CARD
Avenue Hippocrate 55/B1.55.05
1200 Woluwe-Saint-Lambert
Luc Bertrand
Professeur ordinaire
Present Academic Positions
2015-present Senior Research Associate from the National Fund for Scientific Research (FRS-FNRS), UCL, Brussels, Belgium
2011-present Professor at UCL, Faculty of Pharmacy & Biomedical Sciences, Brussels, Belgium
2009-present Visiting Professor, University of Namur, Faculty of Biology, Namur, Belgium
2003-present Group leader in the Pole of Cardiovascular Research, Institute of Experimental and Clinical Research (IREC), UCL, Brussels, Belgium
Career and Education
2003-2015 Research Associate from FRS-FNRS, CARD/IREC/UCL, Brussels, Belgium
2003-2011 Assistant Professor at UCL, Faculty of Pharmacy & Biomedical Sciences, Brussels, Belgium
2000-2003 UCL Postdoctoral Researcher at the de Duve Institute (Head: Prof. L. Hue), UCL, Brussels, Belgium
1998 FEBS Fellowship - Medical Research Council Protein Phosphorylation Unit (Prof. Philip Cohen and Dario Alessi), University of Dundee, Scotland
1997-2000 Postdoctoral Researcher from FRS-FNRS, de Duve Institute, UCL, Brussels, Belgium
1992-1997 Ph.D. in Biological Sciences, University of Namur, Molecular and Structural Biology Unit, Namur, Belgium (Promoter: Prof. E. Feytmans)
Thesis entitled: Structure/function relationship of mammalian PFK2 - Suma cum laude1987-1991 Master in Zoological Sciences, University of Namur, Molecular and Structural Biology Unit, Namur, Belgium - Magna cum laude
Fellowship Awards
1997-2000 Postdoctoral Researcher of the FNRS (Belgium)
1992-1994 Ph.D. student of the Institute for Scientific Research in Industries and Agriculture (Belgium)
Research Awards
2007 Camille and Germaine Damman Prize of the Cardiologic Research Foundation “Study of the regulation of cardiac metabolism by hormones and during ischemia”
2006 Léopold and Marthe Delsaux-Champy Prize “Study of the molecular mechanims involved in the regulation of cardiac metabolism by insulin and during ischemia”
1992 Adrien Bauchau Award, Best master thesis
International and National Scientific Activities
2014-present Academic Editor & Member of the Editorial Board of PLOS ONE (Roles: Editor and Reviewer)
2011-present Member of the Editorial Board of the American Journal of Physiology Heart and Circulatory Physiology (Roles: Reviewer and Editorial writer)
2012-present Member of the International Board of Directors of the GRRC, Basic Branch of the French Society of Cardiology (Roles: administration of the GRRC, member of the organizing committee of the annual GRRC meetings called “Printemps de la Cardiologie” and “Automnales du GRRC”)
2008-present Invited expert for the evaluation of grant applications for different international research agencies: Belgium (AstraZeneca foundation), France (ANR, CORDDIM, FRM, ATIP-Avenir), Switzerland (Swiss National Science Foundation), Denmark (Danish Council for Independent Research), Netherland (CardioVasculair Onderzoek Nederland-CVON, Dutch Heart Foundation), USA (Boston Area Diabetes Endocrinology Research Center), Israel (Israel Science Foundation), Poland (Polish National Science Center).
2004-2015 Member of FRIA scientific commission (FNRS, Belgium)
2015 Invited HCERES Expert (President of the commission) for the evaluation of research center of French Universities for the Haut Conseil de l'évaluation de la recherche et de l'enseignement supérieur (HCERES, France).
2012-2014 Member of the International Board of Directors of the Society for Heart and Vascular Metabolism (SHVM) (Role: administration of SHVM)
2011 Organizer of the 9th international Scientific Meeting of the Society for Heart and Vascular Metabolism: “Exploring New Links Between Metabolism and Cardiac Function” (Brussels, 2011)
2010-2012 Member of ANR evaluation committee « Pathophysiologie, Physiologie, Santé Publique » (SVSE1), Agence Nationale de la Recherche (ANR, France)
2010 Invited AERES expert for the evaluation of research center of French Universities for the Agence d’Evaluation de la Recherche et des établissements d’Enseignement Supérieur (AERES, France).
2010 Member of FNRS scientific commission, Life and Health Sciences 2 (Belgium)
Academic activities
2016-present Board member of the Academic Staff Council (UCL, Belgium)
2010-present Board Member of the IREC Institute (UCL, Belgium)
2009-present Member of the commission of the Master in Biomedical Sciences « finalité approfondie » (UCL, Belgium)
2012-2014, 2017 Master of Ceremony for the annual faculty awards and prizes night (UCL, Belgium)
2009-present Representing member of IREC in the “animal facility commission” of the campus (UCL, Belgium)
2008-present Board Member of the doctoral school, Experimental and Clinical Research (UCL, Belgium)
2002-present Member of the PhD thesis committee of more than 90 Ph.D. students (National and international)
- Diploma
Year Label Educational Organization 1989 Candidat en Sciences Biologiques Facultés Universitaires Notre Dame de la Paix à Namur 1991 Licencié en sciences zoologiques Facultés Universitaires Notre Dame de la Paix à Namur 1997 Docteur en sciences biologiques Facultés Universitaires Notre Dame de la Paix à Namur
Teaching Activities
2015-present ‘’Post-translational modifications of proteins’’, Coordinator and Co-titular (5h), Master in Biomedical Sciences, UCL
2015-present ‘’Cellular and molecular pathophysiology of human diseases’’, Co-titular (3h), Master in Biomedical Sciences, UCL
2014-present ‘’Molecular and cellular aspects of nutrition’’, Co-titular (6h), Master in Biomedical Sciences, UCL
2009-present ‘’Tutorial in scientific communication’’, Co-titular (10h), Master in Biomedical Sciences, UCL
2007-present ‘’Protein structure, function and regulation’’, Co-titular (9h), Master in Biomedical Sciences, UCL
2006-present ‘’Experimental strategies in molecular and cellular biology’’, Co-titular (20h), Bachelor in Biomedical Sciences, UCL
- Courses
Name ID Molecular biology and integrated biochemistry WSBIM1227 Workshop on experimental strategy in cellular and molecular biology WSBIM1303 Experimental design in biomedical sciences WSBIM1313 Introduction to experimental approaches in cellular and molecular biology WSBIM1320 Genetics and applied biotechnology WSBIM1382 Protein structure / Function relationships WSBIM2115 Molecular and cellular aspects of nutrition WSBIM2181 Post-translational regulation of proteins WSBIM2215 Special issues in molecular and cellular pathophysiology WSBIM2218 Scientific communication workshop WSBIM2280 Cellular and molecular pathophysiology of human diseases (Part 2) WSBIM2284
2024
Dufeys, Cécile ; Bodart, Julie ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine. Fibroblasts and platelets: a face-to-face dialogue at the heart of cardiac fibrosis.. In: American journal of physiology. Heart and circulatory physiology, Vol. 326, no.3, p. H655-H669 (2024). doi:10.1152/ajpheart.00559.2023.
2024
Falcão-Pires, Inês ; Ferreira, Ana Filipa ; Trindade, Fábio ; Bertrand, Luc ; Ciccarelli, Michele ; Visco, Valeria ; Dawson, Dana ; Hamdani, Nazha ; Van Laake, Linda W ; Lezoualc'h, Frank ; Linke, Wolfgang A ; Lunde, Ida G ; Rainer, Peter P ; Abdellatif, Mahmoud ; Van der Velden, Jolanda ; Cosentino, Nicola ; Paldino, Alessia ; Pompilio, Giulio ; Zacchigna, Serena ; Heymans, Stephane ; Thum, Thomas ; Tocchetti, Carlo Gabriele. Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function.. In: European journal of heart failure, Vol. , no., p. (2024). doi:10.1002/ejhf.3264.
2024
Pouleur, Anne-Catherine ; Menghoum, Nassiba ; Cumps, Julien ; Marino, Alice ; Badii, Maria ; Lejeune, Sibille ; Legault, Julie Thompson ; Boucher, Gabrielle ; Gruson, Damien ; Roy, Clotilde ; Battault, Sylvain ; Mahrouche, Louiza ; Pedneault-Gagnon, Valérie ; Charpentier, Daniel ; Furtos, Alexandra ; Hussin, Julie ; Rhainds, David ; Tardif, Jean-Claude ; Bertrand, Luc ; Rosiers, Christine Des ; Horman, Sandrine ; Beauloye, Christophe. Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project. In: eBioMedicine, Vol. 107, p. 105264 (2024). doi:10.1016/j.ebiom.2024.105264 (Accepté/Sous presse).
2024
Pirotton, Laurence ; de Cartier d'Yves, Emma ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine. Platelet lipidomics and de novo lipogenesis: impact on health and disease.. In: Current opinion in hematology, Vol. , no., p. (2024). doi:10.1097/MOH.0000000000000820.
2023
Michel, Lauriane ; Esfahani, Hrag ; Verdoy, Roxane ; de Mulder, Delphine ; Ambroise, Jérôme ; Roelants, Véronique ; Bouchard Bertrand ; Savary, Jérôme ; Dewulf, Joseph P ; Doumont, Thomas ; Bouzin, Caroline ; Haufroid, Vincent ; Luiken, Joost J.F.P. ; Nabben, Miranda ; Singleton, Michael L. ; Bertrand, Luc ; Ruiz, Matthieu ; Des Rosiers, Christine ; Balligand, Jean-Luc. A NRF2/beta3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress. In: Biorxiv, Vol. 14, no. Nov (2023) (2023). doi:10.1101/2023.11.10.564735.
2023
Ciccarelli, Michele ; Pires, Inês Falcão ; Bauersachs, Johann ; Bertrand, Luc ; Beauloye, Christophe ; Dawson, Dana ; Hamdani, Nazha ; Hilfiker-Kleiner, Denise ; van Laake, Linda W ; Lezoualc'h, Frank ; Linke, Wolfgang A ; Lunde, Ida G ; Rainer, Peter P ; Rispoli, Antonella ; Visco, Valeria ; Carrizzo, Albino ; Ferro, Matteo Dal ; Stolfo, Davide ; van der Velden, Jolanda ; Zacchigna, Serena ; Heymans, Stephane ; Thum, Thomas ; Tocchetti, Carlo Gabriele. Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.. In: Cardiovascular research, Vol. 119, no. 14, p. 2390-2404 (2023). doi:10.1093/cvr/cvad088.
2023
Dechamps, Mélanie ; De Poortere, Julien ; Octave, Marie ; Ginion, Audrey ; Robaux, Valentine ; Pirotton, Laurence ; Bodart, Julie ; Gruson, Damien ; van Dievoet, Marie-Astrid ; Douxfils, Jonathan ; Haguet, Hélène ; Morimont, Laure ; Derive, Marc ; Jolly, Lucie ; Bertrand, Luc ; Laterre, Pierre-François ; Horman, Sandrine ; Beauloye, Christophe. Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill. In: International journal of molecular sciences, Vol. 24, no. 8, p. 7278 [1-12] (2023). doi:10.3390/ijms24087278.
2023
Robaux, Valentine ; Kautbally, Shakeel ; Ginion, Audrey ; Dechamps, Mélanie ; Lejeune, Sibille ; Menghoum, Nassiba ; Bertrand, Luc ; Pouleur, Anne-Catherine ; Horman, Sandrine ; Beauloye, Christophe. Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients. In: Platelets, Vol. 34, no. 1, p. 2250002 [1-11] (2023). doi:10.1080/09537104.2023.2250002.
2023
De Loof, Marine ; Renguet, Edith ; Ginion, Audrey ; Bouzin, Caroline ; Horman, Sandrine ; Beauloye, Christophe ; Bertrand, Luc ; Bultot, Laurent. Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport.. In: American journal of physiology. Heart and circulatory physiology, Vol. 324, no. 3, p. H305-H317 (2023). doi:10.1152/ajpheart.00449.2022.
2023
Lindsey, Merry L ; LeBlanc, Amanda J ; Bertrand, Luc ; Bradshaw, Amy D ; Kleinbongard, Petra. Improving rigor and reproducibility in cardiovascular research.. In: American journal of physiology. Heart and circulatory physiology, Vol. 325, no.4, p. H866-H868 (2023). doi:10.1152/ajpheart.00524.2023.
2023
Menghoum, Nassiba ; Beauloye, Christophe ; Lejeune, Sibille ; Badii, Maria Chiara ; Gruson, Damien ; van Dievoet, Marie-Astrid ; Pasquet, Agnes ; Vancraeynest, David ; Gerber, Bernhard ; Bertrand, Luc ; Horman, Sandrine ; Pouleur, Anne-Catherine. Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction.. In: Platelets, Vol. 34, no.1, p. 2188965 (2023). doi:10.1080/09537104.2023.2188965.
2022
van der Velden, Jolanda ; Asselbergs, Folkert W ; Bakkers, Jeroen ; Batkai, Sandor ; Bertrand, Luc ; Bezzina, Connie R ; Bot, Ilze ; Brundel, Bianca ; Carrier, Lucie ; Chamuleau, Steven ; Ciccarelli, Michele ; Dawson, Dana ; Davidson, Sean M ; Dendorfer, Andreas ; Duncker, Dirk J ; Eschenhagen, Thomas ; Fabritz, Larissa ; Falcão-Pires, Ines ; Ferdinandy, Péter ; Giacca, Mauro ; Girao, Henrique ; Gollmann-Tepeköylü, Can ; Gyongyosi, Mariann ; Guzik, Tomasz J ; Hamdani, Nazha ; Heymans, Stephane ; Hilfiker, Andres ; Hilfiker-Kleiner, Denise ; Hoekstra, Alfons G ; Hulot, Jean-Sébastien ; Kuster, Diederik W D ; van Laake, Linda W ; Lecour, Sandrine ; Leiner, Tim ; Linke, Wolfgang A ; Lumens, Joost ; Lutgens, Esther ; Madonna, Rosalinda ; Maegdefessel, Lars ; Mayr, Manuel ; van der Meer, Peter ; Passier, Robert ; Perbellini, Filippo ; Perrino, Cinzia ; Pesce, Maurizio ; Priori, Silvia ; Remme, Carol Ann ; Rosenhahn, Bodo ; Schotten, Ulrich ; Schulz, Rainer ; Sipido, Karin ; Sluijter, Joost P G ; van Steenbeek, Frank ; Steffens, Sabine ; Terracciano, Cesare M ; Tocchetti, Carlo Gabriele ; Vlasman, Patricia ; Yeung, Kak Khee ; Zacchigna, Serena ; Zwaagman, Dayenne ; Thum, Thomas. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart.. In: Cardiovascular research, Vol. 118, no. 15, p. 3016-305 (2022). doi:10.1093/cvr/cvab370.
2022
Maes, Arne ; Pestiaux, Camille ; Marino, Alice ; Balcaen, Tim ; Leyssens, Lisa ; Vangrunderbeeck, Sarah ; Pyka, Grzegorz ; De Borggraeve, Wim M. ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine ; Wevers, Martine ; Kerckhofs, Greet. Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues. In: Nature communications, Vol. 13, no. 1, p. 6207 [1-14] (2022). doi:10.1038/s41467-022-34048-4.
2022
Dechamps, Mélanie ; De Poortere, Julien ; Martin, Manon ; Gatto, Laurent ; Daumerie, Aurélie ; Bouzin, Caroline ; Octave, Marie ; Ginion, Audrey ; Robaux, Valentine ; Pirotton, Laurence ; Bodart, Julie ; Gérard, Ludovic ; Montiel, Virginie ; Campion, Alessandro ; Gruson, Damien ; Van Dievoet, Marie-Astrid ; Douxfils, Jonathan ; Haguet, Hélène ; Morimont, Laure ; Derive, Marc ; Jolly, Lucie ; Bertrand, Luc ; Dumoutier, Laure ; Castanares Zapatero, Diego ; Laterre, Pierre-François ; Horman, Sandrine ; Beauloye, Christophe. Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study.. In: Frontiers in medicine, Vol. 8, p. 780750 [1-14] (2022). doi:10.3389/fmed.2021.780750.
2022
Ferté, Laura ; Cumps, Julien ; Battault, Sylvain ; Esfahani, Hrag ; Balligand, Jean-Luc ; Horman, Sandrine ; Bertrand, Luc ; Beauloye, Christophe ; Marino, Alice. Letter by Ferté, et al. Regarding Article, "Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice".. In: International heart journal, Vol. 63, no. 1, p. 184-186 (2022). doi:10.1536/ihj.21-442.
2022
Peugnet, Victoriane ; Chwastyniak, Maggy ; Mulder, Paul ; Lancel, Steve ; Bultot, Laurent ; Fourny, Natacha ; Renguet, Edith ; Bugger, Heiko ; Beseme, Olivia ; Loyens, Anne ; Heyse, Wilfried ; Richard, Vincent ; Amouyel, Philippe ; Bertrand, Luc ; Pinet, Florence ; Dubois-Deruy, Emilie. Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes.. In: Antioxidants, Vol. 11, no. 4, p. 723 1-22 (2022). doi:10.3390/antiox11040723.
2022
Rodriguez, Julie ; Neyrinck, Audrey M. ; Van Kerckhoven, Maxime ; Gianfrancesco, Marco A ; Renguet, Edith ; Bertrand, Luc ; Cani, Patrice D. ; Lanthier, Nicolas ; Cnop, Miriam ; Paquot, Nicolas ; Thissen, Jean-Paul ; Bindels, Laure B. ; Delzenne, Nathalie M.. Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals.. In: BMC medicine, Vol. 20, no.1, p. 110 [1-20] (2022). doi:10.1186/s12916-022-02299-z.
2022
Angin, Yeliz ; Beauloye, Christophe ; Horman, Sandrine ; Bertrand, Luc. Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK.. In: Experientia supplementum (2012), Vol. 107, no.1, p. 23-43 (2022). doi:10.1007/978-3-319-43589-3_2.
2022
Dontaine, Justine ; Bouali, Asma ; Daussin, Frederic ; Bultot, Laurent ; Vertommen, Didier ; Martin, Manon ; Rathagirishnan, Raahulan ; Cuillerier, Alexanne ; Horman, Sandrine ; Beauloye, Christophe ; Gatto, Laurent ; Lauzier, Benjamin ; Bertrand, Luc ; Burelle, Yan. The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart.. In: Communications biology, Vol. 5, no. 1, p. 349 [1-14] (2022). doi:10.1038/s42003-022-03282-3.
2022
Renguet, Edith ; De Loof, Marine ; Fourny, Natacha ; Ginion, Audrey ; Bouzin, Caroline ; Poüs, Christian ; Horman, Sandrine ; Beauloye, Christophe ; Bultot, Laurent ; Bertrand, Luc. α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake.. In: American journal of physiology. Heart and circulatory physiology, Vol. 322, no. 6, p. H1032-H1043 (2022). doi:10.1152/ajpheart.00664.2021.
2021
Bertrand, Luc ; De Loof, Marine ; Beauloye, Christophe ; Horman, Sandrine ; Bultot, Laurent. A new degree of complexi(n)ty in the regulation of GLUT4 trafficking.. In: The Biochemical journal, Vol. 478, no. 7, p. 1315-1319 (2021). doi:10.1042/BCJ20210008.
2021
Marino, Alice ; Hausenloy, Derek J ; Andreadou, Ioanna ; Horman, Sandrine ; Bertrand, Luc ; Beauloye, Christophe. AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury.. In: Free radical biology & medicine, Vol. 166, p. 238-254 (2021). doi:10.1016/j.freeradbiomed.2021.02.047.
2021
Dufeys, Cécile ; Daskalopoulos, Evangelos-Panagiotis (co-first author) ; Castanares Zapatero, Diego ; Conway, Simon J. ; Ginion, Audrey ; Bouzin, Caroline ; Ambroise, Jérôme ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Heymans, Stephane ; Papageorgiou, Anna-Pia ; Vinckier, Stefan ; Cumps, Julien ; Balligand, Jean-Luc ; Vanhaverbeke, Maarten ; Sinnaeve, Peter ; Janssens, Stefan ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine. AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism. In: Basic Research in Cardiology, Vol. 116, p. 10 [1-20] (2021). doi:10.1007/s00395-021-00846-y.
2021
Octave, Marie ; Pirotton, Laurence ; Ginion, Audrey ; Robaux, Valentine ; Lepropre, Sophie ; Ambroise, Jérôme ; Bouzin, Caroline ; Guigas, Bruno ; Giera, Martin ; Foretz, Marc ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine. Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation.. In: International journal of molecular sciences, Vol. 22, no. 23, p. 13129 [1-17] (2021). doi:10.3390/ijms222313129.
2021
Denis, Manon ; Dupas, Thomas ; Persello, Antoine ; Dontaine, Justine ; Bultot, Laurent ; Betus, Charlotte ; Pelé, Thomas ; Dhot, Justine ; Erraud, Angélique ; Maillard, Anaïs ; Montnach, Jérôme ; Leroux, Aurélia A. ; Bigot-Corbel, Edith ; Vertommen, Didier ; Rivière, Matthieu ; Lebreton, Jacques ; Tessier, Arnaud ; Waard, Michel De ; Bertrand, Luc ; Rozec, Bertrand ; Lauzier, Benjamin. An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat. In: International Journal of Molecular Sciences, Vol. 22, no.17, p. 9236 (2021). doi:10.3390/ijms22179236.
2021
Ange, Marine ; De Poortere, Julien ; Ginion, Audrey ; Battault, Sylvain ; Dechamps, Mélanie ; Muccioli, Giulio ; Roumain, Martin ; Morelle, Johann ; Druart, Sébastien ; Mathivet, Thomas ; Bertrand, Luc ; Castanares Zapatero, Diego ; Horman, Sandrine ; Beauloye, Christophe. Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK.. In: Scientific reports, Vol. 11, no. 1, p. 13700 [1-13] (2021). doi:10.1038/s41598-021-93156-1.
2021
Ferté, Laura ; Marino, Alice ; Battault, Sylvain ; Bultot, Laurent ; Van Steenbergen, Anne ; Bol, Anne ; Cumps, Julien ; Ginion, Audrey ; Koepsell, Hermann ; Dumoutier, Laure ; Hue, Louis ; Horman, Sandrine ; Bertrand, Luc ; Beauloye, Christophe. New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans.. In: American journal of physiology. Heart and circulatory physiology, Vol. 320, no. 2, p. H838-H853 (2021). doi:10.1152/ajpheart.00736.2019.
2021
Contino, Sabrina ; Suelves Caballol, Nuria ; Vrancx, Céline ; Vadukul, Devkee Mahesh ; Payen Valery L. ; Stanga, Serena ; Bertrand, Luc ; Kienlen-Campard, Pascal. Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes. In: Frontiers in Neuroscience, Vol. 14, p. 586108 (2021).
2021
Dupas, Thomas ; Denis, Manon ; Dontaine, Justine ; Persello, Antoine ; Bultot, Laurent ; Erraud, Angélique ; Vertommen, Didier ; Bouchard, Bertrand ; Tessier, Arnaud ; Rivière, Matthieu ; Lebreton, Jacques ; Bigot-Corbel, Edith ; Montnach, Jérôme ; De Waard, Michel ; Gauthier, Chantal ; Burelle, Yan ; Olson, Aaron K ; Rozec, Bertrand ; Des Rosiers, Christine ; Bertrand, Luc ; Issad, Tarik ; Lauzier, Benjamin. Protein O-GlcNAcylation levels are regulated independently of dietary intake in a tissue and time-specific manner during rat postnatal development.. In: Acta physiologica (Oxford, England), Vol. 231, no. 3, p. e13566 (2021). doi:10.1111/apha.13566 (Accepté/Sous presse).
2021
Fourny, Natacha ; Beauloye, Christophe ; Bernard, Monique ; Horman, Sandrine ; Desrois, Martine ; Bertrand, Luc. Sex Differences of the Diabetic Heart.. In: Frontiers in physiology, Vol. 12, p. 661297 [1-9] (2021). doi:10.3389/fphys.2021.661297.
2021
Zacchigna, Serena ; Paldino, Alessia ; Falcão-Pires, Inês ; Daskalopoulos, Evangelos-Panagiotis ; Dal Ferro, Matteo ; Vodret, Simone ; Lesizza, Pierluigi ; Cannatà, Antonio ; Miranda-Silva, Daniela ; Lourenço, André P ; Pinamonti, Bruno ; Sinagra, Gianfranco ; Weinberger, Florian ; Eschenhagen, Thomas ; Carrier, Lucie ; Kehat, Izhak ; Tocchetti, Carlo G ; Russo, Michele ; Ghigo, Alessandra ; Cimino, James ; Hirsch, Emilio ; Dawson, Dana ; Ciccarelli, Michele ; Oliveti, Marco ; Linke, Wolfgang A ; Cuijpers, Ilona ; Heymans, Stephane ; Hamdani, Nazha ; de Boer, Martine ; Duncker, Dirk ; Kuster, Diederik ; van der Velden, Jolanda ; Beauloye, Christophe ; Bertrand, Luc ; Mayr, Manuel ; Giacca, Mauro ; Leuschner, Florian ; Backs, Johannes ; Thum, Thomas. Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function., collab. Working Group on Myocardial Function of the European Society of Cardiology.. In: Cardiovascular research, Vol. 117, no. 1, p. 43-59 (2021). doi:10.1093/cvr/cvaa110.
2021
Balligand, Jean-Luc ; Bertrand, Luc. You “heart” what you eat!. In: Cardiovascular research, Vol. 117, no. 11, p. 2294-2296 (2021). doi:10.1093/cvr/cvab118.
2020
Dubois-Deruy, Emilie ; Gelinas, Roselle ; Beauloye, Christophe ; Esfahani, Hrag ; Michel, Lauriane ; Dessy, Chantal ; Bertrand, Luc ; Balligand, Jean-Luc. Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP-activated protein kinase and autophagy.. In: ESC heart failure, Vol. 7, no. 3, p. 920-932 (2020). doi:10.1002/ehf2.12648.
2020
Tocchetti, Carlo Gabriele ; Ameri, Pietro ; de Boer, Rudolf A ; D'Alessandra, Yuri ; Russo, Michele ; Sorriento, Daniela ; Ciccarelli, Michele ; Kiss, Bernadett ; Bertrand, Luc ; Dawson, Dana ; Falcao-Pires, Ines ; Giacca, Mauro ; Hamdani, Nazha ; Linke, Wolfgang A ; Mayr, Manuel ; van der Velden, Jolanda ; Zacchigna, Serena ; Ghigo, Alessandra ; Hirsch, Emilio ; Lyon, Alexander R ; Görbe, Anikó ; Ferdinandy, Péter ; Madonna, Rosalinda ; Heymans, Stephane ; Thum, Thomas. Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.. In: Cardiovascular research, Vol. 116, no. 11, p. 1820-1834 (2020). doi:10.1093/cvr/cvaa222.
2020
Zuurbier, Coert J ; Bertrand, Luc ; Beauloye, Christophe ; Andreadou, Ioanna ; Ruiz-Meana, Marisol ; Jespersen, Nichlas R ; Kula-Alwar, Duvaraka ; Prag, Hiran A ; Eric Botker, Hans ; Dambrova, Maija ; Montessuit, Christophe ; Kaambre, Tuuli ; Liepinsh, Edgars ; Brookes, Paul S ; Krieg, Thomas. Cardiac metabolism as a driver and therapeutic target of myocardial infarction.. In: Journal of cellular and molecular medicine, Vol. 24, no. 11, p. 5937-5954 (2020). doi:10.1111/jcmm.15180.
2020
Crisafulli, Antonio ; Pagliaro, Pasquale ; Roberto, Silvana ; Cugusi, Lucia ; Mercuro, Giuseppe ; Lazou, Antigone ; Beauloye, Christophe ; Bertrand, Luc ; Hausenloy, Derek J ; Aragno, Manuela ; Penna, Claudia. Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning.. In: International journal of molecular sciences, Vol. 21, no. 8, p. 2896 [1-22] (2020). doi:10.3390/ijms21082896.
2020
Verhaegen, Carole ; Kautbally, Shakeel ; Zapareto, Diego Castanares ; Brusa, Davide ; Courtoy, Guillaume ; Aydin, Selda ; Bouzin, Caroline ; Oury, Cecile ; Bertrand, Luc ; Jacques, Pascal J ; Beauloye, Christophe ; Horman, Sandrine ; Kefer, Joelle. Early thrombogenicity of coronary stents: comparison of bioresorbable polymer sirolimus-eluting and bare metal stents in an aortic rat model.. In: American journal of cardiovascular disease, Vol. 10, no.2, p. 72-83 (2020).
2020
Penna, Claudia ; Andreadou, Ioanna ; Aragno, Manuela ; Beauloye, Christophe ; Bertrand, Luc ; Lazou, Antigone ; Falcão-Pires, Ines ; Bell, Robert ; Zuurbier, Coert J ; Pagliaro, Pasquale ; Hausenloy, Derek J. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols.. In: British journal of pharmacology, Vol. 177, no. 23, p. 5312-5335 (2020). doi:10.1111/bph.14993.
2020
Bertrand, Luc ; Auquier, Julien ; Renguet, Edith ; Ange, Marine ; Cumps, Julien ; Horman, Sandrine ; Beauloye, Christophe. Glucose transporters in cardiovascular system in health and disease. In: Pflügers Archiv - European Journal of Physiology, Vol. 472, no. 9, p. 1385-1399 (2020). doi:10.1007/s00424-020-02444-8.
2020
Montiel, Virginie ; Bella, Ramona ; Michel, Lauriane ; Esfahani, Hrag ; De Mulder, Delphine ; Robinson, Emma L ; Deglasse, Jean-Philippe ; Tiburcy, Malte ; Chow, Pak Hin ; Jonas, Jean-Christophe ; Gilon, Patrick ; Steinhorn, Benjamin ; Michel, Thomas ; Beauloye, Christophe ; Bertrand, Luc ; Farah, Charlotte ; Dei Zotti, Flavia ; Debaix, Huguette ; Bouzin, Caroline ; Brusa, Davide ; Horman, Sandrine ; Vanoverschelde, Jean-Louis ; Bergmann, Olaf ; Gilis, Dimitri ; Rooman, Marianne ; Ghigo, Alessandra ; Geninatti-Crich, Simonetta ; Yool, Andrea ; Zimmermann, Wolfram H ; Roderick, H Llewelyn ; Devuyst, Olivier ; Balligand, Jean-Luc. Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.. In: Science translational medicine, Vol. 12, no. 564, p. eaay2176 [1-16] (2020). doi:10.1126/scitranslmed.aay2176.
2020
Battault, Sylvain ; Renguet, Edith ; Van Steenbergen, Anne ; Horman, Sandrine ; Beauloye, Christophe ; Bertrand, Luc. Myocardial glucotoxicity: Mechanisms and potential therapeutic targets.. In: Archives of cardiovascular diseases, Vol. 113, no. 11, p. 736-748 (2020). doi:10.1016/j.acvd.2020.06.006.
2020
Ange, Marine ; Castanares Zapatero, Diego ; De Poortere, Julien ; Dufeys, Cécile ; Courtoy, Guillaume ; Bouzin, Caroline ; Quarck, Rozenn ; Bertrand, Luc ; Beauloye, Christophe ; Horman, Sandrine. α1AMP-Activated Protein Kinase Protects against Lipopolysaccharide-Induced Endothelial Barrier Disruption via Junctional Reinforcement and Activation of the p38 MAPK/HSP27 Pathway. In: International Journal of Molecular Sciences, Vol. 21, no. 15, p. 5581 [1-19] (2020). doi:10.3390/ijms21155581.
2019
Verhaegen, Carole ; Lepropre, Sophie ; Octave, Marie ; Brusa, Davide ; Bertrand, Luc ; Beauloye, Christophe ; Jacques, Pascal ; Kefer, Joëlle ; Horman, Sandrine. Bioreactivity of Stent Material: In Vitro Impact of New Twinning-Induced Plasticity Steel on Platelet Activation. In: Journal of Biomaterials and Nanobiotechnology, Vol. 10, no.04, p. 175-189 (2019). doi:10.4236/jbnb.2019.104010.
2019
André, Emilie ; De Pauw, Aurélia ; Verdoy, Roxane ; Brusa, Davide ; Bouzin, Caroline ; Timmermans, Aurélie ; Bertrand, Luc ; Balligand, Jean-Luc. Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase.. In: Stem cells and development, Vol. 28, no. 22, p. 1498-1513 (2019). doi:10.1089/scd.2019.0129.
2019
Kautbally, Shakeel ; Lepropre, Sophie ; Onselaer, Marie-Blanche ; Le Rigoleur, Astrid ; Ginion, Audrey ; De Meester de Ravenstein, Christophe ; Ambroise, Jerome ; Boudjeltia, Karim Z. ; Octave, Marie ; Wéra, Odile ; Hego, Alexandre ; Pincemail, Joël ; Cheramy-Bien, Jean-Paul ; Huby, Thierry ; Giera, Martin ; Gerber, Bernhard ; Pouleur, Anne-Catherine ; Guigas, Bruno ; Vanoverschelde, Jean-Louis ; Kefer, Joelle ; Bertrand, Luc ; Oury, Cécile ; Horman, Sandrine ; Beauloye, Christophe. Platelet Acetyl-CoA Carboxylase Phosphorylation A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients. In: JACC: Basic to Translational Science, Vol. 4, no.5, p. 596-610 (2019). doi:10.1016/j.jacbts.2019.04.005.
2019
Angé, Marine ; Castanares Zapatero, Diego ; Bertrand, Luc ; Horman, Sandrine ; Beauloye, Christophe. Role of AMP-activated protein kinase in sepsis-induced cardiovascular dysfunction.. In: American journal of physiology. Heart and circulatory physiology, Vol. 316, no. 4, p. H934-H935 (2019). doi:10.1152/ajpheart.00015.2019.
2020
Horman, Sandrine ; Dechamps, Mélanie ; Octave, Marie ; Lepropre, Sophie ; Bertrand, Luc ; Beauloye, Christophe. Platelet Function and Coronary Microvascular Dysfunction. In: Dorobantu Maria, Badimon Lina, Microcirculation: From bench to bedsite, Springer Nature: (Switzerland) Cham, 2020, 63-76. 978-3-030-28199-1. doi:10.1007/978-3-030-28199-1_5.