Roumain, Martin ; Jensen, Kristian Høj Reveles ; Kjær, Viktoria Madeline Skovgaard ; Daugvilaite, Viktorija ; Kearney, John F ; Christensen, Jan Pravsgaard ; Hjortø, Gertrud Malene ; Muccioli, Giulio ; Holst, Peter Johannes ; Rosenkilde, Mette Marie. GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.. In: Cells, Vol. 11, no.3, p. 494 [1-18] (2022). doi:10.3390/cells11030494.
2022
Berland, Chloé ; Castel, Julien ; Terrasi, Romano ; Montalban, Enrica ; Foppen, Ewout ; Martin, Claire ; Muccioli, Giulio ; Luquet, Serge ; Gangarossa, Giuseppe. Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis.. In: Molecular psychiatry, Vol. 27, no.4, p. 2340-2354 (2022). doi:10.1038/s41380-021-01428-z.
2022
Labrak, Yasmine ; Heurtault, Béatrice ; Frisch, Benoît ; Saulnier, Patrick ; Lepeltier, Elise ; Miron, Veronique E ; Muccioli, Giulio ; des Rieux, Anne. Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells.. In: International journal of pharmaceutics, Vol. 618, p. 121623 (2022). doi:10.1016/j.ijpharm.2022.121623.
2022
Valderrama, Jaime A. ; Pérez-Herrera, Andrea ; Muccioli, Giulio ; Venegas-Casanova, Edmundo A. ; Jara-Aguilar, Rafael ; Calderon, Pedro Buc ; Benites, Julio ; Mitu, Liviu. On the Reaction of 2-Alkanoylnaphthohydroquinones with Hydroxylamine: Access to Cytotoxic 2-(Hydroxyamino)-1,4-naphthoquinone and Their 3-(Hydroxyimino)alkyl Analogous. In: Journal of Chemistry, Vol. 2022, p. 1-8 (2022). doi:10.1155/2022/7664037.
2022
De Berdt, Pauline ; Vanvarenberg, Kevin ; Ucakar, Bernard ; Bouzin, Caroline ; Paquot, Adrien ; Gratpain, Viridiane ; Loriot, Axelle ; Payen, Valery ; Bearzatto, Bertrand ; Muccioli, Giulio ; Gatto, Laurent ; Diogenes, A ; des Rieux, Anne. The human dental apical papilla promotes spinal cord repair through a paracrine mechanism.. In: Cellular and molecular life sciences : CMLS, Vol. 79, no.5, p. 252 (2022). doi:10.1007/s00018-022-04210-8.
2022
Yelek, Caner ; Mignion, Lionel ; Paquot, Adrien ; Bouzin, Caroline ; Corbet, Cyril ; Muccioli, Giulio ; Cani, Patrice D. ; Jordan, Bénédicte. Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. In: Cancers, Vol. 14, no. 3, p. 562 [1-16] (2022). doi:10.3390/cancers14030562.
2021
Bottemanne, Pauline ; Paquot, Adrien ; Ameraoui, Hafsa ; Guillemot-Legris, Owein ; Al Houayek, Mireille ; Muccioli, Giulio. 25-Hydroxycholesterol metabolism is altered by lung inflammation, and its local administration modulates lung inflammation in mice.. In: FASEB journal, Vol. 35, no.4, p. e21514 [1-19] (2021). doi:10.1096/fj.202002555R.
2021
Stillemans, Gabriel ; Paquot, Adrien ; Muccioli, Giulio ; Hoste, Emilia ; Panin, Nadtha ; Åsberg, Anders ; Balligand, Jean-Luc ; Haufroid, Vincent ; Elens, Laure. Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response. In: Clinical and Translational Science, (2021). doi:10.1111/cts.13185.
2021
Thibaut, Morgane ; Gillard, Justine ; Dolly, Adeline ; Roumain, Martin ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Bindels, Laure B.. Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. In: Cancers, Vol. 13, no.24, p. 6389 [1-17] (2021). doi:10.3390/cancers13246389.
2021
Al Houayek, Mireille ; Ameraoui, Hafsa ; Muccioli, Giulio. Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities.. In: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1866, no.2, p. 158854 [1-18] (2021). doi:10.1016/j.bbalip.2020.158854.
2021
Ange, Marine ; De Poortere, Julien ; Ginion, Audrey ; Battault, Sylvain ; Dechamps, Mélanie ; Muccioli, Giulio ; Roumain, Martin ; Morelle, Johann ; Druart, Sébastien ; Mathivet, Thomas ; Bertrand, Luc ; Castanares Zapatero, Diego ; Horman, Sandrine ; Beauloye, Christophe. Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK.. In: Scientific reports, Vol. 11, no. 1, p. 13700 [1-13] (2021). doi:10.1038/s41598-021-93156-1.
2021
Van Den Brûle, Sybille ; Rappe, Margaux ; Ambroise, Jérôme ; Bouzin, Caroline ; Dessy, Chantal ; Paquot, Adrien ; Muccioli, Giulio ; Lison, Dominique. Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice.. In: Particle and fibre toxicology, Vol. 18, no. 1, p. 7 [1-15] (2021). doi:10.1186/s12989-021-00400-7.
2021
Perez, Laeticia ; Scarcello, Eleonora ; Ibouraadaten, Saloua ; Yakoub, Yousof ; Leinardi, Riccardo ; Ambroise, Jérôme ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Paquot, Adrien ; Muccioli, Giulio ; Bouzin, Caroline ; Van Den Brûle, Sybille ; Lison, Dominique. Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure.. In: Food and chemical toxicology, Vol. 154, p. 112352 [1-13] (2021). doi:10.1016/j.fct.2021.112352.
2021
Buisseret, Baptiste ; Guillemot-Legris, Owein ; Ben Kouidar, Youssef ; Paquot, Adrien ; Muccioli, Giulio ; Al Houayek, Mireille. Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.. In: The FASEB Journal, Vol. 35, no. 4, p. e21411 [1-16] (2021). doi:10.1096/fj.202002468R.
2021
Gratpain, Viridiane ; Mwema, Ariane ; Labrak, Yasmine ; Muccioli, Giulio ; Van Pesch, Vincent ; des Rieux, Anne. Extracellular vesicles for the treatment of central nervous system diseasesExtracellular vesicles for the treatment of central nervous system diseases. In: Advanced drug delivery reviews, Vol. 174, p. 535-552 (2021). doi:10.1016/j.addr.2021.05.006.
2021
Genton, Laurence ; Pruijm, Menno ; Teta, Daniel ; Bassi, Isabelle ; Cani, Patrice D. ; Gaïa, Nadia ; Herrmann, François R ; Marangon, Nicola ; Mareschal, Julie ; Muccioli, Giulio ; Stoermann, Catherine ; Suriano, Francesco ; Wurzner-Ghajarzadeh, Arlene ; Lazarevic, Vladimir ; Schrenzel, Jacques. Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients.. In: Journal of cachexia, sarcopenia and muscle, , p. [1-13] (2021). doi:10.1002/jcsm.12781 (Accepté/Sous presse).
2021
Abot, Anne ; Wemelle, Eve ; Laurens, Claire ; Paquot, Adrien ; Pomie, Nicolas ; Carper, Deborah ; Bessac, Arnaud ; Mas Orea, Xavier ; Fremez, Christophe ; Fontanie, Maxime ; Lucas, Alexandre ; Lesage, Jean ; Everard, Amandine ; Meunier, Etienne ; Dietrich, Gilles ; Muccioli, Giulio ; Moro, Cedric ; Cani, Patrice D. ; Knauf, Claude. Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice.. In: Gut, Vol. 70, no. 6, p. 1078-1087 (2021). doi:10.1136/gutjnl-2019-320230.
2021
Cloos, Anne-Sophie ; Daenen, Laura G. M. ; Maja, Mauriane ; Stommen, Amaury ; Vanderroost, Juliette ; Van Der Smissen, Patrick ; Rab, Minke ; Westerink, Jan ; Mignolet, Eric ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; Dumitru, Andra-Cristina ; Alsteens, David ; van Wijk, Richard ; Tyteca, Donatienne. Impaired Cytoskeletal and Membrane Biophysical Properties of Acanthocytes in Hypobetalipoproteinemia – A Case Study. In: Frontiers in Physiology, Vol. 12, no. 2, p. 638027 [1-22] (2021). doi:10.3389/fphys.2021.638027.
2021
Thibaut, Morgane ; Sboarina, Martina ; Roumain, Martin ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Destrée, Florence ; Gillard, Justine ; Leclercq, Isabelle ; Dachy, Guillaume ; Demoulin, Jean-Baptiste ; Tailleux, Anne ; Lestavel, Sophie ; Rastelli, Marialetizia ; Everard, Amandine ; Cani, Patrice D. ; Porporato, Paolo E ; Loumaye, Audrey ; Thissen, Jean-Paul ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Bindels, Laure B.. Inflammation-induced cholestasis in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 70-20 (2021). doi:10.1002/jcsm.12652.
2021
Bottemanne, Pauline ; Guillemot-Legris, Owein ; Paquot, Adrien ; Masquelier, Julien ; Malamas, Michael ; Makriyannis, Alexandros ; Al Houayek, Mireille ; Muccioli, Giulio. N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice.. In: Neurotherapeutics, , p. [1-19] (2021). doi:10.1007/s13311-021-01074-x (Accepté/Sous presse).
2021
Suriano, Francesco ; Vieira-Silva, Sara ; Falony, Gwen ; Roumain, Martin ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Delzenne, Nathalie M. ; Raes, Jeroen ; Muccioli, Giulio ; Van Hul, Matthias ; Cani, Patrice D.. Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin. In: Microbiome, Vol. 9, no.1, p. 147 (2021). doi:10.1186/s40168-021-01097-8.
2021
Neyrinck, Audrey M. ; Rodriguez, Julie (co-first author) ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Robles Sanchez, Candido ; Roumain, Martin ; Hiel, Sophie ; Bindels, Laure B. ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Nazare, Julie-Anne ; Laville, Martine ; Muccioli, Giulio ; Bischoff, Stephan C ; Walter, Jens ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.. In: European journal of nutrition, Vol. 60, no. 6, p. 3159-3170 (2021). doi:10.1007/s00394-021-02484-5 (Accepté/Sous presse).
2021
Buya, Aristote ; Terrasi, Romano ; Mbinze, Jérémie K ; Muccioli, Giulio ; Beloqui Garcia, Ana ; Memvanga, Patrick B ; Préat, Véronique. Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes.. In: Pharmaceutics, Vol. 13, no.9, p. 1388 [1-20] (2021). doi:10.3390/pharmaceutics13091388.
2021
Lison, Dominique ; Ambroise, Jérôme ; Leinardi, Riccardo ; Ibouraadaten, Saloua ; Yakoub, Yousof ; Deumer, Gladys ; Haufroid, Vincent ; Paquot, Adrien ; Muccioli, Giulio ; Van Den Brûle, Sybille. Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats.. In: Archives of toxicology, Vol. 95, no. 4, p. 1251-1266 (2021). doi:10.1007/s00204-021-02998-1.
2021
Guillemot-Legris, Owein ; Muccioli, Giulio. The oxysterome and its receptors as pharmacological targets in inflammatory diseases.. In: British journal of pharmacology, (2021). doi:10.1111/bph.15479 (Accepté/Sous presse).
2020
Pollet, Hélène ; Cloos, Anne-Sophie (co-first author) ; Stommen, Amaury ; Vanderroost, Juliette ; Conrard, Louise ; Paquot, Adrien ; Ghodsi, Marine ; Carquin, Mélanie ; Léonard, Anne-Catherine ; Guthmann, Manuel ; Lingurski, Maxime ; Vermylen, Christiane ; Killian, Theodore ; Gatto, Laurent ; Rider, Mark H. ; Pyr dit Ruys, Sébastien ; Vertommen, Didier ; Vikkula, Miikka ; Brouillard, Pascal ; Van Der Smissen, Patrick ; Muccioli, Giulio ; Tyteca, Donatienne. Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis. In: Biomolecules, Vol. 10, no. 8, p. 1120 [1-25] (2020). doi:10.3390/biom10081120.
2020
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
2020
Phung, Austin S. ; Bannenberg, Gerard ; Vigor, Claire ; Reversat, Guillaume ; Oger, Camille ; Roumain, Martin ; Galano, Jean-Marie ; Durand, Thierry ; Muccioli, Giulio ; Ismail, Adam ; Wang, Selina C.. Chemical Compositional Changes in Over-Oxidized Fish Oils. In: Foods, Vol. 9, no.10, p. 1501 (2020). doi:10.3390/foods9101501.
2020
Tsakiris, Nikolaos ; Fauvet, Frédérique ; Ruby, Samia ; Puisieux, Alain ; Paquot, Adrien ; Muccioli, Giulio ; Vigneron, Arnaud M ; Préat, Véronique. Combined nanomedicines targeting colorectal cancer stem cells and cancer cells.. In: Journal of controlled release, Vol. 326, p. 387-395 (2020). doi:10.1016/j.jconrel.2020.07.025.
2020
Le Roy, Tiphaine ; Van Der Smissen, Patrick ; Paquot, Adrien ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Collet, Jean-François ; Cani, Patrice D.. Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter.. In: International journal of systematic and evolutionary microbiology, Vol. 70, no. 9, p. 4851-4858 (2020). doi:10.1099/ijsem.0.003547.
2020
Al Houayek, Mireille ; Bannenberg, Gerard ; Muccioli, Giulio ; Norel, Xavier ; Yao, Chengcan ; Schebb, Nils Helge. Editorial-Special issue of the 7 European workshop on lipid mediators.. In: Prostaglandins & other lipid mediators, Vol. 148, p. 106421 [1-3] (2020). doi:10.1016/j.prostaglandins.2020.106421.
2020
Van Hul, Matthias ; Le Roy, Tiphaine ; Prifti, Edi ; Dao, Maria Carlota ; Paquot, Adrien ; Zucker, Jean-Daniel ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Clément, Karine ; Cani, Patrice D.. From correlation to causality: the case of Subdoligranulum. In: Gut Microbes, Vol. 12, no.1, p. 1-13 (2020). doi:10.1080/19490976.2020.1849998.
2020
Manca, Claudia ; Boubertakh, Besma ; Leblanc, Nadine ; Deschênes, Thomas ; Lacroix, Sebastien ; Martin, Cyril ; Houde, Alain ; Veilleux, Alain ; Flamand, Nicolas ; Muccioli, Giulio ; Raymond, Frédéric ; Cani, Patrice D. ; Di Marzo, Vincenzo ; Silvestri, Cristoforo. Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling.. In: Journal of lipid research, Vol. 61, no.1, p. 70-85 (2020). doi:10.1194/jlr.RA119000424.
2020
Briand-Mésange, Fabienne ; Pons, Véronique ; Allart, Sophie ; Masquelier, Julien ; Chicanne, Gaëtan ; Beton, Nicolas ; Payrastre, Bernard ; Muccioli, Giulio ; Ausseil, Jérôme ; Davignon, Jean-Luc ; Salles, Jean-Pierre ; Chap, Hugues. Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch.. In: The Journal of biological chemistry, Vol. 295, no.46, p. 15767-15781 (2020). doi:10.1074/jbc.RA120.015278.
2020
Lefort, Charlotte ; Roumain, Martin ; Van Hul, Matthias ; Rastelli, Marialetizia ; Manco, Rita ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Di Marzo, Vincenzo ; Flamand, Nicolas ; Luquet, Serge ; Silvestri, Cristoforo ; Muccioli, Giulio ; Cani, Patrice D.. Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. In: Cells, Vol. 9, no. 5, p. 1247 [1-23] (2020). doi:10.3390/cells9051247.
2020
Demaret, Tanguy ; Evraerts, Jonathan ; Ravau, Joachim ; Roumain, Martin ; Muccioli, Giulio ; Najimi, Mustapha ; Sokal, Etienne. High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in -G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment. In: Cells, Vol. 10, no.1, p. 40 [1-12] (2020). doi:10.3390/cells10010040.
2020
Demaret, Tanguy ; Evraerts, Jonathan ; Ravau, Joachim ; Roumain, Martin ; Muccioli, Giulio ; Najimi, Mustapha ; Sokal, Etienne. High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in -G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment.. In: Cells, Vol. 10, no. 1, p. 40 [1-12] (2020). doi:10.3390/cells10010040.
2020
Valderrama, Jaime A. ; Ríos, David ; Muccioli, Giulio ; Buc Calderon, Pedro ; Benites, Julio. In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study. In: Molecules, Vol. 25, no.4, p. 953 (2020). doi:10.3390/molecules25040953 (Accepté/Sous presse).
2020
Cloos, Anne-Sophie ; Ghodsi, Marine ; Stommen, Amaury ; Vanderroost, Juliette ; Dauguet, Nicolas ; Pollet, Hélène ; D'Auria, Ludovic ; Mignolet, Eric ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; Van Der Smissen, Patrick ; Tyteca, Donatienne. Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage.. In: Frontiers in Physiology, Vol. 11, p. 712 [1-23] (2020). doi:10.3389/fphys.2020.00712.
2020
Rastelli, Marialetizia ; Van Hul, Matthias ; Terrasi, Romano ; Lefort, Charlotte ; Régnier, Marion ; Beiroa, Daniel ; Delzenne, Nathalie M. ; Everard, Amandine ; Nogueiras, Rubén ; Luquet, Serge ; Muccioli, Giulio ; Cani, Patrice D.. Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis.. In: American journal of physiology. Endocrinology and metabolism, Vol. 319, no.3, p. E647-E657 (2020). doi:10.1152/ajpendo.00146.2020.
2020
Demaret, Tanguy ; Roumain, Martin ; Ambroise, Jérôme ; Evraerts, Jonathan ; Ravau, Joachim ; Bouzin, Caroline ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Stepman, Hedwig ; Marie, Sandrine ; Vincent, Marie-Françoise ; Muccioli, Giulio ; Najimi, Mustapha ; Sokal, Etienne. Longitudinal study of Pex1-G844D NMRI mouse model: A robust pre-clinical model for mild Zellweger spectrum disorder. In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1866, no. 11, p. 165900 [1-18] (2020). doi:10.1016/j.bbadis.2020.165900.
2020
Rodriguez, Julie ; Neyrinck, Audrey M. ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Nazare, Julie-Anne ; Robles Sanchez, Candido ; Roumain, Martin ; Muccioli, Giulio ; Bindels, Laure B. ; Cani, Patrice D. ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota.. In: Gut microbes, Vol. 12, no. 1, p. 1810530 [1-15] (2020). doi:10.1080/19490976.2020.1810530.
2020
Ríos, David ; Valderrama, Jaime A ; Cautin, Miriam ; Tapia, Milko ; Salas, Felipe ; Guerrero-Castilla, Angélica ; Muccioli, Giulio ; Buc Calderon, Pedro ; Benites, Julio. New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and Antiproliferative Activities on Breast and Prostate Human Cancer Cells.. In: Oxidative medicine and cellular longevity, Vol. 2020, p. 8939716 [1-11] (2020). doi:10.1155/2020/8939716.
2020
Diermeier, Theresa ; Meredith, Sean J ; Irrgang, James J ; Zaffagnini, Stefano ; Kuroda, Ryosuke ; Hochino, Yuichi ; Samuelsson, Kristian ; Smith, Clair Nicole ; Popchak, Adam ; Musahl, Volker ; Sheean, Andrew ; Burnham, Jeremy M ; Lian, Jayson ; Smith, Clair ; Popchak, Adam ; Herbst, Elmar ; Pfeiffer, Thomas ; Araujo, Paulo ; Oostdyk, Alicia ; Guenther, Daniel ; Ohashi, Bruno ; Irrgang, James J ; Fu, Freddie H ; Nagamune, Kouki ; Kurosaka, Masahiro ; Kuroda, Ryosuke ; Hochino, Yuichi ; Grassi, Alberto ; Muccioli, Giulio ; Lopomo, Nicola ; Signorelli, Cecilia ; Raggi, Federico ; Zaffagnini, Stefano ; Horvath, Alexandra ; Svantesson, Eleonor ; Senorski, Eric Hamrin ; Sundemo, David ; Bjoernsson, Haukur ; Ahlden, Mattias ; Desai, Neel ; Samuelsson, Kristian ; Karlsson, Jon. Patient-Reported and Quantitative Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts., collab. PIVOT Study Group. In: Orthopaedic journal of sports medicine, Vol. 8, no.7, p. [1-7] (2020). doi:10.1177/2325967120926159 (Accepté/Sous presse).
2020
Orefice, Nicola S ; Guillemot-Legris, Owein ; Capasso, Rosanna ; Bottemanne, Pauline ; Hantraye, Philippe ; Caraglia, Michele ; Orefice, Giuseppe ; Al Houayek, Mireille ; Muccioli, Giulio. miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions.. In: eLife, Vol. 9, p. e56916 [1-25] (2020). doi:10.7554/eLife.56916.
2020
Morelle, Axel ; Caruano, Joséphine ; Feledziak, Marion ; Michaux, Catherine ; Perpète, Eric ; Muccioli, Giulio ; Marchand-Brynaert, Jacqueline ; Robiette, Raphaël. β-lactams to act on the endocannabinoid system. In: Chimie Nouvelle, Vol. 134, p. 41 (2020).
2019
Le Roy, Tiphaine ; Van Der Smissen, Patrick ; Paquot, Adrien ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Collet, Jean-François ; Cani, Patrice D.. Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas.. In: International journal of systematic and evolutionary microbiology, Vol. 69, no.3, p. 833-838 (2019). doi:10.1099/ijsem.0.003249.
2019
Ippolito, Luigi ; Morandi, Andrea ; Taddei, Maria Letizia ; Parri, Matteo ; Comito, Giuseppina ; Iscaro, Alessandra ; Raspollini, Maria Rosaria ; Magherini, Francesca ; Rapizzi, Elena ; Masquelier, Julien ; Muccioli, Giulio ; Sonveaux, Pierre ; Chiarugi, Paola ; Giannoni, Elisa. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.. In: Oncogene, Vol. 38, no. 27, p. 5339-5355 (2019). doi:10.1038/s41388-019-0805-7 (Accepté/Sous presse).
2019
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Buisseret, Baptiste ; Paquot, Adrien ; Palmieri, Vittoria ; Bottemanne, Pauline ; Lemaire, Julien ; Rahier, Jean-François ; Al Houayek, Mireille ; Muccioli, Giulio. Colitis alters oxysterol metabolism and is affected by 4β-hydroxycholesterol administration.. In: Journal of Crohn's & colitis, Vol. 13, no. 2, p. 218-229 (2019). doi:10.1093/ecco-jcc/jjy157.
2019
Buisseret, Baptiste ; Al Houayek, Mireille ; Guillemot-Legris, Owein ; Muccioli, Giulio. Endocannabinoid and Prostanoid Crosstalk in Pain. In: Trends in Molecular Medicine, Vol. 25, p. 882-896 (2019). doi:10.1016/j.molmed.2019.04.009.
2019
Benites, Julio ; Valderrama, Jaime A ; Ramos, Maryan ; Valenzuela, Maudy ; Guerrero-Castilla, Angélica ; Muccioli, Giulio ; Buc Calderon, Pedro. Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-(phenylamino)-1,4-benzoquinones on Cancer Cells.. In: Molecules (Basel, Switzerland), Vol. 24, no.9, p. 1780 [1-14] (2019). doi:10.3390/molecules24091780.
2019
Everard, Amandine ; Plovier, Hubert ; Rastelli, Marialetizia ; Van Hul, Matthias ; de Wouters d’Oplinter, Alice ; Geurts, Lucie ; Druart, Céline ; Robine, Sylvie ; Delzenne, Nathalie M. ; Muccioli, Giulio ; de Vos, Willem M. ; Luquet, Serge ; Flamand, Nicolas ; Di Marzo, Vincenzo ; Cani, Patrice D.. Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis. In: Nature Communications, Vol. 10, p. 457 [1-17] (2019). doi:10.1038/s41467-018-08051-7.
2019
Buisseret, Baptiste ; Guillemot-Legris, Owein ; Muccioli, Giulio ; Al Houayek, Mireille. Prostaglandin D2-glycerol ester decreases carrageenan-induced inflammation and hyperalgesia in mice. In: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1864, p. 609-619 (2019).
2019
Bottemanne, Pauline ; Paquot, Adrien ; Ameraoui, Hafsa ; Al Houayek, Mireille ; Muccioli, Giulio. The α/β–hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. In: The FASEB Journal, Vol. 33, no. 6, p. 7635-7646 (2019). doi:10.1096/fj.201802259r.
2018
Muccioli, Giulio ; Lizard, Gérard ; Iuliano, Luigi. Current trends in oxysterols & related sterols.. In: Biochimie : an international journal of biochemistry and molecular biology, Vol. 153, p. 1-2 (2018). doi:10.1016/j.biochi.2018.08.008.
2018
Masquelier, Julien ; Al Houayek, Mireille ; Terrasi, Romano ; Bottemanne, Pauline ; Paquot, Adrien ; Muccioli, Giulio. Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects.. In: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1863, no.12, p. 1458-1468 (2018). doi:10.1016/j.bbalip.2018.09.003.
2018
Al Houayek, Mireille ; Masquelier, Julien ; Muccioli, Giulio. Lysophosphatidylinositols, from Cell Membrane Constituents to GPR55 Ligands. In: Trends in Pharmacological Sciences, Vol. 39, no.6, p. 586-604 (2018). doi:10.1016/j.tips.2018.02.011.
2018
Verstraeten, Sandrine ; Albert, Marie ; Paquot, Adrien ; Muccioli, Giulio ; Tyteca, Donatienne ; Mingeot-Leclercq, Marie-Paule. Membrane cholesterol delays cellular apoptosis induced by ginsenoside RH2, a steroid saponin. In: Toxicology and Applied Pharmacology, Vol. 352, p. 59–67 (2018). doi:10.1016/j.taap.2018.05.014.
2018
Milosevic, Tamara ; Payen, Valéry ; Sonveaux, Pierre ; Muccioli, Giulio ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 3, p. e01599-17 [1-17] (2018). doi:10.1128/AAC.01599-17.
2018
Bottemanne, Pauline ; Muccioli, Giulio ; Al Houayek, Mireille. N -acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities. In: Drug Discovery Today, Vol. 23, no. 8, p. 1520-1529 (2018). doi:10.1016/j.drudis.2018.03.007.
2018
Mutemberezi, Valentin ; Buisseret, Baptiste ; Masquelier, Julien ; Guillemot-Legris, Owein ; Al Houayek, Mireille ; Muccioli, Giulio. Oxysterol levels and metabolism in the course of neuroinflammation: insights from in vitro and in vivo models. In: Journal of Neuroinflammation, Vol. 15, no.1, p. 1-10 (2018). doi:10.1186/s12974-018-1114-8.
2018
Guillemot-Legris, Owein ; Buisseret, Baptiste ; Mutemberezi, Valentin ; Hermans, Emmanuel ; Deumens, Ronald ; Al Houayek, Mireille ; Muccioli, Giulio. Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention.. In: Brain, Behavior, and Immunity, (2018). doi:10.1016/j.bbi.2018.07.022.
2018
Xu, Yining ; Carradori, Dario ; Al Houayek, Mireille ; Muccioli, Giulio ; Cani, Patrice D. ; Préat, Véronique ; Beloqui Garcia, Ana. Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells.. In: Molecular pharmaceutics, Vol. 15, no. 1, p. 108-115 (2018). doi:10.1021/acs.molpharmaceut.7b00742.
2018
De Berdt, Pauline ; Bottemanne, Pauline ; Bianco, John ; Al Houayek, Mireille ; Diogenes, Anibal ; Llyod, Amy ; Gerardo-Nava, Jose ; Brook, Gary A. ; Miron, Véronique ; Muccioli, Giulio ; des Rieux, Anne. Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. In: Cellular and Molecular Life Sciences, Vol. 75, p. 2843-2856 (2018). doi:10.1007/s00018-018-2764-5.
2018
Benites, Julio ; Valderrama, Jaime A ; Ramos, Maryan ; Muccioli, Giulio ; Buc Calderon, Pedro. Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study.. In: Biomedicine & Pharmacotherapy, Vol. 97, p. 778-783 (2017). doi:10.1016/j.biopha.2017.10.108.
2018
Al Houayek, Mireille ; Buisseret, Baptiste ; Paquot, Adrien ; Guillemot-Legris, Owein ; Muccioli, Giulio. The endogenous bioactive lipid prostaglandin D2-glycerol ester reduces murine colitis via DP1 and PPARγ receptors. In: The FASEB Journal, , p. fj.201701205R (2018). doi:10.1096/fj.201701205r (Accepté/Sous presse).
2018
Beaumont, Martin ; Neyrinck, Audrey M. ; Olivares Sevilla, Marta ; Rodriguez, Julie ; de Rocca Serra, Audrey ; Roumain, Martin ; Bindels, Laure B. ; Cani, Patrice D. ; Evenepoel, Pieter ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M.. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: The FASEB Journal, Vol. 32, no. 12, p. fj201800544 [1-13] (2018). doi:10.1096/fj.201800544.
2018
Carradori, Dario ; Dos Santos, Andreia ; Masquelier, Julien ; Paquot, Adrien ; Saulnier, Patrick ; Eyer, Joël ; Préat, Véronique ; Muccioli, Giulio ; Mingeot-Leclercq, Marie-Paule ; des Rieux, Anne. The origin of neural stem cells impacts their interactions with targeted-lipid nanocapsules: Potential role of plasma membrane lipid composition and fluidity. In: Journal of Controlled Release, Vol. 292, p. 248-255 (2018). doi:10.1016/j.jconrel.2018.11.005.
2017
Newson, Justine ; Motwani, Madhur P. ; Kendall, Alexandra C. ; Nicolaou, Anna ; Muccioli, Giulio ; Al Houayek, Mireille ; Bennett, Melanie ; Van De Merwe, Rachel ; James, Sarah ; De Maeyer, Roel P.H. ; Gilroy, Derek W.. Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2. In: Cell Reports, Vol. 20, no. 13, p. 3162-3175 (2017). doi:10.1016/j.celrep.2017.08.098.
2017
Al Houayek, Mireille ; Bottemanne, Pauline ; Makriyannis, Alexandros ; Muccioli, Giulio. N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation. In: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1862, no. 5, p. 474-484 (2017). doi:10.1016/j.bbalip.2017.01.001.
2017
Guillemot, Owein ; Muccioli, Giulio. Obesity-Induced Neuroinflammation: Beyond the Hypothalamus. In: Trends in Neurosciences, Vol. 40, no.4, p. 237-253 (2017). doi:10.1016/j.tins.2017.02.005.
2017
Buyck, Julien ; Luyckx, C. ; Muccioli, Giulio ; Krause, K.M. ; Nichols, W. W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1400-1409 (2017). doi:10.1093/jac/dkw587.
2017
Van Hee, Vincent F ; Labar, Daniel ; Dehon, Gwenaël ; Grasso, Debora ; Gregoire, Vincent ; Muccioli, Giulio ; Frédérick, Raphaël ; Sonveaux, Pierre. Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. In: OncoTarget, Vol. 8, no. 15, p. 24415-24428 (2017). doi:10.18632/oncotarget.14705.
2017
Bindels, Laure B. ; Segura Munoz, Rafael R ; Gomes-Neto, João Carlos ; Mutemberezi, Valentin ; Martínez, Inés ; Salazar, Nuria ; Cody, Elizabeth A ; Quintero-Villegas, Maria I ; Kittana, Hatem ; de Los Reyes-Gavilán, Clara G ; Schmaltz, Robert J ; Muccioli, Giulio ; Walter, Jens ; Ramer-Tait, Amanda E. Resistant starch can improve insulin sensitivity independently of the gut microbiota. In: Microbiome, Vol. 5, no.1, p. 12 [1-16] (2017). doi:10.1186/s40168-017-0230-5.
2017
Valderrama, Jaime A. ; Cabrera, Mónica ; Benites, Julio ; Ríos, David ; Inostroza-Rivera, Ricardo ; Muccioli, Giulio ; Buc Calderon, Pedro. Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones. In: R S C Advances : an international journal to further the chemical sciences, Vol. 7, no.40, p. 24813-24821 (2017). doi:10.1039/c7ra03238b.
2016
Beloqui Garcia, Ana ; Al Houayek, Mireille ; Carradori, Dario ; Vanvarenberg, Kevin ; Muccioli, Giulio ; Cani, Patrice D. ; Préat, Véronique. A Mechanistic Study on Nanoparticle-Mediated Glucagon-Like Peptide-1 (GLP-1) Secretion from Enteroendocrine L Cells.. In: Molecular Pharmaceutics, Vol. 13, no.12, p. 4222-4230 (2016). doi:10.1021/acs.molpharmaceut.6b00871.
2016
Beloqui Garcia, Ana ; Memvanga Bondo, Patrick ; Coco, Régis ; Reimondez-Troitiño, Sonia ; Al Houayek, Mireille ; Muccioli, Giulio ; Alonso, María José ; Csaba, Noemi ; de la Fuente, María ; Préat, Véronique. A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease.. In: Colloids and Surfaces B: Biointerfaces, Vol. 143, p. 327-335 (2016). doi:10.1016/j.colsurfb.2016.03.038.
2016
Ibacache, Juana Andrea ; Valderrama, Jaime A ; Arancibia, Verónica ; Theoduloz, Cristina ; Muccioli, Giulio ; Benites, Julio. Antiproliferative activity of new 6-bromine derivatives of 7-anilino-1-arylisoquinolinequinones. In: Journal of the Chilean Chemical Sociaty, Vol. 61, no. 4, p. 3191-3194 (2016). doi:10.4067/S0717-97072016000400008.
2016
Caruano, Joséphine ; Muccioli, Giulio ; Robiette, Raphaël. Biologically active γ-lactams: synthesis and natural sources. In: Organic & Biomolecular Chemistry, Vol. 14, no.43, p. 10134-10156 (2016). doi:10.1039/C6OB01349J.
2016
Guada ramirez, Melissa ; Beloqui Garcia, Ana ; Al Houayek, Mireille ; Muccioli, Giulio ; Dios-Viéitez, Maria del Carmen ; Préat, Véronique ; Blanco-Prieto, Maria J.. Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease. In: International Journal of Pharmaceutics, Vol. 503, no. 1-2, p. 196-198 (2016). doi:10.1016/j.ijpharm.2016.03.012.
2016
Masquelier, Julien ; Muccioli, Giulio. Development and validation of a specific and sensitive HPLC-ESI-MS method for quantification of lysophosphatidylinositols and evaluation of their levels in mice tissues. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 126, no.1, p. 132-140 (2016). doi:10.1016/j.jpba.2016.04.011.
2016
Mutemberezi, Valentin ; Masquelier, Julien ; Guillemot-Legris, Owein ; Muccioli, Giulio. Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols, endocannabinoids, and ceramides: variations in metabolic syndrome. In: Analytical and Bioanalytical Chemistry, Vol. 408, no. 3, p. 733-745 (2016). doi:10.1007/s00216-015-9150-z.
2016
Guillemot-Legris, Owein ; Masquelier, Julien ; Everard, Amandine ; Cani, Patrice D. ; Al Houayek, Mireille ; Muccioli, Giulio. High-fat diet feeding differentially affects the development of inflammation in the central nervous system. In: Journal of Neuroinflammation, Vol. 13, no.1, p. 206 [1-11] (2016). doi:10.1186/s12974-016-0666-8.
2016
Gerin, Isabelle ; Ury, Benoît ; Breloy, Isabelle ; Bouchet-Seraphin, Céline ; Bolsée, Jennifer ; Halbout, Mathias ; Graff, Julie ; Vertommen, Didier ; Muccioli, Giulio ; Seta, Nathalie ; Cuisset, Jean-Marie ; Dabaj, Ivana ; Quijano-Roy, Susana ; Grahn, Ammi ; Van Schaftingen, Emile ; Bommer, Guido. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. In: Nature Communications, Vol. 7, no. 1, p. 11534 [1-15] (2016). doi:10.1038/ncomms11534.
2016
Mignion, Lionel ; Danhier, Pierre ; Magat, Julie ; Porporato, Paolo ; Masquelier, Julien ; Grégoire, Vincent ; Muccioli, Giulio ; Sonveaux, Pierre ; Gallez, Bernard ; Jordan, Bénédicte. Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.. In: International Journal of Cancer, Vol. 138, no. 8, p. 2043-2049 (2016). doi:10.1002/ijc.29932.
2016
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Cani, Patrice D. ; Muccioli, Giulio. Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma.. In: Scientific Reports, Vol. 6, p. 19694 [1-11] (2016). doi:10.1038/srep19694.
2016
Orefice, Nicola S. ; Al Houayek, Mireille ; Carotenuto, Antonio ; Montella, Silvana ; Barbato, Franscesco ; Comelli, Albert ; Calignano, Antonio ; Muccioli, Giulio ; Orefice, Giuseppe. Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple Sclerosis. In: Neurotherapeutics, Vol. 13, no. 2, p. 428-438 (2016). doi:10.1007/s13311-016-0420-z.
2016
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Muccioli, Giulio. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. In: Trends in Molecular Medicine, Vol. 22, no. 7, p. 594-614 (2016). doi:10.1016/j.molmed.2016.05.006.
2016
Mutemberezi, Valentin ; Guillemot-Legris, Owein ; Muccioli, Giulio. Oxysterols: From cholesterol metabolites to key mediators. In: Progress in Lipid Research, Vol. 64, p. 152-169 (2016). doi:10.1016/j.plipres.2016.09.002.
2016
Luo, Tian ; Loira Pastoriza, Cristina ; Patil, Harshad Padmanabh ; Ucakar, Bernard ; Muccioli, Giulio ; Bosquillon, Cynthia ; Vanbever, Rita. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.. In: Journal of Controlled Release, Vol. 239, p. 62-71 (2016). doi:10.1016/j.jconrel.2016.08.008.
2016
Lepannetier, Sophie ; Zanou, Bidossessi Nadège ; Yerna, Xavier ; Emeriau, Noémie ; Dufour, Inès ; Masquelier, Julien ; Muccioli, Giulio ; Tajeddine, Nicolas ; Gailly, Philippe. Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells.. In: Cell Calcium, Vol. 60, no. 6, p. 373-383 (2016). doi:10.1016/j.ceca.2016.09.002.
2016
Valderrama, Jaime ; Delgado, Virginia ; Sepúlveda, Sandra ; Benites, Julio ; Theoduloz, Cristina ; Buc Calderon, Pedro ; Muccioli, Giulio. Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives. In: Molecules : a journal of synthetic organic and natural product chemistry, Vol. 21, no. 9, p. 1199 [1-14] (2016). doi:10.3390/molecules21091199.
2015
Geurts, Lucie ; Everard, Amandine ; Van Hul, Matthias ; Essaghir, Ahmed ; Duparc, Thibaut ; Matamoros, Sébastien ; Plovier, Hubert ; Castel, Julien ; Denis, Raphael G P ; Bergiers, Marie ; Druart, Céline ; Al Houayek, Mireille ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Luquet, Serge ; Cani, Patrice D.. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. In: Nature Communications, Vol. 6, p. 6495 [1-15] (2015). doi:10.1038/ncomms7495.
2015
El Bakali, Jamal ; Muccioli, Giulio ; Body-Malapel, Mathilde ; Djouina, Madjid ; Klupsch, Frédérique ; Ghinet, Alina ; Barczyk, Amélie ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis. In: ACS Medicinal Chemistry Letters, Vol. 6, no.2, p. 198-203 (2015). doi:10.1021/ml500439x.
2015
Izzo, Angelo A ; Muccioli, Giulio ; Ruggieri, Michael R ; Schicho, Rudolf. Endocannabinoids and the Digestive Tract and Bladder in Health and Disease.. In: Handbook of Experimental Pharmacology, Vol. 231, p. 423-447 (2015). doi:10.1007/978-3-319-20825-1_15.
2015
Valderrama, Jaime A. ; Ríos, David ; Muccioli, Giulio ; Buc Calderon, Pedro ; Brito, Iván ; Benites, Julio. Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones. In: Tetrahedron Letters, Vol. 56, no.36, p. 5103-5105 (2015). doi:10.1016/j.tetlet.2015.07.034.
2015
Bosier, Barbara ; Doyen, Pierre ; Brolet, Amandine ; Muccioli, Giulio ; Ahmed, Eman ; Desmet, Nathalie ; Hermans, Emmanuel ; Deumens, Ronald. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.. In: British Journal of Pharmacology, Vol. 172, no.22, p. 5333-5346 (2015). doi:10.1111/bph.13324.
2015
Vandevelde, Nathalie ; Tulkens, Paul M. ; Muccioli, Giulio ; Van Bambeke, Françoise. Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 6, p. 1713-1726 (2015). doi:10.1093/jac/dkv032.
2015
Al Houayek, Mireille ; Bottemanne, Pauline ; Subramanian, Kumar V ; Lambert, Didier ; Makriyannis, Alexandros ; Cani, Patrice D. ; Muccioli, Giulio. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. In: The FASEB Journal, Vol. 29, no.2, p. 650-661 (2015). doi:10.1096/fj.14-255208.
2015
Bindels, Laure B. ; Neyrinck, Audrey M. (co-first author) ; Salazar Garzo, Nuria ; Taminiau, Bernard ; Druart, Céline ; Muccioli, Giulio ; François, Emmanuelle ; Blecker, Christophe ; Richel, Aurore ; Daube, Georges ; Mahillon, Jacques ; de Los Reyes-Gavilán, Clara G ; Cani, Patrice D. ; Delzenne, Nathalie M.. Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. In: PLoS One, Vol. 10, no. 6, p. e0131009 [1-16] (2015). doi:10.1371/journal.pone.0131009.
2014
Caruano, Joséphine ; Feledziak, Marion ; Labar, Geoffray ; Michaux, Catherine ; Perpete, Eric ; Muccioli, Giulio ; Robiette, Raphaël ; Marchand-Brynaert, Jacqueline. (S)-1-(Pent-4’-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling. In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 29, no. /, p. 654-662 (2014). doi:10.3109/14756366.2013.837900.
2014
Al Houayek, Mireille ; Muccioli, Giulio. COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. In: Trends in Pharmacological Sciences, Vol. 35, no.6, p. 284-292 (2014). doi:10.1016/j.tips.2014.03.001.
2014
Al Houayek, Mireille ; Masquelier, Julien ; Muccioli, Giulio. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. In: Drug Discovery Today, Vol. 19, no. 3, p. 295-304 (2014). doi:10.1016/j.drudis.2013.07.009.
2014
Reychler, Gregory ; Aubriot, Anne-Sophie ; Masquelier, Julien ; Muccioli, Giulio ; Liistro, Giuseppe. Effect of drug-targeting nebulization on lung delivery. In: Archivos de Bronconeumologia, Vol. 50, no. 3, p. 500-501 (2014). doi:10.1016/j.arbres.2013.10.014.
2014
Al Houayek, Mireille ; Muccioli, Giulio. Harnessing the anti-inflammatory potential of palmitoylethanolamide.. In: Drug discovery today, , no.1-8 (2014). doi:10.1016/j.drudis.2014.06.007 (Accepté/Sous presse).
2014
Everard, Amandine ; Geurts, Lucie ; Caesar, Robert ; Van Hul, Matthias ; Matamoros, Sébastien ; Duparc, Thibaut ; Denis, Raphael G P ; Cochez, Perrine ; Pierard, Florian ; Castel, Julien ; Bindels, Laure B. ; Plovier, Hubert ; Robine, Sylvie ; Muccioli, Giulio ; Renauld, Jean-Christophe ; Dumoutier, Laure ; Delzenne, Nathalie M. ; Luquet, Serge ; Bäckhed, Fredrik ; Cani, Patrice D.. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. In: Nature Communications, Vol. 5, no. 1, p. 5648 [1-12] (2014). doi:10.1038/ncomms6648.
2014
Ibacache, Juana Andrea ; Delgado, Virginia ; Benites, Julio ; Theoduloz, Cristina ; Arancibia, Verónica ; Muccioli, Giulio ; Valderrama, Jaime A. Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.. In: Molecules (Basel, Switzerland), Vol. 19, no.1, p. 726-39 (2014). doi:10.3390/molecules19010726.
2013
Tourteau, Aurélien ; Andrzejak, Virginie ; Body-Malapel, Mathilde ; Lemaire, Lucas ; Lemoine, Amélie ; Mansouri, Roxane ; Djouina, Madjid ; Renault, Nicolas ; El Bakali, Jamal ; Desreumaux, Pierre ; Muccioli, Giulio ; Lambert, Didier M ; Chavatte, Philippe ; Rigo, Benoît ; Leleu-Chavain, Natascha ; Millet, Régis. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.. In: Bioorganic & medicinal chemistry, Vol. 21, no. 17, p. 5383-94 (2013). doi:10.1016/j.bmc.2013.06.010.
2013
Beloqui Garcia, Ana ; Coco, Régis ; Al Houayek, Mireille ; Solinís, María Ángeles ; Rodríguez-Gascón, Alicia ; Muccioli, Giulio ; Préat, Véronique. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. In: International Journal of Pharmaceutics, Vol. 454, no. 2, p. 775-783 (2013). doi:10.1016/j.ijpharm.2013.05.017.
2013
Geurts, Lucie ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Cani, Patrice D.. Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. In: PLoS One, Vol. 8, no.2, p. e55963 [1-10] (2013). doi:10.1371/journal.pone.0055963.
2013
Everard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke P ; Druart, Céline ; Bindels, Laure B. ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie M. ; de Vos, Willem M ; Cani, Patrice D.. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.22, p. 9066-9071 (2013). doi:10.1073/pnas.1219451110.
2013
Arenas, Paola ; Peña, Andrés ; Ríos, David ; Benites, Julio ; Muccioli, Giulio ; Buc Calderon, Pedro ; Valderrama, Jaime A. Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones. In: Molecules, Vol. 18, no. 8, p. 9818-9832 (2013). doi:10.3390/molecules18089818.
2013
Al Houayek, Mireille ; Masquelier, Julien ; Cani, Patrice D. ; Lambert, Didier M. ; Muccioli, Giulio. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.43, p. 17558-17563 (2013). doi:10.1073/pnas.1314017110.
2013
Bosier, Barbara ; Muccioli, Giulio ; Lambert, Didier. The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms. In: British Journal of Pharmacology, Vol. 169, no. 4, p. 794-807 (2013). doi:10.1111/j.1476-5381.2012.02208.x.
2012
El Bakali, Jamal ; Gilleron, Pauline ; Body-Malapel, Mathilde ; Mansouri, Roxane ; Muccioli, Giulio ; Djouina, Madjid ; Barczyk, Amélie ; Klupsch, Frédérique ; Andrzejak, Virginie ; Lipka, Emmanuelle ; Furman, Christophe ; Lambert, Didier ; Chavatte, Philippe ; Desreumaux, Pierre ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis. In: Journal of Medicinal Chemistry, Vol. 55, no. 20, p. 8948-8952 (2012). doi:10.1021/jm3008568.
2012
Bosier, Barbara ; Muccioli, Giulio ; Mertens, Birgit ; Sarre, Sophie ; Michotte, Yvette ; Lambert, Didier M ; Hermans, Emmanuel. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.. In: Neuropharmacology, Vol. 62, no. 7, p. 2328-2336 (2012). doi:10.1016/j.neuropharm.2012.02.003.
2012
Matuszak, Nicolas ; Hamtiaux, Laurie ; Baldeyroux, Brigitte ; Muccioli, Giulio ; Poupaert, Jacques H ; Lansiaux, Amélie ; Lambert, Didier M. Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.. In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 45, no. 3, p. 263-71 (2012). doi:10.1016/j.ejps.2011.11.011.
2012
Bindels, Laure B. ; Porporato, Paolo ; Dewulf, Evelyne ; Verrax, Julien ; Neyrinck, Audrey M. ; Martin, J C ; Scott, K P ; Buc Calderon, Pedro ; Feron, Olivier ; Muccioli, Giulio ; Sonveaux, Pierre ; Cani, Patrice D. ; Delzenne, Nathalie M.. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. In: The British journal of cancer, Vol. 107, no. 8, p. 1337-1344 (2012). doi:10.1038/bjc.2012.409.
2012
Feledziak, Marion ; Lambert, Didier, M. ; Marchand-Brynaert, Jacqueline ; Muccioli, Giulio. Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoid's Activity by Preventing their Hydrolysis. In: Recent Patents on C N S Drug Discovery, Vol. 7, no.1, p. 49-70 (2012). doi:10.2174/157488912798842223.
2012
Kapanda, Coco N ; Masquelier, Julien ; Labar, Geoffray ; Muccioli, Giulio ; Poupaert, Jacques H ; Lambert, Didier M. Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.. In: Journal of medicinal chemistry, Vol. 55, no. 12, p. 5774-83 (2012). doi:10.1021/jm3006004.
2012
Hamtiaux, Laurie ; Masquelier, Julien ; Muccioli, Giulio ; Bouzin, Caroline ; Feron, Olivier ; Gallez, Bernard ; Lambert, Didier. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. In: BMC Cancer, Vol. 12, p. 92 [1-12] (2012). doi:10.1186/1471-2407-12-92.
2012
Al Houayek, Mireille ; Muccioli, Giulio. The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. In: Trends in Molecular Medicine, Vol. 18, no. 10, p. 615-625 (2012). doi:10.1016/j.molmed.2012.07.009.
2011
Geurts, Lucie ; Lazarevic, Vladimir ; Derrien, Muriel ; Everard, Amandine ; Van Roye, Marie ; Knauf, Claude ; Valet, Philippe ; Girard, Myriam ; Muccioli, Giulio ; François, Patrice ; de Vos, Willem M. ; Schrenzel, Jacques ; Delzenne, Nathalie M. ; Cani, Patrice D.. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice : impact on apelin regulation in adipose tissue.. In: Frontiers in Microbiology, Vol. 2, p. [1-17] (2011). doi:10.3389/fmicb.2011.00149.
2011
Marrs, William R. ; Horne, Eric A. ; Ortega-Gutierrez, Silvia ; Cisneros, Jose Antonio ; Xu, Cong ; Lin, Yi Hsing ; Muccioli, Giulio ; Lopez-Rodriguez, Maria L. ; Stella, Nephi. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. In: Journal of Biological Chemistry, Vol. 286, no. 33, p. 28723-8 (2011). doi:10.1074/jbc.M110.202853.
2011
Pachikian, Barbara D. ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Neyrinck, Audrey M. ; Catry, Emilie ; De Backer, Fabienne ; Dejeans, Nicolas ; Dewulf, Evelyne ; Sohet, Florence ; Portois, Laurence ; Deldicque, Louise ; Molendi-Coste, Olivier ; Leclercq, Isabelle ; Francaux, Marc ; Carpentier, Yvon A ; Foufelle, Fabienne ; Muccioli, Giulio ; Cani, Patrice D. ; Delzenne, Nathalie M.. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice : genomic analysis of cellular targets.. In: PLoS One, Vol. 6, no. 8, p. e23365 (2011). doi:10.1371/journal.pone.0023365.
2011
Hamtiaux, Laurie ; Hansoulle, Laurie ; Dauguet, Nicolas ; Muccioli, Giulio ; Gallez, Bernard ; Lambert, Didier. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. In: PLoS One, Vol. 6, no. 10, p. [1-14] (2011). doi:10.1371/journal.pone.0026823.
2011
Al Houayek, Mireille ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D. ; Muccioli, Giulio. Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. In: The FASEB Journal, Vol. 25, no. 8, p. 2711-2721 (2011). doi:10.1096/fj.10-176602.
2011
Dewulf, Evelyne ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; Muccioli, Giulio ; Deldicque, Louise ; Bindels, Laure B. ; Pachikian, Barbara D. ; Sohet, Florence ; Mignolet, Eric ; Francaux, Marc ; Larondelle, Yvan ; Delzenne, Nathalie M.. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.. In: The Journal of Nutritional Biochemistry, Vol. 22, no. 8, p. 712-722 (2011). doi:10.1016/j.jnutbio.2010.05.009.
2011
Duparc, Thibaut ; Naslain, Damien ; Colom, André ; Muccioli, Giulio ; Massaly, Nicolas ; Delzenne, Nathalie M. ; Valet, Philippe ; Cani, Patrice D. ; Knauf, Claude. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.. In: Antioxidants & Redox Signaling, Vol. 14, no. 3, p. 415-423 (2011). doi:10.1089/ars.2010.3330.
2011
Thabuis, Clémentine ; Destaillats, Frédéric ; Lambert, Didier ; Muccioli, Giulio ; Maillot, Matthieu ; Harach, Touafiq ; Tissot-Favre, Delphine ; Martin, Jean-Charles. Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice. In: Journal of Lipid Research, Vol. 52, no. 7, p. 1373-82 (2011). doi:10.1194/jlr.M013391.
2011
Sexton, Michelle ; Woodruff, Grace ; Horne, Eric A. ; Lin, Yi Hsing ; Muccioli, Giulio ; Bai, Mingfeng ; Stern, Eric ; Bornhop, Darryl J. ; Stella, Nephi. NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening. In: Chemistry & Biology, Vol. 18, no. 5, p. 563-568 (2011). doi:10.1016/j.chembiol.2011.02.016.
2011
Andrzejak, Virginie ; Muccioli, Giulio ; Body-Malapel, Mathilde ; El Bakali, Jamal ; Djouina, Madjid ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 12, p. 3777-3786 (2011). doi:10.1016/j.bmc.2011.04.057.
2011
Everard, Amandine ; Lazarevic, Vladimir ; Derrien, Muriel ; Girard, Myriam ; Muccioli, Giulio ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; François, Patrice ; de Vos, Willem M ; Delzenne, Nathalie M. ; Schrenzel, Jacques ; Cani, Patrice D.. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. In: Diabetes, Vol. 60, no. 11, p. 2775-2786 (2011). doi:10.2337/db11-0227.
2011
Feledziak, Marion ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH) : evidence of a nonhydrolytic process. In: Journal of Medicinal Chemistry, Vol. 54, no. 19, p. 6812-6823 (2011). doi:10.1021/jm200723m.
2011
Evens, Nele ; Vandeputte, Caroline ; Muccioli, Giulio ; Lambert, Didier ; Baekelandt, Veerle ; Verbruggen, Alfons M. ; Debyser, Zeger ; Van Laere, Koen ; Bormans, Guy M.. Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 15, p. 4499-4505 (2011). doi:10.1016/j.bmc.2011.06.033.
2010
El Bakali, Jamal ; Muccioli, Giulio ; Renault, Nicolas ; Pradal, Delphine ; Body-Malapel, Mathilde ; Djouina, Madjid ; Hamtiaux, Laurie ; Andrzejak, Virginie ; Desreumaux, Pierre ; Chavatte, Philippe ; Lambert, Didier ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands : structural insights into the design of a novel inverse agonist series.. In: Journal of Medicinal Chemistry, Vol. 53, no. 22, p. 7918-7931 (2010). doi:10.1021/jm100286k.
2010
De Wael, Frédéric ; Muccioli, Giulio ; Lambert, Didier ; Sergent, Thérèse ; Schneider, Yves-Jacques ; Rees, Jean-François ; Marchand-Brynaert, Jacqueline. Chemistry around imidazopyrazine and ibuprofen : discovery of novel fatty acid amide hydrolase (FAAH) inhibitors. In: European Journal of Medicinal Chemistry, Vol. 45, no. 9, p. 3564-3574 (2010). doi:10.1016/j.ejmech.2010.04.040.
2010
Muccioli, Giulio. Endocannabinoid biosynthesis and inactivation, from simple to complex.. In: Drug Discovery Today, Vol. 15, no. 11-12, p. 474-483 (2010). doi:10.1016/j.drudis.2010.03.007.
2010
Bosier, Barbara ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Functionally selective cannabinoid receptor signalling : therapeutic implications and opportunities. In: Biochemical Pharmacology, Vol. 80, no. 1, p. 1-12 (2010). doi:10.1016/j.bcp.2010.02.013.
2010
Collard, François ; Stroobant, Vincent ; Lamosa, Pedro ; Kapanda Nankwa, Coco ; Lambert, Didier ; Muccioli, Giulio ; Poupaert, Jacques ; Opperdoes, Frederik ; Van Schaftingen, Emile. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.. In: Journal of Biological Chemistry, Vol. 285, no. 39, p. 29826-29833 (2010). doi:10.1074/jbc.M110.152629.
2010
Wyffels, Leonie ; Muccioli, Giulio ; Kapanda Nankwa, Coco ; Labar, Geoffray ; De Bruyne, Sylvie ; De Vos, Filip ; Lambert, Didier. PET imaging of fatty acid amide hydrolase in the brain : synthesis and biological evaluation of an C-11-labelled URB597 analogue. In: Nuclear Medicine and Biology, Vol. 37, no. 5, p. 665-75 (2010). doi:10.1016/j.nucmedbio.2010.03.009.
2010
Muccioli, Giulio ; Naslain, Damien ; Bäckhed, Fredrik ; Reigstad, Christopher S. ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D.. The endocannabinoid system links gut microbiota to adipogenesis. In: Molecular Systems Biology, Vol. 6, p. 392 [1-15] (2010). doi:10.1038/msb.2010.46.
2010
Marrs, William R. ; Blankman, Jacqueline L. ; Horne, Eric A. ; Thomazeau, Aurore ; Lin, Yi Hsing ; Coy, Jonathan ; Bodor, Agnes L. ; Muccioli, Giulio ; Hu, Sherry Shu-Jung ; Woodruff, Grace ; Fung, Susan ; Lafourcade, Mathieu ; Alexander, Jessica P. ; Long, Jonathan Z. ; Li, Weiwei ; Xu, Cong ; Moeller, Thomas ; Mackie, Ken ; Manzoni, Olivier J. ; Cravatt, Benjamin F. ; Stella, Nephi. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. In: Nature Neuroscience, Vol. 13, no. 8, p. 951-7 (2010). doi:10.1038/nn.2601.
2009
Feledziak, Marion ; Michaux, Catherine ; Urbach, Allan ; Labar, Geoffray ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. Beta-lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7054-7068 (2009). doi:10.1021/jm9008532.
2009
Kapanda, Coco N. ; Muccioli, Giulio ; Labar, Geoffray ; Poupaert, Jacques ; Lambert, Didier. Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7310-7314 (2009). doi:10.1021/jm901323s.
2009
Cani, Patrice D. ; Possemiers, S. ; Van de Wiele, T. ; Guiot, Yves ; Everard, Amandine ; Rottier, O. ; Geurts, Lucie ; Naslain, Damien ; Neyrinck, Audrey M. ; Lambert, Didier ; Muccioli, Giulio ; Delzenne, Nathalie M.. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. In: Gut, Vol. 58, no. 8, p. 1091-1103 (2009). doi:10.1136/gut.2008.165886.
2009
Muccioli, Giulio ; Sia, Angela ; Muchowski, Paul J. ; Stella, Nephi. Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae.. In: PLoS One, Vol. 4, no. 6, p. e5942 (2009). doi:10.1371/journal.pone.0005942.
2009
Kapanda Nankwa, Coco ; Muccioli, Giulio ; Labar, Geoffray ; Draoui, Nihed ; Lambert, Didier ; Poupaert, Jacques. Search for monoglyceride lipase inhibitors : synthesis and screening of arylthioamides derivatives. In: Medicinal Chemistry Research, Vol. 18, no. 4, p. 243-254 (2009). doi:10.1007/s00044-008-9123-2.
2009
Evens, Nele ; Muccioli, Giulio ; Houbrechts, Nele ; Lambert, Didier ; Verbruggen, Alfons M. ; Van Laere, Koen ; Bormans, Guy M.. Synthesis and biological evaluation of carbon-11-and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. In: Nuclear Medicine and Biology, Vol. 36, no. 4, p. 455-465 (2009). doi:10.1016/j.nucmedbio.2009.01.009.
2009
Matuszak, Nicolas ; Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 23, p. 7410-7420 (2009). doi:10.1021/jm900461w.
2009
Wyffels, Leonie ; Muccioli, Giulio ; De Bruyne, Sylvie ; Moerman, Lieselotte ; Sambre, Johan ; Lambert, Didier ; De Vos, Filip. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. In: Journal of Medicinal Chemistry, Vol. 52, no. 15, p. 4613-4622 (2009). doi:10.1021/jm900324e.
2008
Urbach, Allan ; Muccioli, Giulio ; Stern, Eric ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.. In: Bioorganic & Medicinal Chemistry Letters, Vol. 18, no. 14, p. 4163-4167 (2008). doi:10.1016/j.bmcl.2008.05.081.
2008
Muccioli, Giulio ; Stella, Nephi. An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. In: Analytical Biochemistry, Vol. 373, no.2, p. 220-228 (2008). doi:10.1016/j.ab.2007.09.030.
2008
Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. In: ChemBioChem : a European journal of chemical biology, Vol. 9, no. 16, p. 2704-2710 (2008). doi:10.1002/cbic.200800428.
2008
Gallienne, Estelle ; Muccioli, Giulio ; Lambert, Didier ; Shipman, Michael. Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase. In: Tetrahedron Letters, Vol. 49, no. 46, p. 6495-6497 (2008). doi:10.1016/j.tetlet.2008.08.100.
2007
Hoet, Sara ; Pieters, Luc ; Muccioli, Giulio ; Habib Jiwan, Jean-Louis ; Opperdoes, Frederik ; Quetin-Leclercq, Joëlle. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.. In: Journal of Natural Products, Vol. 70, no. 8, p. 1360-1363 (2007). doi:10.1021/np070038q.
2007
Muccioli, Giulio. Blocking the cannabinoid receptors: Drug candidates and therapeutic promises. In: Chemistry & Biodiversity, Vol. 4, no. 8, p. 1805-1827 (2007). doi:10.1002/cbdv.200790153.
2007
Labar, Geoffray ; Bauvois, Cedric ; Muccioli, Giulio ; Wouters, Johan ; Lambert, Didier. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. In: ChemBioChem, Vol. 8, no. 11, p. 1293-1297 (2007). doi:10.1002/cbic.200700139.
2007
Lambert, Didier ; Muccioli, Giulio. Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players.. In: Current opinion in clinical nutrition and metabolic care, Vol. 10, no. 6, p. 735-744 (2007). doi:10.1097/MCO.0b013e3282f00061.
2007
Muccioli, Giulio ; Xu, Cong ; Odah, Emma ; Cudaback, Eiron ; Antonio Cisneros, Jose ; Lambert, Didier ; Lopez Rodriguez, Maria Luz ; Bajjalieh, Sandra ; Stella, Nephi. Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. In: The Journal of Neuroscience, Vol. 27, no. 11, p. 2883-9 (2007). doi:10.1523/JNEUROSCI.4830-06.2007.
2007
Stern, Eric ; Muccioli, Giulio ; Bosier, Barbara ; Hamtiaux, Laurie ; Millet, Regis ; Poupaert, Jacques ; Henichart, Jean-Pierre ; Depreux, Patrick ; Goossens, Jean-Francois ; Lambert, Didier. Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality. In: Journal of Medicinal Chemistry, Vol. 50, no. 22, p. 5471-84 (2007). doi:10.1021/jm070387h.
2007
Philip, Ashok E. ; Poupaert, Jacques ; Cheve, Gwenael ; Muccioli, Giulio ; Lambert, Didier ; McCurdy, Christopher R.. Structure-activity relationship of phenytoinergic antiepileptic drugs related to ameltolide. In: Medicinal Chemistry Research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Vol. 16, no. 3, p. 130-135 (2007). doi:10.1007/s00044-007-9016-9.
2006
Michaux, Catherine ; Muccioli, Giulio ; Lambert, Didier ; Wouters, Johan. Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104. In: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 16, no. 18, p. 4772-4776 (2006). doi:10.1016/j.bmcl.2006.06.087.
2006
Muccioli, Giulio ; Lambert, Didier. Latest advances in cannabinoid receptor antagonists and inverse agonists. In: Expert Opinion on Therapeutic Patents, Vol. 16, no. 10, p. 1405-1423 (2006). doi:10.1517/13543776.16.10.1405.
2006
Stern, Eric ; Muccioli, Giulio ; Millet, R ; Goossens, JF ; Farce, A ; Chavatte, P ; Poupaert, Jacques ; Lambert, Didier ; Depreux, P. ; Hénichart, Jean-Pierre. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: Synthesis, pharmacological properties and molecular modeling. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 70-79 (2006). doi:10.1021/jm050467q.
2006
Muccioli, Giulio ; Fazio, Nicola ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Cannata, Fabio ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 417-425 (2006). doi:10.1021/jm050977k.
2006
Muccioli, Giulio ; Wouters, Johan ; Charlier, Caroline ; Scriba, Gerhard K E ; Pizza, Teresa ; Di Pace, Pierluigi ; De Martino, Paolo ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.. In: Journal of medicinal chemistry, Vol. 49, no. 3, p. 872-82 (2006). doi:10.1021/jm050484f.
2005
Muccioli, Giulio ; Wouters, Johan ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.. In: Journal of medicinal chemistry, Vol. 48, no. 23, p. 7486-90 (2005). doi:10.1021/jm0503906.
2005
Muccioli, Giulio ; Lambert, Didier. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors.. In: Current medicinal chemistry, Vol. 12, no. 12, p. 1361-94 (2005). doi:10.2174/0929867054020891.
2005
Gbaguidi, F. ; Muccioli, Giulio ; Accrombessi, Georges C. ; Moudachirou, M. ; Quetin-Leclercq, Joëlle. Densitometric HPTLC quantification of 2-azaanthraquinone isolated from Mitracarpus scaber and antimicrobial activity against Dermatophilus congolensis. In: Journal of Planar Chromatography - Modern TLC, Vol. 18, no. 105, p. 377-379 (2005). doi:10.1556/JPC.18.2005.5.8.
2005
Muccioli, Giulio ; Martin, Diana ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.. In: Journal of medicinal chemistry, Vol. 48, no. 7, p. 2509-17 (2005). doi:10.1021/jm049263k.
2004
Govaerts, Sophie ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors.. In: European Journal of Pharmacology, Vol. 495, no. 1, p. 43-53 (2004). doi:10.1016/j.ejphar.2004.05.023.
2003
Muccioli, Giulio ; Poupaert, Jacques ; Wouters, Johan ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K. E. ; Lambert, Didier. A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins. In: Tetrahedron, Vol. 59, no. 8, p. 1301-1307 (2003). doi:10.1016/S0040-4020(03)00033-4.
2003
Muccioli, Giulio ; Wouters, Johan ; Poupaert, Jacques ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K E ; Lambert, Didier. Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins.. In: Organic letters, Vol. 5, no. 20, p. 3599-602 (2003). doi:10.1021/ol035282x.