FATH
Avenue Hippocrate 57/B1.57.04
1200 Woluwe-Saint-Lambert
Olivier Feron
Professeur ordinaire
- Diploma
Year Label Educational Organization 1990 Pharmacien Université catholique de Louvain 1992 Licencié en sciences biomédicales (3ème cycle) Université catholique de Louvain 1995 Docteur en sciences pharmaceutiques Université catholique de Louvain 2004 Agrégé de l'enseignement supérieur Université catholique de Louvain
- Courses
Name ID Eléments de physiologie générale WFARM1212 Human physiology and basics of physiopathology WFARM1213 Elements of General Pathology WFARM1305 Séminaire de pharmacothérapie intégrée (1re partie) WFARM2111 Pharmacologie spéciale et éléments de pharmacothérapie 1re partie WFARM2114 Pharmacologie spéciale et éléments de pharmacothérapie 2e partie WFARM2116 Organotoxicity : molecular, cellular and functional aspects WFARM2180 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 General physiology WSBIM1201 Signalisation intercellulaire et biologie des tumeurs WSBIM2141 Cellular and molecular pathophysiology of human diseases (Part 1) WSBIM2184 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
2022
Lan, Junjie ; Cadassou, Octavia ; Corbet, Cyril ; Riant, Olivier ; Feron, Olivier. Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release. In: Cancers, Vol. 14, no.21, p. 5454 (2022). doi:10.3390/cancers14215454.
2022
Van de Gucht, Melissa ; Dufait, Inès ; Kerkhove, Lisa ; Corbet, Cyril ; de Mey, Sven ; Jiang, Heng ; Law, Ka Lun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. In: Cancers, Vol. 14, no.20, p. 5060 (2022). doi:10.3390/cancers14205060.
2022
Johanns, Manuel ; Corbet, Cyril ; Jacobs, Roxane ; Drappier, Melissa ; Bommer, Guido ; Herinckx, Gaëtan ; Vertommen, Didier ; Tajeddine, Nicolas ; Young, David ; Messens, Joris ; Feron, Olivier ; Steinberg, Gregory R ; Hue Louis ; Rider, Mark H.. Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.. In: The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022). doi:10.1042/BCJ20220170.
2022
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Camboni, Alessandra ; Feron, Olivier ; Azevedo, Ricardo Bentes ; Andrade Amorim, Christiani. Photodynamic therapy using OR141-loaded nanovesicles for eradication of leukemic cells from ovarian tissue.. In: Photodiagnosis and photodynamic therapy, Vol. 40, no.-, p. 103139 (2022). doi:10.1016/j.pdpdt.2022.103139.
2022
Deskeuvre, Marine ; Lan, Junjie ; Dierge, Emeline ; Messens, Joris ; Riant, Olivier ; Corbet, Cyril ; Feron, Olivier ; Frédérick, Raphaël. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides. In: International Journal of Pharmaceutics, Vol. 624, no.1, p. 122041 (2022). doi:10.1016/j.ijpharm.2022.122041.
2021
Valenti, Maria Teresa ; Mottes, Monica ; Dalle Carbonare, Luca ; Feron, Olivier. Editorial: Bone Metastases.. In: Frontiers in oncology, Vol. 11, p. 741515 (2021). doi:10.3389/fonc.2021.741515.
2021
Buyse, Chloé ; Joudiou, Nicolas ; Corbet, Cyril ; Feron, Olivier ; Mignion, Lionel ; Flament, Julien ; Gallez, Bernard. Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. In: Cancers, Vol. 13, no.17, p. 4278 (2021). doi:10.3390/cancers13174278.
2021
Virga, Federico ; Cappellesso, Federica ; Stijlemans, Benoit ; Henze, Anne-Theres ; Trotta, Rosa ; Van Audenaerde, Jonas ; Mirchandani, Ananda S. ; Sanchez-Garcia, Manuel A. ; Vandewalle, Jolien ; Orso, Francesca ; Riera-Domingo, Carla ; Griffa, Alberto ; Ivan, Cristina ; Smits, Evelien ; Laoui, Damya ; Martelli, Fabio ; Langouche, Lies ; Van den Berghe, Greet ; Feron, Olivier ; Ghesquière, Bart ; Prenen, Hans ; Libert, Claude ; Walmsley, Sarah R. ; Corbet, Cyril ; Van Ginderachter, Jo A. ; Ivan, Mircea ; Taverna, Daniela ; Mazzone, Massimiliano. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. In: Science Advances, Vol. 7, no.19, p. eabf0466 (2021). doi:10.1126/sciadv.abf0466.
2021
Dierge, Emeline ; Debock, Elena ; Guilbaud, Céline ; Corbet, Cyril ; Mignolet, Eric ; Mignard, Louise ; Bastien, Estelle ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. In: Cell Metabolism, Vol. S1550-4131, no.21, p. 00233-3 (2021). doi:10.1016/j.cmet.2021.05.016.
2021
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Azevedo, Ricardo Bentes ; Feron, Olivier ; Amorim, Christiani A. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 339, p. 75-90 (2021). doi:10.1016/j.jconrel.2021.09.024 (Accepté/Sous presse).
2021
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Azevedo, Ricardo Bentes ; Feron, Olivier ; Andrade Amorim, Christiani. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 339, no.-, p. 75-90 (2021). doi:10.1016/j.jconrel.2021.09.024.
2021
Vermonden, Perrine ; Vancoppenolle, Matthias ; Dierge, Emeline ; Mignolet, Eric ; Cuvelier, Géraldine ; Knoops, Bernard ; Page, Melissa ; Debier, Cathy ; Feron, Olivier ; Larondelle, Yvan. Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells. In: Nutrients, Vol. 13, no. 8, p. 2751 [1-16] (2021). doi:10.3390/nu13082751.
2021
Vander Linden, Catherine ; Corbet, Cyril ; Bastien, Estelle ; Martherus, Ruben ; Guilbaud, Céline ; Petit, Laurenne ; Wauthier, Loris ; Loriot, Axelle ; De Smet, Charles ; Feron, Olivier. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. In: Cell Reports, Vol. 35, no.9, p. 109202 (2021). doi:10.1016/j.celrep.2021.109202.
2021
Spillier, Quentin ; Ravez, Séverine ; Dochain Simon ; Vertommen, Didier ; Thabault, Léopold ; Feron, Olivier ; Frédérick, Raphaël. Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments. In: Molecules, Vol. 26, no. 2, p. 477 (2021). doi:10.3390/molecules26020477.
2020
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
2020
Trempolec, Natalia ; Degavre, Charline ; Doix, Bastien ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier. Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. In: Cancers, Vol. 12, no. 5, p. 1284 [1-17] (2020). doi:10.3390/cancers12051284.
2020
Schoonjans, Céline ; Joudiou, Nicolas ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier ; Gallez, Bernard. Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. In: Cancer Letters, Vol. 470, p. 18-28 (2020). doi:10.1016/j.canlet.2019.12.003.
2020
Dierge, Emeline ; Larondelle, Yvan ; Feron, Olivier. Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors. In: Biochimie, Vol. 178, p. 56-68 (2020). doi:10.1016/j.biochi.2020.08.020.
2020
Delprat, Victor ; Tellier, Céline ; Demazy, Catherine ; Raes, Martine ; Feron, Olivier ; Michiels, Carine. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. In: Scientific Report, Vol. 10, no. 1, p. 882 (2020).
2020
de Mey, Sven ; Dufait, Inès ; Jiang, Heng ; Corbet, Cyril ; Wang, Hui ; Van De Gucht, Melissa ; Kerkhove, Lisa ; Law, Ka Lun ; Vandenplas, Hugo ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. In: International Journal of Molecular Sciences, Vol. 21, no.24, p. 9367 (2020). doi:10.3390/ijms21249367.
2020
Fourniols, Thibaut ; Bastien, Estelle ; Canevat, Alizée ; Feron, Olivier ; Préat, Véronique. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel.. In: International journal of pharmaceutics, Vol. 584, p. 119337 (2020). doi:10.1016/j.ijpharm.2020.119337 (Accepté/Sous presse).
2020
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels, Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts.. In: Clinical cancer research, Vol. 15, no. 26(8), p. 1932-1943 (2020). doi:10.1158/1078-0432.CCR-19-1369.
2020
Gourgue, Florian ; Mignion, Lionel ; Van Hul, Matthias ; Dehaen, Natacha ; Bastien, Estelle ; Payen, Valery ; Leroy, Baptiste ; Joudiou, Nicolas ; Vertommen, Didier ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Gallez, Bernard ; Feron, Olivier ; Jordan, Bénédicte ; Cani, Patrice D.. Obesity and triple-negative-breast-cancer: Is apelin a new key target?. In: Journal of cellular and molecular medicine, Vol. 24, p. 10233-44 (2020). doi:10.1111/jcmm.15639.
2020
Trempolec, Natalia ; Doix, Bastien ; Degavre, Charline ; Brusa, Davide ; Bouzin, Caroline ; Riant, Olivier ; Feron, Olivier. Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma. In: Cancers, Vol. 12, no. 3, p. pii:E545 (2020).
2020
Ward, Jennifer A ; Pinto-Fernandez, Adan ; Cornelissen, Loïc ; Bonham, Sarah ; Díaz-Sáez, Laura ; Riant, Olivier ; Huber, Kilian V M ; Kessler, Benedikt M ; Feron, Olivier ; Tate, Edward W. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.. In: Journal of medicinal chemistry, Vol. 63, no. 7, p. 3756-3762 (2020). doi:10.1021/acs.jmedchem.0c00144.
2020
Spillier, Quentin ; Ravez, Severine ; Unterlass, Judith ; Corbet, Cyril ; Degavre, Charline ; Feron, Olivier ; Frédérick, Raphaël. Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). In: Pharmaceuticals, Vol. 13, no.2, p. 20 (2020). doi:10.3390/ph13020020.
2020
Corbet, Cyril ; Bastien, Estelle ; Santiago de Jesus, Joao Pedro ; Dierge, Emeline ; Martherus, Ruben ; Vander Linden, Catherine ; Doix, Bastien ; Degavre, Charline ; Guilbaud, Céline ; Petit, Laurenne ; Michiels, Carine ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. In: Nature Communications, Vol. 11, no.1, p. 1 (2020). doi:10.1038/s41467-019-14262-3.
2020
Schoonjans, Céline A ; Mathieu, Barbara ; Joudiou, Nicolas ; Zampieri, Luca X ; Brusa, Davide ; Sonveaux, Pierre ; Feron, Olivier ; Gallez, Bernard. Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.. In: Journal of clinical medicine, Vol. 9, no.10, p. 14pp (2020). doi:10.3390/jcm9103308.
2019
Spillier, Quentin ; Vertommen, Didier ; Séverine Ravez ; Marteau, Romain ; THÉMANS, Quentin ; Corbet, Cyril ; Feron, Olivier ; Wouters, Johan ; Frédérick, Raphaël. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. In: Scientific Reports, Vol. 9, no. 1, p. 4737 (2019).
2019
Li, Sha ; Bouchy, Sandra ; Penninckx, Sebastien ; Marega, Riccardo ; Fichera, Ornella ; Gallez, Bernard ; Feron, Olivier ; Martinive, Philippe ; HEUSKIN, Anne-Catherine ; Michiels, Carine ; Lucas, Stéphane. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy.. In: Nanomedicine (London, England), Vol. 14, p. 317-333 (2019). doi:10.2217/nnm-2018-0161.
2019
Bernard, Antoine ; Chevrier, Sandy ; Beltjens, Françoise ; Dosset, Magalie ; Viltard, Etienne ; Lagrange, Anaïs ; Derangère, Valentin ; Oudot, Alexandra ; Ghiringhelli, François ; Collin, Bertrand ; Apetoh, Lionel ; Feron, Olivier ; Chen, Suzie ; Arnould, Laurent ; Végran, Frédérique ; Boidot, Romain. Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance. In: Cancer Research, Vol. 79, no. 23, p. 5958-5970 (2019). doi:10.1158/0008-5472.CAN-19-0840.
2019
Dierge, Emeline ; Feron, Olivier. Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy.. In: Current opinion in clinical nutrition and metabolic care, Vol. 22, no.6, p. 427-433 (2019). doi:10.1097/MCO.0000000000000601.
2019
Bevernaegie, Robin ; Doix, Bastien ; Bastien, Estelles ; Diman, Aurélie ; Decottignies, Anabelle ; Feron, Olivier ; Elias, Benjamin. Exploring the phototoxicity of hypoxic active iridium(III)-based sensitizers in 3D tumor spheroids. In: Journal of the American chemical society, Vol. 141, no.46, p. 18486-18491 (2019).
2019
Doix, Bastien ; Trempolec, Natalia ; Riant, Olivier ; Feron, Olivier. Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination.. In: Frontiers in oncology, Vol. 9, p. 811 (2019). doi:10.3389/fonc.2019.00811 (Accepté/Sous presse).
2019
Wang, Hui ; Jiang, Heng ; Corbet, Cyril ; de Mey, Sven ; Law, Kalun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. In: Cancer Letters, (2019). doi:10.1016/j.canlet.2019.02.034.
2019
Strickaert Aurélie ; Corbet, Cyril ; Spinette SA ; Craciun L ; Dom G ; Andry G ; Larsimont D ; Wattiez R ; Dumont JE ; Feron, Olivier ; Maenhaut C. Reprogramming of energetic metabolism: increased expression and roles of pyruvate carboxylase in papillary thyroid cancer.. In: Thyroid, (2019). doi:10.1089/thy.2018.0435.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no. Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Aboubakar Nana, Frank ; Lecocq, Marylène ; Ladjemi, Maha Zohra ; Detry, Bruno ; Dupasquier, Sébastien ; Feron, Olivier ; Massion, Pierre P. ; Sibille, Yves ; Pilette, Charles ; Ocak, Sebahat. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer. In: Molecular Cancer Therapeutics, Vol. 18, no. 1, p. 17-27 (2019). doi:10.1158/1535-7163.mct-18-0328.
2019
Choumessi Tchewonpi, Aphrodite ; Johanns, Manuel ; Beaufay, Claire ; Herent, Marie-France ; Stroobant, Vincent ; Vertommen, Didier ; Corbet, Cyril ; Jacobs, Roxane ; Herinckx, Gaëtan ; Steinberg, Gregory R ; Feron, Olivier ; Quetin-Leclercq, Joëlle ; Rider, Mark H.. Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. In: Biochemical Journal, Vol. 476, no. 24, p. 3687-3704 (2019). doi:10.1042/BCJ20190326.
2018
de Mey, Sven ; Jiang, Heng ; Corbet, Cyril ; Wang, H. ; Dufait, Inès ; Law, Kalun ; Bastien, Estelle ; Verovski, Valeri ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption. In: Frontiers in Pharmacology, Vol. 9, p. 1073 [1-12] (2018). doi:10.3389/fphar.2018.01073.
2018
Corbet, Cyril ; Bastien, Estelle ; Draoui, Nihed ; Doix, Bastien ; Mignion, Lionel ; Jordan, Bénédicte ; Marchand, Arnaud ; Vanherck, Jean-Christophe ; Chaltin, Patrick ; Schakman, Olivier ; Becker, Holger M ; Riant, Olivier ; Feron, Olivier. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.. In: Nature Communications, Vol. 9, no.1, p. 1208 (2018). doi:10.1038/s41467-018-03525-0.
2018
Montigaud, Yoann ; Ucakar, Bernard ; Krishnamachary, Balaji ; Bhujwalla, Zaver M ; Feron, Olivier ; Préat, Véronique ; Danhier, Fabienne ; Gallez, Bernard ; Danhier, Pierre. Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer.. In: International journal of pharmaceutics, Vol. 551, no.1-2, p. 322-328 (2018). doi:10.1016/j.ijpharm.2018.09.034.
2018
de Mey, Sven ; Jiang, Heng ; Wang, Hui ; Engels, Benedikt ; Gevaert, Thierry ; Dufait, Inès ; Feron, Olivier ; Aerts, Joeri ; Verovski, Valeri ; De Ridder, Mark. Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.. In: Radiotherapy & Oncology, (2018). doi:10.1016/j.radonc.2018.04.003 (Accepté/Sous presse).
2018
Doix, Bastien ; Bastien, Estelle ; Rambaud, Alix ; Pinto, Adán ; Louis, Caroline ; Grégoire, Vincent ; Riant, Olivier ; Feron, Olivier. Preclinical Evaluation of White Led-Activated Non-porphyrinic Photosensitizer OR141 in 3D Tumor Spheroids and Mouse Skin Lesions.. In: Frontiers in oncology, Vol. 8, p. 393 (2018). doi:10.3389/fonc.2018.00393.